Details for: Foxa2

Gene ID: 15376

Symbol: Foxa2

Ensembl ID: ENSMUSG00000037025

Description: forkhead box A2

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Cell development
    (GO:0048468)
  • Cell differentiation
    (GO:0030154)
  • Cell differentiation in hindbrain
    (GO:0021533)
  • Cell fate specification
    (GO:0001708)
  • Cell junction
    (GO:0030054)
  • Cellular response to cadmium ion
    (GO:0071276)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Connective tissue development
    (GO:0061448)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral neural tube patterning
    (GO:0021904)
  • Dorsal/ventral pattern formation
    (GO:0009953)
  • Double-stranded dna binding
    (GO:0003690)
  • Ectoderm formation
    (GO:0001705)
  • Endocrine pancreas development
    (GO:0031018)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Gene expression
    (GO:0010467)
  • Glucose mediated signaling pathway
    (GO:0010255)
  • In utero embryonic development
    (GO:0001701)
  • Kinase binding
    (GO:0019900)
  • Lung development
    (GO:0030324)
  • Lung epithelial cell differentiation
    (GO:0060487)
  • Mesendoderm development
    (GO:0048382)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of glucokinase activity
    (GO:0033132)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of transcription from rna polymerase ii promoter by glucose
    (GO:0061987)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate specification
    (GO:0048665)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleic acid binding
    (GO:0003676)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dopaminergic neuron differentiation
    (GO:1904340)
  • Positive regulation of embryonic development
    (GO:0040019)
  • Positive regulation of gastrulation
    (GO:2000543)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription by rna polymerase iii
    (GO:0045945)
  • Positive regulation of transcription from rna polymerase ii promoter by glucose
    (GO:0000432)
  • Primitive streak formation
    (GO:0090009)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0061178)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Regulation of steroid metabolic process
    (GO:0019218)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to interleukin-6
    (GO:0070741)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii general transcription initiation factor activity
    (GO:0016251)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Signal transduction involved in regulation of gene expression
    (GO:0023019)
  • Smad binding
    (GO:0046332)
  • Smoothened signaling pathway
    (GO:0007224)
  • Somite rostral/caudal axis specification
    (GO:0032525)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 3897784977

Symbol: FOXA2_MOUSE

Name: Hepatocyte nuclear factor 3-beta

UniProtKB Accession Codes:

P35583 A2AR89 Q60602

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 73 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8034310

Title: The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.

PubMed ID: 8034310

DOI: 10.1006/geno.1994.1191

PubMed ID: 8375339

Title: Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.

PubMed ID: 8375339

DOI: 10.1242/dev.118.1.47

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8306889

Title: The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.

PubMed ID: 8306889

DOI: 10.1242/dev.119.4.1301

PubMed ID: 8069909

Title: HNF-3 beta is essential for node and notochord formation in mouse development.

PubMed ID: 8069909

DOI: 10.1016/0092-8674(94)90522-3

PubMed ID: 11445544

Title: Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.

PubMed ID: 11445544

DOI: 10.1101/gad.901601

PubMed ID: 11875061

Title: Foxa2 (HNF3beta) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.

PubMed ID: 11875061

DOI: 10.1074/jbc.m111037200

PubMed ID: 14500912

Title: Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

PubMed ID: 14500912

DOI: 10.1073/pnas.1931483100

PubMed ID: 15616563

Title: Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

PubMed ID: 15616563

DOI: 10.1038/nature03047

PubMed ID: 15668254

Title: Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.

PubMed ID: 15668254

DOI: 10.1074/jbc.m414122200

PubMed ID: 15959514

Title: The initiation of liver development is dependent on Foxa transcription factors.

PubMed ID: 15959514

DOI: 10.1038/nature03649

PubMed ID: 16740652

Title: The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.

PubMed ID: 16740652

DOI: 10.1210/me.2006-0008

PubMed ID: 17596284

Title: Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.

PubMed ID: 17596284

DOI: 10.1242/dev.000141

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18336786

Title: Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.

PubMed ID: 18336786

DOI: 10.1016/j.bbrc.2008.02.158

PubMed ID: 19141476

Title: Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.

PubMed ID: 19141476

DOI: 10.1101/gad.1752608

PubMed ID: 19436110

Title: Foxa1 and Foxa2 regulate bile duct development in mice.

PubMed ID: 19436110

DOI: 10.1172/jci38201

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 459
  • Mass: 48498
  • Checksum: 2F20F15AB372F557
  • Sequence:
    • MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGGGSGNMSA 
GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM SGSAGAAGVA GMGPHLSPSL SPLGGQAAGA 
MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML 
TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG 
NMFENGCYLR RQKRFKCEKQ LALKEAAGAA SSGGKKTAPG SQASQAQLGE AAGSASETPA 
GTESPHSSAS PCQEHKRGGL SELKGAPASA LSPPEPAPSP GQQQQAAAHL LGPPHHPGLP 
PEAHLKPEHH YAFNHPFSIN NLMSSEQQHH HSHHHHQPHK MDLKAYEQVM HYPGGYGSPM 
PGSLAMGPVT NKAGLDASPL AADTSYYQGV YSRPIMNSS

Genular Protein ID: 2581995590

Symbol: G5E8P5_MOUSE

Name: N/A

UniProtKB Accession Codes:

G5E8P5

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneTree 1 InterPro 7 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 465
  • Mass: 49099
  • Checksum: 664B12E3C2142589
  • Sequence:
    • MHSASSMLGA VKMEGHEPSD WSSYYAEPEG YSSVSNMNAG LGMNGMNTYM SMSAAAMGGG 
SGNMSAGSMN MSSYVGAGMS PSLAGMSPGA GAMAGMSGSA GAAGVAGMGP HLSPSLSPLG 
GQAAGAMGGL APYANMNSMS PMYGQAGLSR ARDPKTYRRS YTHAKPPYSY ISLITMAIQQ 
SPNKMLTLSE IYQWIMDLFP FYRQNQQRWQ NSIRHSLSFN DCFLKVPRSP DKPGKGSFWT 
LHPDSGNMFE NGCYLRRQKR FKCEKQLALK EAAGAASSGG KKTAPGSQAS QAQLGEAAGS 
ASETPAGTES PHSSASPCQE HKRGGLSELK GAPASALSPP EPAPSPGQQQ QAAAHLLGPP 
HHPGLPPEAH LKPEHHYAFN HPFSINNLMS SEQQHHHSHH HHQPHKMDLK AYEQVMHYPG 
GYGSPMPGSL AMGPVTNKAG LDASPLAADT SYYQGVYSRP IMNSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.