CYLD | ENSG00000083799 | NCBI 1540

Details for: CYLD

Gene ID: 1540

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CYLD

Ensembl ID: ENSG00000083799

Description: CYLD lysine 63 deubiquitinase

Cell Significance Landscape

Display Count:

Associated with

Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Negative regulators of ddx58/ifih1 signaling
(R-HSA-936440)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Post-translational protein modification
(R-HSA-597592)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Signal transduction
(R-HSA-162582)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnf signaling
(R-HSA-75893)
Ub-specific processing proteases
(R-HSA-5689880)
Cd4-positive or cd8-positive, alpha-beta t cell lineage commitment
(GO:0043369)
Centrosome
(GO:0005813)
Ciliary basal body
(GO:0036064)
Ciliary tip
(GO:0097542)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cytoplasmic microtubule
(GO:0005881)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Homeostasis of number of cells
(GO:0048872)
Innate immune response
(GO:0045087)
K48-linked deubiquitinase activity
(GO:1990380)
K63-linked deubiquitinase activity
(GO:0061578)
Met1-linked polyubiquitin deubiquitinase activity
(GO:0061815)
Midbody
(GO:0030496)
Necroptotic process
(GO:0070266)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-18-mediated signaling pathway
(GO:2000493)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of non-canonical nf-kappab signal transduction
(GO:1901223)
Negative regulation of p38mapk cascade
(GO:1903753)
Negative regulation of type i interferon production
(GO:0032480)
Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
(GO:0035872)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of protein localization
(GO:1903829)
Positive regulation of t cell differentiation
(GO:0045582)
Positive regulation of t cell receptor signaling pathway
(GO:0050862)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Protein k63-linked deubiquitination
(GO:0070536)
Protein kinase binding
(GO:0019901)
Protein linear deubiquitination
(GO:1990108)
Proteolysis
(GO:0006508)
Regulation of b cell differentiation
(GO:0045577)
Regulation of cilium assembly
(GO:1902017)
Regulation of inflammatory response
(GO:0050727)
Regulation of intrinsic apoptotic signaling pathway
(GO:2001242)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of necroptotic process
(GO:0060544)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Ripoptosome assembly involved in necroptotic process
(GO:1901026)
Spindle
(GO:0005819)
Wnt signaling pathway
(GO:0016055)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

