Details for: CYBA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 567.2305
Cell Significance Index: -88.2300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 255.1538
Cell Significance Index: -105.1100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 238.3465
Cell Significance Index: -60.4600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 220.2182
Cell Significance Index: -103.9700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 214.9167
Cell Significance Index: -110.5500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 155.3004
Cell Significance Index: -104.2100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 71.2597
Cell Significance Index: -87.8600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 30.9007
Cell Significance Index: -94.9100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 23.9721
Cell Significance Index: -94.6000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.5253
Cell Significance Index: -47.1100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 12.4409
Cell Significance Index: 229.9400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 11.2601
Cell Significance Index: 301.2000 - Cell Name: peg cell (CL4033014)
Fold Change: 10.4488
Cell Significance Index: 241.4000 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 6.4430
Cell Significance Index: 17.2600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.2123
Cell Significance Index: 400.7900 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 6.1966
Cell Significance Index: 25.7900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 5.7024
Cell Significance Index: 3114.2400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.3172
Cell Significance Index: 156.1600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.1532
Cell Significance Index: 748.7000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.5912
Cell Significance Index: 33.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.4412
Cell Significance Index: 423.1300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.7709
Cell Significance Index: 326.7700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.4881
Cell Significance Index: 116.9400 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.3547
Cell Significance Index: 301.8600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.5547
Cell Significance Index: 80.7600 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.4929
Cell Significance Index: 11.9200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4181
Cell Significance Index: 64.2800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3172
Cell Significance Index: 180.8900 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.1621
Cell Significance Index: 150.1400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8860
Cell Significance Index: 66.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8127
Cell Significance Index: 23.4200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7426
Cell Significance Index: 328.3200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5311
Cell Significance Index: 105.4000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4923
Cell Significance Index: 13.4000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4669
Cell Significance Index: 46.1900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3791
Cell Significance Index: 5.6800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3113
Cell Significance Index: 59.2500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1663
Cell Significance Index: 5.8500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0397
Cell Significance Index: 2.8100 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0233
Cell Significance Index: 2.3800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0110
Cell Significance Index: 8.0300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0059
Cell Significance Index: -4.4400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0371
Cell Significance Index: -69.9300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0468
Cell Significance Index: -2.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0495
Cell Significance Index: -91.3100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0616
Cell Significance Index: -94.8300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0625
Cell Significance Index: -1.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0717
Cell Significance Index: -12.2500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0785
Cell Significance Index: -106.7700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1410
Cell Significance Index: -104.4200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1551
Cell Significance Index: -98.5300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1595
Cell Significance Index: -2.6700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1721
Cell Significance Index: -107.4800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1788
Cell Significance Index: -100.8200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2345
Cell Significance Index: -106.4400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2529
Cell Significance Index: -8.1000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2775
Cell Significance Index: -99.5400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3061
Cell Significance Index: -7.8200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3241
Cell Significance Index: -93.2500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.4839
Cell Significance Index: -97.0700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4916
Cell Significance Index: -56.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5267
Cell Significance Index: -110.9300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5375
Cell Significance Index: -11.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5762
Cell Significance Index: -67.1500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6418
Cell Significance Index: -93.3000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.7071
Cell Significance Index: -76.9100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.7332
Cell Significance Index: -12.6400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.7753
Cell Significance Index: -31.7700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8012
Cell Significance Index: -40.4900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8216
Cell Significance Index: -17.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9113
Cell Significance Index: -94.8900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.0639
Cell Significance Index: -63.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.2563
Cell Significance Index: -96.4100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.2788
Cell Significance Index: -19.7900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2862
Cell Significance Index: -101.8700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.3933
Cell Significance Index: -19.0100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.4350
Cell Significance Index: -35.8700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.4499
Cell Significance Index: -40.5200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.5622
Cell Significance Index: -105.0400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.5796
Cell Significance Index: -97.0900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.5882
Cell Significance Index: -55.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.6530
Cell Significance Index: -92.7600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.6992
Cell Significance Index: -44.6800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.6999
Cell Significance Index: -107.1400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.7257
Cell Significance Index: -105.8000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.8697
Cell Significance Index: -55.0700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.9468
Cell Significance Index: -52.1700 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -1.9825
Cell Significance Index: -12.9300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -2.0789
Cell Significance Index: -109.1500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -2.0897
Cell Significance Index: -17.0400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -2.1796
Cell Significance Index: -46.4200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -2.2176
Cell Significance Index: -63.5700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.3042
Cell Significance Index: -101.9200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -2.3043
Cell Significance Index: -47.8000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -2.4013
Cell Significance Index: -27.2800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -2.5396
Cell Significance Index: -26.2900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.6375
Cell Significance Index: -96.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.6925
Cell Significance Index: -101.9600 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -2.7619
Cell Significance Index: -15.0600 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -2.8320
Cell Significance Index: -55.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1696406250
Symbol: CY24A_HUMAN
Name: Cytochrome b-245 light chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3368442
Title: Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
PubMed ID: 3368442
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2243141
Title: Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
PubMed ID: 2243141
DOI: 10.1172/jci114898
PubMed ID: 2469497
Title: Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils.
