Details for: CYP1A1

Gene ID: 1543

Symbol: CYP1A1

Ensembl ID: ENSG00000140465

Description: cytochrome P450 family 1 subfamily A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 9.34
    Marker Score: 16546
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6842
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.42
    Marker Score: 1341
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.38
    Marker Score: 844
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.34
    Marker Score: 882
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.13
    Marker Score: 1073
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.94
    Marker Score: 32501
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5350
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.71
    Marker Score: 274
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.69
    Marker Score: 728.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.64
    Marker Score: 427
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.63
    Marker Score: 699
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 467
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.54
    Marker Score: 1111
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8142
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 868
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.45
    Marker Score: 1106
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.44
    Marker Score: 742
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.43
    Marker Score: 445
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.37
    Marker Score: 194
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 684
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 267
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.27
    Marker Score: 403
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.26
    Marker Score: 154
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 125.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.24
    Marker Score: 235
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 92.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.21
    Marker Score: 130
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.18
    Marker Score: 376
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.18
    Marker Score: 873
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.18
    Marker Score: 841
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 226
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.15
    Marker Score: 93
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 92
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 310
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.12
    Marker Score: 4237
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 85
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 90.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.12
    Marker Score: 207
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.11
    Marker Score: 684
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.1
    Marker Score: 307
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.09
    Marker Score: 226
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.09
    Marker Score: 755
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 445
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.07
    Marker Score: 256
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 63.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 99
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.06
    Marker Score: 94

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Other Information

**Key characteristics:** * The CYP1A1 gene is located on chromosome 19p13.3. * It is a large gene, encoding for a protein that is composed of 311 amino acids. * The CYP1A1 gene is expressed in high levels in the liver, lungs, and mammary gland. * It is also expressed in lower levels in other tissues, such as muscle, kidney, and brain. **Pathways and functions:** * The CYP1A1 enzyme is involved in a number of metabolic pathways, including the metabolism of arachidonic acid, fatty acids, and cholesterol. * It is involved in the synthesis of protective proteins called spms, which are involved in immune regulation. * It is also involved in the regulation of lipid metabolism by pparalpha, a key regulator of metabolism. **Clinical significance:** * Mutations in the CYP1A1 gene have been linked to a number of human diseases, including liver disease, cancer, and metabolic disorders. * CYP1A1 inhibitors are being developed as drugs to treat these diseases. **Additional notes:** * The CYP1A1 enzyme is a member of the cytochrome P450 family of enzymes, which are involved in a wide range of metabolic reactions. * CYP1A1 is a highly potent enzyme, which means that it can catalyze reactions at a rapid rate. * The CYP1A1 enzyme is also a multi-functional enzyme, which means that it can perform multiple different reactions.

Genular Protein ID: 1002409985

Symbol: CP1A1_HUMAN

Name: Cytochrome P450 form 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2989797

Title: Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.

PubMed ID: 2989797

DOI: 10.1093/nar/13.12.4503

PubMed ID: 3838385

Title: Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.

PubMed ID: 3838385

DOI: 10.1126/science.3838385

PubMed ID: 3019683

Title: Structure and drug inducibility of the human cytochrome P-450c gene.

PubMed ID: 3019683

DOI: 10.1111/j.1432-1033.1986.tb09857.x

PubMed ID: 11207026

Title: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.

PubMed ID: 11207026

DOI: 10.1097/00008571-200102000-00001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9500998

Title: Identification of cytochrome P450 1A1 in human brain.

PubMed ID: 9500998

DOI: 10.1006/bbrc.1998.8171

PubMed ID: 3000715

Title: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.

PubMed ID: 3000715

DOI: 10.1089/dna.1985.4.395

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11555828

Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.

PubMed ID: 11555828

DOI: 10.1053/meta.2001.25592

PubMed ID: 14559847

Title: Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.

PubMed ID: 14559847

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15041462

Title: Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.

PubMed ID: 15041462

DOI: 10.1016/j.bcp.2003.12.023

PubMed ID: 15805301

Title: Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.

PubMed ID: 15805301

DOI: 10.1158/0008-5472.can-04-3543

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21068195

Title: Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.

PubMed ID: 21068195

DOI: 10.1124/dmd.110.035121

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23508959

Title: Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism.

PubMed ID: 23508959

DOI: 10.1074/jbc.m113.452953

PubMed ID: 1722803

Title: Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.

PubMed ID: 1722803

DOI: 10.1093/oxfordjournals.jbchem.a123594

PubMed ID: 8895751

Title: A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.

PubMed ID: 8895751

PubMed ID: 10739168

Title: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.

PubMed ID: 10739168

DOI: 10.1097/00008571-200002000-00003

PubMed ID: 11295847

Title: Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.

PubMed ID: 11295847

DOI: 10.1002/humu.49

PubMed ID: 15618738

Title: Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.

PubMed ID: 15618738

DOI: 10.2133/dmpk.18.218

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 15643613

Title: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.

PubMed ID: 15643613

DOI: 10.1002/humu.20134

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 512
  • Mass: 58165
  • Checksum: 3C62366044148EFD
  • Sequence:
  • MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH 
    LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS 
    MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG 
    PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL 
    RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 
    QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS 
    DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL 
    WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF 
    SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS

Genular Protein ID: 2440584349

Symbol: E7EMT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 483
  • Mass: 54800
  • Checksum: 6DC7808EA30FACB1
  • Sequence:
  • MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH 
    LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS 
    MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG 
    PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL 
    RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 
    QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS 
    DRSHLPYMEA FILETFRHSS FVPFTIPHRK LWVNPSEFLP ERFLTPDGAI DKVLSEKVII 
    FGMGKRKCIG ETIARWEVFL FLAILLQRVE FSVPLGVKVD MTPIYGLTMK HACCEHFQMQ 
    LRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.