Details for: CYLD
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 279.8543
Cell Significance Index: -43.5300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 160.6586
Cell Significance Index: -40.7500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 98.3121
Cell Significance Index: -39.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 97.2205
Cell Significance Index: -45.9000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 87.5608
Cell Significance Index: -45.0400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.1579
Cell Significance Index: -40.2500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.0191
Cell Significance Index: -44.4100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.2640
Cell Significance Index: -40.8900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.0455
Cell Significance Index: -43.1400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.3607
Cell Significance Index: -44.8300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.7369
Cell Significance Index: -21.3100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.2096
Cell Significance Index: 63.3400 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.0866
Cell Significance Index: 22.1700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4572
Cell Significance Index: 292.3200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3517
Cell Significance Index: 133.7100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.2745
Cell Significance Index: 37.4300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1867
Cell Significance Index: 1071.4900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9962
Cell Significance Index: 357.3300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.8866
Cell Significance Index: 14.6100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8721
Cell Significance Index: 56.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7216
Cell Significance Index: 33.9200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.7198
Cell Significance Index: 31.8400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6892
Cell Significance Index: 26.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6135
Cell Significance Index: 66.7400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5465
Cell Significance Index: 63.6900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5137
Cell Significance Index: 83.5500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5031
Cell Significance Index: 10.7200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.4677
Cell Significance Index: 53.3900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4287
Cell Significance Index: 77.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4037
Cell Significance Index: 30.9800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3972
Cell Significance Index: 48.8500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3512
Cell Significance Index: 69.7000 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3495
Cell Significance Index: 45.1600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3429
Cell Significance Index: 237.1400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3392
Cell Significance Index: 8.4800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3219
Cell Significance Index: 61.2600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2748
Cell Significance Index: 7.4800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2577
Cell Significance Index: 113.9500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2531
Cell Significance Index: 17.5000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2503
Cell Significance Index: 34.3700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2057
Cell Significance Index: 3.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1364
Cell Significance Index: 6.3600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1256
Cell Significance Index: 236.4300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1211
Cell Significance Index: 5.4900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1166
Cell Significance Index: 63.6700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1078
Cell Significance Index: 13.8200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1028
Cell Significance Index: 6.3200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0986
Cell Significance Index: 2.8400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0601
Cell Significance Index: 1.1100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0576
Cell Significance Index: 6.7900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0562
Cell Significance Index: 35.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0514
Cell Significance Index: 23.3400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0323
Cell Significance Index: 49.7800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0276
Cell Significance Index: 4.7100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0201
Cell Significance Index: 37.0200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0008
Cell Significance Index: 1.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0089
Cell Significance Index: -6.5900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0147
Cell Significance Index: -9.1700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0305
Cell Significance Index: -4.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0320
Cell Significance Index: -23.4800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0347
Cell Significance Index: -3.9800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0476
Cell Significance Index: -36.0500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0490
Cell Significance Index: -27.6200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0490
Cell Significance Index: -1.3100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0521
Cell Significance Index: -1.3400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0608
Cell Significance Index: -4.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0828
Cell Significance Index: -8.4600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0988
Cell Significance Index: -20.8200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1100
Cell Significance Index: -5.7300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1188
Cell Significance Index: -3.3200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1262
Cell Significance Index: -1.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1298
Cell Significance Index: -37.3500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1416
Cell Significance Index: -9.5200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1517
Cell Significance Index: -7.8800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2177
Cell Significance Index: -2.9700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2264
Cell Significance Index: -16.0100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2504
Cell Significance Index: -15.7900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2772
Cell Significance Index: -7.9100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2796
Cell Significance Index: -14.6800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3071
Cell Significance Index: -31.9800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3103
Cell Significance Index: -7.5700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3179
Cell Significance Index: -17.8400 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.3360
Cell Significance Index: -2.5900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4824
Cell Significance Index: -5.7500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5148
Cell Significance Index: -40.7700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5366
Cell Significance Index: -12.8700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5402
Cell Significance Index: -14.4800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5403
Cell Significance Index: -11.5500 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.5585
Cell Significance Index: -8.9600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6213
Cell Significance Index: -38.0900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6454
Cell Significance Index: -20.6700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6465
Cell Significance Index: -32.6700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6740
Cell Significance Index: -11.5500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6903
Cell Significance Index: -14.3200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.7330
Cell Significance Index: -15.8800 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.7344
Cell Significance Index: -12.6600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7511
Cell Significance Index: -14.6600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8280
Cell Significance Index: -27.1100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.8488
Cell Significance Index: -17.0400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8647
Cell Significance Index: -27.5400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1057081307
Symbol: CYLD_HUMAN
Name: Ubiquitin carboxyl-terminal hydrolase CYLD
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10835629
Title: Identification of the familial cylindromatosis tumor suppressor gene.