keratinocyte CL0000312

CSI 25.74

rCSI 21.58%

PRS 39.59
common myeloid progenitor CL0000049

CSI 16.76

rCSI 13.55%

PRS 35.15
CD4-positive helper T cell CL0000492

CSI 14.33

rCSI 10.84%

PRS 45.66
T follicular helper cell CL0002038

CSI 13.4

rCSI 10.03%

PRS 48.82
transit amplifying cell CL0009010

CSI 12.84

rCSI 19.63%

PRS 50.91
renal beta-intercalated cell CL0002201

CSI 9.39

rCSI 22.39%

PRS 37.82
lymphoid lineage restricted progenitor cell CL0000838

CSI 7.83

rCSI 30.46%

PRS 53.83
type B pancreatic cell CL0000169

CSI 7.81

rCSI 17.29%

PRS 32.22
naive T cell CL0000898

CSI 7.74

rCSI 5.39%

PRS 46.5
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 6.74

rCSI 13.43%

PRS 52.27
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 6.62

rCSI 11.69%

PRS 21.41
regular ventricular cardiac myocyte CL0002131

CSI 6.36

rCSI 39.7%

PRS 28.74
retinal cone cell CL0000573

CSI 6.04

rCSI 9.72%

PRS 27.23
myoepithelial cell CL0000185

CSI 5.24

rCSI 13.25%

PRS 42.04
pulmonary capillary endothelial cell CL4028001

CSI 5.17

rCSI 9.86%

PRS 50.98
lung ciliated cell CL1000271

CSI 5.05

rCSI 5.84%

PRS 26.49
unswitched memory B cell CL0000970

CSI 4.89

rCSI 4.12%

PRS 51.02
basophil CL0000767

CSI 4.47

rCSI 9.45%

PRS 56.73
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 4.47

rCSI 4.39%

PRS 49.21
rod bipolar cell CL0000751

CSI 4.16

rCSI 7.47%

PRS 29.45
lung pericyte CL0009089

CSI 3.67

rCSI 9.69%

PRS 41.01
ciliated cell CL0000064

CSI 3.59

rCSI 5.82%

PRS 34.01
lamp5 GABAergic cortical interneuron CL4023011

CSI 3.46

rCSI 5.8%

PRS 22.15
fallopian tube secretory epithelial cell CL4030006

CSI 3.38

rCSI 3.25%

PRS 35.5
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.05

rCSI 2.44%

PRS 55.42
direct pathway medium spiny neuron CL4023026

CSI 2.99

rCSI 71.69%

PRS 21.66
promyelocyte CL0000836

CSI 2.97

rCSI 4.29%

PRS 44.57
indirect pathway medium spiny neuron CL4023029

CSI 2.94

rCSI 70.99%

PRS 22.45
L6b glutamatergic cortical neuron CL4023038

CSI 2.91

rCSI 9.1%

PRS 23.17
cerebral cortex endothelial cell CL1001602

CSI 2.91

rCSI 5.02%

PRS 27.14
Mueller cell CL0000636

CSI 2.79

rCSI 6.36%

PRS 29.94
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.78

rCSI 2.11%

PRS 44.57
dopaminergic neuron CL0000700

CSI 2.77

rCSI 15.64%

PRS 23.65
lung macrophage CL1001603

CSI 2.67

rCSI 5.97%

PRS 40.4
inflammatory macrophage CL0000863

CSI 2.67

rCSI 4.56%

PRS 61.07
pulmonary alveolar type 1 cell CL0002062

CSI 2.64

rCSI 15.22%

PRS 38.5
dendritic cell, human CL0001056

CSI 2.6

rCSI 4%

PRS 40.81
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.6

rCSI 13.04%

PRS 44.45
interneuron CL0000099

CSI 2.59

rCSI 5.2%

PRS 26.49
class switched memory B cell CL0000972

CSI 2.58

rCSI 1.93%

PRS 52.64
ON-bipolar cell CL0000749

CSI 2.5

rCSI 3.72%

PRS 38.11
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.5

rCSI 1.48%

PRS 47.72
retinal bipolar neuron CL0000748

CSI 2.49

rCSI 4.67%

PRS 26.49
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.48

rCSI 2.24%

PRS 31.99
astrocyte of the cerebral cortex CL0002605

CSI 2.48

rCSI 5.55%

PRS 22.69
naive B cell CL0000788

CSI 2.46

rCSI 2.11%

PRS 45.42
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 2.43

rCSI 1.82%

PRS 69.2
kidney connecting tubule epithelial cell CL1000768

CSI 2.41

rCSI 6.12%

PRS 27.21
nasal mucosa goblet cell CL0002480

CSI 2.38

rCSI 2.76%

PRS 45.58
periportal region hepatocyte CL0019026

CSI 2.37

rCSI 9.2%

PRS 44.34
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 2.36

rCSI 1.66%

PRS 60.17
hematopoietic precursor cell CL0008001

CSI 2.31

rCSI 2.38%

PRS 51.41
mucosal invariant T cell CL0000940

CSI 2.3

rCSI 1.86%

PRS 46.48
cytotoxic T cell CL0000910

CSI 2.29

rCSI 13.11%

PRS 47.06
mature T cell CL0002419

CSI 2.23

rCSI 1.74%

PRS 49.69
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.22

rCSI 1.59%

PRS 46.23
brush cell of tracheobronchial tree CL0002075

CSI 2.19

rCSI 6.49%

PRS 45.49
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 2.17

rCSI 2.73%

PRS 77.97
CD8-positive, alpha-beta memory T cell CL0000909

CSI 2.14

rCSI 2.23%

PRS 67.84
double negative thymocyte CL0002489

CSI 2.1

rCSI 1.46%

PRS 41.79
hepatocyte CL0000182

CSI 2.09

rCSI 3.74%

PRS 32.99
pro-B cell CL0000826

CSI 2.08

rCSI 1.72%

PRS 35.44
