Genular: Defining Cellular Identity and Function

Details for: Hhex

Gene ID: 15242

Symbol: Hhex

Ensembl ID: ENSMUSG00000024986

Description: hematopoietically expressed homeobox

Associated with

Animal organ morphogenesis
(GO:0009887)
Anterior/posterior pattern specification
(GO:0009952)
B cell differentiation
(GO:0030183)
Cell differentiation
(GO:0030154)
Chromatin binding
(GO:0003682)
Common bile duct development
(GO:0061009)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna binding, bending
(GO:0008301)
Dna conformation change
(GO:0071103)
Embryonic heart tube development
(GO:0035050)
Embryonic organ development
(GO:0048568)
Endoderm development
(GO:0007492)
Eukaryotic initiation factor 4e binding
(GO:0008190)
Forebrain development
(GO:0030900)
Forebrain morphogenesis
(GO:0048853)
Gallbladder development
(GO:0061010)
Hemopoiesis
(GO:0030097)
Hepatic duct development
(GO:0061011)
Hepatoblast differentiation
(GO:0061017)
Hepatocyte differentiation
(GO:0070365)
Hmg box domain binding
(GO:0071837)
Interkinetic nuclear migration
(GO:0022027)
In utero embryonic development
(GO:0001701)
Liver development
(GO:0001889)
Morphogenesis of an epithelium
(GO:0002009)
Mrna export from nucleus
(GO:0006406)
Multicellular organism development
(GO:0007275)
Multicellular organism growth
(GO:0035264)
Myeloid leukocyte differentiation
(GO:0002573)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030948)
Notch signaling pathway
(GO:0007219)
Nucleus
(GO:0005634)
Pancreas development
(GO:0031016)
Poly(a)+ mrna export from nucleus
(GO:0016973)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of wnt signaling pathway
(GO:0030177)
Primary lung bud formation
(GO:0060431)
Primitive streak formation
(GO:0090009)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein localization to nucleus
(GO:0034504)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of leukocyte proliferation
(GO:0070663)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Signal transduction
(GO:0007165)
Thyroid gland development
(GO:0030878)
Tissue morphogenesis
(GO:0048729)
Transcription cis-regulatory region binding
(GO:0000976)
Vasculogenesis
(GO:0001570)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Hematopoietically-expressed homeobox protein Hhex

Genular Protein ID: 1770808792

Symbol: HHEX_MOUSE

Name: Hematopoietically-expressed homeobox protein Hhex

UniProtKB Accession Codes:

P43120 Q544N6 Q9CRV1 Q9R1X2

Database IDs:

Citations:

PubMed ID: 8096636

Title: HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.

PubMed ID: 8096636

DOI: 10.1093/nar/21.5.1245

PubMed ID: 10101294

Title: Genomic organization and promoter analysis of a mouse homeobox gene, Hex.

PubMed ID: 10101294

DOI: 10.1093/oxfordjournals.jbchem.a022351

PubMed ID: 10501975

Title: Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex.

PubMed ID: 10501975

DOI: 10.1007/s003359901152

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10804173

Title: Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function.

PubMed ID: 10804173

DOI: 10.1242/dev.127.11.2303

PubMed ID: 12554669

Title: The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

PubMed ID: 12554669

DOI: 10.1093/emboj/cdg069

PubMed ID: 16936074

Title: Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal.

PubMed ID: 16936074

DOI: 10.1242/dev.02516

PubMed ID: 20028982

Title: Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

PubMed ID: 20028982

DOI: 10.1074/jbc.m109.046649

PubMed ID: 23665349

Title: Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

PubMed ID: 23665349

DOI: 10.1016/j.ajpath.2013.03.013

Sequence Information:

Length: 271
Mass: 29987
Checksum: 376765557A71C962
Sequence:

MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP TLPSPNSSFT 
SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPSGFGGP LYPFPRTVND YTHALLRHDP 
LGKPLLWSPF LQRPLHKRKG GQVRFSNDQT VELEKKFETQ KYLSPPERKR LAKMLQLSER 
QVKTWFQNRR AKWRRLKQEN PQSNKKDALD SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS 
PASQEDPDSE ISEDSDQEVD IEGDKGYFNA G

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hhex

Associated with

Other Information

HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. PubMed ID: 8096636

Genomic organization and promoter analysis of a mouse homeobox gene, Hex. PubMed ID: 10101294

Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex. PubMed ID: 10501975

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function. PubMed ID: 10804173

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. PubMed ID: 12554669

Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. PubMed ID: 16936074

Interaction between Hhex and SOX13 modulates Wnt/TCF activity. PubMed ID: 20028982

Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. PubMed ID: 23665349