Details for: CTSZ

Gene ID: 1522

Symbol: CTSZ

Ensembl ID: ENSG00000101160

Description: cathepsin Z

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.8016
    Cell Significance Index: -37.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.1103
    Cell Significance Index: -39.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.0722
    Cell Significance Index: -39.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.5742
    Cell Significance Index: -42.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.4588
    Cell Significance Index: -42.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.4107
    Cell Significance Index: -42.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.8906
    Cell Significance Index: -39.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.7506
    Cell Significance Index: -40.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7003
    Cell Significance Index: -39.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3720
    Cell Significance Index: -38.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3724
    Cell Significance Index: -40.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1581
    Cell Significance Index: 58.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4763
    Cell Significance Index: 115.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9363
    Cell Significance Index: 210.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4125
    Cell Significance Index: 280.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2400
    Cell Significance Index: 677.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1264
    Cell Significance Index: 138.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1041
    Cell Significance Index: 199.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0752
    Cell Significance Index: 28.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0702
    Cell Significance Index: 9.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0308
    Cell Significance Index: 141.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9561
    Cell Significance Index: 26.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9454
    Cell Significance Index: 44.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9130
    Cell Significance Index: 19.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8212
    Cell Significance Index: 105.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8075
    Cell Significance Index: 23.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7360
    Cell Significance Index: 33.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6519
    Cell Significance Index: 15.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5788
    Cell Significance Index: 43.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4523
    Cell Significance Index: 199.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4035
    Cell Significance Index: 28.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3561
    Cell Significance Index: 321.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3523
    Cell Significance Index: 41.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3326
    Cell Significance Index: 42.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2474
    Cell Significance Index: 12.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2209
    Cell Significance Index: 42.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1959
    Cell Significance Index: 56.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1506
    Cell Significance Index: 14.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1248
    Cell Significance Index: 2.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1063
    Cell Significance Index: 6.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0390
    Cell Significance Index: 1.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0305
    Cell Significance Index: 0.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0254
    Cell Significance Index: 18.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0202
    Cell Significance Index: 0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0191
    Cell Significance Index: 1.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0190
    Cell Significance Index: 3.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0056
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0092
    Cell Significance Index: -17.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0165
    Cell Significance Index: -30.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0182
    Cell Significance Index: -28.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0299
    Cell Significance Index: -40.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0435
    Cell Significance Index: -32.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0475
    Cell Significance Index: -32.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0519
    Cell Significance Index: -32.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0689
    Cell Significance Index: -38.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0768
    Cell Significance Index: -34.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0774
    Cell Significance Index: -48.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0797
    Cell Significance Index: -13.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0862
    Cell Significance Index: -30.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1085
    Cell Significance Index: -12.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1807
    Cell Significance Index: -20.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2080
    Cell Significance Index: -10.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2236
    Cell Significance Index: -47.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2342
    Cell Significance Index: -7.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2538
    Cell Significance Index: -36.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2888
    Cell Significance Index: -22.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3696
    Cell Significance Index: -6.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3824
    Cell Significance Index: -5.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3834
    Cell Significance Index: -39.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4277
    Cell Significance Index: -17.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4650
    Cell Significance Index: -36.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4698
    Cell Significance Index: -13.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4797
    Cell Significance Index: -11.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4868
    Cell Significance Index: -10.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5004
    Cell Significance Index: -8.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5273
    Cell Significance Index: -32.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5475
    Cell Significance Index: -8.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5996
    Cell Significance Index: -3.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6013
    Cell Significance Index: -36.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6556
    Cell Significance Index: -44.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6617
    Cell Significance Index: -17.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7119
    Cell Significance Index: -44.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7199
    Cell Significance Index: -5.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7213
    Cell Significance Index: -37.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7304
    Cell Significance Index: -38.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7676
    Cell Significance Index: -11.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8039
    Cell Significance Index: -45.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8210
    Cell Significance Index: -28.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8440
    Cell Significance Index: -24.8600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8488
    Cell Significance Index: -7.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8878
    Cell Significance Index: -39.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9231
    Cell Significance Index: -27.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9822
    Cell Significance Index: -16.5500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -1.0067
    Cell Significance Index: -8.8700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.0103
    Cell Significance Index: -21.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0237
    Cell Significance Index: -21.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0597
    Cell Significance Index: -33.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0674
    Cell Significance Index: -40.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Lysosomal localization**: CTSZ is primarily found in the lysosome, where it contributes to the degradation of proteins and peptides. 2. **Cysteine protease activity**: CTSZ exhibits cysteine protease activity, which involves the cleavage of peptide bonds in proteins, peptides, and other substrates. 3. **Immunomodulatory role**: CTSZ has been implicated in the regulation of immune responses, including the activation of neutrophils, the regulation of plasminogen activation, and the modulation of protein catabolic processes. 4. **Morphogenesis involvement**: CTSZ has been shown to be involved in the regulation of epithelial tube branching, suggesting its role in tissue development and morphogenesis. 5. **Proteolytic activity**: CTSZ exhibits proteolytic activity, which is essential for the degradation of proteins, peptides, and other substrates involved in various cellular processes. **Pathways and Functions** 1. **Angiotensin maturation**: CTSZ has been implicated in the maturation of angiotensinogen to angiotensins, which plays a crucial role in blood pressure regulation and cardiovascular disease. 2. **Asparagine n-linked glycosylation**: CTSZ has been shown to interact with proteins involved in asparagine n-linked glycosylation, which is essential for protein folding and stability. 3. **Cargo concentration in the ER**: CTSZ has been implicated in the regulation of cargo concentration in the endoplasmic reticulum (ER), which is essential for protein processing and secretion. 4. **Immune system regulation**: CTSZ has been shown to regulate immune responses, including the activation of neutrophils, the regulation of plasminogen activation, and the modulation of protein catabolic processes. 5. **Protein degradation**: CTSZ is involved in the degradation of various proteins, peptides, and other substrates, which is essential for protein quality control and cellular homeostasis. **Clinical Significance** 1. **Cardiovascular disease**: Alterations in CTSZ expression have been linked to cardiovascular disease, including hypertension and atherosclerosis. 2. **Neurodegenerative diseases**: CTSZ has been implicated in the regulation of protein degradation in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CTSZ has been shown to be involved in cancer progression, including the regulation of tumor cell invasion and metastasis. 4. **Infectious diseases**: CTSZ has been implicated in the regulation of immune responses during infectious diseases, including tuberculosis and sepsis. 5. **Developmental disorders**: CTSZ has been shown to be involved in the regulation of morphogenesis and tissue development, which is essential for proper development and function of various organs and tissues. In conclusion, CTSZ is a multifunctional protein that plays a crucial role in various cellular processes, including protein degradation, immune response, and morphogenesis. Its dysregulation has been implicated in various diseases, including cardiovascular disease, neurodegenerative diseases, cancer, infectious diseases, and developmental disorders. Further research is needed to fully understand the mechanisms of CTSZ and its role in human disease.

