Genular: Defining Cellular Identity and Function

Details for: Hira

Gene ID: 15260

Symbol: Hira

Ensembl ID: ENSMUSG00000022702

Description: histone cell cycle regulator

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Formation of senescence-associated heterochromatin foci (sahf)
(R-MMU-2559584)
Chromatin
(GO:0000785)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Dna-templated transcription
(GO:0006351)
Gastrulation
(GO:0007369)
Hir complex
(GO:0000417)
Histone binding
(GO:0042393)
Histone chaperone activity
(GO:0140713)
Muscle cell differentiation
(GO:0042692)
Nucleoplasm
(GO:0005654)
Nucleosome assembly
(GO:0006334)
Nucleosome binding
(GO:0031491)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)

Other Information

Proteins

Protein HIRA

Genular Protein ID: 3249663707

Symbol: HIRA_MOUSE

Name: Protein HIRA

UniProtKB Accession Codes:

Q61666 O08845 Q3TFY0 Q3UX35 Q62365 Q7TMW4

Database IDs:

Citations:

PubMed ID: 8611624

Title: The HIR protein family: isolation and characterization of a complete murine cDNA.

PubMed ID: 8611624

DOI: 10.1016/0167-4781(96)00010-3

PubMed ID: 9063745

Title: The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.

PubMed ID: 9063745

DOI: 10.1093/hmg/6.2.247

PubMed ID: 8111380

Title: Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease.

PubMed ID: 8111380

DOI: 10.1093/hmg/2.12.2099

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9731536

Title: HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3.

PubMed ID: 9731536

DOI: 10.1038/1739

PubMed ID: 11238922

Title: HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.

PubMed ID: 11238922

DOI: 10.1128/mcb.21.5.1854-1865.2001

PubMed ID: 15922569

Title: Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.

PubMed ID: 15922569

DOI: 10.1016/j.mod.2005.04.009

PubMed ID: 16399082

Title: Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

PubMed ID: 16399082

DOI: 10.1016/j.devcel.2005.10.017

Sequence Information:

Length: 1015
Mass: 111767
Checksum: 2D84294D45B7A967
Sequence:

MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENIP 
KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLANVEQ 
WRCVSILRSH SGDVMDVAWS PHDAWLASCS VDNTVVIWNA VKFPEILATL RGHSGLVKGL 
TWDPVGKYIA SQADDRSLKV WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA 
HAMNNSGPTA QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS TKPSCPYCCC 
AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG SVAFLDFSQD 
ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE MLKYQRRQQQ QQLDQKNATT 
RETSSASSVT GVVNGESLED IRKNLLKKQV ETRTADGRRR ITPLCIAQLD TGDFSTAFFN 
SIPLSSSLAG TMLSSPSGQQ LLPLDSSTPS FGASKPCTEP VAATSARPTG ESVSKDSMNA 
TSTPAASSPS VLTTPSKIEP MKAFDSRFTE RSKATPGAPS LTSVIPTAVE RLKEQNLVKE 
LRSRELESSS DSDEKVHLAK PSSLSKRKLE LEVETVEKKK KGRPRKDSRL LPMSLSVQSP 
AALSTEKEAM CLSAPALALK LPIPGPQRAF TLQVSSDPSM YIEVENEVTT VGGIRLSRLK 
CNREGKEWET VLSSRVLTAA GSCDVVCVAC EKRMLSVFST CGRRLLPPIL LPSPISTLHC 
TGPYVMALTA AATLSVWDVH RQVVVVKEES LHSILSGSDM TVSQILLTQH GIPVMNLSDG 
KAYCFNPSLS TWNLVSDKQD SLAQCADFRN SLPSQDAMLC SGPLAIIQGR TSNSGRQAAR 
LFSVPHVVQQ ETTLAYLENQ VAAALTLQSS HEYRHWLLLY ARYLVNEGFE YRLREICKDL 
LGPVHCSTGS QWESTVVGLR KRELLKELLP VIGQNLRFQR LFTECQEQLD ILRDK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hira

Associated with

Other Information

The HIR protein family: isolation and characterization of a complete murine cDNA. PubMed ID: 8611624

The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients. PubMed ID: 9063745

Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. PubMed ID: 8111380

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3. PubMed ID: 9731536

HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. PubMed ID: 11238922

Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote. PubMed ID: 15922569

Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. PubMed ID: 16399082