Details for: ADRB2

Gene ID: 154

Symbol: ADRB2

Ensembl ID: ENSG00000169252

Description: adrenoceptor beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.9481
    Cell Significance Index: -12.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.4539
    Cell Significance Index: -12.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.0426
    Cell Significance Index: -10.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 22.8039
    Cell Significance Index: -11.7300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 17.6193
    Cell Significance Index: 52.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.0710
    Cell Significance Index: -10.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.0004
    Cell Significance Index: -12.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.1924
    Cell Significance Index: 57.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1883
    Cell Significance Index: -11.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8614
    Cell Significance Index: -11.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1449
    Cell Significance Index: -12.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.8940
    Cell Significance Index: 33.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.7936
    Cell Significance Index: 44.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6740
    Cell Significance Index: 23.8300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.4948
    Cell Significance Index: 3.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5996
    Cell Significance Index: 27.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3553
    Cell Significance Index: 35.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3397
    Cell Significance Index: 306.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3179
    Cell Significance Index: 14.9400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3014
    Cell Significance Index: 7.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2811
    Cell Significance Index: 14.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2796
    Cell Significance Index: 123.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2502
    Cell Significance Index: 6.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1696
    Cell Significance Index: 21.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1593
    Cell Significance Index: 10.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1585
    Cell Significance Index: 18.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1411
    Cell Significance Index: 7.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1167
    Cell Significance Index: 14.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1015
    Cell Significance Index: 55.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0995
    Cell Significance Index: 18.9400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0859
    Cell Significance Index: 0.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0643
    Cell Significance Index: 10.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0573
    Cell Significance Index: 4.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0508
    Cell Significance Index: 9.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0453
    Cell Significance Index: 2.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0371
    Cell Significance Index: 4.0300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0245
    Cell Significance Index: 0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0149
    Cell Significance Index: 0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0074
    Cell Significance Index: 4.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0056
    Cell Significance Index: 4.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0040
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0088
    Cell Significance Index: -0.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0135
    Cell Significance Index: -0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0156
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0211
    Cell Significance Index: -11.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0231
    Cell Significance Index: -14.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0253
    Cell Significance Index: -11.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0320
    Cell Significance Index: -9.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0355
    Cell Significance Index: -12.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0401
    Cell Significance Index: -2.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0405
    Cell Significance Index: -0.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0538
    Cell Significance Index: -6.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0573
    Cell Significance Index: -4.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0631
    Cell Significance Index: -12.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0638
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0647
    Cell Significance Index: -13.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0665
    Cell Significance Index: -3.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0705
    Cell Significance Index: -3.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0725
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0753
    Cell Significance Index: -12.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0768
    Cell Significance Index: -4.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0817
    Cell Significance Index: -5.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0871
    Cell Significance Index: -11.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1053
    Cell Significance Index: -12.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1085
    Cell Significance Index: -2.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1118
    Cell Significance Index: -4.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1176
    Cell Significance Index: -12.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1313
    Cell Significance Index: -5.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1360
    Cell Significance Index: -3.8000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1513
    Cell Significance Index: -1.6100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1518
    Cell Significance Index: -1.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1916
    Cell Significance Index: -12.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1995
    Cell Significance Index: -12.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2299
    Cell Significance Index: -7.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2354
    Cell Significance Index: -13.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2370
    Cell Significance Index: -8.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2463
    Cell Significance Index: -5.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2616
    Cell Significance Index: -6.8800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2819
    Cell Significance Index: -7.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2838
    Cell Significance Index: -8.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2897
    Cell Significance Index: -12.8200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2900
    Cell Significance Index: -4.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2993
    Cell Significance Index: -3.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3218
    Cell Significance Index: -3.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3231
    Cell Significance Index: -9.4900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3321
    Cell Significance Index: -2.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3385
    Cell Significance Index: -3.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3387
    Cell Significance Index: -5.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3401
    Cell Significance Index: -12.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3455
    Cell Significance Index: -8.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3531
    Cell Significance Index: -7.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3568
    Cell Significance Index: -5.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: The β2AR is a transmembrane receptor consisting of seven transmembrane alpha-helices, an extracellular N-terminus, and an intracellular C-terminus. 2. **Agonist**: The β2AR is activated by epinephrine (adrenaline) and isoproterenol, which bind to the extracellular N-terminus. 3. **G-Protein Coupling**: The β2AR couples to the Gs protein, which activates adenylate cyclase and increases cAMP levels. 4. **Desensitization**: The β2AR undergoes desensitization upon prolonged agonist stimulation, which reduces its sensitivity to further agonist binding. 5. **Regulation**: The β2AR is regulated by various mechanisms, including phosphorylation, ubiquitination, and internalization. **Pathways and Functions** 1. **Adenylate Cyclase-Activating Signaling Pathway**: The β2AR activates adenylate cyclase, leading to an increase in cAMP levels and the activation of downstream signaling pathways. 2. **Smooth Muscle Contraction**: The β2AR regulates smooth muscle contraction by increasing cAMP levels, which activates protein kinase A (PKA) and phosphorylates and relaxes smooth muscle cells. 3. **Thermogenesis**: The β2AR plays a role in diet-induced thermogenesis, which involves the activation of brown adipose tissue and the generation of heat. 4. **Cardiovascular Regulation**: The β2AR regulates heart rate, cardiac output, and blood pressure by modulating the activity of the sinoatrial node and the sympathetic nervous system. 5. **Immune Response**: The β2AR is expressed on various immune cells, including basophils, and plays a role in the regulation of immune responses, including the release of histamine and cytokines. **Clinical Significance** 1. **Hypertension**: The β2AR is involved in the regulation of blood pressure, and its dysfunction has been implicated in the development of hypertension. 2. **Asthma**: The β2AR is a target for bronchodilators in the treatment of asthma, and its dysregulation has been implicated in the pathophysiology of the disease. 3. **Cardiac Arrhythmias**: The β2AR is involved in the regulation of heart rate and rhythm, and its dysfunction has been implicated in the development of cardiac arrhythmias. 4. **Thermoregulation**: The β2AR plays a role in thermoregulation, and its dysregulation has been implicated in the development of hypothermia and hyperthermia. 5. **Cancer**: The β2AR is overexpressed in certain types of cancer, including breast and lung cancer, and its dysregulation has been implicated in the development and progression of these diseases. In conclusion, the β2AR is a critical regulator of various physiological processes, including heart rate regulation, smooth muscle contraction, and thermogenesis. Its dysregulation has been implicated in the development of various diseases, including hypertension, asthma, cardiac arrhythmias, and cancer.

