Genular: Defining Cellular Identity and Function

Details for: Hif1a

Gene ID: 15251

Symbol: Hif1a

Ensembl ID: ENSMUSG00000021109

Description: hypoxia inducible factor 1, alpha subunit

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to hypoxia
(R-MMU-1234174)
Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
Post-translational protein modification
(R-MMU-597592)
Ptk6 promotes hif1a stabilization
(R-MMU-8857538)
Regulation of gene expression by hypoxia-inducible factor
(R-MMU-1234158)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Ub-specific processing proteases
(R-MMU-5689880)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Axonal transport of mitochondrion
(GO:0019896)
B-1 b cell homeostasis
(GO:0001922)
Blood vessel development
(GO:0001568)
Cardiac ventricle morphogenesis
(GO:0003208)
Cerebral cortex development
(GO:0021987)
Chondrocyte differentiation
(GO:0002062)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Connective tissue replacement involved in inflammatory response wound healing
(GO:0002248)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity
(GO:0001217)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Embryonic placenta development
(GO:0001892)
Enzyme binding
(GO:0019899)
Epithelial to mesenchymal transition
(GO:0001837)
Glandular epithelial cell differentiation
(GO:0002067)
Glandular epithelial cell maturation
(GO:0002071)
Heart looping
(GO:0001947)
Histone deacetylase binding
(GO:0042826)
Hsp90 protein binding
(GO:0051879)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular iron ion homeostasis
(GO:0006879)
Lactate metabolic process
(GO:0006089)
Lactation
(GO:0007595)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell migration
(GO:0001755)
Neural fold elevation formation
(GO:0021502)
Neuroblast proliferation
(GO:0007405)
Nuclear receptor binding
(GO:0016922)
Outflow tract morphogenesis
(GO:0003151)
P53 binding
(GO:0002039)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of glycolytic process
(GO:0006110)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hypoxia
(GO:0001666)
Response to muscle activity
(GO:0014850)
Response to reactive oxygen species
(GO:0000302)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Signal transduction
(GO:0007165)
Transcription coactivator binding
(GO:0001223)
Transcription regulator activator activity
(GO:0140537)
Ubiquitin protein ligase binding
(GO:0031625)
Vascular endothelial growth factor production
(GO:0010573)
Vasculature development
(GO:0001944)
Visual learning
(GO:0008542)

Other Information

Proteins

Genular Protein ID: 1473021934

Symbol: HIF1A_MOUSE

Name: Hypoxia-inducible factor 1-alpha

UniProtKB Accession Codes:

Q61221 O08741 O08993 Q61664 Q61665 Q8C681 Q8CC19 Q8CCB6 Q8R385 Q9CYA8

Database IDs:

Citations:

PubMed ID: 8702901

Title: Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha.

PubMed ID: 8702901

DOI: 10.1074/jbc.271.35.21262

PubMed ID: 9368100

Title: Molecular characterization of the murine Hif-1 alpha locus.

PubMed ID: 9368100

PubMed ID: 9210478

Title: The mouse gene for hypoxia-inducible factor-1alpha. Genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence.

PubMed ID: 9210478

DOI: 10.1111/j.1432-1033.1997.t01-1-00155.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8660378

Title: Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha.

PubMed ID: 8660378

DOI: 10.1006/bbrc.1996.0845

PubMed ID: 11707426

Title: Jab1 interacts directly with HIF-1alpha and regulates its stability.

PubMed ID: 11707426

DOI: 10.1074/jbc.c100442200

PubMed ID: 15225651

Title: Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo.

PubMed ID: 15225651

DOI: 10.1016/j.febslet.2004.05.079

PubMed ID: 16777103

Title: TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.

PubMed ID: 16777103

DOI: 10.1016/j.febslet.2006.05.058

PubMed ID: 17981124

Title: SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.

PubMed ID: 17981124

DOI: 10.1016/j.cell.2007.08.045

PubMed ID: 20889502

Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.

PubMed ID: 20889502

DOI: 10.1074/jbc.m110.160325

PubMed ID: 21546903

Title: Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.

PubMed ID: 21546903

DOI: 10.1038/cdd.2011.47

PubMed ID: 22009797

Title: RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.

PubMed ID: 22009797

DOI: 10.1530/erc-11-0211

PubMed ID: 26245371

Title: Structural integration in hypoxia-inducible factors.

PubMed ID: 26245371

DOI: 10.1038/nature14883

Sequence Information:

Length: 836
Mass: 93516
Checksum: 84D64ECAC2CC753B
Sequence:

MEGAGGENEK KKMSSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM 
RLTISYLRVR KLLDAGGLDS EDEMKAQMDC FYLKALDGFV MVLTDDGDMV YISDNVNKYM 
GLTQFELTGH SVFDFTHPCD HEEMREMLTH RNGPVRKGKE LNTQRSFFLR MKCTLTSRGR 
TMNIKSATWK VLHCTGHIHV YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK 
TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 
TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL IFSLQQTESV 
LKPVESSDMK MTQLFTKVES EDTSCLFDKL KKEPDALTLL APAAGDTIIS LDFGSDDTET 
EDQQLEDVPL YNDVMFPSSN EKLNINLAMS PLPSSETPKP LRSSADPALN QEVALKLESS 
PESLGLSFTM PQIQDQPASP SDGSTRQSSP ERLLQENVNT PNFSQPNSPS EYCFDVDSDM 
VNVFKLELVE KLFAEDTEAK NPFSTQDTDL DLEMLAPYIP MDDDFQLRSF DQLSPLESNS 
PSPPSMSTVT GFQQTQLQKP TITATATTTA TTDESKTETK DNKEDIKILI ASPSSTQVPQ 
ETTTAKASAY SGTHSRTASP DRAGKRVIEQ TDKAHPRSLN LSATLNQRNT VPEEELNPKT 
IASQNAQRKR KMEHDGSLFQ AAGIGTLLQQ PGDCAPTMSL SWKRVKGFIS SEQNGTEQKT 
IILIPSDLAC RLLGQSMDES GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN

