Details for: Hfe

Gene ID: 15216

Symbol: Hfe

Ensembl ID: ENSMUSG00000006611

Description: homeostatic iron regulator

Associated with

  • Iron uptake and transport
    (R-MMU-917937)
  • Transferrin endocytosis and recycling
    (R-MMU-917977)
  • Transport of small molecules
    (R-MMU-382551)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Apical part of cell
    (GO:0045177)
  • Basal part of cell
    (GO:0045178)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Bmp signaling pathway
    (GO:0030509)
  • Cellular response to iron ion
    (GO:0071281)
  • Co-receptor binding
    (GO:0039706)
  • Cytoplasmic vesicle
    (GO:0031410)
  • Early endosome
    (GO:0005769)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Hfe-transferrin receptor complex
    (GO:1990712)
  • Hormone biosynthetic process
    (GO:0042446)
  • Intracellular iron ion homeostasis
    (GO:0006879)
  • Iron ion transport
    (GO:0006826)
  • Membrane
    (GO:0016020)
  • Monoatomic ion transport
    (GO:0006811)
  • Multicellular organismal-level iron ion homeostasis
    (GO:0060586)
  • Negative regulation of antigen processing and presentation of endogenous peptide antigen via mhc class i
    (GO:1904283)
  • Negative regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001186)
  • Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032435)
  • Negative regulation of receptor binding
    (GO:1900121)
  • Negative regulation of signaling receptor activity
    (GO:2000272)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of ubiquitin-dependent protein catabolic process
    (GO:2000059)
  • Nucleoplasm
    (GO:0005654)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of ferrous iron binding
    (GO:1904434)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of peptide hormone secretion
    (GO:0090277)
  • Positive regulation of protein binding
    (GO:0032092)
  • Positive regulation of receptor-mediated endocytosis
    (GO:0048260)
  • Positive regulation of receptor binding
    (GO:1900122)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of transferrin receptor binding
    (GO:1904437)
  • Recycling endosome
    (GO:0055037)
  • Regulation of iron ion transport
    (GO:0034756)
  • Regulation of protein localization to cell surface
    (GO:2000008)
  • Response to iron ion
    (GO:0010039)
  • Response to iron ion starvation
    (GO:1990641)
  • Signaling receptor binding
    (GO:0005102)
  • Terminal web
    (GO:1990357)
  • Transferrin receptor binding
    (GO:1990459)

Other Information

Genular Protein ID: 3131660295

Symbol: HFE_MOUSE

Name: Hereditary hemochromatosis protein homolog

UniProtKB Accession Codes:

P70387 Q14AQ5 Q5SZ90 Q9D754

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 9 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9396865

Title: The mouse HFE gene.

PubMed ID: 9396865

DOI: 10.1007/s002510050344

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9020055

Title: Identification of a mouse homolog for the human hereditary haemochromatosis candidate gene.

PubMed ID: 9020055

DOI: 10.1006/bbrc.1996.5889

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 359
  • Mass: 40534
  • Checksum: 586657B7F9FF20B4
  • Sequence:
    • MSLSAGLPVR PLLLLLLLLW SVAPQALPPR SHSLRYLFMG ASEPDLGLPL FEARGYVDDQ 
LFVSYNHESR RAEPRAPWIL EQTSSQLWLH LSQSLKGWDY MFIVDFWTIM GNYNHSKVTK 
LGVVSESHIL QVVLGCEVHE DNSTSGFWRY GYDGQDHLEF CPKTLNWSAA EPGAWATKVE 
WDEHKIRAKQ NRDYLEKDCP EQLKRLLELG RGVLGQQVPT LVKVTRHWAS TGTSLRCQAL 
DFFPQNITMR WLKDNQPLDA KDVNPEKVLP NGDETYQGWL TLAVAPGDET RFTCQVEHPG 
LDQPLTASWE PLQSQAMIIG IISGVTVCAI FLVGILFLIL RKRKASGGTM GGYVLTDCE

Genular Protein ID: 1570398441

Symbol: Q5SZ87_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5SZ87

Database IDs:

AGR 1 ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 InterPro 9 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 271
  • Mass: 30128
  • Checksum: 0A2567D97D190BA3
  • Sequence:
    • MSLSAGLPVR PLLLLLLLLW SVAPQALPPL TKLGVVSESH ILQVVLGCEV HEDNSTSGFW 
RYGYDGQDHL EFCPKTLNWS AAEPGAWATK VEWDEHKIRA KQNRDYLEKD CPEQLKRLLE 
LGRGVLGQQV PTLVKVTRHW ASTGTSLRCQ ALDFFPQNIT MRWLKDNQPL DAKDVNPEKV 
LPNGDETYQG WLTLAVAPGD ETRFTCQVEH PGLDQPLTAS WEPLQSQAMI IGIISGVTVC 
AIFLVGILFL ILRKRKASGG TMGGYVLTDC E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.