sncg GABAergic cortical interneuron CL4023015

CSI 2.03

rCSI 3.26%

PRS 24
mature NK T cell CL0000814

CSI 2.02

rCSI 2.58%

PRS 72.22
renal principal cell CL0005009

CSI 2.01

rCSI 5.23%

PRS 40.82
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 2

rCSI 2.75%

PRS 55.36
respiratory suprabasal cell CL4033048

CSI 1.97

rCSI 2.53%

PRS 39.18
melanocyte CL0000148

CSI 1.95

rCSI 1.44%

PRS 29.84
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.95

rCSI 7.01%

PRS 21.15
lung endothelial cell CL1001567

CSI 1.92

rCSI 4.48%

PRS 62.41
fibroblast of lung CL0002553

CSI 1.92

rCSI 1.79%

PRS 34.52
precursor B cell CL0000817

CSI 1.91

rCSI 1.68%

PRS 43.97
T-helper 17 cell CL0000899

CSI 1.91

rCSI 1.52%

PRS 55.53
pancreatic A cell CL0000171

CSI 1.89

rCSI 1.98%

PRS 36.74
activated CD8-positive, alpha-beta T cell CL0000906

CSI 1.89

rCSI 1.85%

PRS 65.16
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.88

rCSI 2.66%

PRS 32.45
retinal blood vessel endothelial cell CL0002585

CSI 1.86

rCSI 2.97%

PRS 37.72
plasmacytoid dendritic cell, human CL0001058

CSI 1.86

rCSI 1.3%

PRS 36.51
secretory cell CL0000151

CSI 1.85

rCSI 1.93%

PRS 35.34
CD8-positive, alpha-beta thymocyte CL0000811

CSI 1.82

rCSI 2.83%

PRS 61.83
common lymphoid progenitor CL0000051

CSI 1.82

rCSI 2.43%

PRS 57.07
peripheral nervous system neuron CL2000032

CSI 1.81

rCSI 2.46%

PRS 29.9
lung interstitial macrophage CL4033043

CSI 1.8

rCSI 4.04%

PRS 56.49
ionocyte CL0005006

CSI 1.79

rCSI 1.91%

PRS 32.57
choroid plexus epithelial cell CL0000706

CSI 1.77

rCSI 2.9%

PRS 27.35
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.76

rCSI 1.63%

PRS 54.71
cardiac endothelial cell CL0010008

CSI 1.75

rCSI 7.06%

PRS 33.65
early lymphoid progenitor CL0000936

CSI 1.74

rCSI 1.53%

PRS 39.36
pulmonary ionocyte CL0017000

CSI 1.74

rCSI 2.12%

PRS 41.71
Kupffer cell CL0000091

CSI 1.72

rCSI 3.94%

PRS 34.28
activated type II NK T cell CL0000931

CSI 1.69

rCSI 1.9%

PRS 50.27
skin fibroblast CL0002620

CSI 1.69

rCSI 1.46%

PRS 44.65
lung secretory cell CL1000272

CSI 1.68

rCSI 4.16%

PRS 33.02
alpha-beta T cell CL0000789

CSI 1.66

rCSI 1.95%

PRS 48
bronchus fibroblast of lung CL2000093

CSI 1.64

rCSI 1.33%

PRS 35.59
hematopoietic multipotent progenitor cell CL0000837

CSI 1.63

rCSI 3.93%

PRS 51.24
acinar cell CL0000622

CSI 1.62

rCSI 2.38%

PRS 44.52
Langerhans cell CL0000453

CSI 1.6

rCSI 2.45%

PRS 52.24
perivascular cell CL4033054

CSI 1.6

rCSI 2.19%

PRS 38.79
cerebral cortex neuron CL0010012

CSI 1.6

rCSI 6.53%

PRS 34.2

respiratory goblet cell CL0002370

CSI 0.1

rCSI 1.0%

PRS 56.0%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 3.5%

PRS 29.5%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 3.7%

PRS 30.7%
medium spiny neuron CL1001474

CSI 0.2

rCSI 1.6%

PRS 23.8%
luminal cell of prostate epithelium CL0002340

CSI 0.2

rCSI 1.3%

PRS 51.1%
ON parasol ganglion cell CL4033052

CSI 0.3

rCSI 4.0%

PRS 29.2%
lung microvascular endothelial cell CL2000016

CSI 0.3

rCSI 6.1%

PRS 64.1%
vein endothelial cell of respiratory system CL4033008

CSI 0.3

rCSI 2.4%

PRS 54.8%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.4

rCSI 1.2%

PRS 26.0%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.4

rCSI 2.5%

PRS 61.1%
myeloid dendritic cell, human CL0001057

CSI 0.5

rCSI 2.7%

PRS 69.7%
endothelial cell of placenta CL0009092

CSI 0.5

rCSI 2.4%

PRS 45.1%
pancreatic ductal cell CL0002079

CSI 0.5

rCSI 1.0%

PRS 36.1%
elicited macrophage CL0000861

CSI 0.5

rCSI 0.5%

PRS 41.0%
retina horizontal cell CL0000745

CSI 0.6

rCSI 0.8%

PRS 32.3%
amacrine cell CL0000561

CSI 0.6

rCSI 1.7%

PRS 28.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.6

rCSI 3.5%

PRS 23.3%
colon macrophage CL0009038

CSI 0.6

rCSI 2.7%

PRS 58.1%
eosinophil CL0000771

CSI 0.6

rCSI 3.9%

PRS 67.2%
enteroglial cell CL4040002

CSI 0.6

rCSI 3.2%

PRS 45.5%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.6

rCSI 0.8%

PRS 34.9%
central nervous system neuron CL2000029

CSI 0.6

rCSI 4.6%

PRS 24.8%
antibody secreting cell CL0000946

CSI 0.7

rCSI 2.9%

PRS 80.3%
pancreatic acinar cell CL0002064

CSI 0.7

rCSI 0.9%

PRS 38.4%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.7

rCSI 2.5%

PRS 23.0%
Hofbauer cell CL3000001

CSI 0.7

rCSI 1.3%

