CUX1 | ENSG00000257923 | NCBI 1523

Details for: CUX1

Gene ID: 1523

Symbol: CUX1

Ensembl ID: ENSG00000257923

Description: cut like homeobox 1

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intra-golgi traffic
(R-HSA-6811438)
Membrane trafficking
(R-HSA-199991)
Signaling by cytosolic fgfr1 fusion mutants
(R-HSA-1839117)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr in disease
(R-HSA-1226099)
Vesicle-mediated transport
(R-HSA-5653656)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Intra-golgi vesicle-mediated transport
(GO:0006891)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.4
Cell Significance Index: 2
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.39
Cell Significance Index: 2
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.34
Cell Significance Index: 1
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.22
Cell Significance Index: 1
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.18
Cell Significance Index: 1
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.04
Cell Significance Index: 2
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1
Cell Significance Index: 1
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural cell (CL0002319)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: microglial cell (CL0000129)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.98
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** The CUX1 gene is a member of the cut family of transcription factors, which are characterized by their ability to regulate gene expression by interacting with specific DNA sequences. The CUX1 protein is a transcriptional repressor, meaning it can inhibit the expression of target genes by binding to specific DNA sequences and recruiting co-repressors. The CUX1 protein also exhibits sequence-specific DNA binding properties, allowing it to regulate gene expression in a cell-type specific manner. **Pathways and Functions:** The CUX1 gene is involved in several signaling pathways, including those related to cell growth, differentiation, and survival. Some of the key pathways and functions of the CUX1 gene include: 1. **Chromatin regulation:** The CUX1 protein interacts with chromatin-modifying enzymes to regulate gene expression by modifying chromatin structure. 2. **Transcriptional regulation:** The CUX1 protein regulates gene expression by binding to specific DNA sequences and recruiting co-repressors. 3. **Signaling by growth factor receptors:** The CUX1 protein is involved in signaling pathways mediated by growth factor receptors, such as FGF receptors. 4. **Membrane trafficking:** The CUX1 protein is involved in regulating membrane trafficking, including endocytosis and exocytosis. 5. **Dendrite morphogenesis:** The CUX1 protein regulates the development and maintenance of dendrites in neurons. **Clinical Significance:** The CUX1 gene has been implicated in several diseases, including: 1. **Cancer:** Overexpression of the CUX1 protein has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders:** The CUX1 protein is involved in the regulation of dendrite morphogenesis, and abnormalities in this process have been implicated in neurological disorders such as autism and schizophrenia. 3. **Cardiovascular disease:** The CUX1 protein is involved in regulating cardiac development and function, and abnormalities in this process have been implicated in cardiovascular disease. In conclusion, the CUX1 gene is a complex transcription factor that plays a crucial role in regulating gene expression and cellular signaling pathways. Its involvement in various diseases makes it an essential gene in understanding disease mechanisms and developing therapeutic strategies. **References:** * [Insert references to studies on CUX1 gene expression, regulation, and function] Note: As an expert immunologist, I would like to emphasize that the CUX1 gene is not a specific immunoglobulin or immune receptor, but rather a transcription factor that plays a role in regulating gene expression and cellular signaling pathways. Therefore, its clinical significance is more closely related to its role in disease mechanisms and development of therapeutic strategies, rather than its immunological function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.