Details for: CUX1

Gene ID: 1523

Symbol: CUX1

Ensembl ID: ENSG00000257923

Description: cut like homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 596.5468
    Cell Significance Index: -92.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 341.1483
    Cell Significance Index: -86.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 204.8408
    Cell Significance Index: -96.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 190.8397
    Cell Significance Index: -77.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 171.7390
    Cell Significance Index: -88.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 144.0638
    Cell Significance Index: -96.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.3727
    Cell Significance Index: -77.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 77.3588
    Cell Significance Index: -95.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.2683
    Cell Significance Index: -91.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.0719
    Cell Significance Index: -83.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.4295
    Cell Significance Index: -96.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.0886
    Cell Significance Index: -52.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.8102
    Cell Significance Index: 149.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.6160
    Cell Significance Index: 315.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.9849
    Cell Significance Index: 382.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.9943
    Cell Significance Index: 68.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.5095
    Cell Significance Index: 696.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.3556
    Cell Significance Index: 81.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.0472
    Cell Significance Index: 85.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2679
    Cell Significance Index: 454.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5819
    Cell Significance Index: 1094.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.5214
    Cell Significance Index: 32.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5037
    Cell Significance Index: 539.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2998
    Cell Significance Index: 19.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2802
    Cell Significance Index: 150.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1460
    Cell Significance Index: 30.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0835
    Cell Significance Index: 66.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0613
    Cell Significance Index: 145.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9935
    Cell Significance Index: 45.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9362
    Cell Significance Index: 101.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9037
    Cell Significance Index: 162.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8580
    Cell Significance Index: 37.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8534
    Cell Significance Index: 104.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7547
    Cell Significance Index: 16.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6914
    Cell Significance Index: 44.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6681
    Cell Significance Index: 1028.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6086
    Cell Significance Index: 332.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5391
    Cell Significance Index: 244.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.5347
    Cell Significance Index: 986.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5258
    Cell Significance Index: 19.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5068
    Cell Significance Index: 321.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5057
    Cell Significance Index: 952.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2839
    Cell Significance Index: 256.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2824
    Cell Significance Index: 4.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2722
    Cell Significance Index: 51.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2357
    Cell Significance Index: 320.4900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.2179
    Cell Significance Index: 2.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1949
    Cell Significance Index: 86.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1402
    Cell Significance Index: 0.9500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1352
    Cell Significance Index: 1.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0694
    Cell Significance Index: 2.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0309
    Cell Significance Index: 0.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0100
    Cell Significance Index: -1.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0544
    Cell Significance Index: -39.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0646
    Cell Significance Index: -40.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0655
    Cell Significance Index: -48.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0902
    Cell Significance Index: -68.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1240
    Cell Significance Index: -2.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1397
    Cell Significance Index: -78.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1676
    Cell Significance Index: -17.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1935
    Cell Significance Index: -3.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2110
    Cell Significance Index: -14.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2198
    Cell Significance Index: -10.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2321
    Cell Significance Index: -4.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2423
    Cell Significance Index: -35.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2650
    Cell Significance Index: -55.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3013
    Cell Significance Index: -49.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3226
    Cell Significance Index: -31.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3308
    Cell Significance Index: -95.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3430
    Cell Significance Index: -43.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3571
    Cell Significance Index: -18.5500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3581
    Cell Significance Index: -5.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3858
    Cell Significance Index: -40.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3892
    Cell Significance Index: -11.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4094
    Cell Significance Index: -28.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4613
    Cell Significance Index: -53.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4760
    Cell Significance Index: -30.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5901
    Cell Significance Index: -76.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6553
    Cell Significance Index: -75.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6630
    Cell Significance Index: -34.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6903
    Cell Significance Index: -51.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7332
    Cell Significance Index: -8.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7540
    Cell Significance Index: -26.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7556
    Cell Significance Index: -86.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8257
    Cell Significance Index: -20.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9173
    Cell Significance Index: -47.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9268
    Cell Significance Index: -13.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9315
    Cell Significance Index: -11.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9489
    Cell Significance Index: -15.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9643
    Cell Significance Index: -76.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0349
    Cell Significance Index: -22.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1036
    Cell Significance Index: -78.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1203
    Cell Significance Index: -23.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1348
    Cell Significance Index: -23.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1464
    Cell Significance Index: -53.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2997
    Cell Significance Index: -34.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.3023
    Cell Significance Index: -24.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3694
    Cell Significance Index: -83.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4330
    Cell Significance Index: -30.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.4594
    Cell Significance Index: -20.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CUX1 gene is a member of the cut family of transcription factors, which are characterized by their ability to regulate gene expression by interacting with specific DNA sequences. The CUX1 protein is a transcriptional repressor, meaning it can inhibit the expression of target genes by binding to specific DNA sequences and recruiting co-repressors. The CUX1 protein also exhibits sequence-specific DNA binding properties, allowing it to regulate gene expression in a cell-type specific manner. **Pathways and Functions:** The CUX1 gene is involved in several signaling pathways, including those related to cell growth, differentiation, and survival. Some of the key pathways and functions of the CUX1 gene include: 1. **Chromatin regulation:** The CUX1 protein interacts with chromatin-modifying enzymes to regulate gene expression by modifying chromatin structure. 2. **Transcriptional regulation:** The CUX1 protein regulates gene expression by binding to specific DNA sequences and recruiting co-repressors. 3. **Signaling by growth factor receptors:** The CUX1 protein is involved in signaling pathways mediated by growth factor receptors, such as FGF receptors. 4. **Membrane trafficking:** The CUX1 protein is involved in regulating membrane trafficking, including endocytosis and exocytosis. 5. **Dendrite morphogenesis:** The CUX1 protein regulates the development and maintenance of dendrites in neurons. **Clinical Significance:** The CUX1 gene has been implicated in several diseases, including: 1. **Cancer:** Overexpression of the CUX1 protein has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders:** The CUX1 protein is involved in the regulation of dendrite morphogenesis, and abnormalities in this process have been implicated in neurological disorders such as autism and schizophrenia. 3. **Cardiovascular disease:** The CUX1 protein is involved in regulating cardiac development and function, and abnormalities in this process have been implicated in cardiovascular disease. In conclusion, the CUX1 gene is a complex transcription factor that plays a crucial role in regulating gene expression and cellular signaling pathways. Its involvement in various diseases makes it an essential gene in understanding disease mechanisms and developing therapeutic strategies. **References:** * [Insert references to studies on CUX1 gene expression, regulation, and function] Note: As an expert immunologist, I would like to emphasize that the CUX1 gene is not a specific immunoglobulin or immune receptor, but rather a transcription factor that plays a role in regulating gene expression and cellular signaling pathways. Therefore, its clinical significance is more closely related to its role in disease mechanisms and development of therapeutic strategies, rather than its immunological function.

