CX3CR1 | ENSG00000168329 | NCBI 1524

Details for: CX3CR1

Gene ID: 1524

Symbol: CX3CR1

Ensembl ID: ENSG00000168329

Description: C-X3-C motif chemokine receptor 1

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Disease
(R-HSA-1643685)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Infectious disease
(R-HSA-5663205)
Peptide ligand-binding receptors
(R-HSA-375276)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antifungal innate immune response
(GO:0061760)
Autocrine signaling
(GO:0035425)
Brain development
(GO:0007420)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
C-x3-c chemokine binding
(GO:0019960)
C-x3-c chemokine receptor activity
(GO:0016495)
Calcium-mediated signaling
(GO:0019722)
Cell-cell signaling
(GO:0007267)
Cell adhesion
(GO:0007155)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Cellular defense response
(GO:0006968)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Central nervous system maturation
(GO:0021626)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
Cx3c chemokine receptor binding
(GO:0031737)
Dendritic tree
(GO:0097447)
External side of plasma membrane
(GO:0009897)
G protein-coupled peptide receptor activity
(GO:0008528)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Host-mediated regulation of intestinal microbiota composition
(GO:0048874)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Leukocyte chemotaxis
(GO:0030595)
Leukocyte tethering or rolling
(GO:0050901)
Memory
(GO:0007613)
Microglial cell activation involved in immune response
(GO:0002282)
Modulation of chemical synaptic transmission
(GO:0050804)
Multiple spine synapse organization, single dendrite
(GO:0150090)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of hippocampal neuron apoptotic process
(GO:0110091)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of microglial cell mediated cytotoxicity
(GO:1904150)
Neuronal cell body membrane
(GO:0032809)
Neuron projection
(GO:0043005)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of i-kappab phosphorylation
(GO:1903721)
Positive regulation of microglial cell migration
(GO:1904141)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Regulation of microglial cell migration
(GO:1904139)
Regulation of neurogenesis
(GO:0050767)
Regulation of nitric oxide biosynthetic process
(GO:0045428)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of tumor necrosis factor production
(GO:0032680)
Response to ischemia
(GO:0002931)
Response to wounding
(GO:0009611)
Social behavior
(GO:0035176)
Synapse maturation
(GO:0060074)
Synapse pruning
(GO:0098883)

Other Information

Proteins

G-protein coupled receptor 13

Genular Protein ID: 402047493

Symbol: CX3C1_HUMAN

Name: G-protein coupled receptor 13

UniProtKB Accession Codes:

P49238 A0N0N6 B2R5Z4 J3KP17

Database IDs:

Citations:

PubMed ID: 7590284

Title: The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.

PubMed ID: 7590284

DOI: 10.1016/0378-1119(95)00336-5

PubMed ID: 7646814

Title: Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene.

PubMed ID: 7646814

DOI: 10.1089/dna.1995.14.673

PubMed ID: 12551893

Title: Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus.

PubMed ID: 12551893

DOI: 10.1074/jbc.m211422200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9390561

Title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.

PubMed ID: 9390561

DOI: 10.1016/s0092-8674(00)80438-9

PubMed ID: 9782118

Title: Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.

PubMed ID: 9782118

DOI: 10.1084/jem.188.8.1413

PubMed ID: 11477410

Title: CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.

PubMed ID: 11477410

DOI: 10.1038/90675

PubMed ID: 12055230

Title: Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression.

PubMed ID: 12055230

DOI: 10.4049/jimmunol.168.12.6173

PubMed ID: 14607932

Title: Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors.

PubMed ID: 14607932

DOI: 10.4049/jimmunol.171.10.5305

PubMed ID: 9726990

Title: Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.

PubMed ID: 9726990

DOI: 10.1074/jbc.273.37.23799

PubMed ID: 14581400

Title: Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1).

PubMed ID: 14581400

DOI: 10.1161/01.cir.0000097119.57756.ef

PubMed ID: 18971423

Title: CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

PubMed ID: 18971423

DOI: 10.1182/blood-2008-07-170787

PubMed ID: 20974991

Title: Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.

PubMed ID: 20974991

DOI: 10.4049/jimmunol.0904126

PubMed ID: 23125415

Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.

PubMed ID: 23125415

DOI: 10.4049/jimmunol.1200889

PubMed ID: 28791023

Title: TGF-beta1 downregulates the expression of CX3CR1 by inducing miR-27a-5p in primary human NK cells.

PubMed ID: 28791023

DOI: 10.3389/fimmu.2017.00868

PubMed ID: 29326275

Title: CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.

PubMed ID: 29326275

DOI: 10.1126/science.aao1503

PubMed ID: 10731151

Title: Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.

PubMed ID: 10731151

DOI: 10.1126/science.287.5461.2274

PubMed ID: 11264153

Title: Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.

PubMed ID: 11264153

DOI: 10.1182/blood.v97.7.1925

PubMed ID: 15208270

Title: The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.

PubMed ID: 15208270

DOI: 10.1096/fj.04-1862fje

PubMed ID: 17909628

Title: CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

PubMed ID: 17909628

DOI: 10.1172/jci31692

Sequence Information:

Length: 355
Mass: 40396
Checksum: C59DC5F4C4312F22
Sequence:

MDQFPESVTE NFEYDDLAEA CYIGDIVVFG TVFLSIFYSV IFAIGLVGNL LVVFALTNSK 
KPKSVTDIYL LNLALSDLLF VATLPFWTHY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI 
TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP 
EVLQEIWPVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLVVIVF 
FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF 
RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CX3CR1

Associated with

Other Information

The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. PubMed ID: 7590284

Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. PubMed ID: 7646814

Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. PubMed ID: 12551893

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. PubMed ID: 9390561

Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. PubMed ID: 9782118

CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. PubMed ID: 11477410

Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression. PubMed ID: 12055230

Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors. PubMed ID: 14607932

Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. PubMed ID: 9726990

Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1). PubMed ID: 14581400

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. PubMed ID: 18971423

Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1. PubMed ID: 20974991

Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. PubMed ID: 23125415

TGF-beta1 downregulates the expression of CX3CR1 by inducing miR-27a-5p in primary human NK cells. PubMed ID: 28791023

CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi. PubMed ID: 29326275

Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. PubMed ID: 10731151

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. PubMed ID: 11264153

The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. PubMed ID: 15208270

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. PubMed ID: 17909628