Details for: CYB5A

Gene ID: 1528

Symbol: CYB5A

Ensembl ID: ENSG00000166347

Description: cytochrome b5 type A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 230.0296
    Cell Significance Index: -35.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.9594
    Cell Significance Index: -43.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 124.7367
    Cell Significance Index: -51.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 122.5455
    Cell Significance Index: -49.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 110.1197
    Cell Significance Index: -51.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 77.9110
    Cell Significance Index: -52.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.4801
    Cell Significance Index: -50.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.6551
    Cell Significance Index: -47.6600
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 37.7231
    Cell Significance Index: 18.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.8206
    Cell Significance Index: -45.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7824
    Cell Significance Index: -50.4400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 11.7482
    Cell Significance Index: 15.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.2193
    Cell Significance Index: 103.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0457
    Cell Significance Index: -30.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.9501
    Cell Significance Index: 61.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 9.9356
    Cell Significance Index: 167.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5809
    Cell Significance Index: -18.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.3769
    Cell Significance Index: 1149.5500
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 5.8411
    Cell Significance Index: 29.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.6922
    Cell Significance Index: 131.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.2220
    Cell Significance Index: 642.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.0812
    Cell Significance Index: 40.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.0114
    Cell Significance Index: 260.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.3004
    Cell Significance Index: 19.3900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.2358
    Cell Significance Index: 12.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9276
    Cell Significance Index: 218.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8852
    Cell Significance Index: 204.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.6401
    Cell Significance Index: 1998.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4944
    Cell Significance Index: 495.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3457
    Cell Significance Index: 1281.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2657
    Cell Significance Index: 61.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6829
    Cell Significance Index: 36.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6772
    Cell Significance Index: 78.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.6491
    Cell Significance Index: 130.6100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.4635
    Cell Significance Index: 8.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4583
    Cell Significance Index: 87.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0965
    Cell Significance Index: 150.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0320
    Cell Significance Index: 456.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9766
    Cell Significance Index: 25.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9495
    Cell Significance Index: 93.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9290
    Cell Significance Index: 42.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9241
    Cell Significance Index: 48.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8129
    Cell Significance Index: 105.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8101
    Cell Significance Index: 28.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7221
    Cell Significance Index: 33.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7207
    Cell Significance Index: 20.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7157
    Cell Significance Index: 524.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6619
    Cell Significance Index: 9.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5596
    Cell Significance Index: 106.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4301
    Cell Significance Index: 11.4900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3816
    Cell Significance Index: 3.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3806
    Cell Significance Index: 76.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3757
    Cell Significance Index: 5.6300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3560
    Cell Significance Index: 2.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3486
    Cell Significance Index: 9.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2567
    Cell Significance Index: 43.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2260
    Cell Significance Index: 4.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2025
    Cell Significance Index: 2.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1960
    Cell Significance Index: 25.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1807
    Cell Significance Index: 21.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1048
    Cell Significance Index: 3.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1016
    Cell Significance Index: 36.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0800
    Cell Significance Index: 2.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0752
    Cell Significance Index: 4.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0091
    Cell Significance Index: -16.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0137
    Cell Significance Index: -1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0148
    Cell Significance Index: -27.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0233
    Cell Significance Index: -35.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0390
    Cell Significance Index: -53.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0475
    Cell Significance Index: -35.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0541
    Cell Significance Index: -1.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0615
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0695
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0700
    Cell Significance Index: -39.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0704
    Cell Significance Index: -44.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0896
    Cell Significance Index: -55.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1001
    Cell Significance Index: -45.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1416
    Cell Significance Index: -40.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1655
    Cell Significance Index: -2.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2135
    Cell Significance Index: -16.3900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2182
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2252
    Cell Significance Index: -26.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2540
    Cell Significance Index: -53.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2612
    Cell Significance Index: -37.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2730
    Cell Significance Index: -31.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3423
    Cell Significance Index: -6.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3682
    Cell Significance Index: -10.2900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4814
    Cell Significance Index: -3.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4820
    Cell Significance Index: -50.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4971
    Cell Significance Index: -12.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5091
    Cell Significance Index: -12.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5298
    Cell Significance Index: -27.8200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.5379
    Cell Significance Index: -3.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5927
    Cell Significance Index: -29.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6121
    Cell Significance Index: -37.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6449
    Cell Significance Index: -43.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6600
    Cell Significance Index: -7.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6634
    Cell Significance Index: -19.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6721
    Cell Significance Index: -42.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7270
    Cell Significance Index: -40.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CYB5A is a member of the cytochrome b5 family, characterized by its ability to facilitate electron transfer in the electron transport chain. This gene is primarily expressed in cells involved in metabolic processes, such as the pancreas, lung epithelial cells, and kidney collecting duct principal cells. The protein product of CYB5A, cytochrome b5, is a heme-containing enzyme that exhibits high affinity for various substrates, including vitamin C (ascorbate) and other metabolites. **Pathways and Functions:** CYB5A is integral to several cellular pathways, including: 1. **Electron Transport Chain:** CYB5A participates in the electron transport chain, a crucial process for generating energy in cells. By facilitating electron transfer, cytochrome b5 contributes to the production of ATP, the primary energy currency of the cell. 2. **Vitamin C Metabolism:** CYB5A has been shown to play a significant role in the metabolism of vitamin C (ascorbate). The enzyme catalyzes the oxidation of vitamin C, which is essential for its antioxidant properties. 3. **Protein Localization:** CYB5A is involved in the insertion of tail-anchored proteins into the endoplasmic reticulum membrane. This process is crucial for the proper functioning of various cellular proteins. 4. **Proton Transport:** CYB5A is also involved in proton transport across cellular membranes, which is essential for maintaining proper ion balance and pH homeostasis. **Clinical Significance:** Dysregulation of CYB5A has been implicated in various diseases, including: 1. **Metabolic Disorders:** Alterations in CYB5A expression have been linked to metabolic disorders, such as diabetes and obesity. 2. **Cancer:** CYB5A has been shown to play a role in cancer development and progression, particularly in the context of oxidative stress and metabolism. 3. **Neurological Disorders:** CYB5A has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where oxidative stress and metabolism are key factors. In conclusion, CYB5A is a vital gene that plays a crucial role in cellular metabolism. Its dysregulation has significant implications for human health and disease. Further research is necessary to fully elucidate the functions of CYB5A and its role in various diseases. **References:** [Insert relevant references to support the discussion] **Note:** As an expert immunologist, I would like to emphasize that while CYB5A is primarily studied in the context of cellular metabolism, its implications for immunology are still emerging. Further research is necessary to explore the role of CYB5A in immune function and disease.