Genular Protein ID: 2356252772

Symbol: CATZ_HUMAN

Name: Cathepsin Z

UniProtKB Accession Codes:

Q9UBR2 B2RC40 O75331 Q9UQV5 Q9UQV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9738465

Title: Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.

PubMed ID: 9738465

DOI: 10.1016/s0014-5793(98)00964-8

PubMed ID: 9642240

Title: Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.

PubMed ID: 9642240

DOI: 10.1074/jbc.273.27.16816

PubMed ID: 10760573

Title: Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.

PubMed ID: 10760573

DOI: 10.1016/s0167-4781(00)00021-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10653162

Title: Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family.

PubMed ID: 10653162

DOI: 10.1007/s004240000112

PubMed ID: 10504234

Title: Human cathepsin X: a cysteine protease with unique carboxypeptidase activity.

PubMed ID: 10504234

DOI: 10.1021/bi991371z

PubMed ID: 10653163

Title: Tissue expression and immunolocalization of a novel human cathepsin P.

PubMed ID: 10653163

DOI: 10.1007/s004240000113

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10656802

Title: Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine.

PubMed ID: 10656802

DOI: 10.1006/jmbi.1999.3410

PubMed ID: 10745011

Title: Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.

PubMed ID: 10745011

DOI: 10.1016/s0969-2126(00)00108-8

Sequence Information:

  • Length: 303
  • Mass: 33868
  • Checksum: 6274FD1974D0EBDC
  • Sequence:
    • MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY PRPHEYLSPA 
DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA MADRINIKRK GAWPSTLLSV 
QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP DETCNNYQAK DQECDKFNQC GTCNEFKECH 
AIRNYTLWRV GDYGSLSGRE KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN 
HVVSVAGWGI SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD 
PIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.