Hmgcs2 | ENSMUSG00000027875 | NCBI 15360

Details for: Hmgcs2

Gene ID: 15360

Symbol: Hmgcs2

Ensembl ID: ENSMUSG00000027875

Description: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

Associated with

Ketone body metabolism
(R-MMU-74182)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Synthesis of ketone bodies
(R-MMU-77111)
Acetyl-coa metabolic process
(GO:0006084)
Acyltransferase activity
(GO:0016746)
Cholesterol biosynthetic process
(GO:0006695)
Cholesterol metabolic process
(GO:0008203)
Farnesyl diphosphate biosynthetic process, mevalonate pathway
(GO:0010142)
Hydroxymethylglutaryl-coa synthase activity
(GO:0004421)
Identical protein binding
(GO:0042802)
Isoprenoid biosynthetic process
(GO:0008299)
Ketone body biosynthetic process
(GO:0046951)
Lipid metabolic process
(GO:0006629)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Steroid biosynthetic process
(GO:0006694)
Steroid metabolic process
(GO:0008202)
Sterol biosynthetic process
(GO:0016126)
Transferase activity
(GO:0016740)

Other Information

Proteins

Hydroxymethylglutaryl-CoA synthase, mitochondrial

Genular Protein ID: 3416952541

Symbol: HMCS2_MOUSE

Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial

UniProtKB Accession Codes:

P54869 Q64740 Q9DBK1 Q9DBM4

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851882

Title: Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution.

PubMed ID: 7851882

DOI: 10.1006/geno.1994.1542

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24315375

Title: SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

PubMed ID: 24315375

DOI: 10.1016/j.cmet.2013.11.013

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 508
Mass: 56823
Checksum: 5A20ACE918FF4758
Sequence:

MQRLLAPARR VLQVKRAMQE TSLTPAHLLS AAQQRFSTIP PAPLAKTDTW PKDVGILALE 
VYFPAQYVDQ TDLEKFNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERTKLP 
WDAVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM 
ESSYWDGRYA LVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLVLEQGL RGTHMENAYD 
FYKPNLASEY PLVDGKLSIQ CYLRALDRCY AAYRKKIQNQ WKQAGNNQPF TLDDVQYMIF 
HTPFCKMVQK SLARLMFNDF LSSSSDKQNN LYKGLEAFRG LKLEETYTNK DVDKALLKAS 
LDMFNQKTKA SLYLSTNNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF 
FSFRVSKDAS PGSPLEKLVS SVSDLPKRLD SRRRMSPEEF TEIMNQREQF YHKVNFSPPG 
DTSNLFPGTW YLERVDEMHR RKYARCPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmgcs2

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution. PubMed ID: 7851882

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. PubMed ID: 24315375

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753