Genular: Defining Cellular Identity and Function

Details for: Hmgb1

Gene ID: 15289

Symbol: Hmgb1

Ensembl ID: ENSMUSG00000066551

Description: high mobility group box 1

Associated with

Advanced glycosylation endproduct receptor signaling
(R-MMU-879415)
Apoptosis
(R-MMU-109581)
Apoptosis induced dna fragmentation
(R-MMU-140342)
Apoptotic execution phase
(R-MMU-75153)
Cytokine signaling in immune system
(R-MMU-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Neutrophil degranulation
(R-MMU-6798695)
Programmed cell death
(R-MMU-5357801)
Pyroptosis
(R-MMU-5620971)
Regulated necrosis
(R-MMU-5218859)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Signaling by interleukins
(R-MMU-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6 mediated nf-kb activation
(R-MMU-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
5s rrna binding
(GO:0008097)
Activation of innate immune response
(GO:0002218)
Adaptive immune response
(GO:0002250)
Autophagy
(GO:0006914)
Base-excision repair
(GO:0006284)
Bent dna binding
(GO:0003681)
C-x-c chemokine binding
(GO:0019958)
Calcium-dependent protein kinase regulator activity
(GO:0010858)
Chemotaxis
(GO:0006935)
Chromatin organization
(GO:0006325)
Crossed form four-way junction dna binding
(GO:0000402)
Cytokine activity
(GO:0005125)
Damaged dna binding
(GO:0003684)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Dna binding, bending
(GO:0008301)
Dna damage response
(GO:0006974)
Dna polymerase binding
(GO:0070182)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Double-stranded dna binding
(GO:0003690)
Double-stranded rna binding
(GO:0003725)
Endothelial cell proliferation
(GO:0001935)
Eye development
(GO:0001654)
Four-way junction dna binding
(GO:0000400)
Glycogen catabolic process
(GO:0005980)
Glycolipid binding
(GO:0051861)
Heparin binding
(GO:0008201)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Integrin binding
(GO:0005178)
Lipopolysaccharide binding
(GO:0001530)
Lyase activity
(GO:0016829)
Macrophage activation involved in immune response
(GO:0002281)
Myeloid dendritic cell activation
(GO:0001773)
Myeloid progenitor cell differentiation
(GO:0002318)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleic acid binding
(GO:0003676)
Open form four-way junction dna binding
(GO:0000401)
Peptide binding
(GO:0042277)
Phosphatidylserine binding
(GO:0001786)
Plasmacytoid dendritic cell activation
(GO:0002270)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase activator activity
(GO:0030295)
Rage receptor binding
(GO:0050786)
Receptor ligand activity
(GO:0048018)
Regulation of t cell mediated immune response to tumor cell
(GO:0002840)
Regulation of tolerance induction
(GO:0002643)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Single-stranded dna binding
(GO:0003697)
Single-stranded rna binding
(GO:0003727)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)

Other Information

Proteins

High mobility group protein B1

Genular Protein ID: 279043500

Symbol: HMGB1_MOUSE

Name: High mobility group protein B1

UniProtKB Accession Codes:

P63158 P07155 P27109 P27428

Database IDs:

Citations:

PubMed ID: 1630928

Title: Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1).

PubMed ID: 1630928

DOI: 10.1093/nar/20.13.3516

PubMed ID: 7961836

Title: The mouse gene coding for high mobility group 1 protein (HMG1).

PubMed ID: 7961836

DOI: 10.1016/s0021-9258(19)61977-0

PubMed ID: 8180479

Title: Molecular cloning, expression analysis, and chromosomal localization of mouse Hmg1-containing sequences.

PubMed ID: 8180479

DOI: 10.1007/bf00292334

PubMed ID: 9047378

Title: The conserved lymphokine element-0 in the IL5 promoter binds to a high mobility group-1 protein.

PubMed ID: 9047378

DOI: 10.1016/s0161-5890(96)00073-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2461949

Title: The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons.

PubMed ID: 2461949

DOI: 10.1083/jcb.107.6.2293

PubMed ID: 9184213

Title: Stimulation of V(D)J cleavage by high mobility group proteins.

