Genular: Defining Cellular Identity and Function

Details for: Hmgcl

Gene ID: 15356

Symbol: Hmgcl

Ensembl ID: ENSMUSG00000028672

Description: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Associated with

Ketone body metabolism
(R-MMU-74182)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Peroxisomal protein import
(R-MMU-9033241)
Protein localization
(R-MMU-9609507)
Synthesis of ketone bodies
(R-MMU-77111)
Acyl-coa metabolic process
(GO:0006637)
Carboxylic acid binding
(GO:0031406)
Catalytic activity
(GO:0003824)
Embryo development
(GO:0009790)
Fatty-acyl-coa binding
(GO:0000062)
Hydroxymethylglutaryl-coa lyase activity
(GO:0004419)
Ketone body biosynthetic process
(GO:0046951)
Leucine catabolic process
(GO:0006552)
Lipid metabolic process
(GO:0006629)
Lyase activity
(GO:0016829)
Magnesium ion binding
(GO:0000287)
Manganese ion binding
(GO:0030145)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Oxo-acid-lyase activity
(GO:0016833)
Peroxisome
(GO:0005777)
Protein-containing complex
(GO:0032991)
Structural molecule activity
(GO:0005198)

Other Information

Proteins

Hydroxymethylglutaryl-CoA lyase, mitochondrial

Genular Protein ID: 851501373

Symbol: HMGCL_MOUSE

Name: Hydroxymethylglutaryl-CoA lyase, mitochondrial

UniProtKB Accession Codes:

P38060 Q8QZS6

Database IDs:

Citations:

PubMed ID: 8102917

Title: 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes.

PubMed ID: 8102917

DOI: 10.1007/bf00360589

PubMed ID: 8617516

Title: 3-hydroxy-3-methylglutaryl CoA lyase (HL): mouse and human HL gene (HMGCL) cloning and detection of large gene deletions in two unrelated HL-deficient patients.

PubMed ID: 8617516

DOI: 10.1006/geno.1996.0164

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7527399

Title: 3-Hydroxy-3-methylglutaryl-CoA lyase is present in mouse and human liver peroxisomes.

PubMed ID: 7527399

DOI: 10.1016/s0021-9258(18)31784-8

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 325
Mass: 34239
Checksum: E6A85659EBA1D87F
Sequence:

MASVRKAFPR RLVGLTSLRA VSTSSMGTLP KQVKIVEVGP RDGLQNEKSI VPTPVKIRLI 
DMLSEAGLPV IEATSFVSPK WVPQMADHSD VLKGIQKFPG INYPVLTPNM KGFEEAVAAG 
AKEVSVFGAV SELFTRKNAN CSIEESFQRF AGVMQAAQAA SISVRGYVSC ALGCPYEGKV 
SPAKVAEVAK KLYSMGCYEI SLGDTIGVGT PGLMKDMLTA VMHEVPVTAL AVHCHDTYGQ 
ALANTLVALQ MGVSVVDSSV AGLGGCPYAK GASGNLATED LVYMLNGLGI HTGVNLQKLL 
EAGDFICQAL NRKTSSKVAQ ATCKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmgcl

Associated with

Other Information

3-hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes. PubMed ID: 8102917

3-hydroxy-3-methylglutaryl CoA lyase (HL): mouse and human HL gene (HMGCL) cloning and detection of large gene deletions in two unrelated HL-deficient patients. PubMed ID: 8617516

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

3-Hydroxy-3-methylglutaryl-CoA lyase is present in mouse and human liver peroxisomes. PubMed ID: 7527399

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753