PRS 43.6%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.7

rCSI 1.7%

PRS 26.4%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.7

rCSI 1.8%

PRS 21.5%
innate lymphoid cell CL0001065

CSI 0.8

rCSI 1.6%

PRS 43.5%
helper T cell CL0000912

CSI 0.8

rCSI 1.1%

PRS 44.5%
small pre-B-II cell CL0000954

CSI 0.8

rCSI 0.8%

PRS 59.0%
GABAergic amacrine cell CL4030027

CSI 0.8

rCSI 2.8%

PRS 29.3%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 0.8

rCSI 2.0%

PRS 82.6%
corneal epithelial cell CL0000575

CSI 0.8

rCSI 2.3%

PRS 52.8%
multi-ciliated epithelial cell CL0005012

CSI 0.8

rCSI 0.8%

PRS 29.9%
mature B cell CL0000785

CSI 0.8

rCSI 0.7%

PRS 42.9%
IgG plasma cell CL0000985

CSI 0.9

rCSI 1.1%

PRS 53.5%
ciliated epithelial cell CL0000067

CSI 0.9

rCSI 0.8%

PRS 25.9%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 0.9

rCSI 1.2%

PRS 63.4%
conjunctival epithelial cell CL1000432

CSI 0.9

rCSI 1.4%

PRS 35.1%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 0.9

rCSI 2.6%

PRS 50.4%
group 2 innate lymphoid cell CL0001069

CSI 0.9

rCSI 5.0%

PRS 73.3%
endothelial cell of lymphatic vessel CL0002138

CSI 0.9

rCSI 1.9%

PRS 62.5%
basal cell CL0000646

CSI 1.0

rCSI 1.3%

PRS 36.6%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.0

rCSI 1.2%

PRS 20.9%
keratocyte CL0002363

CSI 1.0

rCSI 2.3%

PRS 45.7%
regular atrial cardiac myocyte CL0002129

CSI 1.0

rCSI 3.2%

PRS 35.1%
vascular leptomeningeal cell CL4023051

CSI 1.0

rCSI 1.7%

PRS 28.2%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.0

rCSI 0.8%

PRS 33.2%
sst GABAergic cortical interneuron CL4023017

CSI 1.0

rCSI 1.3%

PRS 22.9%
vascular associated smooth muscle cell CL0000359

CSI 1.0

rCSI 3.3%

PRS 38.5%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.5%

PRS 37.0%
common dendritic progenitor CL0001029

CSI 1.0

rCSI 1.3%

PRS 43.4%
cardiac muscle cell CL0000746

CSI 1.1

rCSI 1.5%

PRS 27.8%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.1

rCSI 1.4%

PRS 47.0%
alveolar adventitial fibroblast CL4028006

CSI 1.1

rCSI 1.7%

PRS 35.4%
squamous epithelial cell CL0000076

CSI 1.1

rCSI 2.5%

PRS 40.5%
parietal epithelial cell CL1000452

CSI 1.1

rCSI 2.8%

PRS 29.5%
myeloid dendritic cell CL0000782

CSI 1.1

rCSI 1.6%

PRS 49.9%
chondrocyte CL0000138

CSI 1.1

rCSI 1.7%

PRS 29.4%
transitional stage B cell CL0000818

CSI 1.1

rCSI 3.5%

PRS 68.4%
basal cell of prostate epithelium CL0002341

CSI 1.1

rCSI 3.1%

PRS 55.7%
memory T cell CL0000813

CSI 1.1

rCSI 2.1%

PRS 64.7%
luminal epithelial cell of mammary gland CL0002326

CSI 1.1

rCSI 2.0%

PRS 50.1%
tracheobronchial smooth muscle cell CL0019019

CSI 1.1

rCSI 1.9%

PRS 43.0%
mature alpha-beta T cell CL0000791

CSI 1.1

rCSI 4.0%

PRS 53.0%
centrilobular region hepatocyte CL0019029

CSI 1.1

rCSI 2.9%

PRS 45.1%
immature B cell CL0000816

CSI 1.1

rCSI 0.8%

PRS 47.1%
mononuclear phagocyte CL0000113

CSI 1.1

rCSI 2.5%

PRS 38.6%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.1

rCSI 1.0%

PRS 49.2%
epithelial cell of lung CL0000082

CSI 1.1

rCSI 0.9%

PRS 33.2%
promonocyte CL0000559

CSI 1.1

rCSI 1.9%

PRS 43.8%
lung neuroendocrine cell CL1000223

CSI 1.2

rCSI 1.7%

PRS 39.1%
cardiac neuron CL0010022

CSI 1.2

rCSI 3.7%

PRS 31.8%
regulatory T cell CL0000815

CSI 1.2

rCSI 1.4%

PRS 61.5%
granulocyte monocyte progenitor cell CL0000557

CSI 1.2

rCSI 1.0%

PRS 38.3%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.2

rCSI 1.5%

PRS 41.3%
club cell CL0000158

CSI 1.2

rCSI 1.8%

PRS 36.0%
adventitial cell CL0002503

CSI 1.2

rCSI 2.9%

PRS 46.3%
mucus secreting cell CL0000319

CSI 1.2

rCSI 2.0%

PRS 43.9%
intestinal tuft cell CL0019032

CSI 1.2

rCSI 1.9%

PRS 39.0%
neural crest cell CL0011012

CSI 1.2

rCSI 1.0%

PRS 24.6%
intermediate monocyte CL0002393

CSI 1.2

rCSI 1.9%

PRS 36.0%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.2

rCSI 1.5%

PRS 53.9%
alveolar type 1 fibroblast cell CL4028004

CSI 1.3

rCSI 1.4%

PRS 38.4%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.3

rCSI 2.2%

PRS 55.6%
alveolar macrophage CL0000583

CSI 1.3

rCSI 2.1%

PRS 39.7%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.3

rCSI 3.4%

PRS 33.9%
granulocyte CL0000094

CSI 1.3

rCSI 2.0%

PRS 43.1%
VIP GABAergic cortical interneuron CL4023016

CSI 1.3

rCSI 1.6%

PRS 22.1%
