Genular: Defining Cellular Identity and Function

Details for: Hk2

Gene ID: 15277

Symbol: Hk2

Ensembl ID: ENSMUSG00000000628

Description: hexokinase 2

Associated with

Glucose metabolism
(R-MMU-70326)
Glycolysis
(R-MMU-70171)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Apoptotic mitochondrial changes
(GO:0008637)
Atp binding
(GO:0005524)
Carbohydrate metabolic process
(GO:0005975)
Carbohydrate phosphorylation
(GO:0046835)
Catalytic activity
(GO:0003824)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment of protein localization to mitochondrion
(GO:0072655)
Fructokinase activity
(GO:0008865)
Fructose 6-phosphate metabolic process
(GO:0006002)
Glucokinase activity
(GO:0004340)
Glucose 6-phosphate metabolic process
(GO:0051156)
Glucose binding
(GO:0005536)
Glucose metabolic process
(GO:0006006)
Glycolytic process
(GO:0006096)
Hexokinase activity
(GO:0004396)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase activity
(GO:0016301)
Maintenance of protein location in mitochondrion
(GO:0072656)
Membrane
(GO:0016020)
Metabolic process
(GO:0008152)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of mitochondrial membrane permeability
(GO:0035795)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Phosphotransferase activity, alcohol group as acceptor
(GO:0016773)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
(GO:1904925)
Regulation of glucose import
(GO:0046324)
Response to ischemia
(GO:0002931)
Sarcoplasmic reticulum
(GO:0016529)
Transferase activity
(GO:0016740)

Other Information

Proteins

HXK2_MOUSE

Genular Protein ID: 905837120

Symbol: HXK2_MOUSE

Name: N/A

UniProtKB Accession Codes:

O08528

Database IDs:

Citations:

PubMed ID: 10656921

Title: Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern.

PubMed ID: 10656921

DOI: 10.1007/s003350010019

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18350175

Title: Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels.

PubMed ID: 18350175

DOI: 10.1371/journal.pone.0001852

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 10428828

Title: Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.

PubMed ID: 10428828

DOI: 10.1074/jbc.274.32.22517

Sequence Information:

Length: 917
Mass: 102535
Checksum: 44293E7A92D724B3
Sequence:

MIASHMIACL FTELNQNQVQ KVDQYLYHMR LSDETLLEIS RRFRKEMEKG LGATTHPTAA 
VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLRVRVTDN GLQRVEMENQ IYAIPEDIMR 
GSGTQLFDHI AECLANFMDK LQIKEKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV 
EGRDVVDLIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DQNCEIGLIV GTGSNACYME 
EMRHIDMVEG DEGRMCINME WGAFGDDGTL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM 
YMGELVRLIL VKMAKAELLF QGKLSPELLT TGSFETKDVS DIEDDKDGIQ KAYQILVRLG 
LSPLQEDCVA THRICQIVST RSASLCAATL AAVLWRIKEN KGEERLRSTI GVDGSVYKKH 
PHFAKRLHKA VRRLVPDCDV RFLRSEDGSG KGAAMVTAVA YRLADQHRAR QKTLESLKLS 
HEQLLEVKRR MKVEMEQGLS KETHEAAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV 
LLVRVRNGKR RGVEMHNKIY SIPQEVMHGT GEELFDHIVQ CIADFLEYMG MKGVSLPLGF 
TFSFPCQQNS LDQSILLKWT KGFKASGCEG EDVVTLLKEA IRRREEFDLD VVAVVNDTVG 
TMMTCGYEDP HCEVGLIVGT GSNACYMEEM RNVELVDGEE GRMCVNMEWG AFGDNGCLDD 
LRTVFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG 
IFETKFLSQI ESDCLALLQV RAILRHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA 
VVDKIRENRG LDNLKVTVGV DGTLYKLHPH FAKVMHETVR DLAPKCDVSF LESEDGSGKG 
AALITAVACR IREAGQR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hk2

Associated with

Other Information

Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern. PubMed ID: 10656921

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PubMed ID: 18350175