CYP1A2 | ENSG00000140505 | NCBI 1544

Details for: CYP1A2

Gene ID: 1544

Symbol: CYP1A2

Ensembl ID: ENSG00000140505

Description: cytochrome P450 family 1 subfamily A member 2

Associated with

Aflatoxin activation and detoxification
(R-HSA-5423646)
Arachidonate metabolism
(R-HSA-2142753)
Aromatic amines can be n-hydroxylated or n-dealkylated by cyp1a2
(R-HSA-211957)
Biological oxidations
(R-HSA-211859)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of maresin-like spms
(R-HSA-9027307)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of protectins
(R-HSA-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Phase ii - conjugation of compounds
(R-HSA-156580)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-HSA-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-HSA-2142670)
Xenobiotics
(R-HSA-211981)
Aflatoxin metabolic process
(GO:0046222)
Alkaloid metabolic process
(GO:0009820)
Aromatase activity
(GO:0070330)
Caffeine oxidase activity
(GO:0034875)
Cellular respiration
(GO:0045333)
Cellular response to cadmium ion
(GO:0071276)
Cholesterol metabolic process
(GO:0008203)
Demethylase activity
(GO:0032451)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Electron transfer activity
(GO:0009055)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epoxygenase p450 pathway
(GO:0019373)
Estrogen 2-hydroxylase activity
(GO:0101021)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Heme binding
(GO:0020037)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Lung development
(GO:0030324)
Methylation
(GO:0032259)
Monocarboxylic acid metabolic process
(GO:0032787)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Omega-hydroxylase p450 pathway
(GO:0097267)
Oxidative demethylation
(GO:0070989)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Porphyrin-containing compound metabolic process
(GO:0006778)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Retinol metabolic process
(GO:0042572)
Steroid catabolic process
(GO:0006706)
Toxin biosynthetic process
(GO:0009403)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thymocyte (CL0000893)
Fold Change: 0.9189
Cell Significance Index: 11.6100
Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.3146
Cell Significance Index: 0.8300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2217
Cell Significance Index: 3.2700
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1716
Cell Significance Index: 17.5300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1222
Cell Significance Index: 1.7500
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.1192
Cell Significance Index: 0.6500
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0763
Cell Significance Index: 1.6700
Cell Name: myometrial cell (CL0002366)
Fold Change: 0.0643
Cell Significance Index: 0.7400
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.0612
Cell Significance Index: 0.5200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0574
Cell Significance Index: 1.0600
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.0444
Cell Significance Index: 0.4900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.0430
Cell Significance Index: 0.7300
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.0281
Cell Significance Index: 0.2600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0181
Cell Significance Index: 9.8700
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.0154
Cell Significance Index: 0.1600
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0151
Cell Significance Index: 0.1600
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.0036
Cell Significance Index: 0.0500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.0035
Cell Significance Index: 0.0600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0006
Cell Significance Index: -1.1700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0009
Cell Significance Index: -0.4200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0011
Cell Significance Index: -1.9900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0012
Cell Significance Index: -1.9100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0016
Cell Significance Index: -0.0700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0016
Cell Significance Index: -1.2200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0021
Cell Significance Index: -1.3400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0021
Cell Significance Index: -1.1900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0028
Cell Significance Index: -1.0100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0037
Cell Significance Index: -1.6900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0047
Cell Significance Index: -0.9400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0050
Cell Significance Index: -1.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0055
Cell Significance Index: -0.9900
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0056
Cell Significance Index: -0.0800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0058
Cell Significance Index: -0.9900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0064
Cell Significance Index: -1.3500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0066
Cell Significance Index: -0.1800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0083
Cell Significance Index: -1.2000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0086
Cell Significance Index: -0.9900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0092
Cell Significance Index: -0.4800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0095
Cell Significance Index: -1.3100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0101
Cell Significance Index: -0.4700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0108
Cell Significance Index: -0.2800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0116
Cell Significance Index: -1.4300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0135
Cell Significance Index: -0.3900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0144
Cell Significance Index: -0.5900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0163
Cell Significance Index: -0.8300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0171
Cell Significance Index: -0.8100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0181
Cell Significance Index: -1.4300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0214
Cell Significance Index: -1.6400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0216
Cell Significance Index: -1.4600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0242
Cell Significance Index: -0.8400
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: -0.0243
Cell Significance Index: -0.1400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0247
Cell Significance Index: -0.6300
