Genular: Defining Cellular Identity and Function

Details for: H2ax

Gene ID: 15270

Symbol: H2ax

Ensembl ID: ENSMUSG00000049932

Description: H2A.X variant histone

Associated with

Base-excision repair, ap site formation
(R-MMU-73929)
Base excision repair
(R-MMU-73884)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Chromosome maintenance
(R-MMU-73886)
Cleavage of the damaged purine
(R-MMU-110331)
Condensation of prophase chromosomes
(R-MMU-2299718)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-MMU-606279)
Depurination
(R-MMU-73927)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Epigenetic regulation of gene expression
(R-MMU-212165)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Inhibition of dna recombination at telomere
(R-MMU-9670095)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Nucleosome assembly
(R-MMU-774815)
Prc2 methylates histones and dna
(R-MMU-212300)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recognition and association of dna glycosylase with site containing an affected purine
(R-MMU-110330)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-MMU-8936459)
Telomere maintenance
(R-MMU-157579)
Transcriptional regulation by runx1
(R-MMU-8878171)
Cell cycle
(GO:0007049)
Cellular response to gamma radiation
(GO:0071480)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Condensed nuclear chromosome
(GO:0000794)
Damaged dna binding
(GO:0003684)
Dna binding
(GO:0003677)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Double-strand break repair via homologous recombination
(GO:0000724)
Enzyme binding
(GO:0019899)
Heterochromatin organization
(GO:0070828)
Histone binding
(GO:0042393)
Male germ cell nucleus
(GO:0001673)
Meiotic cell cycle
(GO:0051321)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Replication fork
(GO:0005657)
Site of dna damage
(GO:0090734)
Site of double-strand break
(GO:0035861)
Spermatogenesis
(GO:0007283)
Structural constituent of chromatin
(GO:0030527)
Xy body
(GO:0001741)

Other Information

Proteins

Histone H2AX

Genular Protein ID: 3533905106

Symbol: H2AX_MOUSE

Name: Histone H2AX

UniProtKB Accession Codes:

P27661

Database IDs:

Citations:

PubMed ID: 2041781

Title: Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene.

PubMed ID: 2041781

DOI: 10.1093/nar/19.9.2441

PubMed ID: 7774939

Title: Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis.

PubMed ID: 7774939

DOI: 10.1016/0888-7543(95)80145-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7407044

Title: Histone 2A, a heteromorphous family of eight protein species.

PubMed ID: 7407044

DOI: 10.1021/bi00555a022

PubMed ID: 7217105

Title: Quantitative determination of histone modification. H2A acetylation and phosphorylation.

PubMed ID: 7217105

DOI: 10.1016/s0021-9258(19)69487-1

PubMed ID: 9488723

Title: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.

PubMed ID: 9488723

DOI: 10.1074/jbc.273.10.5858

PubMed ID: 11571274

Title: ATM phosphorylates histone H2AX in response to DNA double-strand breaks.

PubMed ID: 11571274

DOI: 10.1074/jbc.c100466200

PubMed ID: 11740565

Title: AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.

PubMed ID: 11740565

DOI: 10.1038/414660a

PubMed ID: 11242108

Title: Recombinational DNA double-strand breaks in mice precede synapsis.

PubMed ID: 11242108

DOI: 10.1038/85830

PubMed ID: 12447390

Title: DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

PubMed ID: 12447390

DOI: 10.1038/ncb884

PubMed ID: 12034884

Title: Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.

PubMed ID: 12034884

DOI: 10.1073/pnas.122228699

PubMed ID: 11934988

Title: Genomic instability in mice lacking histone H2AX.

PubMed ID: 11934988

DOI: 10.1126/science.1069398

PubMed ID: 12914700

Title: Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

PubMed ID: 12914700

DOI: 10.1016/s0092-8674(03)00566-x

PubMed ID: 12914701

Title: H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

PubMed ID: 12914701

DOI: 10.1016/s0092-8674(03)00567-1

PubMed ID: 12689589

Title: H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.

