Details for: ADRB1

Gene ID: 153

Symbol: ADRB1

Ensembl ID: ENSG00000043591

Description: adrenoceptor beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.1945
    Cell Significance Index: -7.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.9105
    Cell Significance Index: -6.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.2166
    Cell Significance Index: -6.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 3.5660
    Cell Significance Index: 21.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8918
    Cell Significance Index: -7.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3657
    Cell Significance Index: 36.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2370
    Cell Significance Index: 64.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9120
    Cell Significance Index: 90.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8297
    Cell Significance Index: 749.2000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.7040
    Cell Significance Index: 9.6400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.5951
    Cell Significance Index: 0.7700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.5547
    Cell Significance Index: 7.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5139
    Cell Significance Index: 55.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4930
    Cell Significance Index: 80.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4062
    Cell Significance Index: 28.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4029
    Cell Significance Index: 80.8200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4004
    Cell Significance Index: 4.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3902
    Cell Significance Index: 23.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3548
    Cell Significance Index: 27.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3006
    Cell Significance Index: 20.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2767
    Cell Significance Index: 12.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2215
    Cell Significance Index: 42.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1849
    Cell Significance Index: 9.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1153
    Cell Significance Index: 4.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1031
    Cell Significance Index: 2.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0794
    Cell Significance Index: 1.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0518
    Cell Significance Index: 0.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0430
    Cell Significance Index: 29.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0430
    Cell Significance Index: 18.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0314
    Cell Significance Index: 1.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0258
    Cell Significance Index: 3.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0247
    Cell Significance Index: 4.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0208
    Cell Significance Index: 7.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0174
    Cell Significance Index: 0.3700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0038
    Cell Significance Index: 1.7200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0015
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0085
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0156
    Cell Significance Index: -0.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0212
    Cell Significance Index: -6.1000
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.0372
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0393
    Cell Significance Index: -8.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0402
    Cell Significance Index: -6.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0405
    Cell Significance Index: -8.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0451
    Cell Significance Index: -6.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0460
    Cell Significance Index: -5.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0464
    Cell Significance Index: -4.7400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0470
    Cell Significance Index: -0.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0494
    Cell Significance Index: -1.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0503
    Cell Significance Index: -1.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0549
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0584
    Cell Significance Index: -6.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0591
    Cell Significance Index: -7.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0635
    Cell Significance Index: -0.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0694
    Cell Significance Index: -2.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0700
    Cell Significance Index: -8.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0727
    Cell Significance Index: -7.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0795
    Cell Significance Index: -4.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0852
    Cell Significance Index: -0.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0900
    Cell Significance Index: -7.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0955
    Cell Significance Index: -6.1600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0960
    Cell Significance Index: -1.1000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0981
    Cell Significance Index: -1.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0990
    Cell Significance Index: -5.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1056
    Cell Significance Index: -7.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1061
    Cell Significance Index: -2.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1074
    Cell Significance Index: -7.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1117
    Cell Significance Index: -5.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1120
    Cell Significance Index: -1.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1160
    Cell Significance Index: -7.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1237
    Cell Significance Index: -4.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1244
    Cell Significance Index: -5.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1246
    Cell Significance Index: -1.7000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1256
    Cell Significance Index: -1.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1284
    Cell Significance Index: -2.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1351
    Cell Significance Index: -7.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1367
    Cell Significance Index: -3.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1422
    Cell Significance Index: -4.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1462
    Cell Significance Index: -3.9100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1486
    Cell Significance Index: -3.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1492
    Cell Significance Index: -4.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1545
    Cell Significance Index: -2.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1578
    Cell Significance Index: -3.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1611
    Cell Significance Index: -1.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1681
    Cell Significance Index: -7.3100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1809
    Cell Significance Index: -2.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1823
    Cell Significance Index: -3.6600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1889
    Cell Significance Index: -2.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1932
    Cell Significance Index: -4.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ADRB1 gene is a member of the G protein-coupled receptor (GPCR) family, characterized by its ability to bind epinephrine and norepinephrine, leading to the activation of downstream signaling pathways. The Beta-1 adrenoreceptor is specifically expressed in various tissues, including the heart, brain, and immune cells, where it plays a crucial role in regulating cardiac function, neuronal activity, and immune responses. **Pathways and Functions:** The ADRB1 gene is involved in several key signaling pathways, including: 1. **Adenylate cyclase-activating adrenergic receptor signaling pathway**: The Beta-1 adrenoreceptor activates adenylate cyclase, leading to the production of cyclic AMP (cAMP), which in turn regulates various physiological processes, including heart rate and blood pressure. 2. **Beta-adrenergic receptor activity**: The Beta-1 adrenoreceptor is a key component of the beta-adrenergic receptor family, which plays a crucial role in regulating cardiac function, neuronal activity, and immune responses. 3. **Regulation of circadian sleep/wake cycle**: The Beta-1 adrenoreceptor is involved in regulating the circadian sleep/wake cycle, with its expression being modulated by light-dark cycles. 4. **Negative regulation of multicellular organism growth**: The Beta-1 adrenoreceptor has been shown to inhibit the growth of multicellular organisms, suggesting a role in regulating development and tissue homeostasis. **Clinical Significance:** The ADRB1 gene has significant implications for various diseases and disorders, including: 1. **Cardiovascular disease**: Dysregulation of the Beta-1 adrenoreceptor has been implicated in the development of cardiovascular disease, including hypertension, heart failure, and arrhythmias. 2. **Neurological disorders**: The Beta-1 adrenoreceptor is involved in regulating neuronal activity, and its dysregulation has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Immune system disorders**: The Beta-1 adrenoreceptor has been shown to regulate immune responses, and its dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Cancer**: The Beta-1 adrenoreceptor has been shown to regulate cell growth and differentiation, and its dysregulation has been implicated in the development of certain types of cancer, including breast and lung cancer. In conclusion, the ADRB1 gene plays a critical role in regulating various physiological processes, including heart rate, blood pressure, and thermogenesis. Its dysregulation has significant implications for various diseases and disorders, including cardiovascular disease, neurological disorders, immune system disorders, and cancer. Further research is necessary to fully understand the functions of the ADRB1 gene and its role in maintaining immune system homeostasis.

