Details for: CYP1A1

Gene ID: 1543

Symbol: CYP1A1

Ensembl ID: ENSG00000140465

Description: cytochrome P450 family 1 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 8.8205
    Cell Significance Index: 37.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 5.7483
    Cell Significance Index: 34.7300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.8895
    Cell Significance Index: 13.5700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.8442
    Cell Significance Index: 27.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3050
    Cell Significance Index: 67.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0058
    Cell Significance Index: 549.3100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.9967
    Cell Significance Index: 7.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6745
    Cell Significance Index: 11.9200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.6019
    Cell Significance Index: 7.5600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5974
    Cell Significance Index: 9.8500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.3956
    Cell Significance Index: 4.0900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3525
    Cell Significance Index: 4.0600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3037
    Cell Significance Index: 0.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1886
    Cell Significance Index: 2.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1444
    Cell Significance Index: 1.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0805
    Cell Significance Index: 9.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0669
    Cell Significance Index: 12.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0574
    Cell Significance Index: 2.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0548
    Cell Significance Index: 7.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0245
    Cell Significance Index: 3.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0153
    Cell Significance Index: 0.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0148
    Cell Significance Index: 10.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0133
    Cell Significance Index: 0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0132
    Cell Significance Index: 0.6200
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.0017
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0015
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0010
    Cell Significance Index: 0.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0003
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0024
    Cell Significance Index: -0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0050
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0095
    Cell Significance Index: -3.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0118
    Cell Significance Index: -2.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0133
    Cell Significance Index: -3.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0156
    Cell Significance Index: -3.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0251
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0254
    Cell Significance Index: -3.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0284
    Cell Significance Index: -3.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0319
    Cell Significance Index: -2.0100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0422
    Cell Significance Index: -0.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0524
    Cell Significance Index: -3.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0525
    Cell Significance Index: -2.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0526
    Cell Significance Index: -1.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0606
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0613
    Cell Significance Index: -4.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0618
    Cell Significance Index: -1.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0646
    Cell Significance Index: -3.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0669
    Cell Significance Index: -5.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0731
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0748
    Cell Significance Index: -2.6200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0847
    Cell Significance Index: -1.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0889
    Cell Significance Index: -2.8300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0917
    Cell Significance Index: -0.7000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0930
    Cell Significance Index: -1.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0931
    Cell Significance Index: -4.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0941
    Cell Significance Index: -4.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0947
    Cell Significance Index: -3.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0962
    Cell Significance Index: -4.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0977
    Cell Significance Index: -5.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1024
    Cell Significance Index: -3.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1080
    Cell Significance Index: -1.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1088
    Cell Significance Index: -4.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1147
    Cell Significance Index: -5.3500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1156
    Cell Significance Index: -0.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1200
    Cell Significance Index: -3.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1205
    Cell Significance Index: -3.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1245
    Cell Significance Index: -3.1100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1269
    Cell Significance Index: -1.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1321
    Cell Significance Index: -2.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1336
    Cell Significance Index: -3.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1375
    Cell Significance Index: -2.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1426
    Cell Significance Index: -4.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1437
    Cell Significance Index: -3.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1475
    Cell Significance Index: -3.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1491
    Cell Significance Index: -5.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1494
    Cell Significance Index: -2.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1499
    Cell Significance Index: -3.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1509
    Cell Significance Index: -3.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1549
    Cell Significance Index: -3.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1553
    Cell Significance Index: -3.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1588
    Cell Significance Index: -2.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1601
    Cell Significance Index: -4.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1621
    Cell Significance Index: -3.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1652
    Cell Significance Index: -4.1200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1674
    Cell Significance Index: -2.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1713
    Cell Significance Index: -4.1500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1729
    Cell Significance Index: -1.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1774
    Cell Significance Index: -4.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1782
    Cell Significance Index: -5.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CYP1A1 gene exhibits several key characteristics that distinguish it from other cytochrome P450 genes. These include: * **High expression levels**: CYP1A1 is highly expressed in various tissues, including the liver, lungs, and mammary gland. * **Wide substrate specificity**: CYP1A1 is capable of metabolizing a wide range of substrates, including retinoids, arachidonic acid, and xenobiotics. * **Tight regulation**: The gene's expression is tightly regulated by various transcription factors, including the AhR. * **Responsive to environmental stimuli**: CYP1A1 is responsive to a wide range of environmental and physiological stimuli, including exposure to pollutants, stress, and hormones. **Pathways and Functions** CYP1A1 is involved in a wide range of metabolic pathways, including: * **Biosynthesis of retinoids**: CYP1A1 plays a crucial role in the biosynthesis of retinoids, including all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA). * **Arachidonic acid metabolism**: CYP1A1 is involved in the metabolism of arachidonic acid, including the conversion of arachidonic acid to prostaglandins and leukotrienes. * **Xenobiotic metabolism**: CYP1A1 is capable of metabolizing a wide range of xenobiotics, including pesticides, herbicides, and industrial chemicals. * **Lipid metabolism**: CYP1A1 is involved in the metabolism of lipids, including the hydroxylation of long-chain fatty acids. * **Steroid biosynthesis**: CYP1A1 is involved in the biosynthesis of steroids, including the conversion of cholesterol to testosterone and estrogen. **Clinical Significance** The CYP1A1 gene has significant clinical implications, including: * **Cancer susceptibility**: Variations in the CYP1A1 gene have been associated with an increased risk of certain cancers, including lung, breast, and prostate cancer. * **Toxicity**: CYP1A1 is involved in the metabolism of toxic substances, including pesticides and industrial chemicals. * **Pharmacokinetics**: CYP1A1 plays a crucial role in the metabolism of certain drugs, including warfarin and phenytoin. * **Neurological disorders**: CYP1A1 has been implicated in the pathogenesis of certain neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the CYP1A1 gene is a critical member of the cytochrome P450 superfamily, involved in a wide range of metabolic pathways, including biosynthesis of retinoids, arachidonic acid metabolism, and xenobiotic metabolism. Its clinical significance is evident in its association with cancer susceptibility, toxicity, pharmacokinetics, and neurological disorders. Further research is needed to fully elucidate the role of CYP1A1 in human health and disease.