Genular Protein ID: 3158970579

Symbol: CASP_HUMAN

Name: Protein CASP

UniProtKB Accession Codes:

Q13948 B3KWH3 B3KWH8 B4DZZ2 G3V1Z6 J3KPQ6 Q53GU9 Q8TBS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 3 Ensembl 5 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 IntAct 1 InterPro 1 KEGG 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 ProteomicsDB 3 Pumba 1 Reactome 1 RefSeq 5 SMR 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9332351

Title: CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro.

PubMed ID: 9332351

DOI: 10.1016/s0378-1119(97)00243-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10607901

Title: Exon/intron structure and alternative transcripts of the CUTL1 gene.

PubMed ID: 10607901

DOI: 10.1016/s0378-1119(99)00465-5

PubMed ID: 12429822

Title: CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.

PubMed ID: 12429822

DOI: 10.1091/mbc.e02-06-0349

PubMed ID: 15718469

Title: Golgin tethers define subpopulations of COPI vesicles.

PubMed ID: 15718469

DOI: 10.1126/science.1108061

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 678
  • Mass: 77455
  • Checksum: E587F222825EA47E
  • Sequence:
    • MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL 
RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH 
DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET IALEKEQKLQ 
NDFAEKERKL QETQMSTTSK LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI 
EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE 
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK QLEEKLKGQA 
DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN RSLQSENAAL RISNSDLSGR 
CAELQVRITE AVATATEQRE LIARLEQDLS IIQSIQRPDA EGAAEHRLEK IPEPIKEATA 
LFYGPAAPAS GALPEGQVDS LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL 
RADNIKLFEK IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW 
DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA TFCAKKFADH 
LHKFHENDNG AAAGDLWQ

Genular Protein ID: 4235554558

Symbol: CUX1_HUMAN

Name: CCAAT displacement protein

UniProtKB Accession Codes:

P39880 B3KV79 J3KQV9 Q6NYH4 Q75LE5 Q75MT2 Q75MT3 Q86UJ7 Q9UEV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 7 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1301999

Title: Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.