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0289
Cell Significance Index: -0.2800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0299
Cell Significance Index: -0.3100
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.0302
Cell Significance Index: -0.3400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0312
Cell Significance Index: -1.7500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0314
Cell Significance Index: -1.1000
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0342
Cell Significance Index: -0.4800
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0365
Cell Significance Index: -0.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0371
Cell Significance Index: -0.9900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0380
Cell Significance Index: -1.6800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0388
Cell Significance Index: -0.4400
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0390
Cell Significance Index: -0.5200
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.0397
Cell Significance Index: -0.1900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0414
Cell Significance Index: -1.2200
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0417
Cell Significance Index: -0.4300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0425
Cell Significance Index: -1.3900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0432
Cell Significance Index: -1.6400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0432
Cell Significance Index: -1.0800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0436
Cell Significance Index: -1.3900
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0438
Cell Significance Index: -0.6400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0459
Cell Significance Index: -1.2300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0464
Cell Significance Index: -1.3300
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.0465
Cell Significance Index: -0.5500
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.0468
Cell Significance Index: -0.5900
Cell Name: decidual cell (CL2000002)
Fold Change: -0.0474
Cell Significance Index: -0.7600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0493
Cell Significance Index: -0.6500
Cell Name: granule cell (CL0000120)
Fold Change: -0.0509
Cell Significance Index: -0.5800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0515
Cell Significance Index: -1.4700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0518
Cell Significance Index: -1.5200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0541
Cell Significance Index: -1.3500
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0543
Cell Significance Index: -0.6600
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0559
Cell Significance Index: -1.3400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0563
Cell Significance Index: -0.8200
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.0568
Cell Significance Index: -0.6900
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0584
Cell Significance Index: -0.6200
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0587
Cell Significance Index: -0.7800
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: -0.0595
Cell Significance Index: -0.4700
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0597
Cell Significance Index: -1.1900
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0600
Cell Significance Index: -0.4100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0603
Cell Significance Index: -0.8200
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0603
Cell Significance Index: -0.8200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0606
Cell Significance Index: -1.5100
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0608
Cell Significance Index: -0.6400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0609
Cell Significance Index: -1.0200
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0609
Cell Significance Index: -0.6300
Cell Name: ionocyte (CL0005006)
Fold Change: -0.0631
Cell Significance Index: -0.6600
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.0631
Cell Significance Index: -0.8100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0634
Cell Significance Index: -1.3700
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.0634
Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** CYP1A2 is a member of the cytochrome P450 superfamily, which is a family of enzymes responsible for metabolizing a wide range of compounds. CYP1A2 is specifically involved in the metabolism of aromatic amines, including those found in tobacco smoke and certain environmental toxins. Its expression is induced by various stimuli, including exposure to xenobiotics, and its activity is influenced by several regulatory mechanisms, including transcriptional and post-transcriptional regulation. **Pathways and Functions:** CYP1A2 is involved in various metabolic pathways, including: 1. **Aflatoxin activation and detoxification**: CYP1A2 is responsible for the metabolism of aflatoxins, a class of toxic compounds produced by certain fungi. 2. **Arachidonic acid metabolism**: CYP1A2 is involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid that plays a crucial role in inflammation and immune response. 3. **Aromatase activity**: CYP1A2 is responsible for the aromatization of androgens, which is essential for the development of male reproductive organs. 4. **Biosynthesis of specialized proresolving mediators (spms)**: CYP1A2 is involved in the biosynthesis of spms, which are molecules that play a crucial role in resolving inflammation. **Clinical Significance:** Dysregulation of CYP1A2 has been implicated in several diseases, including: 1. **Immune-related disorders**: CYP1A2 has been shown to play a crucial role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CYP1A2 has been shown to be involved in the metabolism of carcinogens, and its dysregulation has been implicated in the development of certain types of cancer. 3. **Neurological disorders**: CYP1A2 has been shown to be involved in the metabolism of neurotransmitters, and its dysregulation has been implicated in neurological disorders, such as Parkinson's disease and schizophrenia. In conclusion, CYP1A2 is a complex enzyme that plays a crucial role in various biological processes, including metabolism, detoxification, and immune response. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human health and disease. **Significantly expressed cells:** * Progenitor cell * Blood vessel endothelial cell * Plasma cell * Goblet cell * Hepatocyte * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell * Absorptive cell * Intestinal crypt stem cell of colon * Transit amplifying cell **Proteins:** CP1A2_HUMAN (CYPIA2)

