Genular: Defining Cellular Identity and Function

Details for: Hbegf

Gene ID: 15200

Symbol: Hbegf

Ensembl ID: ENSMUSG00000024486

Description: heparin-binding EGF-like growth factor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Egfr downregulation
(R-MMU-182971)
Egfr interacts with phospholipase c-gamma
(R-MMU-212718)
Egfr transactivation by gastrin
(R-MMU-2179392)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Gab1 signalosome
(R-MMU-180292)
G alpha (q) signalling events
(R-MMU-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-MMU-881907)
Gpcr downstream signalling
(R-MMU-388396)
Grb2 events in egfr signaling
(R-MMU-179812)
Grb2 events in erbb2 signaling
(R-MMU-1963640)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Membrane trafficking
(R-MMU-199991)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi3k events in erbb4 signaling
(R-MMU-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Ptk6 promotes hif1a stabilization
(R-MMU-8857538)
Raf/map kinase cascade
(R-MMU-5673001)
Shc1 events in egfr signaling
(R-MMU-180336)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Shc1 events in erbb4 signaling
(R-MMU-1250347)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by gpcr
(R-MMU-372790)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Vesicle-mediated transport
(R-MMU-5653656)
Angiogenesis
(GO:0001525)
Blastocyst growth
(GO:0001832)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Membrane
(GO:0016020)
Negative regulation of elastin biosynthetic process
(GO:0051545)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of wound healing
(GO:0090303)
Receptor ligand activity
(GO:0048018)
Regulation of heart contraction
(GO:0008016)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

Proheparin-binding EGF-like growth factor

Genular Protein ID: 267108726

Symbol: HBEGF_MOUSE

Name: Proheparin-binding EGF-like growth factor

UniProtKB Accession Codes:

Q06186

Database IDs:

Citations:

PubMed ID: 7678488

Title: Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues.

PubMed ID: 7678488

DOI: 10.1006/bbrc.1993.1020

PubMed ID: 8647467

Title: Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor.

PubMed ID: 8647467

DOI: 10.1016/0378-1119(95)00861-6

Sequence Information:

Length: 208
Mass: 22808
Checksum: 7086934E23D25F8E
Sequence:

MKLLPSVMLK LFLAAVLSAL VTGESLERLR RGLAAATSNP DPPTGSTNQL LPTGGDRAQG 
VQDLEGTDLN LFKVAFSSKP QGLATPSKER NGKKKKKGKG LGKKRDPCLR KYKDYCIHGE 
CRYLQEFRTP SCKCLPGYHG HRCHGLTLPV ENPLYTYDHT TVLAVVAVVL SSVCLLVIVG 
LLMFRYHRRG GYDLESEEKV KLGVASSH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.