Gene CTSW - ENSG00000172543 | NCBI Gene ID: 1521

Details for: CTSW

Gene ID: 1521

Symbol: CTSW

Ensembl ID: ENSG00000172543

Description: cathepsin W

Associated with

Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Platelet dense granule lumen
(GO:0031089)
Proteolysis involved in protein catabolic process
(GO:0051603)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.38
Marker Score: 4306
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.11
Marker Score: 14918
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.53
Marker Score: 12503
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.5
Marker Score: 14212
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.11
Marker Score: 6054
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.6
Marker Score: 10108
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.31
Marker Score: 3198
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.26
Marker Score: 1061
Cell Name: mature T cell (CL0002419)
Fold Change: 3.22
Marker Score: 31920
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 3.19
Marker Score: 1051
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.19
Marker Score: 1758
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.13
Marker Score: 1349
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.02
Marker Score: 2687
Cell Name: ILC1, human (CL0001077)
Fold Change: 2.84
Marker Score: 721
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.64
Marker Score: 2220
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.47
Marker Score: 1521
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.42
Marker Score: 9908
Cell Name: late promyelocyte (CL0002151)
Fold Change: 2.28
Marker Score: 571
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.07
Marker Score: 639
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.07
Marker Score: 1501
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.99
Marker Score: 2750.5
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.91
Marker Score: 591
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.76
Marker Score: 566
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.76
Marker Score: 1278
Cell Name: blood cell (CL0000081)
Fold Change: 1.74
Marker Score: 20212
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.71
Marker Score: 835
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 1.7
Marker Score: 1888
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.61
Marker Score: 924
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.59
Marker Score: 360
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1150
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.52
Marker Score: 2977
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.43
Marker Score: 499
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.42
Marker Score: 2544
Cell Name: basophil (CL0000767)
Fold Change: 1.42
Marker Score: 673
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4
Marker Score: 1394
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.39
Marker Score: 815
Cell Name: memory T cell (CL0000813)
Fold Change: 1.38
Marker Score: 595
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.3
Marker Score: 5587
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.27
Marker Score: 1793
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.26
Marker Score: 1068
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.25
Marker Score: 967
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.24
Marker Score: 838
Cell Name: natural killer cell (CL0000623)
Fold Change: 1.23
Marker Score: 1589
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.21
Marker Score: 947
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.19
Marker Score: 714
Cell Name: Unknown (CL0000548)
Fold Change: 1.17
Marker Score: 849
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.15
Marker Score: 478
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.15
Marker Score: 727
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4780
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 1.09
Marker Score: 1769
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.06
Marker Score: 519
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.03
Marker Score: 356
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.02
Marker Score: 367
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.02
Marker Score: 514
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.02
Marker Score: 284
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71774
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48001
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1
Marker Score: 512
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.98
Marker Score: 661
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.96
Marker Score: 784
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.94
Marker Score: 495
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5231
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2730
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.91
Marker Score: 381
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.9
Marker Score: 791
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.89
Marker Score: 46883
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.89
Marker Score: 963
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5274
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.86
Marker Score: 358
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.85
Marker Score: 800
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.81
Marker Score: 555
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.81
Marker Score: 595
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.81
Marker Score: 373
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.78
Marker Score: 797.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1246
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 586
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 697
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.73
Marker Score: 1378
Cell Name: myelocyte (CL0002193)
Fold Change: 0.72
Marker Score: 311
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 454
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.71
Marker Score: 187
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.69
Marker Score: 17658
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.68
Marker Score: 10707
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.67
Marker Score: 330
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.67
Marker Score: 505
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.65
Marker Score: 1588
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.65
Marker Score: 324
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.65
Marker Score: 297
Cell Name: mast cell (CL0000097)
Fold Change: 0.63
Marker Score: 367
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.62
Marker Score: 674
Cell Name: oocyte (CL0000023)
Fold Change: 0.62
Marker Score: 154
Cell Name: platelet (CL0000233)
Fold Change: 0.61
Marker Score: 274

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**Key characteristics:** - Cathepsin W is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in immune cells, including neutrophils, macrophages, dendritic cells, and platelets. - Cathepsin W is a protease that is involved in the regulation of inflammation, immune responses, and platelet activation. **Pathways and functions:** - Cathepsin W is involved in the regulation of inflammation by cleaving various cytokines and chemokines, including tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8. - It also plays a role in the regulation of immune responses by cleaving immune checkpoint molecules, such as PD-L1 and CD80. - Cathepsin W is involved in the activation of platelets by cleaving factors such as von Willebrand factor and factor VIII. This activation leads to the formation of platelet aggregates, which are involved in hemostasis and immune responses. **Clinical significance:** - Cathepsin W is a potential therapeutic target for a variety of diseases, including cancer, inflammation, and autoimmune disorders. - In cancer, cathepsin W is overexpressed in many tumor cells, which can lead to tumor growth and metastasis. - Inhibition of cathepsin W can inhibit tumor growth and metastasis. **Additional notes:** - Cathepsin W is a highly conserved protein that is found in humans, mice, and rats. - It is a secreted protein that is present in the plasma and extracellular space. - Cathepsin W is a protease that is involved in a variety of cellular processes, including inflammation, immune responses, and platelet activation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cathepsin W

Genular Protein ID: 3802744878

Symbol: CATW_HUMAN

Name: Cathepsin W

UniProtKB Accession Codes:

P56202 Q86VT4

Database IDs:

Citations:

PubMed ID: 9823953

Title: Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.

PubMed ID: 9823953

DOI: 10.1038/sj.leu.2401164

PubMed ID: 9108299

Title: Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes.

PubMed ID: 9108299

DOI: 10.1016/s0014-5793(97)00118-x

PubMed ID: 9675123

Title: Genomic structure, chromosomal localization, and expression of human cathepsin W.

PubMed ID: 9675123

DOI: 10.1006/bbrc.1998.8954

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11490002

Title: Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.

PubMed ID: 11490002

DOI: 10.4049/jimmunol.167.4.2172

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 26060270

Title: Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes.

PubMed ID: 26060270

DOI: 10.1128/mbio.00297-15

Sequence Information:

Length: 376
Mass: 42120
Checksum: D2956524D17B593A
Sequence:

MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN RSYLSPEEHA 
HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG QLYGYRRAAG GVPSMGREIR 
SEEPEESVPF SCDWRKVASA ISPIKDQKNC NCCWAMAAAG NIETLWRISF WDFVDVSVQE 
LLDCGRCGDG CHGGFVWDAF ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF 
IMLQNNEHRI AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS 
VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN TCGITKFPLT 
ARVQKPDMKP RVSCPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CTSW

Associated with

Cells (max top 100)

Other Information

Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. PubMed ID: 9823953

Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. PubMed ID: 9108299

Genomic structure, chromosomal localization, and expression of human cathepsin W. PubMed ID: 9675123

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. PubMed ID: 11490002

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes. PubMed ID: 26060270