Details for: TEX28

Gene ID: 1527

Symbol: TEX28

Ensembl ID: ENSG00000278057

Description: testis expressed 28

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5827
    Cell Significance Index: 14.1200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1451
    Cell Significance Index: 2.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0789
    Cell Significance Index: 1.9700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0264
    Cell Significance Index: 0.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0212
    Cell Significance Index: 0.5500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0204
    Cell Significance Index: 0.2300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0103
    Cell Significance Index: 0.1000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0101
    Cell Significance Index: 0.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0060
    Cell Significance Index: 0.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0052
    Cell Significance Index: 1.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0014
    Cell Significance Index: 0.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0008
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0017
    Cell Significance Index: -0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0022
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0024
    Cell Significance Index: -0.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0031
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0038
    Cell Significance Index: -0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0044
    Cell Significance Index: -0.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0049
    Cell Significance Index: -0.5100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0050
    Cell Significance Index: -0.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0063
    Cell Significance Index: -0.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0070
    Cell Significance Index: -0.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0098
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0107
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0107
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0114
    Cell Significance Index: -0.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0124
    Cell Significance Index: -0.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0132
    Cell Significance Index: -0.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0140
    Cell Significance Index: -0.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0142
    Cell Significance Index: -0.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0146
    Cell Significance Index: -0.3700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0148
    Cell Significance Index: -0.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0155
    Cell Significance Index: -0.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0159
    Cell Significance Index: -0.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0167
    Cell Significance Index: -0.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0176
    Cell Significance Index: -0.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0177
    Cell Significance Index: -0.3700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0178
    Cell Significance Index: -0.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0179
    Cell Significance Index: -0.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0180
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0189
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0196
    Cell Significance Index: -0.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0197
    Cell Significance Index: -0.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0201
    Cell Significance Index: -0.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0201
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0203
    Cell Significance Index: -0.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0205
    Cell Significance Index: -0.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0206
    Cell Significance Index: -0.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0212
    Cell Significance Index: -0.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0213
    Cell Significance Index: -0.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0216
    Cell Significance Index: -0.5500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0235
    Cell Significance Index: -0.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0254
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0263
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0266
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0271
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0272
    Cell Significance Index: -0.4700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0275
    Cell Significance Index: -0.3400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0285
    Cell Significance Index: -0.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0290
    Cell Significance Index: -0.3800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0305
    Cell Significance Index: -0.3700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0306
    Cell Significance Index: -0.3100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0312
    Cell Significance Index: -0.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0318
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0322
    Cell Significance Index: -0.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0327
    Cell Significance Index: -0.4700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0332
    Cell Significance Index: -0.3800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0338
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0339
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0340
    Cell Significance Index: -0.4800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0342
    Cell Significance Index: -0.4100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0343
    Cell Significance Index: -0.4100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0345
    Cell Significance Index: -0.4500
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0348
    Cell Significance Index: -0.3800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0348
    Cell Significance Index: -0.4200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0351
    Cell Significance Index: -0.5300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0351
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TEX28 is primarily expressed in the testis, with limited expression in other tissues, including the immune system. Its expression is predominantly observed in plasma cells, B cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, and neoplastic cells. This suggests that TEX28 may play a crucial role in the development and maintenance of these cell types. Furthermore, its association with abnormal and neoplastic cells implies that TEX28 may also be involved in carcinogenesis and tumor progression. **Pathways and Functions:** TEX28's involvement in various cellular processes is mediated through its interaction with other proteins and signaling pathways. Its primary function appears to be protein binding, which may facilitate its role in regulating gene expression and cellular behavior. Specifically, TEX28 has been implicated in the endomembrane system, where it may influence the trafficking and processing of proteins. Additionally, its association with the molecular function pathway suggests that TEX28 may be involved in regulating cellular metabolism and energy homeostasis. **Clinical Significance:** The clinical significance of TEX28 is multifaceted. Its expression in plasma cells and B cells suggests that TEX28 may play a role in the regulation of immune responses, particularly in the context of autoimmune diseases and cancer. Its association with goblet cells and absorptive cells implies that TEX28 may also be involved in the regulation of intestinal homeostasis and the maintenance of a healthy gut microbiome. Furthermore, its expression in neoplastic cells raises concerns about its potential role in carcinogenesis and tumor progression. **Implications and Future Directions:** The discovery of TEX28's role in immune regulation and cellular homeostasis has significant implications for our understanding of various diseases, including autoimmune disorders, cancer, and gastrointestinal disorders. Further research is needed to elucidate the mechanisms by which TEX28 regulates cellular behavior and to explore its potential as a therapeutic target. Additionally, the identification of TEX28's regulatory interactions with other proteins and signaling pathways may provide insights into the development of novel therapeutic strategies for diseases characterized by dysregulated immune responses and cellular homeostasis. **Conclusion:** In conclusion, TEX28 is a testis-specific protein with a complex role in immune regulation and cellular homeostasis. Its expression in various cell types, including plasma cells, B cells, and neoplastic cells, suggests that TEX28 may play a crucial role in regulating immune responses and maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms by which TEX28 regulates cellular behavior and to explore its potential as a therapeutic target.

Genular Protein ID: 305226738

Symbol: TEX28_HUMAN

Name: Testis-specific protein TEX28

UniProtKB Accession Codes:

O15482 B1B1E8 D3DWW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 2 GeneCards 3 GeneTree 1 GenomeRNAi 1 HGNC 3 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9268643

Title: Identification of a gene within the tandem array of red and green color pigment genes.

PubMed ID: 9268643

DOI: 10.1006/geno.1997.4830

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 410
  • Mass: 46131
  • Checksum: 8E455A761D52A660
  • Sequence:
    • MVLKAEHTRS PSATLPSNVP SCRSLSSSED GPSGPSSLAD GGLAHNLQDS VRHRILYLSE 
QLRVEKASRD GNTVSYLKLV SKADRHQVPH IQQAFEKVNQ RASATIAQIE HRLHQCHQQL 
QELEEGCRPE GLLLMAESDP ANCEPPSEKA LLSEPPEPGG EDGPVNLPHA SRPFILESRF 
QSLQQGTCLE TEDVAQQQNL LLQKVKAELE EAKRFHISLQ ESYHSLKERS LTDLQLLLES 
LQEEKCRQAL MEEQVNGRLQ GQLNEIYNLK HNLACSEERM AYLSYERAKE IWEITETFKS 
RISKLEMLQQ VTQLEAAEHL QSRPPQMLFK FLSPRLSLAT VLLVFVSTLC ACPSSLISSR 
LCTCTMLMLI GLGVLAWQRW RAIPATDWQE WVPSRCRLYS KDSGPPADGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.