Genular: Defining Cellular Identity and Function

Details for: Hgf

Gene ID: 15234

Symbol: Hgf

Ensembl ID: ENSMUSG00000028864

Description: hepatocyte growth factor

Associated with

Drug-mediated inhibition of met activation
(R-MMU-9734091)
Hemostasis
(R-MMU-109582)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Met activates pi3k/akt signaling
(R-MMU-8851907)
Met activates ptk2 signaling
(R-MMU-8874081)
Met activates ptpn11
(R-MMU-8865999)
Met activates rap1 and rac1
(R-MMU-8875555)
Met activates ras signaling
(R-MMU-8851805)
Met activates stat3
(R-MMU-8875791)
Met interacts with tns proteins
(R-MMU-8875513)
Met promotes cell motility
(R-MMU-8875878)
Met receptor activation
(R-MMU-6806942)
Met receptor recycling
(R-MMU-8875656)
Negative regulation of met activity
(R-MMU-6807004)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Cell chemotaxis
(GO:0060326)
Cell morphogenesis
(GO:0000902)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Chemoattractant activity
(GO:0042056)
Endopeptidase activity
(GO:0004175)
Epithelial cell proliferation
(GO:0050673)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Hepatocyte growth factor receptor signaling pathway
(GO:0048012)
Identical protein binding
(GO:0042802)
Liver development
(GO:0001889)
Myoblast proliferation
(GO:0051450)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of hydrogen peroxide-mediated programmed cell death
(GO:1901299)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of myelination
(GO:0031643)
Positive regulation of neuron projection regeneration
(GO:0070572)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
(GO:0060665)
Regulation of p38mapk cascade
(GO:1900744)
Regulation of tau-protein kinase activity
(GO:1902947)
Serine-type endopeptidase activity
(GO:0004252)
Signaling receptor binding
(GO:0005102)
Skeletal muscle cell proliferation
(GO:0014856)

Other Information

Proteins

Hepatocyte growth factor
Q8C9G5_MOUSE

Genular Protein ID: 1770300220

Symbol: HGF_MOUSE

Name: Hepatocyte growth factor

UniProtKB Accession Codes:

Q08048 O55027 Q53WS5 Q61662 Q64007 Q6LBE6

Database IDs:

Citations:

PubMed ID: 8135822

Title: Identification of mouse mammary fibroblast-derived mammary growth factor as hepatocyte growth factor.

PubMed ID: 8135822

DOI: 10.1006/bbrc.1994.1296

PubMed ID: 8081873

Title: Structure, genetic mapping, and expression of the mouse Hgf/scatter factor gene.

PubMed ID: 8081873

DOI: 10.3109/15419069309095686

PubMed ID: 8241272

Title: Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor.

PubMed ID: 8241272

DOI: 10.1016/0167-4781(93)90159-b

PubMed ID: 9488442

Title: NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo.

PubMed ID: 9488442

DOI: 10.1128/mcb.18.3.1275

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7822318

Title: Characterisation of the scatter factor/hepatocyte growth factor gene promoter: positive and negative regulatory elements direct gene expression to mesenchymal cells.

PubMed ID: 7822318

DOI: 10.1074/jbc.270.2.830

PubMed ID: 2144630

Title: Purified scatter factor stimulates epithelial and vascular endothelial cell migration.

PubMed ID: 2144630

DOI: 10.3181/00379727-195-43115

PubMed ID: 2142751

Title: Hepatocytes and scatter factor.

PubMed ID: 2142751

DOI: 10.1038/346228b0

PubMed ID: 1831975

Title: Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium.

PubMed ID: 1831975

DOI: 10.1042/bj2780035

PubMed ID: 17804794

Title: A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.

PubMed ID: 17804794

DOI: 10.1073/pnas.0704290104

PubMed ID: 20624990

Title: Structural basis for agonism and antagonism of hepatocyte growth factor.

PubMed ID: 20624990

DOI: 10.1073/pnas.1005183107

Sequence Information:

Length: 728
Mass: 82945
Checksum: A0381FC497534328
Sequence:

MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLLKI 
KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY 
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN 
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT 
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP 
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG 
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM 
EDLHRHIFWE PDASKLNKNY CRNPDDDAHG PWCYTGNPLI PWDYCPISRC EGDTTPTIVN 
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR 
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL 
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH 
KVILTYKL

Genular Protein ID: 2614997446

Symbol: Q8C9G5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C9G5

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 728
Mass: 82991
Checksum: 8D5258DF3BCF3545
Sequence:

MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLLKI 
KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY 
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN 
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT 
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTT WEYCAIKTCA HSAVNETDVP 
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG 
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM 
EDLHRHIFWE PDASKLNKNY CRNPDDDAHG PWCYTGNPLI PWDYCPISRC EGDTTPTIVN 
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV ITARQCFPAR 
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL 
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPVIFV RVAYYAKWIH 
KVILTYKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hgf

Associated with

Other Information

Identification of mouse mammary fibroblast-derived mammary growth factor as hepatocyte growth factor. PubMed ID: 8135822

Structure, genetic mapping, and expression of the mouse Hgf/scatter factor gene. PubMed ID: 8081873

Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor. PubMed ID: 8241272

NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo. PubMed ID: 9488442

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterisation of the scatter factor/hepatocyte growth factor gene promoter: positive and negative regulatory elements direct gene expression to mesenchymal cells. PubMed ID: 7822318

Purified scatter factor stimulates epithelial and vascular endothelial cell migration. PubMed ID: 2144630

Hepatocytes and scatter factor. PubMed ID: 2142751

Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium. PubMed ID: 1831975

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. PubMed ID: 17804794

Structural basis for agonism and antagonism of hepatocyte growth factor. PubMed ID: 20624990

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073