Genular: Defining Cellular Identity and Function

Details for: Hmx3

Gene ID: 15373

Symbol: Hmx3

Ensembl ID: ENSMUSG00000040148

Description: H6 homeobox 3

Associated with

Brain development
(GO:0007420)
Cell differentiation
(GO:0030154)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Ear development
(GO:0043583)
Embryo implantation
(GO:0007566)
Inner ear morphogenesis
(GO:0042472)
Maternal process involved in female pregnancy
(GO:0060135)
Multicellular organism development
(GO:0007275)
Nervous system development
(GO:0007399)
Neuromuscular process controlling balance
(GO:0050885)
Nucleus
(GO:0005634)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)

Other Information

Proteins

Homeobox protein HMX3

Genular Protein ID: 2850901304

Symbol: HMX3_MOUSE

Name: Homeobox protein HMX3

UniProtKB Accession Codes:

P42581 B9EIJ0 O88699

Database IDs:

Citations:

PubMed ID: 7510254

Title: A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development.

PubMed ID: 7510254

DOI: 10.1006/dbio.1994.1086

PubMed ID: 10543441

Title: Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities.

PubMed ID: 10543441

DOI: 10.1515/bc.1999.130

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8541222

Title: Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development.

PubMed ID: 8541222

DOI: 10.1016/0925-4773(95)00414-v

PubMed ID: 8970821

Title: Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development.

PubMed ID: 8970821

DOI: 10.1016/s0378-5955(96)00093-7

PubMed ID: 9435283

Title: Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene.

PubMed ID: 9435283

DOI: 10.1242/dev.125.4.621

PubMed ID: 9389661

Title: Nkx5-1 controls semicircular canal formation in the mouse inner ear.

PubMed ID: 9389661

DOI: 10.1242/dev.125.1.33

PubMed ID: 10206974

Title: Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site.

PubMed ID: 10206974

DOI: 10.1074/jbc.274.17.11635

PubMed ID: 11748138

Title: Hmx2 homeobox gene control of murine vestibular morphogenesis.

PubMed ID: 11748138

DOI: 10.1242/dev.128.24.5017

PubMed ID: 11731242

Title: FGFs control the patterning of the inner ear but are not able to induce the full ear program.

PubMed ID: 11731242

DOI: 10.1016/s0925-4773(01)00550-0

PubMed ID: 12874121

Title: The role of Six1 in mammalian auditory system development.

PubMed ID: 12874121

DOI: 10.1242/dev.00628

PubMed ID: 15363417

Title: Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx.

PubMed ID: 15363417

DOI: 10.1016/j.devcel.2004.06.016

PubMed ID: 14695375

Title: Six1 controls patterning of the mouse otic vesicle.

PubMed ID: 14695375

DOI: 10.1242/dev.00943

Sequence Information:

Length: 356
Mass: 37859
Checksum: 5AB4E8D8FCCE296A
Sequence:

MPEPGPDASG TASAPPPQPP PQPPAPKESP FSIRNLLNGD HHRPPPKPQP PPRTLFAPAS 
AAAAAAAAAA AAAKGALEGA AGFALSQVGD LAFPRFEIPA QRFALPAHYL ERSPAWWYPY 
TLTPAGGHLP RPEASEKALL RDSSPASGTD RDSPEPLLKA DPDHKELDSK SPDEIILEES 
DSEEGKKEGE AVPGAAGTTV GATTATPGSE DWKAGAESPE KKPACRKKKT RTVFSRSQVF 
QLESTFDMKR YLSSSERAGL AASLHLTETQ VKIWFQNRRN KWKRQLAAEL EAANLSHAAA 
QRIVRVPILY HENSAAEGAA AAAGAPVPVS QPLLTFPHPV YYSHPVVSSV PLLRPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hmx3

Associated with

Other Information

A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. PubMed ID: 7510254

Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities. PubMed ID: 10543441

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. PubMed ID: 8541222

Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. PubMed ID: 8970821

Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. PubMed ID: 9435283

Nkx5-1 controls semicircular canal formation in the mouse inner ear. PubMed ID: 9389661

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. PubMed ID: 10206974

Hmx2 homeobox gene control of murine vestibular morphogenesis. PubMed ID: 11748138

FGFs control the patterning of the inner ear but are not able to induce the full ear program. PubMed ID: 11731242

The role of Six1 in mammalian auditory system development. PubMed ID: 12874121

Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. PubMed ID: 15363417

Six1 controls patterning of the mouse otic vesicle. PubMed ID: 14695375