Genular Protein ID: 3707054017

Symbol: CYB5_HUMAN

Name: Cytochrome b5

UniProtKB Accession Codes:

P00167 A8MV91 F8WEU4 Q6IB14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3178851

Title: The complete nucleotide sequence of human liver cytochrome b5 mRNA.

PubMed ID: 3178851

DOI: 10.1016/s0006-291x(88)80881-7

PubMed ID: 1712589

Title: The human liver and reticulocyte cytochrome b5 mRNAs are products from a single gene.

PubMed ID: 1712589

DOI: 10.1016/0006-291x(91)91776-9

PubMed ID: 7733981

Title: The isolation and characterization of the human cytochrome b5 gene.

PubMed ID: 7733981

DOI: 10.1006/bbrc.1995.1582

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4030743

Title: Amino acid sequences of cytochrome b5 from human, porcine, and bovine erythrocytes and comparison with liver microsomal cytochrome b5.

PubMed ID: 4030743

DOI: 10.1093/oxfordjournals.jbchem.a135224

PubMed ID: 4993957

Title: Amino acid sequences of tryptic peptides of cytochromes b5 from microsomes of human, monkey, porcine, and chicken liver.

PubMed ID: 4993957

DOI: 10.1016/s0021-9258(18)62368-3

PubMed ID: 5062820

Title: Cytochrome b5 from a normal human liver. Isolation and the partial amino acid sequence.

PubMed ID: 5062820

DOI: 10.1016/s0021-9258(19)45520-8

PubMed ID: 4770377

Title: Structural studies of cytochrome b5. 3. Sequential studies on human liver cytochrome b5.

PubMed ID: 4770377

PubMed ID: 2752049

Title: Structure of cytochrome b5 and its topology in the microsomal membrane.

PubMed ID: 2752049

DOI: 10.1016/0167-4838(89)90143-x

PubMed ID: 8168836

Title: A splicing mutation in the cytochrome b5 gene from a patient with congenital methemoglobinemia and pseudohermaphrodism.

PubMed ID: 8168836

DOI: 10.1007/bf00202825

PubMed ID: 20080843

Title: Isolated 17,20-lyase deficiency due to the cytochrome b5 mutation W27X.

PubMed ID: 20080843

DOI: 10.1210/jc.2008-1745

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 22170710

Title: A missense mutation in the human cytochrome B5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency.

PubMed ID: 22170710

DOI: 10.1210/jc.2011-2413

Sequence Information:

  • Length: 134
  • Mass: 15330
  • Checksum: B6AD2AB747555048
  • Sequence:
    • MAEQSDEAVK YYTLEEIQKH NHSKSTWLIL HHKVYDLTKF LEEHPGGEEV LREQAGGDAT 
ENFEDVGHST DAREMSKTFI IGELHPDDRP KLNKPPETLI TTIDSSSSWW TNWVIPAISA 
VAVALMYRLY MAED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.