PubMed ID: 9184213

DOI: 10.1093/emboj/16.10.2665

PubMed ID: 10391216

Title: The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice.

PubMed ID: 10391216

DOI: 10.1038/10338

PubMed ID: 10398600

Title: HMG-1 as a late mediator of endotoxin lethality in mice.

PubMed ID: 10398600

DOI: 10.1126/science.285.5425.248

PubMed ID: 12110890

Title: Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.

PubMed ID: 12110890

DOI: 10.1038/nature00858

PubMed ID: 16040616

Title: High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.

PubMed ID: 16040616

DOI: 10.1074/jbc.m414549200

PubMed ID: 16267105

Title: High mobility group box 1 protein interacts with multiple Toll-like receptors.

PubMed ID: 16267105

DOI: 10.1152/ajpcell.00401.2005

PubMed ID: 16365390

Title: Extracellular high mobility group box-1 protein is a proangiogenic cytokine.

PubMed ID: 16365390

DOI: 10.4049/jimmunol.176.1.12

PubMed ID: 17114460

Title: Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion.

PubMed ID: 17114460

DOI: 10.4049/jimmunol.177.11.7889

PubMed ID: 17548579

Title: A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.

PubMed ID: 17548579

DOI: 10.1182/blood-2006-09-044776

PubMed ID: 17268551

Title: A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin.

PubMed ID: 17268551

DOI: 10.1038/sj.emboj.7601552

PubMed ID: 17568691

Title: Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin.

PubMed ID: 17568691

DOI: 10.1016/j.imlet.2007.04.011

PubMed ID: 17803946

Title: HMGB1 is a cofactor in mammalian base excision repair.

PubMed ID: 17803946

DOI: 10.1016/j.molcel.2007.06.029

PubMed ID: 18768881

Title: High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine.

PubMed ID: 18768881

DOI: 10.4049/jimmunol.181.6.4240

PubMed ID: 18650382

Title: High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage.

PubMed ID: 18650382

DOI: 10.1073/pnas.0803181105

PubMed ID: 19890330

Title: HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

PubMed ID: 19890330

DOI: 10.1038/nature08512

PubMed ID: 19264983

Title: CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

PubMed ID: 19264983

DOI: 10.1126/science.1168988

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20819940

Title: Endogenous HMGB1 regulates autophagy.

PubMed ID: 20819940

DOI: 10.1083/jcb.200911078

PubMed ID: 20802146

Title: Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia.

PubMed ID: 20802146

DOI: 10.4049/jimmunol.1000803

PubMed ID: 21395369

Title: High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress.

PubMed ID: 21395369

DOI: 10.1089/ars.2010.3666

PubMed ID: 21641551

Title: High-mobility group box 1 is essential for mitochondrial quality control.

PubMed ID: 21641551

DOI: 10.1016/j.cmet.2011.04.008

PubMed ID: 21419643

Title: High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4.

PubMed ID: 21419643

DOI: 10.1016/j.cyto.2011.02.017

PubMed ID: 21319304

Title: Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein.

PubMed ID: 21319304

DOI: 10.1002/pmic.201000491

PubMed ID: 22544226

Title: HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction.

PubMed ID: 22544226

DOI: 10.1007/s00412-012-0373-x

PubMed ID: 22370717

Title: HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.

PubMed ID: 22370717

DOI: 10.1084/jem.20111739

PubMed ID: 22105604

Title: Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).

PubMed ID: 22105604

DOI: 10.2119/molmed.2011.00389

PubMed ID: 33380312

Title: Retraction Note to: Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).

PubMed ID: 33380312

DOI: 10.1186/s10020-020-00264-1

PubMed ID: 22204001

Title: Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis.

PubMed ID: 22204001

DOI: 10.2119/molmed.2011.00203

PubMed ID: 22842346

Title: Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.

PubMed ID: 22842346

DOI: 10.1038/ni.2376

PubMed ID: 23108142

Title: Tissue damage-associated 'danger signals' influence T-cell responses that promote the progression of preneoplasia to cancer.

PubMed ID: 23108142

DOI: 10.1158/0008-5472.can-12-2704

PubMed ID: 23519706

Title: HMGB1: The central cytokine for all lymphoid cells.

