Details for: CX3CR1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.01
Marker Score: 1498.5 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.06
Marker Score: 840 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1991 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.89
Marker Score: 683 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1166 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.51
Marker Score: 4399 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.49
Marker Score: 1308.5 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.47
Marker Score: 4624 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.39
Marker Score: 2047 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.36
Marker Score: 2774 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 852 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.25
Marker Score: 633 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.2
Marker Score: 2266 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 486 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7684 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4810 - Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.11
Marker Score: 253 - Cell Name: microglial cell (CL0000129)
Fold Change: 1.1
Marker Score: 2009 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 501 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.05
Marker Score: 455 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251802 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.02
Marker Score: 985 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.01
Marker Score: 15865 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.94
Marker Score: 2444 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5342 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741 - Cell Name: blood cell (CL0000081)
Fold Change: 0.91
Marker Score: 10559 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.85
Marker Score: 651 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.85
Marker Score: 1655 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.84
Marker Score: 507 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.83
Marker Score: 845 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.73
Marker Score: 40880 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 461 - Cell Name: natural killer cell (CL0000623)
Fold Change: 0.71
Marker Score: 923 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.68
Marker Score: 374 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 463 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.56
Marker Score: 368 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.55
Marker Score: 425 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.53
Marker Score: 1288 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.53
Marker Score: 251 - Cell Name: Unknown (CL0000548)
Fold Change: 0.51
Marker Score: 371 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.49
Marker Score: 793 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.45
Marker Score: 253 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.44
Marker Score: 386 - Cell Name: ILC1, human (CL0001077)
Fold Change: 0.42
Marker Score: 106 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.4
Marker Score: 790 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.39
Marker Score: 961 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.39
Marker Score: 103 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.37
Marker Score: 120 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.35
Marker Score: 242.5 - Cell Name: T cell (CL0000084)
Fold Change: 0.34
Marker Score: 588 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.33
Marker Score: 205 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.31
Marker Score: 764 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.31
Marker Score: 422 - Cell Name: dendritic cell (CL0000451)
Fold Change: 0.29
Marker Score: 199 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.28
Marker Score: 454 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.26
Marker Score: 1097 - Cell Name: monocyte (CL0000576)
Fold Change: 0.26
Marker Score: 341 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.26
Marker Score: 92 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.25
Marker Score: 208 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.25
Marker Score: 112 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.25
Marker Score: 147 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.24
Marker Score: 72 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.24
Marker Score: 162 - Cell Name: Unknown (CL0000003)
Fold Change: 0.24
Marker Score: 744 - Cell Name: macrophage (CL0000235)
Fold Change: 0.24
Marker Score: 264 - Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.23
Marker Score: 70 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.23
Marker Score: 105 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.22
Marker Score: 92 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.21
Marker Score: 178 - Cell Name: mature T cell (CL0002419)
Fold Change: 0.21
Marker Score: 2039 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.2
Marker Score: 201 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.2
Marker Score: 69 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.19
Marker Score: 103 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.18
Marker Score: 210 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.18
Marker Score: 140 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.17
Marker Score: 96 - Cell Name: mast cell (CL0000097)
Fold Change: 0.17
Marker Score: 100 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.17
Marker Score: 84 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.16
Marker Score: 31 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.16
Marker Score: 158 - Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.16
Marker Score: 43 - Cell Name: platelet (CL0000233)
Fold Change: 0.15
Marker Score: 70
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Other Information
Genular Protein ID: 402047493
Symbol: CX3C1_HUMAN
Name: G-protein coupled receptor 13
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7590284
Title: The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.
PubMed ID: 7590284
PubMed ID: 7646814
Title: Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene.
PubMed ID: 7646814
PubMed ID: 12551893
Title: Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus.
PubMed ID: 12551893
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9390561
Title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
PubMed ID: 9390561
PubMed ID: 9782118
Title: Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.
PubMed ID: 9782118
PubMed ID: 11477410
Title: CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.
PubMed ID: 11477410
DOI: 10.1038/90675
PubMed ID: 12055230
Title: Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression.
PubMed ID: 12055230
PubMed ID: 14607932
Title: Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors.
PubMed ID: 14607932
PubMed ID: 9726990
Title: Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.
PubMed ID: 9726990
PubMed ID: 14581400
Title: Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1).
PubMed ID: 14581400
PubMed ID: 18971423
Title: CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.
PubMed ID: 18971423
PubMed ID: 20974991
Title: Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.
PubMed ID: 20974991
PubMed ID: 23125415
Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.
PubMed ID: 23125415
PubMed ID: 28791023
Title: TGF-beta1 downregulates the expression of CX3CR1 by inducing miR-27a-5p in primary human NK cells.
PubMed ID: 28791023
PubMed ID: 29326275
Title: CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.
PubMed ID: 29326275
PubMed ID: 10731151
Title: Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.
PubMed ID: 10731151
PubMed ID: 11264153
Title: Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.
PubMed ID: 11264153
PubMed ID: 15208270
Title: The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.
PubMed ID: 15208270
PubMed ID: 17909628
Title: CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.
PubMed ID: 17909628
DOI: 10.1172/jci31692
Sequence Information:
- Length: 355
- Mass: 40396
- Checksum: C59DC5F4C4312F22
- Sequence:
MDQFPESVTE NFEYDDLAEA CYIGDIVVFG TVFLSIFYSV IFAIGLVGNL LVVFALTNSK KPKSVTDIYL LNLALSDLLF VATLPFWTHY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP EVLQEIWPVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLVVIVF FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.