Details for: CXADR
Gene ID: 1525
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CXADR
Ensembl ID: ENSG00000154639
Description: CXADR Ig-like cell adhesion molecule
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 28.2rCSI 40.65%PRS 82.35
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CSI 23.1rCSI 19.37%PRS 77.13
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CSI 22.84rCSI 44.42%PRS 77.16
-
CSI 17.16rCSI 19.91%PRS 79.26
-
CSI 15.67rCSI 23.17%PRS 78.62
-
CSI 14.47rCSI 19.34%PRS 81.48
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CSI 13.06rCSI 31.13%PRS 74.2
-
CSI 12.59rCSI 33.93%PRS 79.82
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CSI 11.47rCSI 11.99%PRS 71.77
-
CSI 10.47rCSI 22.29%PRS 81.69
-
CSI 9.82rCSI 19.72%PRS 63.6
-
CSI 9.59rCSI 11.93%PRS 75.36
-
CSI 9.35rCSI 49.1%PRS 81.22
-
CSI 9.24rCSI 59.22%PRS 72.19
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CSI 9.09rCSI 12.09%PRS 80.11
-
CSI 8.96rCSI 13.68%PRS 74.35
-
CSI 8.89rCSI 9.32%PRS 71.12
-
CSI 8.79rCSI 15.73%PRS 73.34
-
CSI 8.32rCSI 16.47%PRS 85.13
-
CSI 8.24rCSI 10.57%PRS 70.36
-
CSI 7.76rCSI 11.46%PRS 86.1
-
CSI 7.52rCSI 7.24%PRS 73.43
-
CSI 6.94rCSI 16.47%PRS 75.56
-
CSI 6.64rCSI 11.71%PRS 70.12
-
CSI 6.15rCSI 15.59%PRS 63.93
-
CSI 6.05rCSI 47.4%PRS 81.21
-
CSI 6.03rCSI 10.11%PRS 55.43
-
CSI 5.98rCSI 8.75%PRS 78.91
-
CSI 5.86rCSI 14.24%PRS 53.61
-
CSI 5.66rCSI 10.1%PRS 84.23
-
CSI 5.56rCSI 12.31%PRS 72.95
-
CSI 5.51rCSI 41.37%PRS 86.04
-
CSI 5.5rCSI 20.74%PRS 57.05
-
CSI 5.48rCSI 4.55%PRS 74.39
-
CSI 5.48rCSI 5.82%PRS 80.74
-
CSI 5.38rCSI 6.43%PRS 55.37
-
CSI 5.38rCSI 32.24%PRS 77.25
-
CSI 5.23rCSI 12.55%PRS 79.82
-
CSI 5.2rCSI 8.38%PRS 74.49
-
CSI 5.17rCSI 8.38%PRS 69.56
-
CSI 5.13rCSI 19.53%PRS 64.42
-
CSI 5.01rCSI 11.57%PRS 62.01
-
CSI 4.87rCSI 3.85%PRS 61.68
-
CSI 4.8rCSI 14.16%PRS 75.67
-
CSI 4.79rCSI 5%PRS 73.73
-
CSI 4.58rCSI 11.9%PRS 75.64
-
CSI 4.43rCSI 6.16%PRS 72.6
-
CSI 4.39rCSI 10.85%PRS 73.14
-
CSI 4.36rCSI 17.78%PRS 66.48
-
CSI 4.35rCSI 3.86%PRS 71.86
-
CSI 4.34rCSI 42.7%PRS 86.67
-
CSI 4.3rCSI 3.78%PRS 62.48
-
CSI 4.3rCSI 6.83%PRS 83.38
-
CSI 4.18rCSI 6.67%PRS 65.64
-
CSI 4.09rCSI 15.91%PRS 75.12
-
CSI 4.07rCSI 9.31%PRS 74.72
-
CSI 4.07rCSI 3.15%PRS 77.3
-
CSI 4.06rCSI 3.92%PRS 66.3
-
CSI 4.06rCSI 10.49%PRS 69.07
-
CSI 4rCSI 15%PRS 66.1
-
CSI 3.81rCSI 23.81%PRS 65.53
-
CSI 3.68rCSI 21.69%PRS 56.38
-
CSI 3.62rCSI 8.5%PRS 75.19
-
CSI 3.45rCSI 3.44%PRS 67.64
-
CSI 3.44rCSI 4.93%PRS 75.84
