Genular: Defining Cellular Identity and Function

Details for: Hmox1

Gene ID: 15368

Symbol: Hmox1

Ensembl ID: ENSMUSG00000005413

Description: heme oxygenase 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cytoprotection by hmox1
(R-MMU-9707564)
Heme degradation
(R-MMU-189483)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(R-MMU-9609523)
Iron uptake and transport
(R-MMU-917937)
Metabolism
(R-MMU-1430728)
Metabolism of porphyrins
(R-MMU-189445)
Protein localization
(R-MMU-9609507)
Regulation of hmox1 expression and activity
(R-MMU-9707587)
Transport of small molecules
(R-MMU-382551)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Arachidonic acid omega-hydroxylase activity
(GO:0052869)
Caveola
(GO:0005901)
Cellular response to arsenic-containing substance
(GO:0071243)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to cisplatin
(GO:0072719)
Cellular response to heat
(GO:0034605)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epithelial cell apoptotic process
(GO:1904019)
Erythrocyte homeostasis
(GO:0034101)
Heme binding
(GO:0020037)
Heme catabolic process
(GO:0042167)
Heme metabolic process
(GO:0042168)
Heme oxidation
(GO:0006788)
Heme oxygenase (decyclizing) activity
(GO:0004392)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular signal transduction
(GO:0035556)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Liver regeneration
(GO:0097421)
Macroautophagy
(GO:0016236)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of macroautophagy
(GO:0016242)
Negative regulation of mast cell cytokine production
(GO:0032764)
Negative regulation of mast cell degranulation
(GO:0043305)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase d activity
(GO:0004630)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903589)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of epithelial cell apoptotic process
(GO:1904037)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of blood pressure
(GO:0008217)
Response to arachidonic acid
(GO:1904550)
Response to estrogen
(GO:0043627)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to nicotine
(GO:0035094)
Response to oxidative stress
(GO:0006979)
Small gtpase-mediated signal transduction
(GO:0007264)
Structural molecule activity
(GO:0005198)
Wound healing involved in inflammatory response
(GO:0002246)

Other Information

Proteins

Heme oxygenase 1

Genular Protein ID: 1044221433

Symbol: HMOX1_MOUSE

Name: Heme oxygenase 1

UniProtKB Accession Codes:

P14901

Database IDs:

Citations:

PubMed ID: 3409220

Title: Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells.

PubMed ID: 3409220

PubMed ID: 8288554

Title: Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals.

PubMed ID: 8288554

DOI: 10.1016/s0021-9258(17)42211-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18474359

Title: Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.

PubMed ID: 18474359

DOI: 10.1016/j.chom.2008.03.007

PubMed ID: 18400743

Title: Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.

PubMed ID: 18400743

DOI: 10.1074/jbc.m802274200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 32973183

Title: MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.

PubMed ID: 32973183

DOI: 10.1038/s41467-020-18607-1

Sequence Information:

Length: 289
Mass: 32929
Checksum: 19DB0DCCD574044B
Sequence:

MERPQPDSMP QDLSEALKEA TKEVHIQAEN AEFMKNFQKG QVSREGFKLV MASLYHIYTA 
LEEEIERNKQ NPVYAPLYFP EELHRRAALE QDMAFWYGPH WQEIIPCTPA TQHYVKRLHE 
VGRTHPELLV AHAYTRYLGD LSGGQVLKKI AQKAMALPSS GEGLAFFTFP NIDSPTKFKQ 
LYRARMNTLE MTPEVKHRVT EEAKTAFLLN IELFEELQVM LTEEHKDQSP SQMASLRQRP 
ASLVQDTAPA ETPRGKPQIS TSSSQTPLLQ WVLTLSFLLA TVAVGIYAM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmox1

Associated with

Other Information

Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. PubMed ID: 3409220

Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals. PubMed ID: 8288554

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection. PubMed ID: 18474359

Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. PubMed ID: 18400743

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. PubMed ID: 32973183