Details for: CYP1B1

Gene ID: 1545

Symbol: CYP1B1

Ensembl ID: ENSG00000138061

Description: cytochrome P450 family 1 subfamily B member 1

Associated with

Other Information

Genular Protein ID: 3801965362

Symbol: CP1B1_HUMAN

Name: CYPIB1

UniProtKB Accession Codes:

Q16678 Q5TZW8 Q93089 Q9H316

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 52 DrugCentral 1 EC 2 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 65 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 64 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8175734

Title: Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

PubMed ID: 8175734

DOI: 10.1016/s0021-9258(17)36803-5

PubMed ID: 8910454

Title: Isolation and characterization of the human cytochrome P450 CYP1B1 gene.

PubMed ID: 8910454

DOI: 10.1074/jbc.271.45.28324

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10426814

Title: Catalytic properties of polymorphic human cytochrome P450 1B1 variants.

PubMed ID: 10426814

DOI: 10.1093/carcin/20.8.1607

PubMed ID: 10681376

Title: Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.

PubMed ID: 10681376

PubMed ID: 11555828

Title: Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.

PubMed ID: 11555828

DOI: 10.1053/meta.2001.25592

PubMed ID: 12865317

Title: Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

PubMed ID: 12865317

DOI: 10.1210/en.2003-0192

PubMed ID: 15258110

Title: Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.

PubMed ID: 15258110

DOI: 10.1124/dmd.32.8.840

PubMed ID: 19005183

Title: CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression.

PubMed ID: 19005183

DOI: 10.1182/blood-2008-03-145219

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21068195

Title: Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.

PubMed ID: 21068195

DOI: 10.1124/dmd.110.035121

PubMed ID: 22888116

Title: Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation.

PubMed ID: 22888116

DOI: 10.1093/jb/mvs087

PubMed ID: 22935222

Title: The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonising xenobiotic-responsive element binding.

PubMed ID: 22935222

DOI: 10.1017/s0007114512003595

PubMed ID: 23821647

Title: Specificity determinants of CYP1B1 estradiol hydroxylation.

PubMed ID: 23821647

DOI: 10.1124/mol.113.087700

PubMed ID: 21147782

Title: Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1.

PubMed ID: 21147782

DOI: 10.1074/jbc.m110.204420

PubMed ID: 9463332

Title: Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia.

PubMed ID: 9463332

DOI: 10.1086/301725

PubMed ID: 9497261

Title: Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1.

PubMed ID: 9497261

DOI: 10.1086/301764

PubMed ID: 9823305

Title: Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer.

PubMed ID: 9823305

PubMed ID: 10227395

Title: Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma.

PubMed ID: 10227395

PubMed ID: 10655546

Title: Multiple CYP1B1 mutations and incomplete penetrance in an inbred population segregating primary congenital glaucoma suggest frequent de novo events and a dominant modifier locus.

PubMed ID: 10655546

DOI: 10.1093/hmg/9.3.367

PubMed ID: 11184479

Title: Novel compound heterozygous mutations in the cytochrome P4501B1 gene (CYP1B1) in a Japanese patient with primary congenital glaucoma.

PubMed ID: 11184479

DOI: 10.1076/1381-6810(200009)21:3;1-z;ft191

PubMed ID: 10739169

Title: Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.

PubMed ID: 10739169

DOI: 10.1097/00008571-200002000-00004

PubMed ID: 11527932

Title: Novel cytochrome P4501B1 (CYP1B1) gene mutations in Japanese patients with primary congenital glaucoma.

PubMed ID: 11527932

PubMed ID: 11403040

Title: Phenotypic heterogeneity of CYP1B1: mutations in a patient with Peters' anomaly.

PubMed ID: 11403040

DOI: 10.1136/jmg.38.5.324

PubMed ID: 11774072

Title: Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.

PubMed ID: 11774072

DOI: 10.1086/338709

PubMed ID: 11980847

Title: Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees.

PubMed ID: 11980847

PubMed ID: 12036985

Title: Molecular genetics of primary congenital glaucoma in Brazil.

PubMed ID: 12036985

PubMed ID: 11854439

Title: Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population.