Genular Protein ID: 1002409985

Symbol: CP1A1_HUMAN

Name: Cytochrome P450 form 6

UniProtKB Accession Codes:

P04798 A4F3V9 A4F3W0 Q53G18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 2 EMBL 12 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 5 RefSeq 3 Rhea 100 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2989797

Title: Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.

PubMed ID: 2989797

DOI: 10.1093/nar/13.12.4503

PubMed ID: 3838385

Title: Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.

PubMed ID: 3838385

DOI: 10.1126/science.3838385

PubMed ID: 3019683

Title: Structure and drug inducibility of the human cytochrome P-450c gene.

PubMed ID: 3019683

DOI: 10.1111/j.1432-1033.1986.tb09857.x

PubMed ID: 11207026

Title: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.

PubMed ID: 11207026

DOI: 10.1097/00008571-200102000-00001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9500998

Title: Identification of cytochrome P450 1A1 in human brain.

PubMed ID: 9500998

DOI: 10.1006/bbrc.1998.8171

PubMed ID: 3000715

Title: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.

PubMed ID: 3000715

DOI: 10.1089/dna.1985.4.395

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11555828

Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.

PubMed ID: 11555828

DOI: 10.1053/meta.2001.25592

PubMed ID: 14559847

Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

PubMed ID: 14559847

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15041462

Title: Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.

PubMed ID: 15041462

DOI: 10.1016/j.bcp.2003.12.023

PubMed ID: 15805301

Title: Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.

PubMed ID: 15805301

DOI: 10.1158/0008-5472.can-04-3543

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21068195

Title: Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.

PubMed ID: 21068195

DOI: 10.1124/dmd.110.035121

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23508959

Title: Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism.

PubMed ID: 23508959

DOI: 10.1074/jbc.m113.452953

PubMed ID: 1722803

Title: Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.

PubMed ID: 1722803

DOI: 10.1093/oxfordjournals.jbchem.a123594

PubMed ID: 8895751

Title: A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

PubMed ID: 8895751

PubMed ID: 10739168

Title: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.

PubMed ID: 10739168

DOI: 10.1097/00008571-200002000-00003

PubMed ID: 11295847

Title: Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.

PubMed ID: 11295847

DOI: 10.1002/humu.49

PubMed ID: 15618738

Title: Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.

PubMed ID: 15618738

DOI: 10.2133/dmpk.18.218

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 15643613

Title: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.

PubMed ID: 15643613

DOI: 10.1002/humu.20134

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 512
  • Mass: 58165
  • Checksum: 3C62366044148EFD
  • Sequence:
    • MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH 
LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS 
MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG 
PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL 
RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS 
DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL 
WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF 
SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS

Genular Protein ID: 2440584349

Symbol: E7EMT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EMT5

Database IDs:

ARBA 25 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 92 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 3 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 52 RuleBase 2 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 483
  • Mass: 54800
  • Checksum: 6DC7808EA30FACB1
  • Sequence:
    • MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH 
LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS 
MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG 
PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL 
RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS 
DRSHLPYMEA FILETFRHSS FVPFTIPHRK LWVNPSEFLP ERFLTPDGAI DKVLSEKVII 
FGMGKRKCIG ETIARWEVFL FLAILLQRVE FSVPLGVKVD MTPIYGLTMK HACCEHFQMQ 
LRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.