Details for: CYC1

Gene ID: 1537

Symbol: CYC1

Ensembl ID: ENSG00000179091

Description: cytochrome c1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.8192
    Cell Significance Index: -45.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 221.4527
    Cell Significance Index: -56.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.9033
    Cell Significance Index: -67.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 141.9914
    Cell Significance Index: -57.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.8991
    Cell Significance Index: -65.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 101.3677
    Cell Significance Index: -68.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.6082
    Cell Significance Index: -58.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.1105
    Cell Significance Index: -64.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.3895
    Cell Significance Index: -68.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.2349
    Cell Significance Index: -46.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6971
    Cell Significance Index: -42.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4340
    Cell Significance Index: -16.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.3060
    Cell Significance Index: 173.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8736
    Cell Significance Index: 31.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5145
    Cell Significance Index: 117.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1573
    Cell Significance Index: 152.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9966
    Cell Significance Index: 359.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9624
    Cell Significance Index: 88.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9442
    Cell Significance Index: 52.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8842
    Cell Significance Index: 130.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7251
    Cell Significance Index: 36.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6723
    Cell Significance Index: 36.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6702
    Cell Significance Index: 86.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6148
    Cell Significance Index: 221.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5780
    Cell Significance Index: 21.5300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5155
    Cell Significance Index: 12.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4999
    Cell Significance Index: 96.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4978
    Cell Significance Index: 662.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4793
    Cell Significance Index: 181.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4618
    Cell Significance Index: 188.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4478
    Cell Significance Index: 33.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3930
    Cell Significance Index: 36.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3677
    Cell Significance Index: 12.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3115
    Cell Significance Index: 45.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2664
    Cell Significance Index: 691.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2145
    Cell Significance Index: 57.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1916
    Cell Significance Index: 62.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1669
    Cell Significance Index: 86.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0850
    Cell Significance Index: 127.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9995
    Cell Significance Index: 902.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8592
    Cell Significance Index: 25.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8471
    Cell Significance Index: 108.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7610
    Cell Significance Index: 20.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5385
    Cell Significance Index: 33.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5298
    Cell Significance Index: 90.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5192
    Cell Significance Index: 14.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4303
    Cell Significance Index: 11.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4128
    Cell Significance Index: 4.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3697
    Cell Significance Index: 5.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3616
    Cell Significance Index: 11.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3440
    Cell Significance Index: 65.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2651
    Cell Significance Index: 3.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2240
    Cell Significance Index: 164.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2221
    Cell Significance Index: 44.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1775
    Cell Significance Index: 35.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1699
    Cell Significance Index: 5.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1287
    Cell Significance Index: 3.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0574
    Cell Significance Index: 0.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0433
    Cell Significance Index: 32.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0274
    Cell Significance Index: 2.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0262
    Cell Significance Index: 9.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0096
    Cell Significance Index: -6.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0218
    Cell Significance Index: -41.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0369
    Cell Significance Index: -23.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0432
    Cell Significance Index: -79.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0526
    Cell Significance Index: -80.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0560
    Cell Significance Index: -9.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0615
    Cell Significance Index: -83.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0752
    Cell Significance Index: -47.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0809
    Cell Significance Index: -45.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1128
    Cell Significance Index: -51.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1179
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1420
    Cell Significance Index: -29.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2039
    Cell Significance Index: -5.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2116
    Cell Significance Index: -60.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2611
    Cell Significance Index: -29.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2628
    Cell Significance Index: -20.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3021
    Cell Significance Index: -35.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3658
    Cell Significance Index: -5.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3963
    Cell Significance Index: -30.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4023
    Cell Significance Index: -7.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4028
    Cell Significance Index: -58.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4494
    Cell Significance Index: -12.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4682
    Cell Significance Index: -53.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4949
    Cell Significance Index: -9.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5169
    Cell Significance Index: -12.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5654
    Cell Significance Index: -16.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6080
    Cell Significance Index: -10.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6300
    Cell Significance Index: -37.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6587
    Cell Significance Index: -68.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6754
    Cell Significance Index: -16.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6796
    Cell Significance Index: -41.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8005
    Cell Significance Index: -44.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8131
    Cell Significance Index: -6.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8501
    Cell Significance Index: -8.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8609
    Cell Significance Index: -57.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8630
    Cell Significance Index: -25.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8834
    Cell Significance Index: -54.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** CYC1 is a mitochondrial protein, specifically a subunit of the respiratory electron transport chain complex III. It consists of a heme group that binds to oxygen, facilitating the transfer of electrons and the production of ATP. 2. **Function:** CYC1 is responsible for the transfer of electrons from ubiquinol to cytochrome c, which is a critical step in the electron transport chain. This process involves the reduction of oxygen to water and the generation of a proton gradient across the mitochondrial inner membrane. 3. **Expression:** CYC1 is significantly expressed in various cell types, including erythroid progenitor cells, kidney loop of Henle thick ascending limb epithelial cells, myeloid leukocytes, enterocytes, colon epithelial cells, stratified epithelial cells, kidney collecting duct intercalated cells, glycinergic neurons, and epithelial cells of the esophagus. **Pathways and Functions:** 1. **Cellular Respiration:** CYC1 is a crucial component of the mitochondrial respiratory chain complex III, which is responsible for the transfer of electrons and the production of ATP through the chemiosmotic coupling mechanism. 2. **Heme Binding:** CYC1 contains a heme group that binds to oxygen, facilitating the transfer of electrons and the production of ATP. 3. **Mitochondrial Electron Transport:** CYC1 is involved in the electron transport chain, where it facilitates the transfer of electrons from ubiquinol to cytochrome c. 4. **Proton Transmembrane Transport:** CYC1 is responsible for the generation of a proton gradient across the mitochondrial inner membrane, which is essential for the production of ATP. 5. **ATP Synthesis by Chemiosmotic Coupling:** CYC1 plays a critical role in the chemiosmotic coupling mechanism, where the proton gradient is used to drive the production of ATP. **Clinical Significance:** 1. **Mitochondrial Diseases:** Mutations in the CYC1 gene have been associated with various mitochondrial diseases, including Leigh syndrome, MELAS syndrome, and Kearns-Sayre syndrome. 2. **Cancer:** CYC1 has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. 3. **Neurological Disorders:** CYC1 has been linked to various neurological disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. 4. **Atherosclerosis:** CYC1 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. In conclusion, CYC1 is a vital protein that plays a crucial role in cellular respiration and mitochondrial function. Its significant expression in various cell types and its involvement in various diseases highlight its importance in human health and disease. Further research is necessary to fully understand the mechanisms of CYC1 and its role in human disease.

