Genular: Defining Cellular Identity and Function

Details for: Hells

Gene ID: 15201

Symbol: Hells

Ensembl ID: ENSMUSG00000025001

Description: helicase, lymphoid specific

Associated with

Apoptotic process
(GO:0006915)
Atp-dependent chromatin remodeler activity
(GO:0140658)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin binding
(GO:0003682)
Chromosome, centromeric region
(GO:0000775)
Dna methylation
(GO:0006306)
Dna methylation-dependent heterochromatin formation
(GO:0006346)
Helicase activity
(GO:0004386)
Heterochromatin formation
(GO:0031507)
Hydrolase activity
(GO:0016787)
Kidney development
(GO:0001822)
Lymphocyte differentiation
(GO:0030098)
Lymphocyte proliferation
(GO:0046651)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression via cpg island methylation
(GO:0044027)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Pericentric heterochromatin
(GO:0005721)
Pericentric heterochromatin formation
(GO:0031508)
Protein binding
(GO:0005515)
Urogenital system development
(GO:0001655)

Other Information

Proteins

Lymphocyte-specific helicase

Genular Protein ID: 3050446302

Symbol: HELLS_MOUSE

Name: Lymphocyte-specific helicase

UniProtKB Accession Codes:

Q60848 Q497T3 Q8VDZ1 Q9CYV7

Database IDs:

Citations:

PubMed ID: 8647447

Title: A novel putative helicase produced in early murine lymphocytes.

PubMed ID: 8647447

DOI: 10.1016/0378-1119(95)00843-8

PubMed ID: 11357197

Title: An SNF2 factor involved in mammalian development and cellular proliferation.

PubMed ID: 11357197

DOI: 10.1002/dvdy.1128

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9878251

Title: Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).

PubMed ID: 9878251

DOI: 10.1006/geno.1998.5557

PubMed ID: 10781083

Title: Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes.

PubMed ID: 10781083

DOI: 10.1073/pnas.97.9.4772

PubMed ID: 11325543

Title: Lsh, a SNF2 family member, is required for normal murine development.

PubMed ID: 11325543

DOI: 10.1016/s0304-4165(01)00129-5

PubMed ID: 11711429

Title: Lsh, a member of the SNF2 family, is required for genome-wide methylation.

PubMed ID: 11711429

DOI: 10.1101/gad.929101

PubMed ID: 14517253

Title: Lsh, a modulator of CpG methylation, is crucial for normal histone methylation.

PubMed ID: 14517253

DOI: 10.1093/emboj/cdg493

PubMed ID: 14612388

Title: Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin.

PubMed ID: 14612388

DOI: 10.1128/mcb.23.23.8416-8428.2003

PubMed ID: 15105378

Title: Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.

PubMed ID: 15105378

DOI: 10.1101/gad.1176104

PubMed ID: 15647320

Title: Lsh controls silencing of the imprinted Cdkn1c gene.

PubMed ID: 15647320

DOI: 10.1242/dev.01612

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 821
Mass: 95126
Checksum: 8DEC2F2EEFBBD2F5
Sequence:

MAEQTEPAVI TPAMLEEEEQ LEAAGLEKER KMLEEAQKSW DRESTEIRYR RLQHLLEKSN 
IYSKFLLTKM EQQQLEEQKK KEKLEKKKRS LKLTEGKSLV DGNGEKPVMK KKRGREDESY 
NISEVMSKEE ILSVAKKHKD NEDESSSTTS LCVEDIQKNK DSNSMIKDRL SQTVRQNSKF 
FFDPVRKCNG QPVPFQQPKH FTGGVMRWYQ VEGMEWLRML WENGINGILA DEMGLGKTVQ 
CIATIALMIQ RGVPGPFLVC GPLSTLPNWM AEFKRFTPEI PTLLYHGTRE DRRKLVKNIH 
KRQGTLQIHP VVVTSFEIAM RDQNALQHCY WKYLIVDEGH RIKNMKCRLI RELKRFNADN 
KLLLTGTPLQ NNLSELWSLL NFLLPDVFDD LKSFESWFDI TSLSETAEDI IAKEREQNVL 
HMLHQILTPF LLRRLKSDVA LEVPPKREVV VYAPLCNKQE IFYTAIVNRT IANMFGSCEK 
ETVELSPTGR PKRRSRKSIN YSELDQFPSE LEKLISQIQP EVNRERTVVE GNIPIESEVN 
LKLRNIMMLL RKCCNHPYMI EYPIDPVTQE FKIDEELVTN SGKFLILDRM LPELKKRGHK 
VLVFSQMTSM LDILMDYCHL RNFIFSRLDG SMSYSEREKN IYSFNTDPDV FLFLVSTRAG 
GLGINLTAAD TVIIYDSDWN PQSDLQAQDR CHRIGQTKPV VVYRLVTANT IDQKIVERAA 
AKRKLEKLII HKNHFKGGQS GLSQSKNFLD AKELMELLKS RDYEREVKGS REKVISDEDL 
ELLLDRSDLI DQMKASRPIK GKTGIFKILE NSEDSSAECL F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hells

Associated with

Other Information

A novel putative helicase produced in early murine lymphocytes. PubMed ID: 8647447

An SNF2 factor involved in mammalian development and cellular proliferation. PubMed ID: 11357197

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh). PubMed ID: 9878251

Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. PubMed ID: 10781083

Lsh, a SNF2 family member, is required for normal murine development. PubMed ID: 11325543

Lsh, a member of the SNF2 family, is required for genome-wide methylation. PubMed ID: 11711429

Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. PubMed ID: 14517253

Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. PubMed ID: 14612388

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. PubMed ID: 15105378

Lsh controls silencing of the imprinted Cdkn1c gene. PubMed ID: 15647320

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079