ADRB2 | ENSG00000169252 | NCBI 154

Details for: ADRB2

Gene ID: 154

Symbol: ADRB2

Ensembl ID: ENSG00000169252

Description: adrenoceptor beta 2

Associated with

Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Deubiquitination
(R-HSA-5688426)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Ub-specific processing proteases
(R-HSA-5689880)
Vesicle-mediated transport
(R-HSA-5653656)
Activation of adenylate cyclase activity
(GO:0007190)
Activation of transmembrane receptor protein tyrosine kinase activity
(GO:0007171)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Adenylate cyclase binding
(GO:0008179)
Adrenergic receptor signaling pathway
(GO:0071875)
Amyloid-beta binding
(GO:0001540)
Apical plasma membrane
(GO:0016324)
Beta2-adrenergic receptor activity
(GO:0004941)
Bone resorption
(GO:0045453)
Brown fat cell differentiation
(GO:0050873)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to amyloid-beta
(GO:1904646)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Desensitization of g protein-coupled receptor signaling pathway by arrestin
(GO:0002032)
Diet induced thermogenesis
(GO:0002024)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Golgi apparatus
(GO:0005794)
Heat generation
(GO:0031649)
Identical protein binding
(GO:0042802)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Negative regulation of multicellular organism growth
(GO:0040015)
Negative regulation of smooth muscle contraction
(GO:0045986)
Neuronal dense core vesicle
(GO:0098992)
Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
(GO:0002025)
Norepinephrine binding
(GO:0051380)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of ampa receptor activity
(GO:2000969)
Positive regulation of autophagosome maturation
(GO:1901098)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of camp-dependent protein kinase activity
(GO:2000481)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of lipophagy
(GO:1904504)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mini excitatory postsynaptic potential
(GO:0061885)
Positive regulation of protein kinase a signaling
(GO:0010739)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Potassium channel regulator activity
(GO:0015459)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Receptor-mediated endocytosis
(GO:0006898)
Receptor complex
(GO:0043235)
Regulation of sodium ion transport
(GO:0002028)
Response to cold
(GO:0009409)
Response to psychosocial stress
(GO:1990911)
Smooth muscle contraction
(GO:0006939)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Beta-2 adrenergic receptor

Genular Protein ID: 2646416881

Symbol: ADRB2_HUMAN

Name: Beta-2 adrenergic receptor

UniProtKB Accession Codes:

P07550 B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Database IDs:

Citations:

PubMed ID: 3026848

Title: Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.

PubMed ID: 3026848

DOI: 10.1016/0014-5793(87)81436-9

PubMed ID: 3034889

Title: Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

PubMed ID: 3034889

DOI: 10.1016/s0021-9258(18)48239-7

PubMed ID: 3033609

Title: Primary structure of the human beta-adrenergic receptor gene.

PubMed ID: 3033609

DOI: 10.1093/nar/15.8.3636

PubMed ID: 3025863

Title: cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

PubMed ID: 3025863

DOI: 10.1073/pnas.84.1.46

PubMed ID: 2823249

Title: Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

PubMed ID: 2823249

DOI: 10.1073/pnas.84.20.6995

PubMed ID: 8383511

Title: Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.

PubMed ID: 8383511

DOI: 10.1165/ajrcmb/8.3.334

PubMed ID: 11246467

Title: Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.

PubMed ID: 11246467

DOI: 10.1017/s0003480000008009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2831218

Title: Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.

PubMed ID: 2831218

DOI: 10.1016/s0021-9258(18)68888-x

PubMed ID: 2540197

Title: Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

PubMed ID: 2540197

DOI: 10.1016/s0021-9258(18)83271-9

PubMed ID: 8521811

Title: Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

PubMed ID: 8521811

DOI: 10.1002/j.1460-2075.1995.tb00241.x

PubMed ID: 7822302

Title: Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.

PubMed ID: 7822302

DOI: 10.1074/jbc.270.2.720

PubMed ID: 9388255

Title: Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.

PubMed ID: 9388255

DOI: 10.1074/jbc.272.49.31051

PubMed ID: 10499588

Title: A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.

PubMed ID: 10499588

DOI: 10.1038/45816

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 11146000

Title: The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.

PubMed ID: 11146000

DOI: 10.1046/j.1471-4159.2001.00005.x

PubMed ID: 12142540

Title: Modulation of postendocytic sorting of G protein-coupled receptors.

PubMed ID: 12142540

DOI: 10.1126/science.1073308

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19424180

Title: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

PubMed ID: 19424180

DOI: 10.1038/emboj.2009.128

PubMed ID: 19584355

Title: Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

PubMed ID: 19584355

DOI: 10.1126/scisignal.2000444

PubMed ID: 20559325

Title: Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

PubMed ID: 20559325

DOI: 10.1038/embor.2010.80

PubMed ID: 20733053

Title: SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.

PubMed ID: 20733053

DOI: 10.1083/jcb.201004060

PubMed ID: 21602791

Title: SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.

PubMed ID: 21602791

DOI: 10.1038/ncb2252

PubMed ID: 23166351

Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.

PubMed ID: 23166351

DOI: 10.1083/jcb.201208192

PubMed ID: 25220262

Title: Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.

PubMed ID: 25220262

DOI: 10.1002/pro.2549

PubMed ID: 24405750

Title: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

PubMed ID: 24405750

DOI: 10.1111/tra.12148

PubMed ID: 27481942

Title: S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.

PubMed ID: 27481942

DOI: 10.1074/jbc.m116.725762

PubMed ID: 17952055

Title: Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

PubMed ID: 17952055

DOI: 10.1038/nature06325

PubMed ID: 17962520

Title: High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

PubMed ID: 17962520

DOI: 10.1126/science.1150577

PubMed ID: 18547522

Title: A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

PubMed ID: 18547522

DOI: 10.1016/j.str.2008.05.001

PubMed ID: 7915137

Title: Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

PubMed ID: 7915137

DOI: 10.1021/bi00198a006

PubMed ID: 7706471

Title: Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

PubMed ID: 7706471

DOI: 10.1172/jci117838

Sequence Information:

Length: 413
Mass: 46459
Checksum: 408C22731C6EDFBE
Sequence:

MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK 
FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS 
IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE 
AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF 
HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD 
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT 
GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRB2

Associated with

Other Information

Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors. PubMed ID: 3026848

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. PubMed ID: 3034889

Primary structure of the human beta-adrenergic receptor gene. PubMed ID: 3033609

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. PubMed ID: 3025863

Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization. PubMed ID: 2823249

Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. PubMed ID: 8383511

Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. PubMed ID: 11246467

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation. PubMed ID: 2831218

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. PubMed ID: 2540197

Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor. PubMed ID: 8521811

Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors. PubMed ID: 7822302

Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. PubMed ID: 9388255

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. PubMed ID: 10499588

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. PubMed ID: 9924018

The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization. PubMed ID: 11146000

Modulation of postendocytic sorting of G protein-coupled receptors. PubMed ID: 12142540

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. PubMed ID: 19424180

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. PubMed ID: 19584355

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. PubMed ID: 20559325

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. PubMed ID: 20733053

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. PubMed ID: 21602791

MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors. PubMed ID: 23166351

Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. PubMed ID: 25220262

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. PubMed ID: 24405750

S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. PubMed ID: 27481942

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. PubMed ID: 17952055

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. PubMed ID: 17962520

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. PubMed ID: 18547522

Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. PubMed ID: 7915137

Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. PubMed ID: 7706471