Genular: Defining Cellular Identity and Function

Details for: Hnf4a

Gene ID: 15378

Symbol: Hnf4a

Ensembl ID: ENSMUSG00000017950

Description: hepatic nuclear factor 4, alpha

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Nuclear receptor transcription pathway
(R-MMU-383280)
Rna polymerase ii transcription
(R-MMU-73857)
Acyl-coa metabolic process
(GO:0006637)
Anatomical structure development
(GO:0048856)
Arachidonic acid binding
(GO:0050544)
Blood coagulation
(GO:0007596)
Cell-cell junction organization
(GO:0045216)
Cell differentiation
(GO:0030154)
Cholesterol homeostasis
(GO:0042632)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Establishment of tissue polarity
(GO:0007164)
Fatty-acyl-coa binding
(GO:0000062)
Fatty acid binding
(GO:0005504)
Glucose homeostasis
(GO:0042593)
Lipid homeostasis
(GO:0055088)
Lipid metabolic process
(GO:0006629)
Long-chain fatty acyl-coa binding
(GO:0036042)
Metal ion binding
(GO:0046872)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of protein import into nucleus
(GO:0042308)
Negative regulation of tyrosine phosphorylation of stat protein
(GO:0042532)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ornithine metabolic process
(GO:0006591)
Phospholipid homeostasis
(GO:0055091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gastrulation
(GO:0010470)
Regulation of insulin secretion
(GO:0050796)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of microvillus assembly
(GO:0032534)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to glucose
(GO:0009749)
Response to trichostatin a
(GO:0035983)
Rhythmic process
(GO:0048511)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Sex differentiation
(GO:0007548)
Signaling receptor binding
(GO:0005102)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Stearic acid binding
(GO:0070540)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transcription corepressor binding
(GO:0001222)
Triglyceride homeostasis
(GO:0070328)
Xenobiotic metabolic process
(GO:0006805)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 3926798680

Symbol: HNF4A_MOUSE

Name: Hepatocyte nuclear factor 4-alpha

UniProtKB Accession Codes:

P49698 A2A5I5 A2ICH0 Q3UNX3 Q8CFY1

Database IDs:

Citations:

PubMed ID: 7999795

Title: Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4).

PubMed ID: 7999795

DOI: 10.1016/0167-4781(94)00177-5

PubMed ID: 16670015

Title: Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.

PubMed ID: 16670015

DOI: 10.1186/1471-2164-7-102

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17407387

Title: Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.

PubMed ID: 17407387

DOI: 10.1371/journal.pmed.0040118

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20159955

Title: The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors.

PubMed ID: 20159955

DOI: 10.1101/gad.564110

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 30530698

Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

PubMed ID: 30530698

DOI: 10.1073/pnas.1816411115

PubMed ID: 30555544

Title: Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity.

PubMed ID: 30555544

DOI: 10.7150/thno.28676

Sequence Information:

Length: 474
Mass: 52684
Checksum: 10843D528EAE87EE
Sequence:

MRLSKTLAGM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGANLNS SNSLGVSALC 
AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR QCVVDKDKRN QCRYCRLKKC 
FRAGMKKEAV QNERDRISTR RSSYEDSSLP SINALLQAEV LSQQITSPIS GINGDIRAKK 
IANITDVCES MKEQLLVLVE WAKYIPAFCE LLLDDQVALL RAHAGEHLLL GATKRSMVFK 
DVLLLGNDYI VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYACLK AIIFFDPDAK 
GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ MIEQIQFIKL 
FGMAKIDNLL QEMLLGGSAS DAPHTHHPLH PHLMQEHMGT NVIVANTMPS HLSNGQMCEW 
PRPRGQAATP ETPQPSPPSG SGSESYKLLP GAITTIVKPP SAIPQPTITK QEAI

Genular Protein ID: 463658541

Symbol: B9VVT6_MOUSE

Name: N/A

UniProtKB Accession Codes:

B9VVT6

Database IDs:

Sequence Information:

Length: 413
Mass: 46290
Checksum: DDEDF59549F107A2
Sequence:

MSDRGQGFLQ ITSDTSPSEG ANLNSSNSLG VSALCAICGD RATGKHYGAS SCDGCKGFFR 
RSVRKNHMYS CRFSRQCVVD KDKRNQCRYC RLKKCFRAGM KKEAVQNERD RISTRRSSYE 
DSSLPSINAL LQAEVLSQQI TSPISGINGD IRAKKIANIT DVCESMKEQL LVLVEWAKYI 
PAFCELLLDD QVALLRAHAG EHLLLGATKR SMVFKDVLLL GNDYIVPRHC PELAEMSRVS 
IRILDELVLP FQELQIDDNE YACLKAIIFF DPDAKGLSDP GKIKRLRSQV QVSLEDYIND 
RQYDSRGRFG ELLLLLPTLQ SITWQMIEQI QFIKLFGMAK IDNLLQEMLL GGSASDAPHT 
HHPLHPHLMQ EHMGTNVIVA NTMPSHLSNG QMCEWPRPRG QAATPETPQP SPP

Genular Protein ID: 261152303

Symbol: B9VVT5_MOUSE

Name: N/A

UniProtKB Accession Codes:

B9VVT5

Database IDs:

Sequence Information:

Length: 403
Mass: 45125
Checksum: FA5FF046678A208A
Sequence:

MSDRGQGFLQ ITSDTSPSEG ANLNSSNSLG VSALCAICGD RATGKHYGAS SCDGCKGFFR 
RSVRKNHMYS CRFSRQCVVD KDKRNQCRYC RLKKCFRAGM KKEAVQNERD RISTRRSSYE 
DSSLPSINAL LQAEVLSQQI TSPISGINGD IRAKKIANIT DVCESMKEQL LVLVEWAKYI 
PAFCELLLDD QVALLRAHAG EHLLLGATKR SMVFKDVLLL GNDYIVPRHC PELAEMSRVS 
IRILDELVLP FQELQIDDNE YACLKAIIFF DPDAKGLSDP GKIKRLRSQV QVSLEDYIND 
RQYDSRGRFG ELLLLLPTLQ SITWQMIEQI QFIKLFGMAK IDNLLQEMLL GGSASDAPHT 
HHPLHPHLMQ EHMGTNVIVA NTMPSHLSNG QMSTPETPQP SPP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hnf4a

Associated with

Other Information

Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4). PubMed ID: 7999795

Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains. PubMed ID: 16670015

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. PubMed ID: 17407387

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. PubMed ID: 20159955

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. PubMed ID: 28751364

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. PubMed ID: 30530698

Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity. PubMed ID: 30555544

Database document:

PubMed ID: 7999795

PubMed ID: 16670015

PubMed ID: 16141072

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 17407387

PubMed ID: 17242355

PubMed ID: 21183079

PubMed ID: 20159955

PubMed ID: 28751364

PubMed ID: 30530698

PubMed ID: 30555544