Details for: CYLD

Gene ID: 1540

Symbol: CYLD

Ensembl ID: ENSG00000083799

Description: CYLD lysine 63 deubiquitinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 279.8543
    Cell Significance Index: -43.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.6586
    Cell Significance Index: -40.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.3121
    Cell Significance Index: -39.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.2205
    Cell Significance Index: -45.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.5608
    Cell Significance Index: -45.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.1579
    Cell Significance Index: -40.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.0191
    Cell Significance Index: -44.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2640
    Cell Significance Index: -40.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0455
    Cell Significance Index: -43.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3607
    Cell Significance Index: -44.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7369
    Cell Significance Index: -21.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2096
    Cell Significance Index: 63.3400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.0866
    Cell Significance Index: 22.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4572
    Cell Significance Index: 292.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3517
    Cell Significance Index: 133.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2745
    Cell Significance Index: 37.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1867
    Cell Significance Index: 1071.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9962
    Cell Significance Index: 357.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8866
    Cell Significance Index: 14.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8721
    Cell Significance Index: 56.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7216
    Cell Significance Index: 33.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7198
    Cell Significance Index: 31.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6892
    Cell Significance Index: 26.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6135
    Cell Significance Index: 66.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5465
    Cell Significance Index: 63.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5137
    Cell Significance Index: 83.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5031
    Cell Significance Index: 10.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4677
    Cell Significance Index: 53.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4287
    Cell Significance Index: 77.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4037
    Cell Significance Index: 30.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3972
    Cell Significance Index: 48.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3512
    Cell Significance Index: 69.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3495
    Cell Significance Index: 45.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3429
    Cell Significance Index: 237.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3392
    Cell Significance Index: 8.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3219
    Cell Significance Index: 61.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2748
    Cell Significance Index: 7.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2577
    Cell Significance Index: 113.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2531
    Cell Significance Index: 17.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2503
    Cell Significance Index: 34.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2057
    Cell Significance Index: 3.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1364
    Cell Significance Index: 6.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1256
    Cell Significance Index: 236.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1211
    Cell Significance Index: 5.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1166
    Cell Significance Index: 63.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1078
    Cell Significance Index: 13.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1028
    Cell Significance Index: 6.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0986
    Cell Significance Index: 2.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0601
    Cell Significance Index: 1.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0576
    Cell Significance Index: 6.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0562
    Cell Significance Index: 35.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0514
    Cell Significance Index: 23.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0323
    Cell Significance Index: 49.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0276
    Cell Significance Index: 4.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0201
    Cell Significance Index: 37.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0147
    Cell Significance Index: -9.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0320
    Cell Significance Index: -23.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0347
    Cell Significance Index: -3.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0476
    Cell Significance Index: -36.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0490
    Cell Significance Index: -27.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0490
    Cell Significance Index: -1.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0521
    Cell Significance Index: -1.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0608
    Cell Significance Index: -4.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0828
    Cell Significance Index: -8.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0988
    Cell Significance Index: -20.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1100
    Cell Significance Index: -5.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1188
    Cell Significance Index: -3.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1262
    Cell Significance Index: -1.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1298
    Cell Significance Index: -37.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1416
    Cell Significance Index: -9.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1517
    Cell Significance Index: -7.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2177
    Cell Significance Index: -2.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2264
    Cell Significance Index: -16.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2504
    Cell Significance Index: -15.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2772
    Cell Significance Index: -7.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2796
    Cell Significance Index: -14.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3071
    Cell Significance Index: -31.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3103
    Cell Significance Index: -7.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3179
    Cell Significance Index: -17.8400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3360
    Cell Significance Index: -2.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4824
    Cell Significance Index: -5.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5148
    Cell Significance Index: -40.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5366
    Cell Significance Index: -12.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5402
    Cell Significance Index: -14.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5403
    Cell Significance Index: -11.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.5585
    Cell Significance Index: -8.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6213
    Cell Significance Index: -38.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6454
    Cell Significance Index: -20.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6465
    Cell Significance Index: -32.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6740
    Cell Significance Index: -11.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6903
    Cell Significance Index: -14.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7330
    Cell Significance Index: -15.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7344
    Cell Significance Index: -12.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7511
    Cell Significance Index: -14.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8280
    Cell Significance Index: -27.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8488
    Cell Significance Index: -17.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8647
    Cell Significance Index: -27.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Lysine 63 deubiquitinase**: CYLD is a member of the ubiquitin-specific processing protease family, which deubiquitinates proteins at lysine 63 (K63) residues. 2. **Negative regulator**: CYLD is a negative regulator of multiple signaling pathways, including death receptor signaling, NF-κB, and JNK cascades. 3. **T cell-specific expression**: CYLD is highly expressed in T cells, particularly in effector CD4-positive, alpha-beta T cells, and memory regulatory T cells. 4. **Regulation of apoptosis**: CYLD regulates apoptosis by deubiquitininating pro-apoptotic proteins, such as TRAIL-R1 and TRAIL-R2. **Pathways and Functions** CYLD is involved in various cellular pathways, including: 1. **Death receptor signaling**: CYLD deubiquitinates death receptors, such as TRAIL-R1 and TRAIL-R2, thereby regulating apoptosis. 2. **NF-κB signaling**: CYLD deubiquitinates NF-κB components, such as p105, thereby regulating NF-κB activity. 3. **JNK cascade**: CYLD deubiquitinates JNK components, such as JNK1 and JNK2, thereby regulating JNK activity. 4. **T cell differentiation**: CYLD regulates T cell differentiation by deubiquitinating key transcription factors, such as NF-κB and TCF1. 5. **Apoptosis**: CYLD regulates apoptosis by deubiquitinating pro-apoptotic proteins, such as TRAIL-R1 and TRAIL-R2. **Clinical Significance** Dysregulation of CYLD has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: CYLD mutations have been associated with immunodeficiency disorders, such as X-linked inhibitor of apoptosis protein (XIAP) deficiency. 2. **Cancer**: CYLD is overexpressed in various types of cancer, including colon, breast, and lung cancer. 3. **Autoimmune diseases**: CYLD dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, CYLD is a critical regulator of cellular homeostasis and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis and preventing disease. Further research is needed to fully understand the role of CYLD in human disease and to develop therapeutic strategies to target this gene in the treatment of various diseases.

