Gene CYBA - ENSG00000051523 | NCBI Gene ID: 1535

Details for: CYBA

Gene ID: 1535

Symbol: CYBA

Ensembl ID: ENSG00000051523

Description: cytochrome b-245 alpha chain

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cross-presentation of particulate exogenous antigens (phagosomes)
(R-HSA-1236973)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Killing mechanisms
(R-HSA-9664420)
Leishmania infection
(R-HSA-9658195)
Neutrophil degranulation
(R-HSA-6798695)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Ros and rns production in phagocytes
(R-HSA-1222556)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Wnt5:fzd7-mediated leishmania damping
(R-HSA-9673324)
Cytochrome complex assembly
(GO:0017004)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Establishment of localization in cell
(GO:0051649)
Heme binding
(GO:0020037)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mucus secretion
(GO:0070254)
Nadph oxidase complex
(GO:0043020)
Phagocytic vesicle membrane
(GO:0030670)
Plasma membrane
(GO:0005886)
Positive regulation of defense response to bacterium
(GO:1900426)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mucus secretion
(GO:0070257)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of toll-like receptor 2 signaling pathway
(GO:0034137)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of release of sequestered calcium ion into cytosol
(GO:0051279)
Respiratory burst
(GO:0045730)
Secretory granule
(GO:0030141)
Sh3 domain binding
(GO:0017124)
Smooth muscle hypertrophy
(GO:0014895)
Specific granule membrane
(GO:0035579)
Superoxide-generating nad(p)h oxidase activity
(GO:0016175)
Superoxide anion generation
(GO:0042554)
Superoxide metabolic process
(GO:0006801)
Tertiary granule membrane
(GO:0070821)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.12
Marker Score: 14939
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.99
Marker Score: 4250
Cell Name: mature T cell (CL0002419)
Fold Change: 4.55
Marker Score: 45015
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.32
Marker Score: 241700
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.1
Marker Score: 4551
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.03
Marker Score: 11300
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.01
Marker Score: 12654
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.98
Marker Score: 5857
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.96
Marker Score: 2873
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.78
Marker Score: 3722
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.76
Marker Score: 4305.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.76
Marker Score: 9159
Cell Name: germinal center B cell (CL0000844)
Fold Change: 3.76
Marker Score: 2285
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.72
Marker Score: 1208
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.71
Marker Score: 2174
Cell Name: acinar cell (CL0000622)
Fold Change: 3.64
Marker Score: 2569
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.64
Marker Score: 3422
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.58
Marker Score: 3009
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.56
Marker Score: 3130
Cell Name: naive T cell (CL0000898)
Fold Change: 3.55
Marker Score: 2286
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.52
Marker Score: 1810
Cell Name: naive B cell (CL0000788)
Fold Change: 3.52
Marker Score: 3143.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.44
Marker Score: 7258.5
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.4
Marker Score: 14595
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.39
Marker Score: 1871
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.36
Marker Score: 116525
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.31
Marker Score: 7986
Cell Name: secretory cell (CL0000151)
Fold Change: 3.28
Marker Score: 5980
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.27
Marker Score: 6380
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.25
Marker Score: 3248
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.18
Marker Score: 1373
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.18
Marker Score: 2698
Cell Name: memory T cell (CL0000813)
Fold Change: 3.18
Marker Score: 1365
Cell Name: basophil (CL0000767)
Fold Change: 3.13
Marker Score: 1485
Cell Name: myelocyte (CL0002193)
Fold Change: 3.12
Marker Score: 1350
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.12
Marker Score: 1558
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.1
Marker Score: 2539.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 3.09
Marker Score: 8012
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.09
Marker Score: 4262
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 3.07
Marker Score: 3693
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.07
Marker Score: 5483.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.05
Marker Score: 1788
Cell Name: memory B cell (CL0000787)
Fold Change: 3.05
Marker Score: 2308
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.03
Marker Score: 6350
Cell Name: blood cell (CL0000081)
Fold Change: 3.03
Marker Score: 35211
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 3.02
Marker Score: 1821
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3
Marker Score: 7480
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3
Marker Score: 10658
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.97
Marker Score: 18956
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.97
Marker Score: 3011
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.97
Marker Score: 75984
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.96
Marker Score: 1047
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.96
Marker Score: 29949
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.95
Marker Score: 972
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.95
Marker Score: 1030
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.95
Marker Score: 155797
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.94
Marker Score: 2750
Cell Name: immature B cell (CL0000816)
Fold Change: 2.92
Marker Score: 1937
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.92
Marker Score: 1797
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 2.91
Marker Score: 799
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 2.9
Marker Score: 1009
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.88
Marker Score: 893
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.88
Marker Score: 886
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.87
Marker Score: 1414
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.84
Marker Score: 1161
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.82
Marker Score: 24520
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.81
Marker Score: 17983
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.79
Marker Score: 4789
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.76
Marker Score: 4818
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.75
Marker Score: 1147
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.75
Marker Score: 11243
Cell Name: ILC1, human (CL0001077)
Fold Change: 2.74
Marker Score: 695
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.7
Marker Score: 1977
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.68
Marker Score: 19975
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.68
Marker Score: 1541
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.66
Marker Score: 707
Cell Name: Unknown (CL0000548)
Fold Change: 2.61
Marker Score: 1899
Cell Name: club cell (CL0000158)
Fold Change: 2.6
Marker Score: 3030
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.59
Marker Score: 5884
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.58
Marker Score: 15673
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 2.56
Marker Score: 1118
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.56
Marker Score: 1215
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.55
Marker Score: 610
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.49
Marker Score: 2710
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.49
Marker Score: 2755
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.49
Marker Score: 1707
Cell Name: microglial cell (CL0000129)
Fold Change: 2.49
Marker Score: 4529
Cell Name: PP cell (CL0000696)
Fold Change: 2.48
Marker Score: 559
Cell Name: granulocyte (CL0000094)
Fold Change: 2.48
Marker Score: 1112
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.47
Marker Score: 6025
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 2.46
Marker Score: 524
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 2.46
Marker Score: 3998
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.45
Marker Score: 2160
Cell Name: enterocyte (CL0000584)
Fold Change: 2.45
Marker Score: 11755
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.44
Marker Score: 10153.5
Cell Name: natural killer cell (CL0000623)
Fold Change: 2.44
Marker Score: 3160
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.44
Marker Score: 3587
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.43
Marker Score: 2626
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.42
Marker Score: 1906
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.41
Marker Score: 6316