PubMed ID: 23519706

DOI: 10.3389/fimmu.2013.00068

PubMed ID: 23446148

Title: The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.

PubMed ID: 23446148

DOI: 10.1189/jlb.1212662

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24302768

Title: Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.

PubMed ID: 24302768

DOI: 10.1073/pnas.1320808110

PubMed ID: 23994764

Title: Menage a Trois in stress: DAMPs, redox and autophagy.

PubMed ID: 23994764

DOI: 10.1016/j.semcancer.2013.08.002

PubMed ID: 24606906

Title: High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo.

PubMed ID: 24606906

DOI: 10.1016/j.cmet.2014.01.014

PubMed ID: 25048472

Title: The role of high mobility group box 1 in innate immunity.

PubMed ID: 25048472

DOI: 10.3349/ymj.2014.55.5.1165

PubMed ID: 25642769

Title: Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.

PubMed ID: 25642769

DOI: 10.1172/jci76344

PubMed ID: 26078984

Title: HMGB1 promotes systemic lupus erythematosus by enhancing macrophage inflammatory response.

PubMed ID: 26078984

DOI: 10.1155/2015/946748

PubMed ID: 25660970

Title: Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis.

PubMed ID: 25660970

DOI: 10.1016/j.molimm.2015.01.023

Sequence Information:

Length: 215
Mass: 24894
Checksum: 8A868DE266D552B5
Sequence:

MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF 
EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL 
SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK 
SKKKKEEEDD EEDEEDEEEE EEEEDEDEEE DDDDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmgb1

Associated with

Other Information

Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1). PubMed ID: 1630928

The mouse gene coding for high mobility group 1 protein (HMG1). PubMed ID: 7961836

Molecular cloning, expression analysis, and chromosomal localization of mouse Hmg1-containing sequences. PubMed ID: 8180479

The conserved lymphokine element-0 in the IL5 promoter binds to a high mobility group-1 protein. PubMed ID: 9047378

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons. PubMed ID: 2461949

Stimulation of V(D)J cleavage by high mobility group proteins. PubMed ID: 9184213

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. PubMed ID: 10391216

HMG-1 as a late mediator of endotoxin lethality in mice. PubMed ID: 10398600

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. PubMed ID: 12110890

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding. PubMed ID: 16040616

High mobility group box 1 protein interacts with multiple Toll-like receptors. PubMed ID: 16267105

Extracellular high mobility group box-1 protein is a proangiogenic cytokine. PubMed ID: 16365390

Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. PubMed ID: 17114460

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. PubMed ID: 17548579

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. PubMed ID: 17268551

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. PubMed ID: 17568691

HMGB1 is a cofactor in mammalian base excision repair. PubMed ID: 17803946

High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. PubMed ID: 18768881

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage. PubMed ID: 18650382

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. PubMed ID: 19890330

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. PubMed ID: 19264983

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Endogenous HMGB1 regulates autophagy. PubMed ID: 20819940

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. PubMed ID: 20802146

High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress. PubMed ID: 21395369

High-mobility group box 1 is essential for mitochondrial quality control. PubMed ID: 21641551

High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4. PubMed ID: 21419643

Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein. PubMed ID: 21319304

HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. PubMed ID: 22544226

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. PubMed ID: 22370717

Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). PubMed ID: 22105604

Retraction Note to: Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). PubMed ID: 33380312

Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis. PubMed ID: 22204001

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. PubMed ID: 22842346

Tissue damage-associated 'danger signals' influence T-cell responses that promote the progression of preneoplasia to cancer. PubMed ID: 23108142

HMGB1: The central cytokine for all lymphoid cells. PubMed ID: 23519706

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. PubMed ID: 23446148

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. PubMed ID: 24302768

Menage a Trois in stress: DAMPs, redox and autophagy. PubMed ID: 23994764

High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. PubMed ID: 24606906

The role of high mobility group box 1 in innate immunity. PubMed ID: 25048472

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. PubMed ID: 25642769

HMGB1 promotes systemic lupus erythematosus by enhancing macrophage inflammatory response. PubMed ID: 26078984

Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. PubMed ID: 25660970