Details for: ADRB2

Gene ID: 154

Symbol: ADRB2

Ensembl ID: ENSG00000169252

Description: adrenoceptor beta 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.79
    Marker Score: 3482
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.09
    Marker Score: 708
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.76
    Marker Score: 2124
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.59
    Marker Score: 754
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.53
    Marker Score: 2904
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.52
    Marker Score: 1595
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.33
    Marker Score: 2248
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19792
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.22
    Marker Score: 3550
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 729
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.19
    Marker Score: 3754
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.14
    Marker Score: 1262
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2217.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.07
    Marker Score: 941
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.04
    Marker Score: 467
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.01
    Marker Score: 2088
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.01
    Marker Score: 1302
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.99
    Marker Score: 879
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.96
    Marker Score: 1395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 630
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.89
    Marker Score: 227
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5019
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.88
    Marker Score: 2463
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.83
    Marker Score: 357
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.8
    Marker Score: 630
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.79
    Marker Score: 392
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.79
    Marker Score: 2019
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.78
    Marker Score: 1151
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 660
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.72
    Marker Score: 598
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2987
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.7
    Marker Score: 349
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.69
    Marker Score: 955
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 217
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.65
    Marker Score: 4264
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.62
    Marker Score: 343
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.62
    Marker Score: 359
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.61
    Marker Score: 790
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.59
    Marker Score: 694
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.59
    Marker Score: 508
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.58
    Marker Score: 241
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 335
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1351
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.56
    Marker Score: 374
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.56
    Marker Score: 8995
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.53
    Marker Score: 128
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.53
    Marker Score: 326
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.52
    Marker Score: 188
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.52
    Marker Score: 4097
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.52
    Marker Score: 150
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.52
    Marker Score: 286
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.51
    Marker Score: 548
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 334
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 321
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 238
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.48
    Marker Score: 350
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.48
    Marker Score: 869
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.47
    Marker Score: 4669
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.47
    Marker Score: 4021
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.46
    Marker Score: 187.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.45
    Marker Score: 3900
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.45
    Marker Score: 95
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.45
    Marker Score: 375
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.45
    Marker Score: 101
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.44
    Marker Score: 2330
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 652
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.44
    Marker Score: 425.5
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.44
    Marker Score: 199
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.44
    Marker Score: 197
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.44
    Marker Score: 2654
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.43
    Marker Score: 109
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.43
    Marker Score: 432
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.43
    Marker Score: 692
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.42
    Marker Score: 615
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.42
    Marker Score: 102
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.41
    Marker Score: 3059
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.41
    Marker Score: 104
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.41
    Marker Score: 989
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4
    Marker Score: 22601
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.4
    Marker Score: 730
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.4
    Marker Score: 350
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.39
    Marker Score: 199

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Other Information

**Key characteristics:** - It is a member of the beta-2 adrenoceptor family of receptors. - It is a G protein-coupled receptor (GPCR). - It is expressed in high levels in the retina of the eye. - It is also expressed in other tissues, including skin, lung, and cardiac tissue. **Pathways and functions:** - ADRB2 is a key regulator of retinal ganglion cell survival and function. - It is involved in the regulation of the blood-aqueous barrier, which protects the eye from harmful substances in the environment. - It also plays a role in the regulation of immune responses. - ADRB2 is involved in the regulation of skin physiology, including hair growth, sweat production, and inflammation. **Clinical significance:** - Mutations in the ADRB2 gene have been linked to several eye diseases, including retinal degenerative diseases, such as age-related macular degeneration (AMD). - ADRB2 is a potential target for the treatment of these diseases. **Other important points:** - ADRB2 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a relatively new receptor, with the gene first identified in humans in 1994. - It is a promising target for the development of new drugs for a variety of diseases.

Genular Protein ID: 2646416881

Symbol: ADRB2_HUMAN

Name: Beta-2 adrenergic receptor

UniProtKB Accession Codes:

P07550 B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 87 DrugCentral 1 ELM 1 EMBL 20 EMDB 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 53 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 54 PDBsum 43 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3026848

Title: Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.

