Details for: Hes5

Gene ID: 15208

Symbol: Hes5

Ensembl ID: ENSMUSG00000048001

Description: hes family bHLH transcription factor 5

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Astrocyte differentiation
    (GO:0048708)
  • Bmp signaling pathway
    (GO:0030509)
  • Brain development
    (GO:0007420)
  • Camera-type eye development
    (GO:0043010)
  • Cartilage development
    (GO:0051216)
  • Cell adhesion
    (GO:0007155)
  • Cell differentiation
    (GO:0030154)
  • Cell maturation
    (GO:0048469)
  • Central nervous system myelination
    (GO:0022010)
  • Chondrocyte differentiation
    (GO:0002062)
  • Chromatin binding
    (GO:0003682)
  • Comma-shaped body morphogenesis
    (GO:0072049)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Establishment of epithelial cell polarity
    (GO:0090162)
  • Forebrain radial glial cell differentiation
    (GO:0021861)
  • Glial cell fate commitment
    (GO:0021781)
  • Inner ear auditory receptor cell differentiation
    (GO:0042491)
  • Inner ear receptor cell stereocilium organization
    (GO:0060122)
  • Metanephric nephron tubule morphogenesis
    (GO:0072282)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of astrocyte differentiation
    (GO:0048712)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of forebrain neuron differentiation
    (GO:2000978)
  • Negative regulation of inner ear auditory receptor cell differentiation
    (GO:0045608)
  • Negative regulation of inner ear receptor cell differentiation
    (GO:2000981)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of oligodendrocyte differentiation
    (GO:0048715)
  • Negative regulation of pro-b cell differentiation
    (GO:2000974)
  • Negative regulation of stem cell differentiation
    (GO:2000737)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Neural tube development
    (GO:0021915)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Neuron differentiation
    (GO:0030182)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte development
    (GO:0014003)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of notch signaling pathway
    (GO:0045747)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of myelination
    (GO:0031641)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of neuron differentiation
    (GO:0045664)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • S-shaped body morphogenesis
    (GO:0072050)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Smoothened signaling pathway
    (GO:0007224)
  • Specification of loop of henle identity
    (GO:0072086)
  • Telencephalon development
    (GO:0021537)

Other Information

Genular Protein ID: 448491147

Symbol: HES5_MOUSE

Name: Transcription factor HES-5

UniProtKB Accession Codes:

P70120 Q8BVI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 ELM 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 60 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7836401

Title: Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element.

PubMed ID: 7836401

DOI: 10.1074/jbc.270.3.1342

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 23160044

Title: BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.

PubMed ID: 23160044

DOI: 10.1038/nn.3264

Sequence Information:

  • Length: 167
  • Mass: 18425
  • Checksum: CA0E697094F4E760
  • Sequence:
    • MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD 
ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV QFLTLHAASD TQMKLLYHFQ 
RPPAPAAPAK EPPAPGAAPQ PARSSAKAAA AAVSTSRQPA CGLWRPW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.