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CYPIA2

Genular Protein ID: 2226361328

Symbol: CP1A2_HUMAN

Name: CYPIA2

UniProtKB Accession Codes:

P05177 Q16754 Q6NWU3 Q6NWU5 Q9BXX7 Q9UK49

Database IDs:

Citations:

PubMed ID: 3755823

Title: Human P3(450): cDNA and complete amino acid sequence.

PubMed ID: 3755823

DOI: 10.1093/nar/14.16.6773

PubMed ID: 3462722

Title: Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.

PubMed ID: 3462722

DOI: 10.1073/pnas.83.18.6731

PubMed ID: 2575218

Title: Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.

PubMed ID: 2575218

DOI: 10.1210/mend-3-9-1399

PubMed ID: 3681487

Title: Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.

PubMed ID: 3681487

PubMed ID: 11207026

Title: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.

PubMed ID: 11207026

DOI: 10.1097/00008571-200102000-00001

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3517618

Title: Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.

PubMed ID: 3517618

PubMed ID: 3000715

Title: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.

PubMed ID: 3000715

DOI: 10.1089/dna.1985.4.395

PubMed ID: 9435160

Title: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.

PubMed ID: 9435160

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11555828

Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.

PubMed ID: 11555828

DOI: 10.1053/meta.2001.25592

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 14725854

Title: Functional characterization of four allelic variants of human cytochrome P450 1A2.

PubMed ID: 14725854

DOI: 10.1016/j.abb.2003.11.019

PubMed ID: 19965576

Title: Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

PubMed ID: 19965576

DOI: 10.1194/jlr.m003061

PubMed ID: 21068195

Title: Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.

PubMed ID: 21068195

DOI: 10.1124/dmd.110.035121

PubMed ID: 21576599

Title: Cholesterol 25-hydroxylation activity of CYP3A.

PubMed ID: 21576599

DOI: 10.1194/jlr.m014084

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26988023

Title: Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.

PubMed ID: 26988023

DOI: 10.1038/ncomms11030

PubMed ID: 17311915

Title: Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.

PubMed ID: 17311915

DOI: 10.1074/jbc.m611692200

PubMed ID: 9884316

Title: Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.

PubMed ID: 9884316

PubMed ID: 11295848

Title: Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population.

PubMed ID: 11295848

PubMed ID: 14563787

Title: Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

PubMed ID: 14563787

DOI: 10.1124/jpet.103.055798

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 15770072

Title: Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.

PubMed ID: 15770072

DOI: 10.2133/dmpk.20.24

PubMed ID: 15643613

Title: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.

PubMed ID: 15643613

DOI: 10.1002/humu.20134

PubMed ID: 16522833

Title: Coffee, CYP1A2 genotype, and risk of myocardial infarction.

PubMed ID: 16522833

DOI: 10.1001/jama.295.10.1135

Sequence Information:

Length: 516
Mass: 58407
Checksum: 8557AB02860C4806
Sequence:

MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL LGHVLTLGKN 
PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR QGDDFKGRPD LYTSTLITDG 
QSLTFSTDSG PVWAARRRLA QNALNTFSIA SDPASSSSCY LEEHVSKEAK ALISRLQELM 
AGPGHFDPYN QVVVSVANVI GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP 
ILRYLPNPAL QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN 
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV IGRERRPRLS 
DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY IPKKCCVFVN QWQVNHDPEL 
WEDPSEFRPE RFLTADGTAI NKPLSEKMML FGMGKRRCIG EVLAKWEIFL FLAILLQQLE 
FSVPPGVKVD LTPIYGLTMK HARCEHVQAR LRFSIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP1A2

Associated with

Cells (max top 100)

Other Information

Human P3(450): cDNA and complete amino acid sequence. PubMed ID: 3755823

Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA. PubMed ID: 3462722

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. PubMed ID: 2575218

Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15. PubMed ID: 3681487

Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. PubMed ID: 11207026

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat. PubMed ID: 3517618

Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. PubMed ID: 3000715

Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. PubMed ID: 9435160

Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. PubMed ID: 10681376

Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol. PubMed ID: 11555828

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. PubMed ID: 12865317

Functional characterization of four allelic variants of human cytochrome P450 1A2. PubMed ID: 14725854

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450. PubMed ID: 19965576

Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. PubMed ID: 21068195

Cholesterol 25-hydroxylation activity of CYP3A. PubMed ID: 21576599

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. PubMed ID: 26988023

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. PubMed ID: 17311915

Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese. PubMed ID: 9884316

Five novel natural allelic variants-951A-&gt;C, 1042G-&gt;A (D348N), 1156A-&gt;T (I386F), 1217G-&gt;A (C406Y) and 1291C-&gt;T (C431Y)-of the human CYP1A2 gene in a French Caucasian population. PubMed ID: 11295848

Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes. PubMed ID: 14563787

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410

Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. PubMed ID: 15770072

Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. PubMed ID: 15643613

Coffee, CYP1A2 genotype, and risk of myocardial infarction. PubMed ID: 16522833