Hover over a box to see details here...

**Key characteristics:** - The CYBA gene is located on chromosome 15q26.1. - It is a member of the cytochrome b-245 family of proteins. - The protein is expressed in high levels in cells of the immune system. - It is involved in the production of ROS, which are molecules that can damage cells and tissues. **Pathways and functions:** - The CYBA gene is involved in the adaptive immune system, antigen processing-cross presentation, cellular responses to stimuli, cellular responses to stress, cellular response to chemical stress, and the Rho gtpase effectors pathway. - In the adaptive immune system, the CYBA protein is expressed in cells of the immune system, including NKp46-positive innate lymphoid cells, human, IgA plasma cells, mature T cells, CD14-positive, CD16-negative classical monocyte, intraepithelial lymphocyte, CD8-positive, alpha-beta memory T cell, CD45RO-positive, mature gamma-delta T cell, effector memory CD8-positive, alpha-beta T cell, and IgG-negative class switched memory B cell. - The protein is involved in the production of ROS, which are molecules that can damage cells and tissues. This damage can lead to inflammation and tissue damage. **Clinical significance:** - Mutations in the CYBA gene have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. - The CYBA protein is a potential target for therapy in these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1696406250

Symbol: CY24A_HUMAN

Name: Cytochrome b-245 light chain

UniProtKB Accession Codes:

P13498 Q14090 Q9BR72

Database IDs:

Citations:

PubMed ID: 3368442

Title: Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.

PubMed ID: 3368442

DOI: 10.1073/pnas.85.10.3319

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2243141

Title: Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

PubMed ID: 2243141

DOI: 10.1172/jci114898

PubMed ID: 2469497

Title: Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils.

PubMed ID: 2469497

PubMed ID: 12716910

Title: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.

PubMed ID: 12716910

DOI: 10.1074/jbc.m212856200

PubMed ID: 15585859

Title: Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit.

PubMed ID: 15585859

DOI: 10.4049/jimmunol.173.12.7349

PubMed ID: 15561711

Title: Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.

PubMed ID: 15561711

DOI: 10.1074/jbc.m407709200

PubMed ID: 15824103

Title: The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.

PubMed ID: 15824103

DOI: 10.1074/jbc.m414548200

PubMed ID: 15927447

Title: Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.

PubMed ID: 15927447

DOI: 10.1016/j.cellsig.2005.03.023

PubMed ID: 17140397

Title: Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3.

PubMed ID: 17140397

DOI: 10.1042/bj20060819

PubMed ID: 19948736

Title: Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.