PubMed ID: 2469497
PubMed ID: 12716910
Title: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.
PubMed ID: 12716910
PubMed ID: 15585859
Title: Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit.
PubMed ID: 15585859
PubMed ID: 15561711
Title: Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.
PubMed ID: 15561711
PubMed ID: 15824103
Title: The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.
PubMed ID: 15824103
PubMed ID: 15927447
Title: Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.
PubMed ID: 15927447
PubMed ID: 17140397
Title: Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3.
PubMed ID: 17140397
DOI: 10.1042/bj20060819
PubMed ID: 19948736
Title: Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.
PubMed ID: 19948736
PubMed ID: 22808130
Title: Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation.
PubMed ID: 22808130
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 16326715
Title: NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.
PubMed ID: 16326715
PubMed ID: 1415254
Title: Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox).
PubMed ID: 1415254
PubMed ID: 1763037
Title: Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.
PubMed ID: 1763037
PubMed ID: 8168815
Title: Identification of allele-specific p22-phox mutations in a compound heterozygous patient with chronic granulomatous disease by mismatch PCR and restriction enzyme analysis.
PubMed ID: 8168815
DOI: 10.1007/bf00201671
PubMed ID: 7964505
Title: 156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.
PubMed ID: 7964505
PubMed ID: 10910929
Title: Molecular analysis of 9 new families with chronic granulomatous disease caused by mutations in CYBA, the gene encoding p22(phox).
PubMed ID: 10910929
PubMed ID: 10759707
Title: Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients.
PubMed ID: 10759707
PubMed ID: 10914676
Title: Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency.
PubMed ID: 10914676
PubMed ID: 18422995
Title: Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease.
PubMed ID: 18422995
PubMed ID: 19388116
Title: Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation.
PubMed ID: 19388116
DOI: 10.1002/humu.21029
PubMed ID: 23910690
Title: Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients.
PubMed ID: 23910690
Sequence Information:
- Length: 195
- Mass: 21013
- Checksum: 428427AD19398240
- Sequence:
MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC LLEYPRGKRK KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP AGFLLATILG TACLAIASGI YLLAAVRGEQ WTPIEPKPRE RPQIGGTIKQ PPSNPPPRPP AEARKKPSEE EAAVAAGGPP GGPQVNPIPV TDEVV
Genular Protein ID: 633215633
Symbol: H3BNP7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
Sequence Information:
- Length: 210
- Mass: 22827
- Checksum: 6E1F507E8B24CDB9
- Sequence:
MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC LLEYPRGKRK KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP AGFLLATILG TACLAIASGI YLLSQVPPAR RGNCPPLAVR LLVCVRGKGA ALSVYAFRVW KWSSVSSLTD LPPAELSFRT PSCCQVLIWA VALFSGGHPH PPRLPAATHS
Genular Protein ID: 4020219498
Symbol: B4DT46_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 131
- Mass: 14019
- Checksum: 0F8AF47330762B7F
- Sequence:
MERWGQKHMT AVVKLFGPFT RNYYVRAVLH LLLSVPAGFL LATILGTACL AIASGIYLLA AVRGEQWTPI EPKPRERPQI GGTIKQPPSN PPPRPPAEAR KKPSEEEAAV AAGGPPGGPQ VNPIPVTDEV V
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.