Genular: Defining Cellular Identity and Function

Details for: Hpse

Gene ID: 15442

Symbol: Hpse

Ensembl ID: ENSMUSG00000035273

Description: heparanase

Associated with

Glycosaminoglycan metabolism
(R-MMU-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-MMU-1638091)
Hs-gag degradation
(R-MMU-2024096)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Neutrophil degranulation
(R-MMU-6798695)
Angiogenesis involved in wound healing
(GO:0060055)
Cargo receptor ligand activity
(GO:0140355)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Establishment of endothelial barrier
(GO:0061028)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heparanase activity
(GO:0030305)
Heparanase complex
(GO:1904974)
Heparan sulfate proteoglycan catabolic process
(GO:0030200)
Heparin metabolic process
(GO:0030202)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of blood coagulation
(GO:0030194)
Positive regulation of hair follicle development
(GO:0051798)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein transmembrane transport
(GO:0071806)
Receptor-mediated endocytosis
(GO:0006898)
Regulation of hair follicle development
(GO:0051797)
Response to organic substance
(GO:0010033)
Syndecan binding
(GO:0045545)
Vascular wound healing
(GO:0061042)
Wound healing
(GO:0042060)

Other Information

Proteins

Heparanase

Genular Protein ID: 3567106821

Symbol: HPSE_MOUSE

Name: Heparanase

UniProtKB Accession Codes:

Q6YGZ1 B2RS99 Q8K3K3

Database IDs:

Citations:

PubMed ID: 10395326

Title: Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.

PubMed ID: 10395326

DOI: 10.1038/10525

PubMed ID: 12460766

Title: Cloning, expression, and purification of mouse heparanase.

PubMed ID: 12460766

DOI: 10.1016/s1046-5928(02)00558-2

PubMed ID: 12837765

Title: Processing of macromolecular heparin by heparanase.

PubMed ID: 12837765

DOI: 10.1074/jbc.m300925200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15793281

Title: Heparanase regulates murine hair growth.

PubMed ID: 15793281

DOI: 10.1016/s0002-9440(10)62321-8

PubMed ID: 15677344

Title: Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.

PubMed ID: 15677344

DOI: 10.1096/fj.04-1970com

PubMed ID: 17689495

Title: Heparanase induces Akt phosphorylation via a lipid raft receptor.

PubMed ID: 17689495

DOI: 10.1016/j.bbrc.2007.06.188

PubMed ID: 18589009

Title: Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation.

PubMed ID: 18589009

DOI: 10.1016/j.bone.2008.05.022

Sequence Information:

Length: 535
Mass: 60066
Checksum: 6E73A8302FB8A0DF
Sequence:

MLRLLLLWLW GPLGALAQGA PAGTAPTDDV VDLEFYTKRP LRSVSPSFLS ITIDASLATD 
PRFLTFLGSP RLRALARGLS PAYLRFGGTK TDFLIFDPDK EPTSEERSYW KSQVNHDICR 
SEPVSAAVLR KLQVEWPFQE LLLLREQYQK EFKNSTYSRS SVDMLYSFAK CSGLDLIFGL 
NALLRTPDLR WNSSNAQLLL DYCSSKGYNI SWELGNEPNS FWKKAHILID GLQLGEDFVE 
LHKLLQRSAF QNAKLYGPDI GQPRGKTVKL LRSFLKAGGE VIDSLTWHHY YLNGRIATKE 
DFLSSDVLDT FILSVQKILK VTKEITPGKK VWLGETSSAY GGGAPLLSNT FAAGFMWLDK 
LGLSAQMGIE VVMRQVFFGA GNYHLVDENF EPLPDYWLSL LFKKLVGPRV LLSRVKGPDR 
SKLRVYLHCT NVYHPRYQEG DLTLYVLNLH NVTKHLKVPP PLFRKPVDTY LLKPSGPDGL 
LSKSVQLNGQ ILKMVDEQTL PALTEKPLPA GSALSLPAFS YGFFVIRNAK IAACI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hpse

Associated with

Other Information

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. PubMed ID: 10395326

Cloning, expression, and purification of mouse heparanase. PubMed ID: 12460766

Processing of macromolecular heparin by heparanase. PubMed ID: 12837765

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Heparanase regulates murine hair growth. PubMed ID: 15793281

Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. PubMed ID: 15677344

Heparanase induces Akt phosphorylation via a lipid raft receptor. PubMed ID: 17689495

Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. PubMed ID: 18589009