Genular Protein ID: 1147026725

Symbol: A0A0R4J1E9_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J1E9

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 810
Mass: 90615
Checksum: ADE3B2A5E730A58E
Sequence:

MSSERRKEKS RDAARSRRSK ESEVFYELAH QLPLPHNVSS HLDKASVMRL TISYLRVRKL 
LDAGGLDSED EMKAQMDCFY LKALDGFVMV LTDDGDMVYI SDNVNKYMGL TQFELTGHSV 
FDFTHPCDHE EMREMLTHRN GPVRKGKELN TQRSFFLRMK CTLTSRGRTM NIKSATWKVL 
HCTGHIHVYD TNSNQPQCGY KKPPMTCLVL ICEPIPHPSN IEIPLDSKTF LSRHSLDMKF 
SYCDERITEL MGYEPEELLG RSIYEYYHAL DSDHLTKTHH DMFTKGQVTT GQYRMLAKRG 
GYVWVETQAT VIYNTKNSQP QCIVCVNYVV SGIIQHDLIF SLQQTESVLK PVESSDMKMT 
QLFTKVESED TSCLFDKLKK EPDALTLLAP AAGDTIISLD FGSDDTETED QQLEDVPLYN 
DVMFPSSNEK LNINLAMSPL PSSETPKPLR SSADPALNQE VALKLESSPE SLGLSFTMPQ 
IQDQPASPSD GSTRQSSPEP NSPSEYCFDV DSDMVNVFKL ELVEKLFAED TEAKNPFSTQ 
DTDLDLEMLA PYIPMDDDFQ LRSFDQLSPL ESNSPSPPSM STVTGFQQTQ LQKPTITATA 
TTTATTDESK TETKDNKEDI KILIASPSST QVPQETTTAK ASAYSGTHSR TASPDRAGKR 
VIEQTDKAHP RSLNLSATLN QRNTVPEEEL NPKTIASQNA QRKRKMEHDG SLFQAAGIGT 
LLQQPGDCAP TMSLSWKRVK GFISSEQNGT EQKTIILIPS DLACRLLGQS MDESGLPQLT 
SYDCEVNAPI QGSRNLLQGE ELLRALDQVN

Genular Protein ID: 3915883955

Symbol: Q3UCW2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UCW2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 836
Mass: 93603
Checksum: 25DBB1F010E62DDF
Sequence:

MEGAGGENEK KKMSSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM 
RLTISYLRVR KLLDAGGLDS EDEMKAQMDC FYLKALDGFV MVLTDDGDMV YISDNVNKYM 
GLTQFELTGH SVFDFTHPCD HEEMREMLTH RNGPVRKGKE LNTQRSFFLR MKCTLTSRGR 
TMNIKSATWK VLHCTGHIHV YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK 
TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 
TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL IFSLQQTESV 
LKPVESSDMK MTQLFTKVES EDTSCLFDKL KKEPDALTLL APAAGDTIIS LDFGSDDTET 
EDQQLEDVPL YNDVMFPSSN EKLNINLAMS PLPSSETPKP LRSSVDRALN QEVALKLESS 
PESLGLSFTM PQIQDQPASP SDGSTRQSSP ERLLQENVNT PNFSQPNSPS EYCFDVDSDM 
VNVFKLELVE KLFAEDTEAK NPFSTQDTDL DLEMLAPYIP MDDDFQLRSF DQLSPLESNS 
PSPPSMSTVT GFQQTQLQKP TITATATTTA TTDESKTETK DNKEDIKILI ASPSSTQVPQ 
ETTTAKASAY SGTHSRTASP DRAGKRVIEQ TDKAHPRSLN LSATLNQRNT VPEEELNPKT 
IASQNAQRKR KMEHDGSLFQ AAGIGTLLQQ PGDCAPTMSL SWKRVKGFIS SEQNGTEQKT 
IILIPSDLAC RLLGQSMDES GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hif1a

Associated with

Other Information

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. PubMed ID: 8702901

Molecular characterization of the murine Hif-1 alpha locus. PubMed ID: 9368100

The mouse gene for hypoxia-inducible factor-1alpha. Genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence. PubMed ID: 9210478

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. PubMed ID: 8660378

Jab1 interacts directly with HIF-1alpha and regulates its stability. PubMed ID: 11707426

Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. PubMed ID: 15225651

TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. PubMed ID: 16777103

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. PubMed ID: 17981124

Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. PubMed ID: 20889502

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. PubMed ID: 21546903

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. PubMed ID: 22009797

Structural integration in hypoxia-inducible factors. PubMed ID: 26245371

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Database document:

PubMed ID: 8702901

PubMed ID: 9368100

PubMed ID: 9210478

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 8660378

PubMed ID: 11707426

PubMed ID: 15225651

PubMed ID: 16777103

PubMed ID: 17981124

PubMed ID: 20889502

PubMed ID: 21546903

PubMed ID: 22009797

PubMed ID: 26245371

PubMed ID: 19468303

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073