Genular Protein ID: 1057081307

Symbol: CYLD_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase CYLD

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10835629

Title: Identification of the familial cylindromatosis tumor suppressor gene.

PubMed ID: 10835629

DOI: 10.1038/76006

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12917689

Title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

PubMed ID: 12917689

DOI: 10.1038/nature01803

PubMed ID: 12917690

Title: Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

PubMed ID: 12917690

DOI: 10.1038/nature01811

PubMed ID: 12917691

Title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

PubMed ID: 12917691

DOI: 10.1038/nature01802

PubMed ID: 14676304

Title: The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.

PubMed ID: 14676304

DOI: 10.1084/jem.20031187

PubMed ID: 15870263

Title: Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.

PubMed ID: 15870263

DOI: 10.1128/mcb.25.10.3886-3895.2005

PubMed ID: 17495026

Title: The tumor suppressor CYLD regulates entry into mitosis.

PubMed ID: 17495026

DOI: 10.1073/pnas.0703268104

PubMed ID: 18636086

Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

PubMed ID: 18636086

DOI: 10.1038/embor.2008.136

PubMed ID: 18222923

Title: The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.

PubMed ID: 18222923

DOI: 10.1074/jbc.m708470200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20194890

Title: CYLD regulates angiogenesis by mediating vascular endothelial cell migration.

