Genular: Defining Cellular Identity and Function

Details for: Nr4a1

Gene ID: 15370

Symbol: Nr4a1

Ensembl ID: ENSMUSG00000023034

Description: nuclear receptor subfamily 4, group A, member 1

Associated with

Akt phosphorylates targets in the nucleus
(R-MMU-198693)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intracellular signaling by second messengers
(R-MMU-9006925)
Nuclear receptor transcription pathway
(R-MMU-383280)
Pip3 activates akt signaling
(R-MMU-1257604)
Rna polymerase ii transcription
(R-MMU-73857)
Signal transduction
(R-MMU-162582)
Apoptotic process
(GO:0006915)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Cellular response to corticotropin-releasing hormone stimulus
(GO:0071376)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to organic substance
(GO:0071310)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Detection of lipopolysaccharide
(GO:0032497)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Endothelial cell chemotaxis
(GO:0035767)
Fat cell differentiation
(GO:0045444)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Lipopolysaccharide binding
(GO:0001530)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Neurotransmitter secretion involved in regulation of skeletal muscle contraction
(GO:0014860)
Non-canonical inflammasome complex assembly
(GO:0160075)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Nuclear membrane
(GO:0031965)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to amphetamine
(GO:0001975)
Response to inorganic substance
(GO:0010035)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
Transcription by rna polymerase ii
(GO:0006366)
Transcription regulator complex
(GO:0005667)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Nuclear receptor subfamily 4 group A member 1

Genular Protein ID: 1371532062

Symbol: NR4A1_MOUSE

Name: Nuclear receptor subfamily 4 group A member 1

UniProtKB Accession Codes:

P12813

Database IDs:

Citations:

PubMed ID: 3186734

Title: A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

PubMed ID: 3186734

DOI: 10.1073/pnas.85.22.8444

PubMed ID: 2555161

Title: Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

PubMed ID: 2555161

DOI: 10.1002/j.1460-2075.1989.tb08494.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18690216

Title: Cytosporone B is an agonist for nuclear orphan receptor Nur77.

PubMed ID: 18690216

DOI: 10.1038/nchembio.106

PubMed ID: 22427340

Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.

PubMed ID: 22427340

DOI: 10.1161/circresaha.111.258814

PubMed ID: 30134173

Title: Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.

PubMed ID: 30134173

DOI: 10.1016/j.celrep.2018.07.065

PubMed ID: 37001519

Title: The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.

PubMed ID: 37001519

DOI: 10.1016/j.immuni.2023.03.003

Sequence Information:

Length: 601
Mass: 64738
Checksum: 8CFF45B58253887B
Sequence:

MPCIQAQYGT PATSPGPRDH LTGDPLALEF GKPTMDLASP ETAPAAPATL PSFSTFMDGY 
TGEFDTFLYQ LPGTTQPCSS ACSSASSTSS SSSSATSPAS ASFKFEDFQV YGCYPGTLSG 
PLDETLSSSG SEYYGSPCSA PSPSTPNFQP SQLSPWDGSF GHFSPSQTYE GLWAWTEQLP 
KASSGPPPPP TFFSFSPPTG PSPSLAQSSL KLFPPPATHQ LGEGESYSMP AAFPGLAPTS 
PNRDTSGILD APVTSTKSRS GASGGSEGRC AVCGDNASCQ HYGVRTCEGC KGFFKRTVQK 
SAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG RLPSKPKQPP 
DASPTNLLTS LIRAHLDSGP STAKLDYSKF QELVLPRFGK EDAGDVQQFY DLLSGSLDVI 
RKWAEKIPGF IELCPGDQDL LLESAFLELF ILRLAYRSKP GEGKLIFCSG LVLHQLQCAR 
GFGDWIDNIL AFSRSLHSLG VDVPAFACLS ALVLITDRHG LQDPRRVEEL QNRIASCLKE 
HMATVAGDPQ PASCLSRLLG KLPELRTLCT QGLQRIFCLK LEDLVPPPPI VDKIFMDTLS 
F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr4a1

Associated with

Other Information

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. PubMed ID: 3186734

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. PubMed ID: 2555161

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cytosporone B is an agonist for nuclear orphan receptor Nur77. PubMed ID: 18690216

The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors. PubMed ID: 22427340

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. PubMed ID: 30134173

The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. PubMed ID: 37001519