Genular: Defining Cellular Identity and Function

Details for: Hgs

Gene ID: 15239

Symbol: Hgs

Ensembl ID: ENSMUSG00000025793

Description: HGF-regulated tyrosine kinase substrate

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Deubiquitination
(R-MMU-5688426)
Egfr downregulation
(R-MMU-182971)
Endosomal sorting complex required for transport (escrt)
(R-MMU-917729)
Lysosome vesicle biogenesis
(R-MMU-432720)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Negative regulation of met activity
(R-MMU-6807004)
Post-translational protein modification
(R-MMU-597592)
Rhobtb3 atpase cycle
(R-MMU-9706019)
Rho gtpase cycle
(R-MMU-9012999)
Rhou gtpase cycle
(R-MMU-9013420)
Signaling by egfr
(R-MMU-177929)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Trans-golgi network vesicle budding
(R-MMU-199992)
Ub-specific processing proteases
(R-MMU-5689880)
Vesicle-mediated transport
(R-MMU-5653656)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endocytic recycling
(GO:0032456)
Endosome
(GO:0005768)
Endosome to lysosome transport
(GO:0008333)
Escrt-0 complex
(GO:0033565)
Identical protein binding
(GO:0042802)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane invagination
(GO:0010324)
Metal ion binding
(GO:0046872)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030948)
Phosphatidylinositol binding
(GO:0035091)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization to membrane
(GO:0072657)
Protein targeting to lysosome
(GO:0006622)
Protein transport
(GO:0015031)
Receptor internalization
(GO:0031623)
Regulation of map kinase activity
(GO:0043405)
Secretory granule
(GO:0030141)
Ubiquitin-dependent protein binding
(GO:0140036)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

Hepatocyte growth factor-regulated tyrosine kinase substrate
Q3UMA3_MOUSE

Genular Protein ID: 4076088135

Symbol: HGS_MOUSE

Name: Hepatocyte growth factor-regulated tyrosine kinase substrate

UniProtKB Accession Codes:

Q99LI8 Q61691 Q8BQW3

Database IDs:

Citations:

PubMed ID: 7565774

Title: Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally-conserved putative zinc finger domain.

PubMed ID: 7565774

DOI: 10.1128/mcb.15.11.6213

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9407053

Title: Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.

PubMed ID: 9407053

DOI: 10.1074/jbc.272.52.32785

PubMed ID: 9630564

Title: Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17.

PubMed ID: 9630564

DOI: 10.1016/s0378-1119(98)00184-x

PubMed ID: 10364163

Title: Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.

PubMed ID: 10364163

DOI: 10.1101/gad.13.11.1475

PubMed ID: 10651905

Title: A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors.

PubMed ID: 10651905

DOI: 10.1046/j.1365-2443.2000.00303.x

PubMed ID: 11094085

Title: Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

PubMed ID: 11094085

DOI: 10.1128/mcb.20.24.9346-9355.2000

PubMed ID: 11493665

Title: FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.

PubMed ID: 11493665

DOI: 10.1242/jcs.114.12.2255

PubMed ID: 11988743

Title: Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes.

PubMed ID: 11988743

DOI: 10.1038/ncb791

PubMed ID: 12953068

Title: The UIM domain of Hrs couples receptor sorting to vesicle formation.

PubMed ID: 12953068

DOI: 10.1242/jcs.00723

PubMed ID: 12802020

Title: TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.

PubMed ID: 12802020

DOI: 10.1073/pnas.0932599100

PubMed ID: 16159959

Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.

PubMed ID: 16159959

DOI: 10.1242/jcs.02571

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19278655

Title: Hybrid structural model of the complete human ESCRT-0 complex.

PubMed ID: 19278655

DOI: 10.1016/j.str.2009.01.012

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 775
Mass: 86015
Checksum: 0E68BF5AB514865B
Sequence:

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 
NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVVTRKH 
HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN KKAEGKASST TELPPEYLTS 
PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERM RQKTTYTAHP KAEPTPLASS 
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ 
PGEGHTAPNS MAEAPLPETD SQPITPCSGP FSEYQNGESE ESHEQFLKAL QNAVSTFVNR 
MKSNHMRGRS ITNDSAVLSL FQSINTMHPQ LLELLNQLDE RRLYYEGLQD KLAQIRDARG 
ALSALREEHR EKLRRAAEEA ERQRQIQLAQ KLEIMRQKKQ EYLEVQRQLA IQRLQEQEKE 
RQMRLEQQKQ TVQMRAQMPA FPLPYAQLQA MPTAGGVLYQ PSGPTSFPAT FSPAGSVEGS 
PMHGVYMSQP APATGPYPSM PGTTADPSMV SAYMYPTGAP GAQAAPQAQA GPTTSPAYSS 
YQPTPTPGYQ SVASQAPQSL PAISQPPQTS NIGYMGSQPM SMGYQPYNMQ NLMTALPGQD 
ASLPAQQPYI PGQQPLYQQM APSTGPPQQQ PPVAQPAPTQ GPPAQGSEAQ LISFD

Genular Protein ID: 1489354657

Symbol: Q3UMA3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UMA3 B1ATZ1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 776
Mass: 86143
Checksum: E53FE4C5F39ECB49
Sequence:

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR 
NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVVTRKH 
HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN KKAEGKASST TELPPEYLTS 
PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERM RQKTTYTAHP KAEPTPLASS 
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ 
PGEGHTAPNS MAEAPLPETD SQPITPCSGP FSEQYQNGES EESHEQFLKA LQNAVSTFVN 
RMKSNHMRGR SITNDSAVLS LFQSINTMHP QLLELLNQLD ERRLYYEGLQ DKLAQIRDAR 
GALSALREEH REKLRRAAEE AERQRQIQLA QKLEIMRQKK QEYLEVQRQL AIQRLQEQEK 
ERQMRLEQQK QTVQMRAQMP AFPLPYAQLQ AMPTAGGVLY QPSGPTSFPA TFSPAGSVEG 
SPMHGVYMSQ PAPATGPYPS MPGTTADPSM VSAYMYPTGA PGAQAAPQAQ AGPTTSPAYS 
SYQPTPTPGY QSVASQAPQS LPAISQPPQT SNIGYMGSQP MSMGYQPYNM QNLMTALPGQ 
DASLPAQQPY IPGQQPLYQQ MAPSTGPPQQ QPPVAQPAPT QGPPAQGSEA QLISFD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hgs

Associated with

Other Information

Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally-conserved putative zinc finger domain. PubMed ID: 7565774

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. PubMed ID: 9407053

Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. PubMed ID: 9630564

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. PubMed ID: 10364163

A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors. PubMed ID: 10651905

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. PubMed ID: 11094085

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. PubMed ID: 11493665

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. PubMed ID: 11988743

The UIM domain of Hrs couples receptor sorting to vesicle formation. PubMed ID: 12953068

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. PubMed ID: 12802020

Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. PubMed ID: 16159959

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Hybrid structural model of the complete human ESCRT-0 complex. PubMed ID: 19278655

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Database document:

PubMed ID: 7565774

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 9407053

PubMed ID: 9630564

PubMed ID: 10364163

PubMed ID: 10651905

PubMed ID: 11094085

PubMed ID: 11493665

PubMed ID: 11988743

PubMed ID: 12953068

PubMed ID: 12802020

PubMed ID: 16159959

PubMed ID: 15592455

PubMed ID: 17947660

PubMed ID: 18034455

PubMed ID: 19278655

PubMed ID: 21183079

PubMed ID: 23806337

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 15592455

PubMed ID: 16141073

PubMed ID: 17947660

PubMed ID: 18034455

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 23806337