Details for: ADRB1

Gene ID: 153

Symbol: ADRB1

Ensembl ID: ENSG00000043591

Description: adrenoceptor beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.73
    Marker Score: 4393
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.67
    Marker Score: 2413
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169563
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.43
    Marker Score: 2915
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4
    Marker Score: 5491
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20006
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.99
    Marker Score: 3518
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1741
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 552
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5219
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.86
    Marker Score: 19202
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.84
    Marker Score: 313
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.74
    Marker Score: 822
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.69
    Marker Score: 359.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.68
    Marker Score: 2346
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.61
    Marker Score: 505
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 288
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.59
    Marker Score: 5163
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.56
    Marker Score: 868
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 355.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.54
    Marker Score: 1240
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.54
    Marker Score: 5122
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.54
    Marker Score: 1019
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.51
    Marker Score: 614
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.51
    Marker Score: 146
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.49
    Marker Score: 711
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.49
    Marker Score: 29857
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.48
    Marker Score: 714
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.48
    Marker Score: 4139
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.48
    Marker Score: 470.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.46
    Marker Score: 9918
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.41
    Marker Score: 277
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.39
    Marker Score: 259
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.39
    Marker Score: 858
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.36
    Marker Score: 605
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.36
    Marker Score: 307
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 90
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 137
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 145
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3
    Marker Score: 175
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3
    Marker Score: 328
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.29
    Marker Score: 2696
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 248
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.28
    Marker Score: 173
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 117
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.26
    Marker Score: 273
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.25
    Marker Score: 2180
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 111
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.24
    Marker Score: 282
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.24
    Marker Score: 112
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 143
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 150
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.24
    Marker Score: 132
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 155
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 204
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.22
    Marker Score: 89
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.22
    Marker Score: 204
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.22
    Marker Score: 99
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.22
    Marker Score: 3454
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.21
    Marker Score: 88
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.21
    Marker Score: 75
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.21
    Marker Score: 103
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.21
    Marker Score: 53
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.21
    Marker Score: 366
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.2
    Marker Score: 1057
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.2
    Marker Score: 367
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.2
    Marker Score: 54
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.19
    Marker Score: 103
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.19
    Marker Score: 1956
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.18
    Marker Score: 94
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.18
    Marker Score: 54
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 48

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Other Information

**Key characteristics:** - Type: Membrane protein - Ensembl ID: ENSG00000043591 - Protein length: 117 amino acids - Subcellular localization: Cytoplasm **Pathways and functions:** - Adrenoceptor signaling: ADRB1 is a receptor for epinephrine and norepinephrine, two hormones that play a role in regulating blood pressure and heart rate. - Vasodilation: When ADRB1 binds to epinephrine or norepinephrine, it activates the G protein-coupled receptor (GPCR) alpha-adrenoceptor. This activation leads to the closure of vascular smooth muscle cells, which results in increased blood flow and vasodilation. - Positive regulation of heart rate: ADRB1 also positively regulates the heart rate by binding to epinephrine and norepinephrine. This binding activates the GPCR alpha-adrenoceptor, which leads to the inhibition of adenylate cyclase and the subsequent increase in heart rate. - Positive regulation of force of heart contraction: ADRB1 positively regulates the force of heart contraction by binding to epinephrine and norepinephrine. This binding activates the GPCR alpha-adrenoceptor, which leads to the inhibition of calcium channels in the sarcoplasmic reticulum, resulting in increased calcium release and improved force of contraction. **Clinical significance:** - Mutations in the ADRB1 gene have been linked to several cardiovascular diseases, including hypertension, heart failure, and stroke. - Drugs targeting ADRB1 are being investigated as potential treatments for these diseases. - ADRB1 is also a target for therapeutic interventions in conditions such as angina pectoris, where it is expressed in the coronary arteries and is involved in the regulation of blood flow to the heart.

Genular Protein ID: 1050501415

Symbol: ADRB1_HUMAN

Name: Beta-1 adrenoreceptor

UniProtKB Accession Codes:

P08588 B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 79 DrugCentral 1 EMBL 6 Ensembl 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2825170

Title: Cloning of the cDNA for the human beta 1-adrenergic receptor.

PubMed ID: 2825170

DOI: 10.1073/pnas.84.22.7920

PubMed ID: 10477438

Title: Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.

PubMed ID: 10477438

DOI: 10.1002/(sici)1098-1004(1999)14:3<271::aid-humu14>3.0.co;2-q

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 12391161

Title: Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.

PubMed ID: 12391161

DOI: 10.1128/mcb.22.22.7942-7952.2002

PubMed ID: 15358775

Title: Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.

PubMed ID: 15358775

DOI: 10.1074/jbc.m404876200

PubMed ID: 21540189

Title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.

PubMed ID: 21540189

DOI: 10.1074/jbc.m111.224071

PubMed ID: 10212248

Title: A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.

PubMed ID: 10212248

DOI: 10.1074/jbc.274.18.12670

PubMed ID: 11052857

Title: A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.

PubMed ID: 11052857

DOI: 10.1053/euhj.1999.1994

PubMed ID: 11854867

Title: A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.

PubMed ID: 11854867

DOI: 10.1086/339621

PubMed ID: 31473062

Title: A rare mutation of beta1-adrenergic receptor affects sleep/wake behaviors.

PubMed ID: 31473062

DOI: 10.1016/j.neuron.2019.07.026

Sequence Information:

  • Length: 477
  • Mass: 51224
  • Checksum: 1D15E6390B5364B8
  • Sequence:
    • MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG 
MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV 
WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC 
TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 
AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP 
LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV 
FFNWLGYANS AFNPIIYCRS PDFRKAFQGL LCCARRAARR RHATHGDRPR ASGCLARPGP 
PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.