PubMed ID: 19948736

DOI: 10.1074/jbc.m109.030643

PubMed ID: 22808130

Title: Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation.

PubMed ID: 22808130

DOI: 10.1371/journal.pone.0040277

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16326715

Title: NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.

PubMed ID: 16326715

DOI: 10.1074/jbc.m505193200

PubMed ID: 1415254

Title: Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox).

PubMed ID: 1415254

PubMed ID: 1763037

Title: Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.

PubMed ID: 1763037

DOI: 10.1073/pnas.88.24.11231

PubMed ID: 8168815

Title: Identification of allele-specific p22-phox mutations in a compound heterozygous patient with chronic granulomatous disease by mismatch PCR and restriction enzyme analysis.

PubMed ID: 8168815

DOI: 10.1007/bf00201671

PubMed ID: 7964505

Title: 156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

PubMed ID: 7964505

DOI: 10.1084/jem.180.6.2329

PubMed ID: 10910929

Title: Molecular analysis of 9 new families with chronic granulomatous disease caused by mutations in CYBA, the gene encoding p22(phox).

PubMed ID: 10910929

PubMed ID: 10759707

Title: Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients.

PubMed ID: 10759707

DOI: 10.1046/j.1365-2141.2000.01857.x

PubMed ID: 10914676

Title: Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency.

PubMed ID: 10914676

DOI: 10.1007/s004390000288

PubMed ID: 18422995

Title: Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease.

PubMed ID: 18422995

DOI: 10.1111/j.1365-2141.2008.07148.x

PubMed ID: 19388116

Title: Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation.

PubMed ID: 19388116

DOI: 10.1002/humu.21029

PubMed ID: 23910690

Title: Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients.

PubMed ID: 23910690

DOI: 10.1016/j.jaci.2013.05.039

Sequence Information:

Length: 195
Mass: 21013
Checksum: 428427AD19398240
Sequence:

MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC LLEYPRGKRK 
KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP AGFLLATILG TACLAIASGI 
YLLAAVRGEQ WTPIEPKPRE RPQIGGTIKQ PPSNPPPRPP AEARKKPSEE EAAVAAGGPP 
GGPQVNPIPV TDEVV

Genular Protein ID: 633215633

Symbol: H3BNP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BNP7

Database IDs:

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

Length: 210
Mass: 22827
Checksum: 6E1F507E8B24CDB9
Sequence:

MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC LLEYPRGKRK 
KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP AGFLLATILG TACLAIASGI 
YLLSQVPPAR RGNCPPLAVR LLVCVRGKGA ALSVYAFRVW KWSSVSSLTD LPPAELSFRT 
PSCCQVLIWA VALFSGGHPH PPRLPAATHS

Genular Protein ID: 4020219498

Symbol: B4DT46_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DT46

Database IDs:

Sequence Information:

Length: 131
Mass: 14019
Checksum: 0F8AF47330762B7F
Sequence:

MERWGQKHMT AVVKLFGPFT RNYYVRAVLH LLLSVPAGFL LATILGTACL AIASGIYLLA 
AVRGEQWTPI EPKPRERPQI GGTIKQPPSN PPPRPPAEAR KKPSEEEAAV AAGGPPGGPQ 
VNPIPVTDEV V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CYBA

Associated with

Cells (max top 100)

Other Information

Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. PubMed ID: 3368442

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. PubMed ID: 2243141

Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils. PubMed ID: 2469497

Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. PubMed ID: 12716910

Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. PubMed ID: 15585859

Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. PubMed ID: 15561711

The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. PubMed ID: 15824103

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. PubMed ID: 15927447

Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. PubMed ID: 17140397

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. PubMed ID: 19948736

Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation. PubMed ID: 22808130

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide. PubMed ID: 16326715

Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). PubMed ID: 1415254

Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. PubMed ID: 1763037

Identification of allele-specific p22-phox mutations in a compound heterozygous patient with chronic granulomatous disease by mismatch PCR and restriction enzyme analysis. PubMed ID: 8168815

156Pro--&gt;Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox. PubMed ID: 7964505

Molecular analysis of 9 new families with chronic granulomatous disease caused by mutations in CYBA, the gene encoding p22(phox). PubMed ID: 10910929

Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients. PubMed ID: 10759707

Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency. PubMed ID: 10914676

Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease. PubMed ID: 18422995

Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. PubMed ID: 19388116

Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients. PubMed ID: 23910690

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

Database document:

PubMed ID: 3368442

PubMed ID: 15616553

PubMed ID: 15489334

PubMed ID: 2243141

PubMed ID: 2469497

PubMed ID: 12716910

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