Genular Protein ID: 2646416881

Symbol: ADRB2_HUMAN

Name: Beta-2 adrenergic receptor

UniProtKB Accession Codes:

P07550 B0LPE4 B2R7X2 O14823 O14824 O14825 O14826 Q4JG18 Q53GA6 Q6GMT4 Q6P4D8 Q8NEQ9 Q96EC3 Q9UCZ0 Q9UCZ1 Q9UCZ2 Q9UCZ3 Q9UH95 Q9UHA1 Q9UMZ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 87 DrugCentral 1 ELM 1 EMBL 20 EMDB 100 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3026848

Title: Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.

PubMed ID: 3026848

DOI: 10.1016/0014-5793(87)81436-9

PubMed ID: 3034889

Title: Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

PubMed ID: 3034889

DOI: 10.1016/s0021-9258(18)48239-7

PubMed ID: 3033609

Title: Primary structure of the human beta-adrenergic receptor gene.

PubMed ID: 3033609

DOI: 10.1093/nar/15.8.3636

PubMed ID: 3025863

Title: cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

PubMed ID: 3025863

DOI: 10.1073/pnas.84.1.46

PubMed ID: 2823249

Title: Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

PubMed ID: 2823249

DOI: 10.1073/pnas.84.20.6995

PubMed ID: 8383511

Title: Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.

PubMed ID: 8383511

DOI: 10.1165/ajrcmb/8.3.334

PubMed ID: 11246467

Title: Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.

PubMed ID: 11246467

DOI: 10.1017/s0003480000008009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2831218

Title: Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.

PubMed ID: 2831218

DOI: 10.1016/s0021-9258(18)68888-x

PubMed ID: 2540197

Title: Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

PubMed ID: 2540197

DOI: 10.1016/s0021-9258(18)83271-9

PubMed ID: 8521811

Title: Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

PubMed ID: 8521811

DOI: 10.1002/j.1460-2075.1995.tb00241.x

PubMed ID: 7822302

Title: Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.

PubMed ID: 7822302

DOI: 10.1074/jbc.270.2.720

PubMed ID: 9388255

Title: Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.

PubMed ID: 9388255

DOI: 10.1074/jbc.272.49.31051

PubMed ID: 10499588

Title: A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.

PubMed ID: 10499588

DOI: 10.1038/45816

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 11146000

Title: The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.

PubMed ID: 11146000

DOI: 10.1046/j.1471-4159.2001.00005.x

PubMed ID: 12142540

Title: Modulation of postendocytic sorting of G protein-coupled receptors.

PubMed ID: 12142540

DOI: 10.1126/science.1073308

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19424180

Title: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

PubMed ID: 19424180

DOI: 10.1038/emboj.2009.128

PubMed ID: 19584355

Title: Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

PubMed ID: 19584355

DOI: 10.1126/scisignal.2000444

PubMed ID: 20559325

Title: Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

PubMed ID: 20559325

DOI: 10.1038/embor.2010.80

PubMed ID: 20733053

Title: SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.

PubMed ID: 20733053

DOI: 10.1083/jcb.201004060

PubMed ID: 21602791

Title: SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.

PubMed ID: 21602791

DOI: 10.1038/ncb2252

PubMed ID: 23166351

Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound beta(2)-adrenergic receptors.

PubMed ID: 23166351

DOI: 10.1083/jcb.201208192

PubMed ID: 25220262

Title: Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.

PubMed ID: 25220262

DOI: 10.1002/pro.2549

PubMed ID: 24405750

Title: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

PubMed ID: 24405750

DOI: 10.1111/tra.12148

PubMed ID: 27481942

Title: S-Palmitoylation of a Novel Site in the beta2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.

PubMed ID: 27481942

DOI: 10.1074/jbc.m116.725762

PubMed ID: 17952055

Title: Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

PubMed ID: 17952055

DOI: 10.1038/nature06325

PubMed ID: 17962520

Title: High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

PubMed ID: 17962520

DOI: 10.1126/science.1150577

PubMed ID: 18547522

Title: A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

PubMed ID: 18547522

DOI: 10.1016/j.str.2008.05.001

PubMed ID: 7915137

Title: Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

PubMed ID: 7915137

DOI: 10.1021/bi00198a006

PubMed ID: 7706471

Title: Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

PubMed ID: 7706471

DOI: 10.1172/jci117838

Sequence Information:

  • Length: 413
  • Mass: 46459
  • Checksum: 408C22731C6EDFBE
  • Sequence:
    • MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK 
FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS 
IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE 
AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF 
HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD 
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT 
GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.