-
CSI 3.29rCSI 6.75%PRS 62.03
-
CSI 3.28rCSI 5.03%PRS 65.19
-
CSI 3.27rCSI 5.25%PRS 57.18
-
CSI 3.23rCSI 7.12%PRS 83.58
-
CSI 3.08rCSI 7.02%PRS 68.61
-
CSI 3.01rCSI 8.62%PRS 82.52
-
CSI 3rCSI 3.66%PRS 80.91
-
CSI 2.99rCSI 4.09%PRS 74.56
-
CSI 2.93rCSI 6.41%PRS 80.33
-
CSI 2.87rCSI 2.72%PRS 73.19
-
CSI 2.83rCSI 3.27%PRS 66.25
-
CSI 2.83rCSI 3.63%PRS 77.68
-
CSI 2.78rCSI 66.48%PRS 54.15
-
CSI 2.64rCSI 45.94%PRS 87.14
-
CSI 2.63rCSI 6.92%PRS 87.77
-
CSI 2.63rCSI 7.79%PRS 83.12
-
CSI 2.47rCSI 8.27%PRS 58.16
-
CSI 2.45rCSI 4.87%PRS 70.2
-
CSI 2.45rCSI 59.14%PRS 54.74
-
CSI 2.38rCSI 3.06%PRS 56.73
-
CSI 2.29rCSI 35.41%PRS 84.82
-
CSI 2.28rCSI 4.36%PRS 89.24
-
CSI 2.28rCSI 2.84%PRS 53.43
-
CSI 2.21rCSI 13.62%PRS 82.35
-
CSI 2.21rCSI 3.61%PRS 63.22
-
CSI 2.2rCSI 3.41%PRS 78.99
-
CSI 2.19rCSI 4.11%PRS 61.87
-
CSI 2.14rCSI 11.49%PRS 82.89
-
CSI 2.1rCSI 3.39%PRS 63.6
-
CSI 2.08rCSI 2.84%PRS 65.4
-
CSI 2.05rCSI 3.01%PRS 66.81
-
CSI 2.02rCSI 3.64%PRS 67.12
-
CSI 2rCSI 2.72%PRS 83.71
-
CSI 1.99rCSI 2.85%PRS 63.54
-
CSI 1.91rCSI 2.25%PRS 76.05
-
CSI 0.2rCSI 5.5%PRS 84.2%
-
CSI 0.3rCSI 3.6%PRS 84.4%
-
CSI 0.5rCSI 4.4%PRS 85.7%
-
CSI 0.5rCSI 2.0%PRS 83.0%
-
CSI 0.5rCSI 3.7%PRS 82.0%
-
CSI 0.5rCSI 1.7%PRS 77.2%
-
CSI 0.6rCSI 2.0%PRS 73.9%
-
CSI 0.6rCSI 2.5%PRS 83.1%
-
CSI 0.7rCSI 2.9%PRS 74.4%
-
CSI 0.7rCSI 2.0%PRS 82.6%
-
CSI 0.7rCSI 1.6%PRS 61.4%
-
CSI 0.7rCSI 1.8%PRS 60.7%
-
CSI 0.7rCSI 3.5%PRS 85.4%
-
CSI 0.8rCSI 1.7%PRS 59.7%
-
CSI 0.8rCSI 23.5%PRS 87.6%
-
CSI 0.8rCSI 6.1%PRS 60.9%
-
CSI 0.9rCSI 2.9%PRS 60.4%
-
CSI 0.9rCSI 3.5%PRS 84.4%
-
CSI 0.9rCSI 3.5%PRS 84.7%
-
CSI 0.9rCSI 1.6%PRS 54.6%
-
CSI 0.9rCSI 2.5%PRS 61.8%
-
CSI 0.9rCSI 3.5%PRS 55.9%
-
CSI 1.0rCSI 3.4%PRS 79.8%
-
CSI 1.0rCSI 3.5%PRS 53.6%
-
CSI 1.0rCSI 2.2%PRS 69.5%
-
CSI 1.0rCSI 2.2%PRS 82.9%
-
CSI 1.1rCSI 1.6%PRS 84.2%
-
CSI 1.1rCSI 3.1%PRS 82.4%
-
CSI 1.2rCSI 1.8%PRS 78.2%
-
CSI 1.2rCSI 3.8%PRS 57.2%
-
CSI 1.2rCSI 1.5%PRS 72.2%
-
CSI 1.3rCSI 5.5%PRS 84.4%
-
CSI 1.3rCSI 3.9%PRS 79.5%
-
CSI 1.3rCSI 29.3%PRS 95.3%
-
CSI 1.3rCSI 7.7%PRS 71.3%
-
CSI 1.4rCSI 4.2%PRS 59.7%
-
CSI 1.4rCSI 3.2%PRS 82.0%
-
CSI 1.5rCSI 8.9%PRS 93.0%
-
CSI 1.5rCSI 3.8%PRS 74.0%
-
CSI 1.5rCSI 2.6%PRS 64.8%
-
CSI 1.5rCSI 1.6%PRS 74.7%
-
CSI 1.6rCSI 2.8%PRS 85.9%
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CSI 1.6rCSI 5.5%PRS 83.5%
-
CSI 1.6rCSI 8.0%PRS 90.7%
-
CSI 1.7rCSI 7.3%PRS 62.7%
-
CSI 1.7rCSI 2.5%PRS 84.3%
-
CSI 1.8rCSI 11.1%PRS 85.3%
-