PubMed ID: 12689589

DOI: 10.1016/s1534-5807(03)00093-5

PubMed ID: 12697768

Title: Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.

PubMed ID: 12697768

DOI: 10.1074/jbc.c300117200

PubMed ID: 12660252

Title: Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

PubMed ID: 12660252

DOI: 10.1074/jbc.m300198200

PubMed ID: 14530383

Title: H2AX regulates meiotic telomere clustering.

PubMed ID: 14530383

DOI: 10.1083/jcb.200305124

PubMed ID: 12792649

Title: Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

PubMed ID: 12792649

DOI: 10.1038/ncb1004

PubMed ID: 15059890

Title: ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

PubMed ID: 15059890

DOI: 10.1158/0008-5472.can-03-3207

PubMed ID: 15589157

Title: BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.

PubMed ID: 15589157

DOI: 10.1016/j.cub.2004.11.032

PubMed ID: 15574327

Title: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

PubMed ID: 15574327

DOI: 10.1016/j.molcel.2004.10.029

PubMed ID: 15610743

Title: Control of sister chromatid recombination by histone H2AX.

PubMed ID: 15610743

DOI: 10.1016/j.molcel.2004.12.007

PubMed ID: 15632067

Title: Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.

PubMed ID: 15632067

DOI: 10.1128/mcb.25.2.661-670.2005

PubMed ID: 15580272

Title: Silencing of unsynapsed meiotic chromosomes in the mouse.

PubMed ID: 15580272

DOI: 10.1038/ng1484

PubMed ID: 19092802

Title: WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.

PubMed ID: 19092802

DOI: 10.1038/nature07668

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20488183

Title: Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway.

PubMed ID: 20488183

DOI: 10.1016/j.febslet.2010.05.017

PubMed ID: 23039116

Title: HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity.

PubMed ID: 23039116

DOI: 10.1111/gtc.12005

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 30272023

Title: Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.

PubMed ID: 30272023

DOI: 10.1038/s42003-018-0154-z

PubMed ID: 30949703

Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.

PubMed ID: 30949703

DOI: 10.1093/nar/gkz226

PubMed ID: 30746471

Title: SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.

PubMed ID: 30746471

DOI: 10.1126/sciadv.aau9780

Sequence Information:

Length: 143
Mass: 15143
Checksum: A3683760C13CC2B9
Sequence:

MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK 
SSATVGPKAP AVGKKASQAS QEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2ax

Associated with

Other Information

Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene. PubMed ID: 2041781

Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis. PubMed ID: 7774939

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Histone 2A, a heteromorphous family of eight protein species. PubMed ID: 7407044

Quantitative determination of histone modification. H2A acetylation and phosphorylation. PubMed ID: 7217105

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. PubMed ID: 9488723

ATM phosphorylates histone H2AX in response to DNA double-strand breaks. PubMed ID: 11571274

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. PubMed ID: 11740565

Recombinational DNA double-strand breaks in mice precede synapsis. PubMed ID: 11242108

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. PubMed ID: 12447390

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. PubMed ID: 12034884

Genomic instability in mice lacking histone H2AX. PubMed ID: 11934988

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. PubMed ID: 12914700

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. PubMed ID: 12914701

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. PubMed ID: 12689589

Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. PubMed ID: 12697768

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. PubMed ID: 12660252

H2AX regulates meiotic telomere clustering. PubMed ID: 14530383

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. PubMed ID: 12792649

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. PubMed ID: 15059890

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. PubMed ID: 15589157

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. PubMed ID: 15574327

Control of sister chromatid recombination by histone H2AX. PubMed ID: 15610743

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. PubMed ID: 15632067

Silencing of unsynapsed meiotic chromosomes in the mouse. PubMed ID: 15580272

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. PubMed ID: 19092802

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway. PubMed ID: 20488183

HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. PubMed ID: 23039116

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. PubMed ID: 30272023

SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. PubMed ID: 30949703

SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. PubMed ID: 30746471