Details for: CYB561

Gene ID: 1534

Symbol: CYB561

Ensembl ID: ENSG00000008283

Description: cytochrome b561

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.95
    Marker Score: 974
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2
    Marker Score: 2819
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.84
    Marker Score: 16006
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.79
    Marker Score: 6158
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.44
    Marker Score: 2733
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.4
    Marker Score: 936
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.38
    Marker Score: 1270
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.38
    Marker Score: 2916
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.34
    Marker Score: 781
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.29
    Marker Score: 2941
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.24
    Marker Score: 1788
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.21
    Marker Score: 566
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.17
    Marker Score: 2649
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1799
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.14
    Marker Score: 561
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.12
    Marker Score: 1161
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.12
    Marker Score: 354
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2096
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.08
    Marker Score: 434
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.06
    Marker Score: 442
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.05
    Marker Score: 9053
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251745
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.03
    Marker Score: 8837
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.01
    Marker Score: 292
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47987
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9377
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.98
    Marker Score: 446
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.98
    Marker Score: 1568
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.97
    Marker Score: 33674
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.97
    Marker Score: 59441
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1418
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7036
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.94
    Marker Score: 352
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.92
    Marker Score: 508
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.92
    Marker Score: 5855
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1866
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.9
    Marker Score: 8462
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.9
    Marker Score: 4724
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 424
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.89
    Marker Score: 201
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.87
    Marker Score: 299
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4927
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.86
    Marker Score: 609
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.84
    Marker Score: 3230
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13078
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.82
    Marker Score: 8484
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3324
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.8
    Marker Score: 6256
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.75
    Marker Score: 191
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.75
    Marker Score: 789
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.75
    Marker Score: 4883
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.75
    Marker Score: 3585
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.74
    Marker Score: 615
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.73
    Marker Score: 375
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.72
    Marker Score: 1153
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.72
    Marker Score: 1282
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3008
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.72
    Marker Score: 1252.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.7
    Marker Score: 673
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7
    Marker Score: 2864
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7
    Marker Score: 2744
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 636
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.7
    Marker Score: 360
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.68
    Marker Score: 296
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.68
    Marker Score: 186
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.66
    Marker Score: 1211
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.66
    Marker Score: 572
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.66
    Marker Score: 1654
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.65
    Marker Score: 2066
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.64
    Marker Score: 23703
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 411
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.64
    Marker Score: 1520.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.64
    Marker Score: 2469
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.63
    Marker Score: 155
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.63
    Marker Score: 12438
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.62
    Marker Score: 537
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.62
    Marker Score: 433
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.62
    Marker Score: 751
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.62
    Marker Score: 433
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.61
    Marker Score: 710
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.6
    Marker Score: 22846
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.6
    Marker Score: 250
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6
    Marker Score: 658
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.59
    Marker Score: 2461
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.59
    Marker Score: 236
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.59
    Marker Score: 1576
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.58
    Marker Score: 395

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Other Information

**Key characteristics:** * The protein is a member of the cytochrome b family of proteins, which are involved in the electron transport chain. * It is expressed in a variety of cell types, including sympathetic neurons, chromaffin cells, ciliated columnar cells of the tracheobronchial tree, and acinar cells of the prostate and salivary gland. * It is a highly conserved protein, with a sequence that is found in organisms from yeast to humans. **Pathways and functions:** * **Ascorbate homeostasis:** Cytochrome b561 is involved in maintaining the body's supply of ascorbate, a powerful antioxidant molecule that protects cells from damage caused by reactive oxygen species. * **Electron transport chain:** Cytochrome b561 is a component of the electron transport chain, a series of protein complexes that allow electrons to flow and generate energy for cellular processes. * **Cellular iron ion homeostasis:** Cytochrome b561 is involved in the regulation of cellular iron ion levels. **Clinical significance:** * Mutations in the CYB561 gene have been linked to several human diseases, including coronary artery disease, stroke, and diabetes. * These mutations can lead to a decrease in the production of cytochrome b561 protein, which can impair cellular function and lead to disease. * As a result of this, research on the role of cytochrome b561 in human health is an active area of investigation.

Genular Protein ID: 3732004602

Symbol: CY561_HUMAN

Name: Cytochrome b-561

UniProtKB Accession Codes:

P49447 B2RE96 B7Z775 D3DU11 Q5BJG9 Q9BU05 Q9BWR9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 Rhea 2 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7559396

Title: Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane.

PubMed ID: 7559396

DOI: 10.1074/jbc.270.39.22714

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7980462

Title: Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information.

PubMed ID: 7980462

DOI: 10.1042/bj3030915

PubMed ID: 29343526

Title: Mutations in CYB561 causing a novel orthostatic hypotension syndrome.

PubMed ID: 29343526

DOI: 10.1161/circresaha.117.311949

Sequence Information:

  • Length: 251
  • Mass: 27559
  • Checksum: 8EE53AE4D2569B77
  • Sequence:
    • MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF NAHPLCMVIG 
LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV GLVAVFDYHR KKGYADLYSL 
HSWCGILVFV LYFVQWLVGF SFFLFPGASF SLRSRYRPQH IFFGATIFLL SVGTALLGLK 
EALLFNLGGK YSAFEPEGVL ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK 
TLTEGDSPGS Q

Genular Protein ID: 1385346022

Symbol: B3KTA1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTA1

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 2 SAM 1 SMART 1 SMR 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 194
  • Mass: 20528
  • Checksum: 7EEE9BC93ABB4C0E
  • Sequence:
    • MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF NAHPLCMVIG 
LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV GEFPDAAFPA TCLPLQAWWR 
CSTTTGRRAT LTCTAYTAGA GSLSLSCTLC SGWWASASSC SPELHSPCGA ATAHSTSSLV 
LPSSSFPWAP PCWA

Genular Protein ID: 2750768337

Symbol: J3QRH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QRH5

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 2 SAM 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 258
  • Mass: 28267
  • Checksum: A2BB84DC230DC9CA
  • Sequence:
    • MSSVCLSMEG GAAAATPTAL PYYVAFSQLL GLTLVAMTGA WLGLYRGGIA WESDLQFNAH 
PLCMVIGLIF LQGNALLVYR VFRNEAKRTT KVLHGLLHIF ALVIALVGLV AVFDYHRKKG 
YADLYSLHSW CGILVFVLYF VQWLVGFSFF LFPGASFSLR SRYRPQHIFF GATIFLLSVG 
TALLGLKEAL LFNLGGKYSA FEPEGVLANV LGLLLACFGG AVLYILTRAD WKRPSQAEEQ 
ALSMDFKTLT EGDSPGSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.