CSI 1.8rCSI 2.1%PRS 65.6%
-
CSI 1.8rCSI 42.0%PRS 88.2%
-
CSI 1.8rCSI 23.7%PRS 83.8%
-
CSI 1.8rCSI 9.9%PRS 84.2%
-
CSI 1.8rCSI 2.7%PRS 68.8%
-
CSI 1.8rCSI 2.6%PRS 70.4%
-
CSI 1.9rCSI 1.9%PRS 78.9%
-
CSI 1.9rCSI 4.9%PRS 65.1%
-
CSI 1.9rCSI 4.4%PRS 80.9%
-
CSI 1.9rCSI 3.5%PRS 83.9%
-
CSI 1.9rCSI 1.8%PRS 76.7%
-
CSI 1.9rCSI 2.3%PRS 76.1%
-
CSI 2.0rCSI 2.9%PRS 63.5%
-
CSI 2.0rCSI 2.7%PRS 83.7%
-
CSI 2.0rCSI 3.6%PRS 67.1%
-
CSI 2.1rCSI 3.0%PRS 66.8%
-
CSI 2.1rCSI 2.8%PRS 65.4%
-
CSI 2.1rCSI 3.4%PRS 63.6%
-
CSI 2.1rCSI 11.5%PRS 82.9%
-
CSI 2.2rCSI 4.1%PRS 61.9%
-
CSI 2.2rCSI 3.4%PRS 79.0%
-
CSI 2.2rCSI 3.6%PRS 63.2%
-
CSI 2.2rCSI 13.6%PRS 82.4%
-
CSI 2.3rCSI 2.8%PRS 53.4%
-
CSI 2.3rCSI 4.4%PRS 89.2%
-
CSI 2.3rCSI 35.4%PRS 84.8%
-
CSI 2.4rCSI 3.1%PRS 56.7%
-
CSI 2.5rCSI 59.1%PRS 54.7%
-
CSI 2.5rCSI 4.9%PRS 70.2%
-
CSI 2.5rCSI 8.3%PRS 58.2%
-
CSI 2.6rCSI 7.8%PRS 83.1%
-
CSI 2.6rCSI 6.9%PRS 87.8%
-
CSI 2.6rCSI 45.9%PRS 87.1%
-
CSI 2.8rCSI 66.5%PRS 54.2%
-
CSI 2.8rCSI 3.6%PRS 77.7%
-
CSI 2.8rCSI 3.3%PRS 66.3%
-
CSI 2.9rCSI 2.7%PRS 73.2%
-
CSI 2.9rCSI 6.4%PRS 80.3%
-
CSI 3.0rCSI 4.1%PRS 74.6%
-
CSI 3.0rCSI 3.7%PRS 80.9%
-
CSI 3.0rCSI 8.6%PRS 82.5%
-
CSI 3.1rCSI 7.0%PRS 68.6%
-
CSI 3.2rCSI 7.1%PRS 83.6%
-
CSI 3.3rCSI 5.3%PRS 57.2%
-
CSI 3.3rCSI 5.0%PRS 65.2%
-
CSI 3.3rCSI 6.8%PRS 62.0%
-
CSI 3.4rCSI 4.9%PRS 75.8%
-
CSI 3.5rCSI 3.4%PRS 67.6%
-
CSI 3.6rCSI 8.5%PRS 75.2%
-
CSI 3.7rCSI 21.7%PRS 56.4%
-
CSI 3.8rCSI 23.8%PRS 65.5%
-
CSI 4.0rCSI 15.0%PRS 66.1%
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CSI 4.1rCSI 10.5%PRS 69.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3179465320
Symbol: CXAR_HUMAN
Name: Coxsackievirus and adenovirus receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9096397
Title: HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
PubMed ID: 9096397
PubMed ID: 9036860
Title: Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.
PubMed ID: 9036860
PubMed ID: 10543405
Title: Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene.
PubMed ID: 10543405
PubMed ID: 11573093
Title: Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor.
PubMed ID: 11573093
DOI: 10.1038/nsb1001-874
PubMed ID: 14978041
Title: Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection.
PubMed ID: 14978041
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10490761
Title: Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers.
PubMed ID: 10490761
PubMed ID: 9733828
Title: The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F.
