CTSZ | ENSG00000101160 | NCBI 1522

Details for: CTSZ

Gene ID: 1522

Symbol: CTSZ

Ensembl ID: ENSG00000101160

Description: cathepsin Z

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Lysosome vesicle biogenesis
(R-HSA-432720)
Membrane trafficking
(R-HSA-199991)
Metabolism of angiotensinogen to angiotensins
(R-HSA-2022377)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Peptide hormone metabolism
(R-HSA-2980736)
Post-translational protein modification
(R-HSA-597592)
Trans-golgi network vesicle budding
(R-HSA-199992)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Angiotensin maturation
(GO:0002003)
Carboxypeptidase activity
(GO:0004180)
Cell cortex
(GO:0005938)
Collagen-containing extracellular matrix
(GO:0062023)
Copii-coated er to golgi transport vesicle
(GO:0030134)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasmic vesicle
(GO:0031410)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum lumen
(GO:0005788)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosome
(GO:0005764)
Negative regulation of plasminogen activation
(GO:0010757)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Specific granule lumen
(GO:0035580)

Other Information

Proteins

Cathepsin Z

Genular Protein ID: 2356252772

Symbol: CATZ_HUMAN

Name: Cathepsin Z

UniProtKB Accession Codes:

Q9UBR2 B2RC40 O75331 Q9UQV5 Q9UQV6

Database IDs:

Citations:

PubMed ID: 9738465

Title: Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.

PubMed ID: 9738465

DOI: 10.1016/s0014-5793(98)00964-8

PubMed ID: 9642240

Title: Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.

PubMed ID: 9642240

DOI: 10.1074/jbc.273.27.16816

PubMed ID: 10760573

Title: Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.

PubMed ID: 10760573

DOI: 10.1016/s0167-4781(00)00021-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10653162

Title: Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family.

PubMed ID: 10653162

DOI: 10.1007/s004240000112

PubMed ID: 10504234

Title: Human cathepsin X: a cysteine protease with unique carboxypeptidase activity.

PubMed ID: 10504234

DOI: 10.1021/bi991371z

PubMed ID: 10653163

Title: Tissue expression and immunolocalization of a novel human cathepsin P.

PubMed ID: 10653163

DOI: 10.1007/s004240000113

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10656802

Title: Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine.

PubMed ID: 10656802

DOI: 10.1006/jmbi.1999.3410

PubMed ID: 10745011

Title: Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.

PubMed ID: 10745011

DOI: 10.1016/s0969-2126(00)00108-8

Sequence Information:

Length: 303
Mass: 33868
Checksum: 6274FD1974D0EBDC
Sequence:

MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY PRPHEYLSPA 
DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA MADRINIKRK GAWPSTLLSV 
QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP DETCNNYQAK DQECDKFNQC GTCNEFKECH 
AIRNYTLWRV GDYGSLSGRE KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN 
HVVSVAGWGI SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD 
PIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSZ

Associated with

Other Information

Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions. PubMed ID: 9738465

Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. PubMed ID: 9642240

Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. PubMed ID: 10760573

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. PubMed ID: 10653162

Human cathepsin X: a cysteine protease with unique carboxypeptidase activity. PubMed ID: 10504234

Tissue expression and immunolocalization of a novel human cathepsin P. PubMed ID: 10653163

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine. PubMed ID: 10656802

Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. PubMed ID: 10745011