Details for: Hey2

Gene ID: 15214

Symbol: Hey2

Ensembl ID: ENSMUSG00000019789

Description: hairy/enhancer-of-split related with YRPW motif 2

Associated with

  • Anterior/posterior axis specification
    (GO:0009948)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Aortic valve morphogenesis
    (GO:0003180)
  • Arterial endothelial cell differentiation
    (GO:0060842)
  • Artery development
    (GO:0060840)
  • Ascending aorta morphogenesis
    (GO:0035910)
  • Atrial septum morphogenesis
    (GO:0060413)
  • Atrioventricular valve development
    (GO:0003171)
  • Blood vessel development
    (GO:0001568)
  • Blood vessel endothelial cell differentiation
    (GO:0060837)
  • Cardiac epithelial to mesenchymal transition
    (GO:0060317)
  • Cardiac left ventricle morphogenesis
    (GO:0003214)
  • Cardiac muscle cell apoptotic process
    (GO:0010659)
  • Cardiac muscle cell proliferation
    (GO:0060038)
  • Cardiac muscle hypertrophy
    (GO:0003300)
  • Cardiac muscle hypertrophy in response to stress
    (GO:0014898)
  • Cardiac right ventricle morphogenesis
    (GO:0003215)
  • Cardiac septum morphogenesis
    (GO:0060411)
  • Cardiac vascular smooth muscle cell development
    (GO:0060948)
  • Cardiac ventricle morphogenesis
    (GO:0003208)
  • Cell fate commitment
    (GO:0045165)
  • Circulatory system development
    (GO:0072359)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cochlea development
    (GO:0090102)
  • Coronary vasculature morphogenesis
    (GO:0060977)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Dorsal aorta morphogenesis
    (GO:0035912)
  • Endocardial cushion to mesenchymal transition involved in heart valve formation
    (GO:0003199)
  • Heart trabecula formation
    (GO:0060347)
  • Histone deacetylase binding
    (GO:0042826)
  • Identical protein binding
    (GO:0042802)
  • Labyrinthine layer blood vessel development
    (GO:0060716)
  • Mesenchymal cell development
    (GO:0014031)
  • Multicellular organism development
    (GO:0007275)
  • Muscular septum morphogenesis
    (GO:0003150)
  • Negative regulation of biomineral tissue development
    (GO:0070168)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cardiac vascular smooth muscle cell differentiation
    (GO:2000723)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of smooth muscle cell differentiation
    (GO:0051151)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription initiation by rna polymerase ii
    (GO:0060633)
  • Negative regulation of transcription regulatory region dna binding
    (GO:2000678)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Pattern specification process
    (GO:0007389)
  • Positive regulation of cardiac muscle cell proliferation
    (GO:0060045)
  • Positive regulation of heart rate
    (GO:0010460)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-dna complex assembly
    (GO:0065004)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Pulmonary artery morphogenesis
    (GO:0061156)
  • Pulmonary valve morphogenesis
    (GO:0003184)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of inner ear auditory receptor cell differentiation
    (GO:0045607)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of vasculogenesis
    (GO:2001212)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator complex
    (GO:0005667)
  • Transcription repressor complex
    (GO:0017053)
  • Tricuspid valve formation
    (GO:0003195)
  • Tricuspid valve morphogenesis
    (GO:0003186)
  • Umbilical cord morphogenesis
    (GO:0036304)
  • Vasculogenesis
    (GO:0001570)
  • Ventricular cardiac muscle cell development
    (GO:0055015)
  • Ventricular septum morphogenesis
    (GO:0060412)
  • Ventricular trabecula myocardium morphogenesis
    (GO:0003222)

Other Information

Genular Protein ID: 3438954450

Symbol: HEY2_MOUSE

Name: Hairy/enhancer-of-split related with YRPW motif protein 2

UniProtKB Accession Codes:

Q9QUS4 Q3TZ99 Q8CD44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 77 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10588864

Title: HRT1, HRT2 and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments.