epithelial cell of lower respiratory tract CL0002632

CSI 1.3

rCSI 1.0%

PRS 34.4%
hematopoietic stem cell CL0000037

CSI 1.4

rCSI 0.9%

PRS 39.1%
enteroendocrine cell CL0000164

CSI 1.4

rCSI 1.9%

PRS 37.5%
retinal pigment epithelial cell CL0002586

CSI 1.4

rCSI 2.8%

PRS 34.9%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.5

rCSI 2.7%

PRS 59.4%
retinal ganglion cell CL0000740

CSI 1.5

rCSI 3.2%

PRS 25.5%
group 3 innate lymphoid cell CL0001071

CSI 1.5

rCSI 1.1%

PRS 37.4%
blood vessel endothelial cell CL0000071

CSI 1.5

rCSI 3.0%

PRS 33.7%
T-helper 1 cell CL0000545

CSI 1.5

rCSI 2.7%

PRS 63.1%
colon epithelial cell CL0011108

CSI 1.5

rCSI 1.6%

PRS 32.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

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Node Color (Target Cell CSI, relative to current network):
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- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CYLD](/details-gene/1540) (CYLD lysine 63 deubiquitinase) is a protein-coding gene located on chromosome 16q12.1 that encodes a deubiquitinating enzyme (DUB). This enzyme specifically cleaves K63- and M1- (linear) linked polyubiquitin chains from substrate proteins, acting as a crucial negative regulator of signal transduction. Functionally, [CYLD](/details-gene/1540) is best known as a tumor suppressor, with mutations causing familial cylindromatosis ([132700](https://omim.org/entry/132700)), a condition characterized by benign tumors of skin appendages [Link](https://doi.org/10.1038/76006). Its mechanism of action largely involves tempering inflammatory and survival pathways, most notably by inhibiting NF-κB, JNK, and Wnt signaling [Link](https://doi.org/10.1038/nature01803), [Link](https://doi.org/10.1038/nature01811). **Overall**, expression data reveals its highest significance in [keratinocytes](/details-cell/CL0000312), consistent with its role in skin biology, as well as in various immune cell populations, including [common myeloid progenitors](/details-cell/CL0000049) and [CD4-positive helper T cells](/details-cell/CL0000492), highlighting its dual role in epithelial homeostasis and immune regulation. ## Cellular Roles and Expression Landscape The expression profile of [CYLD](/details-gene/1540) underscores its importance in two primary biological systems: epithelial tissues and the immune system. Its most significant expression is observed in [keratinocytes](/details-cell/CL0000312) (CSI: 25.74), which aligns with its established role as a tumor suppressor in skin. The high significance in [transit amplifying cells](/details-cell/CL0009010) (CSI: 12.84) further suggests a role in regulating the balance between proliferation and differentiation in stratified epithelia. Concurrently, [CYLD](/details-gene/1540) demonstrates high significance across multiple hematopoietic and immune cell types. It is a key marker in early hematopoietic progenitors, such as [common myeloid progenitors](/details-cell/CL0000049) (CSI: 16.76) and [lymphoid lineage restricted progenitor cells](/details-cell/CL0000838) (CSI: 7.83), pointing to a role in lineage commitment. In the mature immune system, its prominence in T lymphocyte subsets, including [CD4-positive helper T cells](/details-cell/CL0000492) (CSI: 14.33), [T follicular helper cells](/details-cell/CL0002038) (CSI: 13.40), and [naive T cells](/details-cell/CL0000898) (CSI: 7.74), is consistent with its function as a negative regulator of antigen receptor signaling. Beyond these primary contexts, its notable expression in diverse cell types such as [renal beta-intercalated cells](/details-cell/CL0002201) and [type B pancreatic cells](/details-cell/CL0000169) suggests broader, context-specific functions in cellular homeostasis and signaling across various tissues. ## Pathways and Molecular Function The molecular function of [CYLD](/details-gene/1540) is centered on its role as a cysteine-type deubiquitinase, primarily with '[K63-linked deubiquitinase activity](/details-go/GO:0061578)' and '[Met1-linked polyubiquitin deubiquitinase activity](/details-go/GO:0061815)'. This enzymatic activity is the mechanistic basis for its widespread regulatory functions. Functionally, [CYLD](/details-gene/1540) is a master negative regulator of inflammatory and cell survival signaling pathways. It is heavily implicated in