PubMed ID: 10835629
DOI: 10.1038/76006
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 12917689
Title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
PubMed ID: 12917689
DOI: 10.1038/nature01803
PubMed ID: 12917690
Title: Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
PubMed ID: 12917690
DOI: 10.1038/nature01811
PubMed ID: 12917691
Title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
PubMed ID: 12917691
DOI: 10.1038/nature01802
PubMed ID: 14676304
Title: The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.
PubMed ID: 14676304
DOI: 10.1084/jem.20031187
PubMed ID: 15870263
Title: Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.
PubMed ID: 15870263
PubMed ID: 17495026
Title: The tumor suppressor CYLD regulates entry into mitosis.
PubMed ID: 17495026
PubMed ID: 18636086
Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
PubMed ID: 18636086
PubMed ID: 18222923
Title: The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.
PubMed ID: 18222923
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20194890
Title: CYLD regulates angiogenesis by mediating vascular endothelial cell migration.
PubMed ID: 20194890
PubMed ID: 19893491
Title: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
PubMed ID: 19893491
PubMed ID: 20227366
Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
PubMed ID: 20227366
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25134987
Title: The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
PubMed ID: 25134987
DOI: 10.1038/ncomms5585
PubMed ID: 12190880
Title: Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages.
PubMed ID: 12190880
PubMed ID: 12950348
Title: Identification of a recurrent mutation in the CYLD gene in Brooke-Spiegler syndrome.
PubMed ID: 12950348
PubMed ID: 16307661
Title: Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China.
PubMed ID: 16307661
PubMed ID: 15854031
Title: Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation.
PubMed ID: 15854031
PubMed ID: 16922728
Title: CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes.
PubMed ID: 16922728
PubMed ID: 26670046
Title: LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes.
PubMed ID: 26670046
PubMed ID: 27307491
Title: SPATA2 links CYLD to the TNF-alpha receptor signaling complex and modulates the receptor signaling outcomes.
PubMed ID: 27307491
PubMed ID: 27458237
Title: SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death.
PubMed ID: 27458237
PubMed ID: 27545878
Title: SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
PubMed ID: 27545878
PubMed ID: 26997266
Title: CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling.
PubMed ID: 26997266
PubMed ID: 27591049
Title: SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling.
PubMed ID: 27591049
PubMed ID: 29291351
Title: The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
PubMed ID: 29291351
DOI: 10.1038/nm.4461
PubMed ID: 34497368
Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
PubMed ID: 34497368
PubMed ID: 15341735
Title: The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.
PubMed ID: 15341735
PubMed ID: 18313383
Title: The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.
PubMed ID: 18313383
PubMed ID: 14632188
Title: A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome.
PubMed ID: 14632188
PubMed ID: 23338750
Title: Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
PubMed ID: 23338750
PubMed ID: 32666117
Title: CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort.
PubMed ID: 32666117
PubMed ID: 32185393
Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.
PubMed ID: 32185393
Sequence Information:
- Length: 956
- Mass: 107316
- Checksum: 01831F9A83424631
- Sequence:
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV YQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV GETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN RSELFYTLNG SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP PLQPPPVNSL TTENRFHSLP FSLTKMPNTN GSIGHSPLSL SAQSVMEELN TAPVQESPPL AMPPGNSHGL EVGSLAEVKE NPPFYGVIRW IGQPPGLNEV LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR PDSRFASLQP VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI YGYVCATKIM KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL KIRSAGQKVQ DCYFYQIFME KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS CLIIQMPRFG KDFKLFKKIF PSLELNITDL LEDTPRQCRI CGGLAMYECR ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL PKDLPDWDWR HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP TMSLYK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.