PubMed ID: 20194890

DOI: 10.1182/blood-2009-10-248526

PubMed ID: 19893491

Title: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

PubMed ID: 19893491

DOI: 10.1038/emboj.2009.317

PubMed ID: 20227366

Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

PubMed ID: 20227366

DOI: 10.1016/j.molcel.2010.01.035

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25134987

Title: The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.

PubMed ID: 25134987

DOI: 10.1038/ncomms5585

PubMed ID: 12190880

Title: Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages.

PubMed ID: 12190880

DOI: 10.1046/j.1523-1747.2002.01839.x

PubMed ID: 12950348

Title: Identification of a recurrent mutation in the CYLD gene in Brooke-Spiegler syndrome.

PubMed ID: 12950348

DOI: 10.1046/j.1365-2230.2003.01344.x

PubMed ID: 16307661

Title: Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China.

PubMed ID: 16307661

DOI: 10.1111/j.1365-2133.2005.06960.x

PubMed ID: 15854031

Title: Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation.

PubMed ID: 15854031

DOI: 10.1111/j.0022-202x.2005.23688.x

PubMed ID: 16922728

Title: CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes.

PubMed ID: 16922728

DOI: 10.1111/j.1399-0004.2006.00667.x

PubMed ID: 26670046

Title: LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes.

PubMed ID: 26670046

DOI: 10.1016/j.celrep.2015.11.009

PubMed ID: 27307491

Title: SPATA2 links CYLD to the TNF-alpha receptor signaling complex and modulates the receptor signaling outcomes.

PubMed ID: 27307491

DOI: 10.15252/embj.201694300

PubMed ID: 27458237

Title: SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death.

PubMed ID: 27458237

DOI: 10.15252/embr.201642592

PubMed ID: 27545878

Title: SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

PubMed ID: 27545878

DOI: 10.1016/j.celrep.2016.07.086

PubMed ID: 26997266

Title: CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling.

PubMed ID: 26997266

DOI: 10.1016/j.celrep.2016.02.062

PubMed ID: 27591049

Title: SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling.

PubMed ID: 27591049

DOI: 10.1016/j.molcel.2016.08.001

PubMed ID: 29291351

Title: The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.

PubMed ID: 29291351

DOI: 10.1038/nm.4461

PubMed ID: 34497368

Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.

PubMed ID: 34497368

DOI: 10.1038/s41556-021-00732-8

PubMed ID: 15341735

Title: The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.

PubMed ID: 15341735

DOI: 10.1016/j.str.2004.07.012

PubMed ID: 18313383

Title: The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.

PubMed ID: 18313383

DOI: 10.1016/j.molcel.2007.12.018

PubMed ID: 14632188

Title: A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome.

PubMed ID: 14632188

DOI: 10.1046/j.1523-1747.2003.12514.x

PubMed ID: 23338750

Title: Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.

PubMed ID: 23338750

DOI: 10.1007/s00401-013-1078-9

PubMed ID: 32666117

Title: CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort.

PubMed ID: 32666117

DOI: 10.1093/brain/awaa183

PubMed ID: 32185393

Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.

PubMed ID: 32185393

DOI: 10.1093/brain/awaa039

Sequence Information:

  • Length: 956
  • Mass: 107316
  • Checksum: 01831F9A83424631
  • Sequence:
  • MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 
    PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 
    KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV 
    YQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV 
    GETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN 
    DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN RSELFYTLNG 
    SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP PLQPPPVNSL TTENRFHSLP 
    FSLTKMPNTN GSIGHSPLSL SAQSVMEELN TAPVQESPPL AMPPGNSHGL EVGSLAEVKE 
    NPPFYGVIRW IGQPPGLNEV LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR 
    PDSRFASLQP VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS 
    CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI YGYVCATKIM 
    KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL KIRSAGQKVQ DCYFYQIFME 
    KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS CLIIQMPRFG KDFKLFKKIF PSLELNITDL 
    LEDTPRQCRI CGGLAMYECR ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL 
    PKDLPDWDWR HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG 
    FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP TMSLYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.