Genular Protein ID: 3569086420

Symbol: CY1_HUMAN

Name: Cytochrome c1, heme protein, mitochondrial

UniProtKB Accession Codes:

P08574 Q5U062 Q6FHS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 10 Ensembl 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2836796

Title: Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1.

PubMed ID: 2836796

DOI: 10.1093/nar/16.8.3577

PubMed ID: 2536365

Title: Structural organization of the human mitochondrial cytochrome c1 gene.

PubMed ID: 2536365

DOI: 10.1016/s0021-9258(18)94196-7

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3036122

Title: Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library.

PubMed ID: 3036122

DOI: 10.1016/0006-291x(87)91283-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 10453733

Title: A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency.

PubMed ID: 10453733

DOI: 10.1007/s004390050988

PubMed ID: 23910460

Title: Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia.

PubMed ID: 23910460

DOI: 10.1016/j.ajhg.2013.06.015

Sequence Information:

  • Length: 325
  • Mass: 35422
  • Checksum: CC8EA2E60E96BBDC
  • Sequence:
    • MAAAAASLRG VVLGPRGAGL PGARARGLLC SARPGQLPLR TPQAVALSSK SGLSRGRKVM 
LSALGMLAAG GAGLAMALHS AVSASDLELH PPSYPWSHRG LLSSLDHTSI RRGFQVYKQV 
CASCHSMDFV AYRHLVGVCY TEDEAKELAA EVEVQDGPNE DGEMFMRPGK LFDYFPKPYP 
NSEAARAANN GALPPDLSYI VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ 
AIAMAPPIYT DVLEFDDGTP ATMSQIAKDV CTFLRWASEP EHDHRKRMGL KMLMMMALLV 
PLVYTIKRHK WSVLKSRKLA YRPPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.