Details for: CYLC1

Gene ID: 1538

Symbol: CYLC1

Ensembl ID: ENSG00000183035

Description: cylicin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30402
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3174
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2220
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7496
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1560
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 442
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.68
    Marker Score: 1087
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1324
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 373
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.49
    Marker Score: 270
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.37
    Marker Score: 349
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 4935
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 489
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.22
    Marker Score: 379
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 80.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 184
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.08
    Marker Score: 1032
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 24.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 215
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.03
    Marker Score: 130
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 87
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 63
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.02
    Marker Score: 99
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.02
    Marker Score: 93
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 39

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Other Information

**Key characteristics** * The protein encoded by CYLC1 is a cytoskeletal protein that is expressed in significant amounts in tissues that are undergoing cell differentiation or tissue remodeling. * It is a key component of the acrosomal matrix, which is a complex network of proteins that helps to organize and maintain the structure of cell membranes. * CYLC1 is also expressed in the nucleus, where it is involved in the regulation of gene expression. * It is a highly conserved protein, with a sequence that is similar in humans, mice, and flies. **Pathways and functions** * The protein encoded by CYLC1 is involved in a variety of cellular processes, including cell differentiation, tissue morphogenesis, and cell migration. * In cell differentiation, CYLC1 is required for the specification of neural fate in the developing embryo. * In tissue morphogenesis, it is involved in the formation of the blood-brain barrier and the development of the nervous system. * In cell migration, it is required for the migration of cells during development and tissue repair. **Clinical significance** Mutations in the CYLC1 gene have been linked to a number of human diseases, including autism spectrum disorder, schizophrenia, and cancer. These mutations can disrupt the function of the protein encoded by CYLC1, leading to a variety of developmental and neurological problems. **Conclusion** The CYLC1 gene is a critical regulator of cell differentiation and tissue integrity. Its mutations can have a significant impact on human health, highlighting its importance in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 1878524596

Symbol: CYLC1_HUMAN

Name: Cylicin-1

UniProtKB Accession Codes:

P35663 A0AVQ8 Q5JQQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8354692

Title: Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton.

PubMed ID: 8354692

DOI: 10.1083/jcb.122.5.1043

Sequence Information:

  • Length: 651
  • Mass: 74242
  • Checksum: EF63B156ADE67B85
  • Sequence:
    • MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR 
HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD 
EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE 
TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE 
NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 
EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD KKKLKKDDKK 
KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA KKITFSTDSE SELESKESQK 
DEKKDKKDSK TDNKKSVKND EESTDADSEP KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN 
AESTEMESDL ELKKDKKHSK EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG 
SDTESEESLY KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV 
PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL L

Genular Protein ID: 1223864819

Symbol: Q6PEK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PEK4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 334
  • Mass: 38696
  • Checksum: 0C53A01D5B573503
  • Sequence:
    • MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR 
HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD 
EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE 
TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE 
NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 
EDSKDAKKDS KKVKKNVKKD DKKKDVKKKK KKKK

Genular Protein ID: 2134091627

Symbol: A0A087WXC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXC8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 68
  • Mass: 7898
  • Checksum: A34A765F406BB615
  • Sequence:
    • MSLPRLKVNI RTYDNSIPIS ESSRKSWNQK HFALTFPKPL QRGTNDKSRP LKSQITVTPE 
APWIHKLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.