Details for: Foxa1

Gene ID: 15375

Symbol: Foxa1

Ensembl ID: ENSMUSG00000035451

Description: forkhead box A1

Associated with

  • Esr-mediated signaling
    (R-MMU-8939211)
  • Estrogen-dependent gene expression
    (R-MMU-9018519)
  • Signaling by nuclear receptors
    (R-MMU-9006931)
  • Signal transduction
    (R-MMU-162582)
  • Alveolar secondary septum development
    (GO:0061144)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Chromatin remodeling
    (GO:0006338)
  • Connective tissue development
    (GO:0061448)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral neural tube patterning
    (GO:0021904)
  • Double-stranded dna binding
    (GO:0003690)
  • Epithelial cell maturation involved in prostate gland development
    (GO:0060743)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Fibrillar center
    (GO:0001650)
  • Glucose homeostasis
    (GO:0042593)
  • Hormone metabolic process
    (GO:0042445)
  • Lung development
    (GO:0030324)
  • Lung epithelial cell differentiation
    (GO:0060487)
  • Lung morphogenesis
    (GO:0060425)
  • Mesenchymal-epithelial cell signaling involved in prostate gland development
    (GO:0060739)
  • Microvillus
    (GO:0005902)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate specification
    (GO:0048665)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dopaminergic neuron differentiation
    (GO:1904340)
  • Positive regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901300)
  • Positive regulation of intracellular estrogen receptor signaling pathway
    (GO:0033148)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prostate gland epithelium morphogenesis
    (GO:0060740)
  • Prostate gland stromal morphogenesis
    (GO:0060741)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory basal cell differentiation
    (GO:1902691)
  • Response to estradiol
    (GO:0032355)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
    (GO:0060528)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Smoothened signaling pathway
    (GO:0007224)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription factor binding
    (GO:0008134)
  • Tube morphogenesis
    (GO:0035239)

Other Information

Genular Protein ID: 443217152

Symbol: FOXA1_MOUSE

Name: Hepatocyte nuclear factor 3-alpha

UniProtKB Accession Codes:

P35582 Q4VA63 Q61108

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 54 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8034310

Title: The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.

PubMed ID: 8034310

DOI: 10.1006/geno.1994.1191

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10049364

Title: Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.

PubMed ID: 10049364

DOI: 10.1101/gad.13.4.495

PubMed ID: 11571307

Title: Transcription factor FoxA (HNF3) on a nucleosome at an enhancer complex in liver chromatin.

PubMed ID: 11571307

DOI: 10.1074/jbc.m108214200

PubMed ID: 11864602

Title: Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.

PubMed ID: 11864602

DOI: 10.1016/s1097-2765(02)00459-8

PubMed ID: 15252040

Title: Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency.

PubMed ID: 15252040

DOI: 10.1074/jbc.m403354200

PubMed ID: 15987773

Title: Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.

PubMed ID: 15987773

DOI: 10.1242/dev.01917

PubMed ID: 15748903

Title: FoxA1 binding to the MMTV LTR modulates chromatin structure and transcription.

PubMed ID: 15748903

DOI: 10.1016/j.yexcr.2004.12.002

PubMed ID: 15668254

Title: Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.

PubMed ID: 15668254

DOI: 10.1074/jbc.m414122200

PubMed ID: 15959514

Title: The initiation of liver development is dependent on Foxa transcription factors.

PubMed ID: 15959514

DOI: 10.1038/nature03649

PubMed ID: 17596284

Title: Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.

PubMed ID: 17596284

DOI: 10.1242/dev.000141

PubMed ID: 17220277

Title: Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.

PubMed ID: 17220277

DOI: 10.1128/mcb.01133-06

PubMed ID: 19141476

Title: Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.

PubMed ID: 19141476

DOI: 10.1101/gad.1752608

PubMed ID: 19436110

Title: Foxa1 and Foxa2 regulate bile duct development in mice.

PubMed ID: 19436110

DOI: 10.1172/jci38201

Sequence Information:

  • Length: 468
  • Mass: 48854
  • Checksum: 8513D17623D434FD
  • Sequence:
    • MLGTVKMEGH ESNDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 
PASFNMSYAN TGLGAGLSPG AVAGMPGASA GAMNSMTAAG VTAMGTALSP GGMGSMGAQP 
ATSMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT 
MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK 
GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGSGG GGSKGGPESR KDPSGPGNPS 
AESPLHRGVH GKASQLEGAP APGPAASPQT LDHSGATATG GASELKSPAS SSAPPISSGP 
GALASVPPSH PAHGLAPHES QLHLKGDPHY SFNHPFSINN LMSSSEQQHK LDFKAYEQAL 
QYSPYGATLP ASLPLGSASV ATRSPIEPSA LEPAYYQGVY SRPVLNTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.