PubMed ID: 3026848

DOI: 10.1016/0014-5793(87)81436-9

PubMed ID: 3034889

Title: Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

PubMed ID: 3034889

DOI: 10.1016/s0021-9258(18)48239-7

PubMed ID: 3033609

Title: Primary structure of the human beta-adrenergic receptor gene.

PubMed ID: 3033609

DOI: 10.1093/nar/15.8.3636

PubMed ID: 3025863

Title: cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

PubMed ID: 3025863

DOI: 10.1073/pnas.84.1.46

PubMed ID: 2823249

Title: Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

PubMed ID: 2823249

DOI: 10.1073/pnas.84.20.6995

PubMed ID: 8383511

Title: Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.

PubMed ID: 8383511

DOI: 10.1165/ajrcmb/8.3.334

PubMed ID: 11246467

Title: Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.

PubMed ID: 11246467

DOI: 10.1017/s0003480000008009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2831218

Title: Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.

PubMed ID: 2831218

DOI: 10.1016/s0021-9258(18)68888-x

PubMed ID: 2540197

Title: Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

PubMed ID: 2540197

DOI: 10.1016/s0021-9258(18)83271-9

PubMed ID: 8521811

Title: Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

PubMed ID: 8521811

DOI: 10.1002/j.1460-2075.1995.tb00241.x

PubMed ID: 7822302

Title: Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.

PubMed ID: 7822302

DOI: 10.1074/jbc.270.2.720

PubMed ID: 9388255

Title: Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.

PubMed ID: 9388255

DOI: 10.1074/jbc.272.49.31051

PubMed ID: 10499588

Title: A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.

PubMed ID: 10499588

DOI: 10.1038/45816

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 11146000

Title: The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.

PubMed ID: 11146000

DOI: 10.1046/j.1471-4159.2001.00005.x

PubMed ID: 12142540

Title: Modulation of postendocytic sorting of G protein-coupled receptors.

PubMed ID: 12142540

DOI: 10.1126/science.1073308

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19424180

Title: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

PubMed ID: 19424180

DOI: 10.1038/emboj.2009.128

PubMed ID: 19584355

Title: Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

PubMed ID: 19584355

DOI: 10.1126/scisignal.2000444

PubMed ID: 20559325

Title: Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

PubMed ID: 20559325

DOI: 10.1038/embor.2010.80

PubMed ID: 20733053

Title: SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.

PubMed ID: 20733053

DOI: 10.1083/jcb.201004060

PubMed ID: 21602791

Title: SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.

PubMed ID: 21602791

DOI: 10.1038/ncb2252

PubMed ID: 23166351

Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.

PubMed ID: 23166351

DOI: 10.1083/jcb.201208192

PubMed ID: 25220262

Title: Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.

PubMed ID: 25220262

DOI: 10.1002/pro.2549

PubMed ID: 24405750

Title: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

PubMed ID: 24405750

DOI: 10.1111/tra.12148

PubMed ID: 27481942

Title: S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.

PubMed ID: 27481942

DOI: 10.1074/jbc.m116.725762

PubMed ID: 17952055

Title: Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

PubMed ID: 17952055

DOI: 10.1038/nature06325

PubMed ID: 17962520

Title: High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

PubMed ID: 17962520

DOI: 10.1126/science.1150577

PubMed ID: 18547522

Title: A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

PubMed ID: 18547522

DOI: 10.1016/j.str.2008.05.001

PubMed ID: 7915137

Title: Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

PubMed ID: 7915137

DOI: 10.1021/bi00198a006

PubMed ID: 7706471

Title: Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

PubMed ID: 7706471

DOI: 10.1172/jci117838

Sequence Information:

  • Length: 413
  • Mass: 46459
  • Checksum: 408C22731C6EDFBE
  • Sequence:
    • MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK 
FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS 
IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE 
AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF 
HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD 
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT 
GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.