the '[Negative regulation of nf-kappab transcription factor activity](/details-go/GO:0032088)', a process critical for controlling inflammation and preventing inappropriate cell survival [Link](https://doi.org/10.1038/nature01802). This is a central component of its involvement in the '[Innate immune response](/details-go/GO:0045087)' and the '[Regulation of tumor necrosis factor-mediated signaling pathway](/details-go/GO:0010803)', as detailed in Reactome's '[Tnf signaling](/details-reactome/R-HSA-75893)' pathway. Its high significance in T cells is supported by its role in the '[Positive regulation of t cell receptor signaling pathway](/details-go/GO:0050862)', where it likely acts as a brake to prevent over-activation. Beyond immunity, [CYLD](/details-gene/1540) is involved in fundamental cellular processes. Its annotation for '[Regulation of mitotic cell cycle](/details-go/GO:0007346)' [Link](https://doi.org/10.1073/pnas.0703268104) and '[Regulation of microtubule cytoskeleton organization](/details-go/GO:0070507)' [Link](https://doi.org/10.1074/jbc.m708470200) connects its tumor suppressor function to the direct control of cell division and structure. Furthermore, its role in the '[Negative regulation of canonical wnt signaling pathway](/details-go/GO:0090090)' is crucial for developmental processes and is likely a key aspect of its tumor suppressor activity in epithelial tissues. ## Research Directions The established role of [CYLD](/details-gene/1540) as a tumor suppressor and immune regulator, combined with its specific expression profile, opens several avenues for future investigation. **Proposed Hypotheses:** 1. Given its top significance in [keratinocytes](/details-cell/CL0000312) and its function in regulating Wnt signaling and cell cycle progression, it is hypothesized that [CYLD](/details-gene/1540) acts as a critical checkpoint during epidermal differentiation, preventing the hyperproliferation of [transit amplifying cells](/details-cell/CL0009010) by deubiquitinating key signaling components that would otherwise promote tumorigenesis. 2. Based on its high significance in T cell subtypes and its established role in negatively regulating NF-κB and TCR signaling, it is hypothesized that the expression level of [CYLD](/details-gene/1540) dictates the activation threshold of T cells. Dynamic downregulation of [CYLD](/details-gene/1540) may be a prerequisite for mounting an effective T cell response, while its overexpression could contribute to T cell anergy or exhaustion in chronic disease states. **Key Experimental Approach:** To test the second hypothesis regarding the role of [CYLD](/details-gene/1540) in T cell activation, a conditional knockout mouse model (e.g., *Cd4*-Cre; *Cyld*^fl/fl) could be employed to achieve T-cell-specific deletion. Naive CD4+ T cells from these mice and littermate controls would be isolated and stimulated *in vitro* with anti-CD3/CD28 antibodies. The functional consequences of [CYLD](/details-gene/1540) loss would be assessed through multiple assays: proliferation (CFSE dilution via flow cytometry), effector cytokine production (IL-2, IFN-γ, and IL-4 via intracellular staining or multiplex ELISA), and activation of downstream signaling pathways (phosphorylation status of IKK, IκBα, and JNK via Western blot or phosphoflow). This approach would definitively establish the cell-intrinsic role of [CYLD](/details-gene/1540) as a gatekeeper of T cell activation. **Therapeutic Potential:** The therapeutic potential of targeting [CYLD](/details-gene/1540) is complex and highly context-dependent. As a tumor suppressor, strategies aimed at **activating** [CYLD](/details-gene/1540) or restoring its function could be beneficial in cancers characterized by its loss. However, developing small-molecule activators is challenging. Conversely, in immunology, **inhibition** of [CYLD](/details-gene/1540) could represent a novel strategy for immunotherapy. A transient inhibition could lower the T cell activation threshold, potentially enhancing anti-tumor immune responses or improving vaccine efficacy. Such an approach would require careful consideration of dose and timing to avoid inducing systemic autoimmunity or increasing long-term cancer risk.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin carboxyl-terminal hydrolase CYLD