PubMed ID: 9733828
PubMed ID: 10666333
Title: Expression of the adenovirus receptor and its interaction with the fiber knob.
PubMed ID: 10666333
PubMed ID: 10814575
Title: The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus.
PubMed ID: 10814575
PubMed ID: 11549277
Title: Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene.
PubMed ID: 11549277
PubMed ID: 11457744
Title: Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections.
PubMed ID: 11457744
PubMed ID: 11316797
Title: Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting.
PubMed ID: 11316797
PubMed ID: 11734628
Title: The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.
PubMed ID: 11734628
PubMed ID: 12297051
Title: Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.
PubMed ID: 12297051
PubMed ID: 12021372
Title: Fatty acid modification of the coxsackievirus and adenovirus receptor.
PubMed ID: 12021372
PubMed ID: 12468544
Title: The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).
PubMed ID: 12468544
PubMed ID: 15533241
Title: Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs.
PubMed ID: 15533241
PubMed ID: 15364909
Title: The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.
PubMed ID: 15364909
PubMed ID: 15304526
Title: A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth.
PubMed ID: 15304526
DOI: 10.1242/jcs.01300
PubMed ID: 15800062
Title: Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils.
PubMed ID: 15800062
PubMed ID: 19064666
Title: JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.
PubMed ID: 19064666
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10567268
Title: Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR.
PubMed ID: 10567268
PubMed ID: 11080637
Title: Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.
PubMed ID: 11080637
PubMed ID: 14967025
Title: Solution structure of the coxsackievirus and adenovirus receptor domain 1.
PubMed ID: 14967025
DOI: 10.1021/bi035490x
Sequence Information:
- Length: 365
- Mass: 40030
- Checksum: AB01C6346CB7FE64
- Sequence:
MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ GPLDIEWLIS PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS GDASINVTNL QLSDIGTYQC KVKKAPGVAN KKIHLVVLVK PSGARCYVDG SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD SQKMPTSWLA EMTSSVISVK NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA GAIIGTLLAL ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA IPVMIPAQSK DGSIV