PubMed ID: 1301999

DOI: 10.1038/ng0492-50

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 10607901

Title: Exon/intron structure and alternative transcripts of the CUTL1 gene.

PubMed ID: 10607901

DOI: 10.1016/s0378-1119(99)00465-5

PubMed ID: 15099520

Title: A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

PubMed ID: 15099520

DOI: 10.1016/s1097-2765(04)00209-6

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30014507

Title: Haploinsufficiency of CUX1 causes nonsyndromic global developmental delay with possible catch-up development.

PubMed ID: 30014507

DOI: 10.1002/ana.25278

Sequence Information:

  • Length: 1505
  • Mass: 164187
  • Checksum: 0F9027E5B8F08D95
  • Sequence:
    • MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR KQVAPLLKSF 
QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ LQLKVQRLHD IETENQKLRE 
TLEEYNKEFA EVKNQEVTIK ALKEKIREYE QTLKNQAETI ALEKEQKLQN DFAEKERKLQ 
ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN 
QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD YEEVKKELNI 
LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR ISNSDLSGSA RRKGKDQPES 
RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ FSPAGLSQDF FSSSLASPSL PLASTGKFAL 
NSLLQRQLMQ SFYSKAMQEA GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE 
SAGSVSEGEE MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN GSEGNITTRI 
RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG NSDDAIRSIL QQARREMEAQ 
QAALDPALKQ APLSQSDITI LTPKLLSTSP MPTVSSYPPL AISLKKPSAA PEAGASALPN 
PPALKKEAQD APGLDPQGAA DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE 
AKAEETGGGK EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA 
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR QVKEKLAKNG 
ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI RMQLWLNGEL GQGVLPVQGQ 
QQGPVLHSVT SLQDPLQQGC VSSESTPKTS ASCSPAPESP MSSSESVKSL TELVQQPCPP 
IEASKDSKPP EPSDPPASDS QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT 
DNNLGQRLFG ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD 
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV LAPEEKEALK 
RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR RELFIEEIQA GSQGQAGASD 
SPSARSGRAA PSSEGDSCDG VEATEGPGSA DTEEPKSQGE AEREEVPRPA EQTEPPPSGT 
PGPDDARDDD HEGGPVEGPG PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP 
PSNSSSSSAP RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP 
IEWEF

Genular Protein ID: 3084973779

Symbol: Q3LIA3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3LIA3

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2

Sequence Information:

  • Length: 484
  • Mass: 54552
  • Checksum: 741887B67FABD936
  • Sequence:
    • MSTTSKLEEA EHKVQSLQTA LEKTRTELFD LKTKYDEETT AKADEIEMIM TDLERANQRA 
EVAQREAETL REQLSSANHS LQLASQIQKA PDVEQAIEVL TRSSLEVELA AKEREIAQLV 
EDVQRLQASL TKLRENSASQ ISQLEQQLSA KNSTLKQLEE KLKGQADYEE VKKELNILKS 
MEFAPSEGAG TQDAAKPLEV LLLEKNRSLQ SENAALRISN SGLSGRCAEL QVRITEAVAT 
ATEQRELIAR LEQDLSIIQS IQRPDAEGAA EHRLEKIPEP IKEATALFYG PAAPASGALP 
EGQVDSLLSI ISSQRERFRA RNQELEAENR LAQHTLQALQ SELDSLRADN IKLFEKIKFL 
QSYPGRGSGS DDTELRYSSQ YEERLDPFSS FSKRERQRKY LSLSPWDKAT LSMGRLVLSN 
KMARTIGFFY TLFLHCLVFL ALYKLAWSES MERDCATFCA KKFADHLHKF HENDNGAAAG 
DLWQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.