Details for: CYLC1

Gene ID: 1538

Symbol: CYLC1

Ensembl ID: ENSG00000183035

Description: cylicin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7129
    Cell Significance Index: 41.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5235
    Cell Significance Index: 7.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2676
    Cell Significance Index: 2.7700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1923
    Cell Significance Index: 2.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0978
    Cell Significance Index: 2.6200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0917
    Cell Significance Index: 1.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0856
    Cell Significance Index: 1.4400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0575
    Cell Significance Index: 0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0325
    Cell Significance Index: 0.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0247
    Cell Significance Index: 0.6200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0242
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0217
    Cell Significance Index: 0.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0217
    Cell Significance Index: 0.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0193
    Cell Significance Index: 0.6100
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0151
    Cell Significance Index: 0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0148
    Cell Significance Index: 0.3300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0148
    Cell Significance Index: 0.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0075
    Cell Significance Index: 5.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0044
    Cell Significance Index: 0.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0040
    Cell Significance Index: 0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0011
    Cell Significance Index: -0.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0015
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0018
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0033
    Cell Significance Index: -0.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0036
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0063
    Cell Significance Index: -0.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0065
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0072
    Cell Significance Index: -0.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0090
    Cell Significance Index: -0.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0093
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0095
    Cell Significance Index: -0.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0098
    Cell Significance Index: -0.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0120
    Cell Significance Index: -0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0128
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0139
    Cell Significance Index: -0.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0141
    Cell Significance Index: -0.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0141
    Cell Significance Index: -0.7900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0142
    Cell Significance Index: -0.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0147
    Cell Significance Index: -0.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0147
    Cell Significance Index: -0.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0164
    Cell Significance Index: -0.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0164
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0167
    Cell Significance Index: -0.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0175
    Cell Significance Index: -0.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0176
    Cell Significance Index: -0.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0181
    Cell Significance Index: -0.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0184
    Cell Significance Index: -0.2400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0185
    Cell Significance Index: -0.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0203
    Cell Significance Index: -0.4300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0206
    Cell Significance Index: -0.4200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0217
    Cell Significance Index: -0.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0218
    Cell Significance Index: -0.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0221
    Cell Significance Index: -1.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0224
    Cell Significance Index: -0.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0231
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0240
    Cell Significance Index: -0.2900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0246
    Cell Significance Index: -0.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0248
    Cell Significance Index: -0.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0253
    Cell Significance Index: -0.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0256
    Cell Significance Index: -0.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0258
    Cell Significance Index: -0.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0266
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0266
    Cell Significance Index: -0.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0269
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0274
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.0280
    Cell Significance Index: -0.0200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0297
    Cell Significance Index: -0.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0301
    Cell Significance Index: -0.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0302
    Cell Significance Index: -0.6300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0304
    Cell Significance Index: -0.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0307
    Cell Significance Index: -0.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0311
    Cell Significance Index: -0.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0313
    Cell Significance Index: -1.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0321
    Cell Significance Index: -0.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0331
    Cell Significance Index: -0.6600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0333
    Cell Significance Index: -0.4500
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0341
    Cell Significance Index: -0.3600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0347
    Cell Significance Index: -0.4400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0356
    Cell Significance Index: -0.4300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0361
    Cell Significance Index: -0.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CYLC1 is expressed in a wide range of cell types, including progenitor cells, endothelial cells, plasma cells, and cells involved in the gastrointestinal tract. 2. **Cytoskeletal Organization:** CYLC1 is involved in the organization of the cytoskeleton, which is essential for maintaining cell shape, movement, and division. 3. **Cell Differentiation:** CYLC1 plays a critical role in cell differentiation, particularly in the development of spermatozoa during spermatogenesis. 4. **Structural Molecule Activity:** CYLC1 is involved in the formation of structural molecules that provide mechanical support and stability to cells. **Pathways and Functions:** 1. **Acrosomal Matrix:** CYLC1 is involved in the formation of the acrosomal matrix, a complex structure that plays a crucial role in spermatozoa fertilization. 2. **Cytoskeletal Calyx:** CYLC1 is involved in the formation of the cytoskeletal calyx, a structure that provides mechanical support and stability to cells. 3. **Cytoskeleton Organization:** CYLC1 regulates the organization of the cytoskeleton, which is essential for maintaining cell shape, movement, and division. 4. **Spermatogenesis:** CYLC1 is involved in the development of spermatozoa during spermatogenesis, a complex process that requires precise regulation of cell differentiation and cytoskeletal organization. **Clinical Significance:** 1. **Spermatogenesis Disorders:** Mutations or dysregulation of CYLC1 have been implicated in spermatogenesis disorders, such as azoospermia and infertility. 2. **Cancer:** CYLC1 has been identified as a potential oncogene in certain types of cancer, including colon cancer and glioblastoma. 3. **Neurological Disorders:** CYLC1 has been implicated in neurological disorders, such as schizophrenia and bipolar disorder, which may be related to its role in cell differentiation and cytoskeletal organization. 4. **Regenerative Medicine:** CYLC1 has potential applications in regenerative medicine, particularly in the development of therapies for tissue engineering and cell replacement. In conclusion, CYLC1 is a multifunctional gene that plays a critical role in cell differentiation, cytoskeletal organization, and spermatogenesis. Further investigation into the functions and clinical significance of CYLC1 is necessary to fully understand its implications in human health and disease.

Genular Protein ID: 1878524596

Symbol: CYLC1_HUMAN

Name: Cylicin-1

UniProtKB Accession Codes:

P35663 A0AVQ8 Q5JQQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8354692

Title: Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton.

PubMed ID: 8354692

DOI: 10.1083/jcb.122.5.1043

Sequence Information:

  • Length: 651
  • Mass: 74242
  • Checksum: EF63B156ADE67B85
  • Sequence:
    • MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR 
HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD 
EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE 
TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE 
NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 
EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD KKKLKKDDKK 
KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA KKITFSTDSE SELESKESQK 
DEKKDKKDSK TDNKKSVKND EESTDADSEP KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN 
AESTEMESDL ELKKDKKHSK EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG 
SDTESEESLY KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV 
PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL L

Genular Protein ID: 1223864819

Symbol: Q6PEK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PEK4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 334
  • Mass: 38696
  • Checksum: 0C53A01D5B573503
  • Sequence:
    • MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR 
HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD 
EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE 
TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE 
NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 
EDSKDAKKDS KKVKKNVKKD DKKKDVKKKK KKKK

Genular Protein ID: 2134091627

Symbol: A0A087WXC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXC8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 68
  • Mass: 7898
  • Checksum: A34A765F406BB615
  • Sequence:
    • MSLPRLKVNI RTYDNSIPIS ESSRKSWNQK HFALTFPKPL QRGTNDKSRP LKSQITVTPE 
APWIHKLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.