Genular Protein ID: 1057081307

Symbol: CYLD_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase CYLD

UniProtKB Accession Codes:

Q9NQC7 O94934 Q7L3N6 Q96EH0 Q9NZX9

Database IDs:

Citations:

PubMed ID: 10835629

Title: Identification of the familial cylindromatosis tumor suppressor gene.

PubMed ID: 10835629

DOI: 10.1038/76006

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12917689

Title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

PubMed ID: 12917689

DOI: 10.1038/nature01803

PubMed ID: 12917690

Title: Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

PubMed ID: 12917690

DOI: 10.1038/nature01811

PubMed ID: 12917691

Title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

PubMed ID: 12917691

DOI: 10.1038/nature01802

PubMed ID: 14676304

Title: The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.

PubMed ID: 14676304

DOI: 10.1084/jem.20031187

PubMed ID: 15870263

Title: Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.

PubMed ID: 15870263

DOI: 10.1128/mcb.25.10.3886-3895.2005

PubMed ID: 17495026

Title: The tumor suppressor CYLD regulates entry into mitosis.

PubMed ID: 17495026

DOI: 10.1073/pnas.0703268104

PubMed ID: 18636086

Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

PubMed ID: 18636086

DOI: 10.1038/embor.2008.136

PubMed ID: 18222923

Title: The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.

PubMed ID: 18222923

DOI: 10.1074/jbc.m708470200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20194890

Title: CYLD regulates angiogenesis by mediating vascular endothelial cell migration.

PubMed ID: 20194890

DOI: 10.1182/blood-2009-10-248526

PubMed ID: 19893491

Title: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

PubMed ID: 19893491

DOI: 10.1038/emboj.2009.317

PubMed ID: 20227366

Title: Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

PubMed ID: 20227366

DOI: 10.1016/j.molcel.2010.01.035

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25134987

Title: The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.

PubMed ID: 25134987

DOI: 10.1038/ncomms5585

PubMed ID: 12190880

Title: Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages.

PubMed ID: 12190880

DOI: 10.1046/j.1523-1747.2002.01839.x

PubMed ID: 12950348

Title: Identification of a recurrent mutation in the CYLD gene in Brooke-Spiegler syndrome.

PubMed ID: 12950348

DOI: 10.1046/j.1365-2230.2003.01344.x

PubMed ID: 16307661

Title: Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China.

PubMed ID: 16307661

DOI: 10.1111/j.1365-2133.2005.06960.x

PubMed ID: 15854031

Title: Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation.

PubMed ID: 15854031

DOI: 10.1111/j.0022-202x.2005.23688.x

PubMed ID: 16922728

Title: CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes.

