ADRB1 | ENSG00000043591 | NCBI 153

Details for: ADRB1

Gene ID: 153

Symbol: ADRB1

Ensembl ID: ENSG00000043591

Description: adrenoceptor beta 1

Associated with

Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Alpha-2a adrenergic receptor binding
(GO:0031694)
Beta-adrenergic receptor activity
(GO:0004939)
Beta1-adrenergic receptor activity
(GO:0004940)
Brown fat cell differentiation
(GO:0050873)
Diet induced thermogenesis
(GO:0002024)
Early endosome
(GO:0005769)
Fear response
(GO:0042596)
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
(GO:0099579)
Heat generation
(GO:0031649)
Negative regulation of multicellular organism growth
(GO:0040015)
Neuronal dense core vesicle
(GO:0098992)
Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
(GO:0002025)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of heart rate by epinephrine-norepinephrine
(GO:0001996)
Positive regulation of the force of heart contraction by epinephrine-norepinephrine
(GO:0001997)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of circadian sleep/wake cycle, sleep
(GO:0045187)
Regulation of postsynaptic membrane potential
(GO:0060078)
Response to cold
(GO:0009409)
Schaffer collateral - ca1 synapse
(GO:0098685)

Other Information

Proteins

Beta-1 adrenoreceptor

Genular Protein ID: 1050501415

Symbol: ADRB1_HUMAN

Name: Beta-1 adrenoreceptor

UniProtKB Accession Codes:

P08588 B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8

Database IDs:

Citations:

PubMed ID: 2825170

Title: Cloning of the cDNA for the human beta 1-adrenergic receptor.

PubMed ID: 2825170

DOI: 10.1073/pnas.84.22.7920

PubMed ID: 10477438

Title: Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.

PubMed ID: 10477438

DOI: 10.1002/(sici)1098-1004(1999)14:3<271::aid-humu14>3.0.co;2-q

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 12391161

Title: Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.

PubMed ID: 12391161

DOI: 10.1128/mcb.22.22.7942-7952.2002

PubMed ID: 15358775

Title: Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.

PubMed ID: 15358775

DOI: 10.1074/jbc.m404876200

PubMed ID: 21540189

Title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.

PubMed ID: 21540189

DOI: 10.1074/jbc.m111.224071

PubMed ID: 10212248

Title: A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.

PubMed ID: 10212248

DOI: 10.1074/jbc.274.18.12670

PubMed ID: 11052857

Title: A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.

PubMed ID: 11052857

DOI: 10.1053/euhj.1999.1994

PubMed ID: 11854867

Title: A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.

PubMed ID: 11854867

DOI: 10.1086/339621

PubMed ID: 31473062

Title: A rare mutation of beta1-adrenergic receptor affects sleep/wake behaviors.

PubMed ID: 31473062

DOI: 10.1016/j.neuron.2019.07.026

Sequence Information:

Length: 477
Mass: 51224
Checksum: 1D15E6390B5364B8
Sequence:

MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG 
MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV 
WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC 
TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 
AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP 
LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV 
FFNWLGYANS AFNPIIYCRS PDFRKAFQGL LCCARRAARR RHATHGDRPR ASGCLARPGP 
PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRB1

Associated with

Other Information

Cloning of the cDNA for the human beta 1-adrenergic receptor. PubMed ID: 2825170

Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A&gt;G and c1165G&gt;C. PubMed ID: 10477438

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. PubMed ID: 12391161

Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression. PubMed ID: 15358775

Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway. PubMed ID: 21540189

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. PubMed ID: 10212248

A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. PubMed ID: 11052857

A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. PubMed ID: 11854867

A rare mutation of beta1-adrenergic receptor affects sleep/wake behaviors. PubMed ID: 31473062