Genular: Defining Cellular Identity and Function

Details for: Hes1

Gene ID: 15205

Symbol: Hes1

Ensembl ID: ENSMUSG00000022528

Description: hes family bHLH transcription factor 1

Associated with

Adenohypophysis development
(GO:0021984)
Amacrine cell differentiation
(GO:0035881)
Anterior/posterior pattern specification
(GO:0009952)
Aorta morphogenesis
(GO:0035909)
Ascending aorta morphogenesis
(GO:0035910)
Bmp signaling pathway
(GO:0030509)
Cajal-retzius cell differentiation
(GO:0021870)
Cell adhesion
(GO:0007155)
Cell fate commitment
(GO:0045165)
Cell fate determination
(GO:0001709)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity
(GO:0001217)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Embryonic heart tube morphogenesis
(GO:0003143)
Forebrain radial glial cell differentiation
(GO:0021861)
Hair cell differentiation
(GO:0035315)
Hindbrain morphogenesis
(GO:0021575)
Histone deacetylase binding
(GO:0042826)
Hlh domain binding
(GO:0043398)
Identical protein binding
(GO:0042802)
Inhibition of neuroepithelial cell differentiation
(GO:0002085)
Inner ear auditory receptor cell differentiation
(GO:0042491)
In utero embryonic development
(GO:0001701)
Jun kinase binding
(GO:0008432)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Midbrain-hindbrain boundary morphogenesis
(GO:0021555)
Midbrain development
(GO:0030901)
N-box binding
(GO:0071820)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of inner ear auditory receptor cell differentiation
(GO:0045608)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube development
(GO:0021915)
Neuron differentiation
(GO:0030182)
Notch signaling pathway
(GO:0007219)
Oculomotor nerve development
(GO:0021557)
Outflow tract morphogenesis
(GO:0003151)
Pancreas development
(GO:0031016)
Pancreatic a cell differentiation
(GO:0003310)
Pattern specification process
(GO:0007389)
Pituitary gland development
(GO:0021983)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glial cell differentiation
(GO:0045687)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of neuron differentiation
(GO:0045664)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of secondary heart field cardioblast proliferation
(GO:0003266)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smoothened signaling pathway
(GO:0007224)
Somatic stem cell population maintenance
(GO:0035019)
T cell proliferation
(GO:0042098)
Telencephalon development
(GO:0021537)
Transcription corepressor binding
(GO:0001222)
Trochlear nerve development
(GO:0021558)
Ventricular septum development
(GO:0003281)

Other Information

Proteins

Transcription factor HES-1

Genular Protein ID: 3670955971

Symbol: HES1_MOUSE

Name: Transcription factor HES-1

UniProtKB Accession Codes:

P35428

Database IDs:

Citations:

PubMed ID: 7906273

Title: Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.

PubMed ID: 7906273

DOI: 10.1016/s0021-9258(17)37668-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9874198

Title: Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.

PubMed ID: 9874198

DOI: 10.1046/j.1432-1327.1998.2580339.x

PubMed ID: 10851137

Title: The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.

PubMed ID: 10851137

DOI: 10.1242/dev.127.13.2933

Sequence Information:

Length: 282
Mass: 29749
Checksum: 88C7700C5EF7DA26
Sequence:

MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI NESLSQLKTL 
ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL STDPSVLGKY RAGFSECMNE 
VTRFLSTCEG VNTEVRTRLL GHLANCMTQI NAMTYPGQAH PALQAPPPPP PSGPAGPQHA 
PFAPPPPPLV PIPGGAAPPP GSAPCKLGSQ AGEAAKVFGG FQVVPAPDGQ FAFLIPNGAF 
AHSGPVIPVY TSNSGTSVGP NAVSPSSGSS LTSDSMWRPW RN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hes1

Associated with

Other Information

Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. PubMed ID: 7906273

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. PubMed ID: 9874198

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. PubMed ID: 10851137

Database document:

PubMed ID: 7906273

PubMed ID: 15489334

PubMed ID: 9874198

PubMed ID: 10851137