Genular: Defining Cellular Identity and Function

Details for: Hipk1

Gene ID: 15257

Symbol: Hipk1

Ensembl ID: ENSMUSG00000008730

Description: homeodomain interacting protein kinase 1

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by tp53
(R-MMU-3700989)
Adherens junction assembly
(GO:0034333)
Anterior/posterior pattern specification
(GO:0009952)
Atp binding
(GO:0005524)
Cell population proliferation
(GO:0008283)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic retina morphogenesis in camera-type eye
(GO:0060059)
Endothelial cell apoptotic process
(GO:0072577)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Iris morphogenesis
(GO:0061072)
Kinase activity
(GO:0016301)
Lens induction in camera-type eye
(GO:0060235)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Pml body
(GO:0016605)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna binding
(GO:0043388)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Retina layer formation
(GO:0010842)
Smoothened signaling pathway
(GO:0007224)
Transcription corepressor activity
(GO:0003714)
Transferase activity
(GO:0016740)

Other Information

Proteins

Homeodomain-interacting protein kinase 1

Genular Protein ID: 2434133595

Symbol: HIPK1_MOUSE

Name: Homeodomain-interacting protein kinase 1

UniProtKB Accession Codes:

O88904 A6H5Z7 Q80TV5 Q9QUQ8 Q9QZR3 Q9WVN7

Database IDs:

Citations:

PubMed ID: 9748262

Title: Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.

PubMed ID: 9748262

DOI: 10.1074/jbc.273.40.25875

PubMed ID: 10694743

Title: Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system.

PubMed ID: 10694743

DOI: 10.1002/(sici)1098-2795(200004)55:4<372::aid-mrd3>3.0.co;2-a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12693553

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 12693553

DOI: 10.1093/dnares/10.1.35

PubMed ID: 12529400

Title: Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.

PubMed ID: 12529400

DOI: 10.1128/mcb.23.3.950-960.2003

PubMed ID: 12702766

Title: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).

PubMed ID: 12702766

DOI: 10.1073/pnas.0530308100

PubMed ID: 16917507

Title: Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

PubMed ID: 16917507

DOI: 10.1038/sj.emboj.7601273

PubMed ID: 18219322

Title: SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis.

PubMed ID: 18219322

DOI: 10.1038/sj.cdd.4402303

PubMed ID: 20231426

Title: Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.

PubMed ID: 20231426

DOI: 10.1182/blood-2009-07-235093

PubMed ID: 20579985

Title: Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.

PubMed ID: 20579985

DOI: 10.1016/j.febslet.2010.06.020

Sequence Information:

Length: 1210
Mass: 130723
Checksum: 26D264B883220640
Sequence:

MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQASSSH 
QVANFNLPAY DQGLLLPAPA VEHIVVTAAD SSGSAATATF QSSQTLTHRS NVSLLEPYQK 
CGLKRKSEEV ESNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM SHLLDFPHSS HVKSCFQNME 
ICKRRVHMYD TVSQIKSPFT THVAPNTSTN LTMSFSNQLN TVHNQASVLA SSSTAAAATL 
SLANSDVSLL NYQSALYPSS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ TFIVCPPAFQ 
TGLQATTKHS GFPVRMDNAV PIVPQAPAAQ PLQIQSGVLT QGSCTPLMVA TLHPQVATIT 
PQYAVPFTLS CAAGRPALVE QTAAVLQAWP GGTQQILLPS AWQQLPGVAL HNSVQPAAVI 
PEAMGSSQQL ADWRNAHSHG NQYSTIMQQP SLLTNHVTLA TAQPLNVGVA HVVRQQQSSS 
LPSKKNKQSA PVSSKSSLEV LPSQVYSLVG SSPLRTTSSY NSLVPVQDQH QPIIIPDTPS 
PPVSVITIRS DTDEEEDNKY KPNSSSLKAR SNVISYVTVN DSPDSDSSLS SPHPTDTLSA 
LRGNSGTLLE GPGRPAADGI GTRTIIVPPL KTQLGDCTVA TQASGLLSSK TKPVASVSGQ 
SSGCCITPTG YRAQRGGASA VQPLNLSQNQ QSSSASTSQE RSSNPAPRRQ QAFVAPLSQA 
PYAFQHGSPL HSTGHPHLAP APAHLPSQPH LYTYAAPTSA AALGSTSSIA HLFSPQGSSR 
HAAAYTTHPS TLVHQVPVSV GPSLLTSASV APAQYQHQFA TQSYIGSSRG STIYTGYPLS 
PTKISQYSYL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hipk1

Associated with

Other Information

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. PubMed ID: 9748262

Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system. PubMed ID: 10694743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 12693553

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. PubMed ID: 12529400

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). PubMed ID: 12702766

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. PubMed ID: 16917507

SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. PubMed ID: 18219322

Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. PubMed ID: 20231426

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. PubMed ID: 20579985