PubMed ID: 16922728

DOI: 10.1111/j.1399-0004.2006.00667.x

PubMed ID: 26670046

Title: LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes.

PubMed ID: 26670046

DOI: 10.1016/j.celrep.2015.11.009

PubMed ID: 27307491

Title: SPATA2 links CYLD to the TNF-alpha receptor signaling complex and modulates the receptor signaling outcomes.

PubMed ID: 27307491

DOI: 10.15252/embj.201694300

PubMed ID: 27458237

Title: SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death.

PubMed ID: 27458237

DOI: 10.15252/embr.201642592

PubMed ID: 27545878

Title: SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

PubMed ID: 27545878

DOI: 10.1016/j.celrep.2016.07.086

PubMed ID: 26997266

Title: CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling.

PubMed ID: 26997266

DOI: 10.1016/j.celrep.2016.02.062

PubMed ID: 27591049

Title: SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling.

PubMed ID: 27591049

DOI: 10.1016/j.molcel.2016.08.001

PubMed ID: 29291351

Title: The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.

PubMed ID: 29291351

DOI: 10.1038/nm.4461

PubMed ID: 34497368

Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.

PubMed ID: 34497368

DOI: 10.1038/s41556-021-00732-8

PubMed ID: 15341735

Title: The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.

PubMed ID: 15341735

DOI: 10.1016/j.str.2004.07.012

PubMed ID: 18313383

Title: The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.

PubMed ID: 18313383

DOI: 10.1016/j.molcel.2007.12.018

PubMed ID: 14632188

Title: A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome.

PubMed ID: 14632188

DOI: 10.1046/j.1523-1747.2003.12514.x

PubMed ID: 23338750

Title: Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.

PubMed ID: 23338750

DOI: 10.1007/s00401-013-1078-9

PubMed ID: 32666117

Title: CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort.

PubMed ID: 32666117

DOI: 10.1093/brain/awaa183

PubMed ID: 32185393

Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.

PubMed ID: 32185393

DOI: 10.1093/brain/awaa039

Sequence Information:

Length: 956
Mass: 107316
Checksum: 01831F9A83424631
Sequence:

MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 
KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV 
YQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV 
GETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN 
DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN RSELFYTLNG 
SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP PLQPPPVNSL TTENRFHSLP 
FSLTKMPNTN GSIGHSPLSL SAQSVMEELN TAPVQESPPL AMPPGNSHGL EVGSLAEVKE 
NPPFYGVIRW IGQPPGLNEV LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR 
PDSRFASLQP VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS 
CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI YGYVCATKIM 
KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL KIRSAGQKVQ DCYFYQIFME 
KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS CLIIQMPRFG KDFKLFKKIF PSLELNITDL 
LEDTPRQCRI CGGLAMYECR ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL 
PKDLPDWDWR HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG 
FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP TMSLYK

Details for: CYLD

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of the familial cylindromatosis tumor suppressor gene. PubMed ID: 10835629

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. PubMed ID: 12917689

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. PubMed ID: 12917690

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. PubMed ID: 12917691

The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. PubMed ID: 14676304

Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. PubMed ID: 15870263

The tumor suppressor CYLD regulates entry into mitosis. PubMed ID: 17495026

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. PubMed ID: 18636086

The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration. PubMed ID: 18222923

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

CYLD regulates angiogenesis by mediating vascular endothelial cell migration. PubMed ID: 20194890

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. PubMed ID: 19893491

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. PubMed ID: 20227366

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. PubMed ID: 25134987

Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages. PubMed ID: 12190880

Identification of a recurrent mutation in the CYLD gene in Brooke-Spiegler syndrome. PubMed ID: 12950348

Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China. PubMed ID: 16307661

Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. PubMed ID: 15854031

CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes. PubMed ID: 16922728

LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes. PubMed ID: 26670046

SPATA2 links CYLD to the TNF-alpha receptor signaling complex and modulates the receptor signaling outcomes. PubMed ID: 27307491

SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death. PubMed ID: 27458237

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. PubMed ID: 27545878

CYLD limits Lys63- and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling. PubMed ID: 26997266

SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling. PubMed ID: 27591049

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. PubMed ID: 29291351

TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. PubMed ID: 34497368

The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma. PubMed ID: 15341735

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. PubMed ID: 18313383

A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome. PubMed ID: 14632188

Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis. PubMed ID: 23338750

CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort. PubMed ID: 32666117

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis. PubMed ID: 32185393