Details for: CYP1A1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 9.34
Marker Score: 16546 - Cell Name: microglial cell (CL0000129)
Fold Change: 3.76
Marker Score: 6842 - Cell Name: erythrocyte (CL0000232)
Fold Change: 2.42
Marker Score: 1341 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.38
Marker Score: 844 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1172 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.34
Marker Score: 882 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 857 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4819 - Cell Name: B cell (CL0000236)
Fold Change: 1.13
Marker Score: 1073 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 504 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71830 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48055 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5357 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.94
Marker Score: 32501 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292 - Cell Name: mast cell (CL0000097)
Fold Change: 0.83
Marker Score: 483 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.8
Marker Score: 5350 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.71
Marker Score: 274 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.69
Marker Score: 728.5 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.64
Marker Score: 427 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.63
Marker Score: 699 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 467 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.54
Marker Score: 1111 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.52
Marker Score: 8142 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.52
Marker Score: 164 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.46
Marker Score: 868 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.45
Marker Score: 1106 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.44
Marker Score: 742 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.43
Marker Score: 445 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.37
Marker Score: 194 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.34
Marker Score: 684 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.3
Marker Score: 267 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.27
Marker Score: 403 - Cell Name: pericyte (CL0000669)
Fold Change: 0.26
Marker Score: 154 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.24
Marker Score: 125.5 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.24
Marker Score: 235 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.23
Marker Score: 78 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.21
Marker Score: 92.5 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.21
Marker Score: 130 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.19
Marker Score: 117 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.18
Marker Score: 376 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.18
Marker Score: 873 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.18
Marker Score: 102 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.18
Marker Score: 841 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.17
Marker Score: 70 - Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.16
Marker Score: 226 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.15
Marker Score: 151 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.15
Marker Score: 93 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.14
Marker Score: 146 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.14
Marker Score: 67 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.14
Marker Score: 58 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.14
Marker Score: 92 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.13
Marker Score: 310 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.12
Marker Score: 4237 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.12
Marker Score: 85 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.12
Marker Score: 90.5 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.12
Marker Score: 207 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.11
Marker Score: 65 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.11
Marker Score: 108 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.11
Marker Score: 684 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.1
Marker Score: 38 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.1
Marker Score: 36 - Cell Name: Unknown (CL0000003)
Fold Change: 0.1
Marker Score: 307 - Cell Name: podocyte (CL0000653)
Fold Change: 0.1
Marker Score: 36 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.09
Marker Score: 42 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.09
Marker Score: 226 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.09
Marker Score: 755 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.08
Marker Score: 19 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.08
Marker Score: 55 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.08
Marker Score: 20 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.08
Marker Score: 19 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.08
Marker Score: 50 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.07
Marker Score: 31 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.07
Marker Score: 22 - Cell Name: progenitor cell (CL0011026)
Fold Change: 0.07
Marker Score: 445 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.07
Marker Score: 256 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.07
Marker Score: 82 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.07
Marker Score: 63.5 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.06
Marker Score: 74 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.06
Marker Score: 15 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.06
Marker Score: 99 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.06
Marker Score: 94
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Other Information
Genular Protein ID: 1002409985
Symbol: CP1A1_HUMAN
Name: Cytochrome P450 form 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2989797
Title: Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
PubMed ID: 2989797
PubMed ID: 3838385
Title: Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.
PubMed ID: 3838385
PubMed ID: 3019683
Title: Structure and drug inducibility of the human cytochrome P-450c gene.
PubMed ID: 3019683
PubMed ID: 11207026
Title: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.
PubMed ID: 11207026
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9500998
Title: Identification of cytochrome P450 1A1 in human brain.
PubMed ID: 9500998
PubMed ID: 3000715
Title: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.
PubMed ID: 3000715
PubMed ID: 10681376
Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.
PubMed ID: 10681376
PubMed ID: 11555828
Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.
PubMed ID: 11555828
PubMed ID: 14559847
Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.
PubMed ID: 14559847
PubMed ID: 12865317
Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
PubMed ID: 12865317
DOI: 10.1210/en.2003-0192
PubMed ID: 15041462
Title: Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.
PubMed ID: 15041462
PubMed ID: 15805301
Title: Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
PubMed ID: 15805301
PubMed ID: 18577768
Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.
PubMed ID: 18577768
PubMed ID: 19965576
Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.
PubMed ID: 19965576
DOI: 10.1194/jlr.m003061
PubMed ID: 20972997
Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.
PubMed ID: 20972997
DOI: 10.1002/rcm.4760
PubMed ID: 21068195
Title: Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.
PubMed ID: 21068195
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23508959
Title: Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism.
PubMed ID: 23508959
PubMed ID: 1722803
Title: Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.
PubMed ID: 1722803
PubMed ID: 8895751
Title: A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
PubMed ID: 8895751
PubMed ID: 10739168
Title: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.
PubMed ID: 10739168
PubMed ID: 11295847
Title: Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.
PubMed ID: 11295847
DOI: 10.1002/humu.49
PubMed ID: 15618738
Title: Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.
PubMed ID: 15618738
DOI: 10.2133/dmpk.18.218
PubMed ID: 15469410
Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
PubMed ID: 15469410
PubMed ID: 15643613
Title: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
PubMed ID: 15643613
DOI: 10.1002/humu.20134
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 512
- Mass: 58165
- Checksum: 3C62366044148EFD
- Sequence:
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS
Genular Protein ID: 2440584349
Symbol: E7EMT5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 483
- Mass: 54800
- Checksum: 6DC7808EA30FACB1
- Sequence:
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHRK LWVNPSEFLP ERFLTPDGAI DKVLSEKVII FGMGKRKCIG ETIARWEVFL FLAILLQRVE FSVPLGVKVD MTPIYGLTMK HACCEHFQMQ LRS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.