Genular Protein ID: 1050501415

Symbol: ADRB1_HUMAN

Name: Beta-1 adrenoreceptor

UniProtKB Accession Codes:

P08588 B0LPE2 Q5T5Y4 Q9UKG7 Q9UKG8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 79 DrugCentral 1 EMBL 6 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2825170

Title: Cloning of the cDNA for the human beta 1-adrenergic receptor.

PubMed ID: 2825170

DOI: 10.1073/pnas.84.22.7920

PubMed ID: 10477438

Title: Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.

PubMed ID: 10477438

DOI: 10.1002/(sici)1098-1004(1999)14:3<271::aid-humu14>3.0.co;2-q

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 12391161

Title: Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.

PubMed ID: 12391161

DOI: 10.1128/mcb.22.22.7942-7952.2002

PubMed ID: 15358775

Title: Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.

PubMed ID: 15358775

DOI: 10.1074/jbc.m404876200

PubMed ID: 21540189

Title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.

PubMed ID: 21540189

DOI: 10.1074/jbc.m111.224071

PubMed ID: 10212248

Title: A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.

PubMed ID: 10212248

DOI: 10.1074/jbc.274.18.12670

PubMed ID: 11052857

Title: A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.

PubMed ID: 11052857

DOI: 10.1053/euhj.1999.1994

PubMed ID: 11854867

Title: A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.

PubMed ID: 11854867

DOI: 10.1086/339621

PubMed ID: 31473062

Title: A rare mutation of beta1-adrenergic receptor affects sleep/wake behaviors.

PubMed ID: 31473062

DOI: 10.1016/j.neuron.2019.07.026

Sequence Information:

  • Length: 477
  • Mass: 51224
  • Checksum: 1D15E6390B5364B8
  • Sequence:
    • MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG 
MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV 
WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC 
TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 
AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP 
LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV 
FFNWLGYANS AFNPIIYCRS PDFRKAFQGL LCCARRAARR RHATHGDRPR ASGCLARPGP 
PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.