PubMed ID: 10588864

DOI: 10.1006/dbio.1999.9454

PubMed ID: 10860664

Title: Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.

PubMed ID: 10860664

DOI: 10.1006/geno.2000.6200

PubMed ID: 10692439

Title: Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.

PubMed ID: 10692439

DOI: 10.1074/jbc.275.9.6381

PubMed ID: 11486044

Title: HERP, a new primary target of Notch regulated by ligand binding.

PubMed ID: 11486044

DOI: 10.1128/mcb.21.17.6071-6079.2001

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10415358

Title: Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis.

PubMed ID: 10415358

DOI: 10.1016/s0925-4773(99)00080-5

PubMed ID: 10964718

Title: Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.

PubMed ID: 10964718

DOI: 10.1006/bbrc.2000.3354

PubMed ID: 11095750

Title: Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.

PubMed ID: 11095750

DOI: 10.1073/pnas.250485597

PubMed ID: 11160397

Title: The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.

PubMed ID: 11160397

DOI: 10.1523/jneurosci.21-04-01265.2001

PubMed ID: 11486045

Title: HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.

PubMed ID: 11486045

DOI: 10.1128/mcb.21.17.6080-6089.2001

PubMed ID: 12372253

Title: Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice.

PubMed ID: 12372253

DOI: 10.1016/s0960-9822(02)01150-8

PubMed ID: 12372254

Title: Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.

PubMed ID: 12372254

DOI: 10.1016/s0960-9822(02)01149-1

PubMed ID: 11741889

Title: HERP1 is a cell type-specific primary target of Notch.

PubMed ID: 11741889

DOI: 10.1074/jbc.m110495200

PubMed ID: 12454287

Title: Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

PubMed ID: 12454287

DOI: 10.1073/pnas.252648999

PubMed ID: 12947105

Title: The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.

PubMed ID: 12947105

DOI: 10.1074/jbc.m300448200

PubMed ID: 15345511

Title: Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro.

PubMed ID: 15345511

DOI: 10.1161/01.atv.0000143936.77094.a4

PubMed ID: 15297376

Title: Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction.

PubMed ID: 15297376

DOI: 10.1161/01.res.0000141136.85194.f0

PubMed ID: 15107403

Title: The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.

PubMed ID: 15107403

DOI: 10.1101/gad.291004

PubMed ID: 15485867

Title: Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.

PubMed ID: 15485867

DOI: 10.1074/jbc.m409879200

PubMed ID: 15680351

Title: Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system.

PubMed ID: 15680351

DOI: 10.1016/j.ydbio.2004.10.025

PubMed ID: 16199874

Title: Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.

PubMed ID: 16199874

DOI: 10.1128/mcb.25.20.8960-8970.2005

PubMed ID: 17332425

Title: CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression.

PubMed ID: 17332425

DOI: 10.1161/01.res.0000261693.13269.bf

PubMed ID: 17303760

Title: Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

PubMed ID: 17303760

DOI: 10.1161/01.res.0000260913.95642.3b

PubMed ID: 17259303

Title: Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2.

PubMed ID: 17259303

DOI: 10.1242/dev.02777

Sequence Information:

  • Length: 339
  • Mass: 35873
  • Checksum: 105BEEA06DE50444
  • Sequence:
    • MKRPCEETTS ESDLDETIDV GSENNYPGHA TSSVMRSNSP TTTSQIMARK KRRGIIEKRR 
RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG YFDAHALATD 
FMSIGFRECL TEVARYLSSV EGLDPSDPLR VRLVSHLSTC ASQREAAVMT SSMAHHHHPL 
HPHHWAAAFH HLPTALLQPN GLHTSESTPC RLSTSSEVPS AHGSALLTAT FAHADSALRM 
PSGGTVAPCV PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA 
AATAISPPLS VSAASSPQQT STGTNNKPYQ PWGTEVGAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.