Details for: CTSW

Gene ID: 1521

Symbol: CTSW

Ensembl ID: ENSG00000172543

Description: cathepsin W

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.0124
    Cell Significance Index: -12.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.9283
    Cell Significance Index: -20.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.7586
    Cell Significance Index: -21.4800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 32.6386
    Cell Significance Index: 87.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.6669
    Cell Significance Index: -15.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9922
    Cell Significance Index: -12.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.0526
    Cell Significance Index: 248.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5580
    Cell Significance Index: -14.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3828
    Cell Significance Index: -10.3900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.2980
    Cell Significance Index: 14.6700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 2.2069
    Cell Significance Index: 5.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1060
    Cell Significance Index: 45.6300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.9446
    Cell Significance Index: 20.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5939
    Cell Significance Index: 72.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3877
    Cell Significance Index: 21.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1863
    Cell Significance Index: 225.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0210
    Cell Significance Index: 101.0000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.8532
    Cell Significance Index: 5.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7792
    Cell Significance Index: 703.5900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.6240
    Cell Significance Index: 6.4700
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.5033
    Cell Significance Index: 4.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4880
    Cell Significance Index: 79.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4818
    Cell Significance Index: 7.2600
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.4535
    Cell Significance Index: 2.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4151
    Cell Significance Index: 12.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3502
    Cell Significance Index: 22.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3426
    Cell Significance Index: 37.2600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.2349
    Cell Significance Index: 2.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1896
    Cell Significance Index: 1.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1683
    Cell Significance Index: 3.5900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.1425
    Cell Significance Index: 1.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1103
    Cell Significance Index: 7.6300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1001
    Cell Significance Index: 0.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0700
    Cell Significance Index: 0.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0525
    Cell Significance Index: 1.4100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0472
    Cell Significance Index: 0.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0024
    Cell Significance Index: -0.1200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0037
    Cell Significance Index: -0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0059
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0098
    Cell Significance Index: -0.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0110
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.2700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0153
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0155
    Cell Significance Index: -9.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0214
    Cell Significance Index: -9.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0246
    Cell Significance Index: -18.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0254
    Cell Significance Index: -13.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0292
    Cell Significance Index: -1.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0328
    Cell Significance Index: -5.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0341
    Cell Significance Index: -21.6600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0413
    Cell Significance Index: -0.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0421
    Cell Significance Index: -15.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0434
    Cell Significance Index: -19.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0461
    Cell Significance Index: -9.7100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0535
    Cell Significance Index: -0.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0571
    Cell Significance Index: -1.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0633
    Cell Significance Index: -3.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0678
    Cell Significance Index: -13.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0684
    Cell Significance Index: -13.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0713
    Cell Significance Index: -4.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0759
    Cell Significance Index: -21.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0776
    Cell Significance Index: -13.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0781
    Cell Significance Index: -0.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0860
    Cell Significance Index: -1.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0878
    Cell Significance Index: -12.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0926
    Cell Significance Index: -1.9200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0985
    Cell Significance Index: -1.3400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1001
    Cell Significance Index: -1.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1005
    Cell Significance Index: -12.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1067
    Cell Significance Index: -13.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1165
    Cell Significance Index: -13.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1166
    Cell Significance Index: -13.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1296
    Cell Significance Index: -6.0900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1314
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1341
    Cell Significance Index: -13.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1364
    Cell Significance Index: -9.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1420
    Cell Significance Index: -18.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1426
    Cell Significance Index: -16.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1490
    Cell Significance Index: -21.6600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1896
    Cell Significance Index: -2.1000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1901
    Cell Significance Index: -1.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2095
    Cell Significance Index: -16.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2101
    Cell Significance Index: -3.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2299
    Cell Significance Index: -15.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2422
    Cell Significance Index: -6.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2486
    Cell Significance Index: -18.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2661
    Cell Significance Index: -6.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2767
    Cell Significance Index: -17.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2886
    Cell Significance Index: -18.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3174
    Cell Significance Index: -17.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Cathepsin W is a 47-kDa protein, encoded by the CTSW gene in humans. It belongs to the cathepsin family, characterized by its lysosomal localization and cysteine protease activity. CTSW exhibits a broad substrate specificity, cleaving a wide range of proteins, including structural proteins, cytokines, and growth factors. Its expression is highly regulated, with significant levels observed in various immune cells, including natural killer cells, T cells, and platelets. **Pathways and Functions:** CTSW is involved in multiple signaling pathways that regulate immune responses, hemostasis, and cell growth. Some of the key pathways include: 1. **Immune Response:** CTSW is expressed on the surface of immune cells, such as natural killer cells and T cells, where it modulates their activity and cytokine production. 2. **Hemostasis:** CTSW plays a role in platelet activation and aggregation, influencing thrombus formation and resolution. 3. **Cell Signaling:** CTSW interacts with various signaling molecules, including growth factors, cytokines, and chemokines, to regulate cell growth, differentiation, and survival. 4. **Proteolysis:** CTSW is involved in protein degradation, breaking down structural proteins, cytokines, and growth factors, which regulates immune responses and tissue homeostasis. **Clinical Significance:** Dysregulation of CTSW has been implicated in various diseases, including: 1. **Immunodeficiency:** Altered expression of CTSW in immune cells can lead to impaired immune function and increased susceptibility to infections. 2. **Cancer:** Overexpression of CTSW has been observed in various cancers, where it promotes tumor growth, invasion, and metastasis. 3. **Thrombotic Disorders:** Abnormal CTSW activity can contribute to thrombosis and hemostatic disorders. 4. **Neurological Diseases:** CTSW has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CTSW is a multifunctional protein that plays a critical role in regulating immune responses, hemostasis, and cell growth. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying CTSW function and its involvement in human disease.

Genular Protein ID: 3802744878

Symbol: CATW_HUMAN

Name: Cathepsin W

UniProtKB Accession Codes:

P56202 Q86VT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9823953

Title: Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.

PubMed ID: 9823953

DOI: 10.1038/sj.leu.2401164

PubMed ID: 9108299

Title: Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes.

PubMed ID: 9108299

DOI: 10.1016/s0014-5793(97)00118-x

PubMed ID: 9675123

Title: Genomic structure, chromosomal localization, and expression of human cathepsin W.

PubMed ID: 9675123

DOI: 10.1006/bbrc.1998.8954

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11490002

Title: Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.

PubMed ID: 11490002

DOI: 10.4049/jimmunol.167.4.2172

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 26060270

Title: Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes.

PubMed ID: 26060270

DOI: 10.1128/mbio.00297-15

Sequence Information:

  • Length: 376
  • Mass: 42120
  • Checksum: D2956524D17B593A
  • Sequence:
    • MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN RSYLSPEEHA 
HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG QLYGYRRAAG GVPSMGREIR 
SEEPEESVPF SCDWRKVASA ISPIKDQKNC NCCWAMAAAG NIETLWRISF WDFVDVSVQE 
LLDCGRCGDG CHGGFVWDAF ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF 
IMLQNNEHRI AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS 
VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN TCGITKFPLT 
ARVQKPDMKP RVSCPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.