PubMed ID: 11854439

DOI: 10.1124/mol.61.3.586

PubMed ID: 14640114

Title: Gene symbol: CYP1B1. Disease: glaucoma, primary congenital.

PubMed ID: 14640114

DOI: 10.1007/s00439-003-1035-0

PubMed ID: 14635112

Title: Novel cytochrome P450 1B1 (CYP1B1) mutations in patients with primary congenital glaucoma in France.

PubMed ID: 14635112

DOI: 10.1002/humu.9197

PubMed ID: 12525557

Title: CYP1B1 gene analysis in primary congenital glaucoma in Indonesian and European patients.

PubMed ID: 12525557

DOI: 10.1136/jmg.40.1.e9

PubMed ID: 15342693

Title: CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma.

PubMed ID: 15342693

DOI: 10.1136/jmg.2004.020024

PubMed ID: 15475877

Title: Mutation spectrum of the CYP1B1 gene in Indian primary congenital glaucoma patients.

PubMed ID: 15475877

PubMed ID: 15255109

Title: Cytochrome P4501B1 mutations cause only part of primary congenital glaucoma in Ecuador.

PubMed ID: 15255109

DOI: 10.1076/opge.25.1.3.28999

PubMed ID: 16490498

Title: Molecular and clinical evaluation of primary congenital glaucoma in Kuwait.

PubMed ID: 16490498

DOI: 10.1016/j.ajo.2005.11.001

PubMed ID: 16688110

Title: Primary role of CYP1B1 in Indian juvenile-onset POAG patients.

PubMed ID: 16688110

PubMed ID: 16735994

Title: Primary congenital glaucoma and Rieger's anomaly: extended haplotypes reveal founder effects for eight distinct CYP1B1 mutations.

PubMed ID: 16735994

PubMed ID: 16862072

Title: Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.

PubMed ID: 16862072

PubMed ID: 18470941

Title: Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme.

PubMed ID: 18470941

DOI: 10.1002/humu.20786

Sequence Information:

  • Length: 543
  • Mass: 60846
  • Checksum: 46B6DA7368F63EA2
  • Sequence:
    • MGTSLSPNDP WPLNPLSIQQ TTLLLLLSVL ATVHVGQRLL RQRRRQLRSA PPGPFAWPLI 
GNAAAVGQAA HLSFARLARR YGDVFQIRLG SCPIVVLNGE RAIHQALVQQ GSAFADRPAF 
ASFRVVSGGR SMAFGHYSEH WKVQRRAAHS MMRNFFTRQP RSRQVLEGHV LSEARELVAL 
LVRGSADGAF LDPRPLTVVA VANVMSAVCF GCRYSHDDPE FRELLSHNEE FGRTVGAGSL 
VDVMPWLQYF PNPVRTVFRE FEQLNRNFSN FILDKFLRHC ESLRPGAAPR DMMDAFILSA 
EKKAAGDSHG GGARLDLENV PATITDIFGA SQDTLSTALQ WLLLLFTRYP DVQTRVQAEL 
DQVVGRDRLP CMGDQPNLPY VLAFLYEAMR FSSFVPVTIP HATTANTSVL GYHIPKDTVV 
FVNQWSVNHD PLKWPNPENF DPARFLDKDG LINKDLTSRV MIFSVGKRRC IGEELSKMQL 
FLFISILAHQ CDFRANPNEP AKMNFSYGLT IKPKSFKVNV TLRESMELLD SAVQNLQAKE 
TCQ

Genular Protein ID: 2092858289

Symbol: Q53TK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53TK1

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 543
  • Mass: 60832
  • Checksum: 71BB6CA8055122DF
  • Sequence:
    • MGTSLSPNDP WPLNPLSIQQ TTLLLLLSVL ATVHVGQRLL RQRRRQLRSA PPGPFAWPLI 
GNAAAVGQAA HLSFARLARR YGDVFQIRLG SCPIVVLNGE RAIHQALVQQ GSAFADRPAF 
ASFRVVSGGR SMAFGHYSEH WKVQRRAAHS MMRNFFTRQP RSRQVLEGHV LSEARELVAL 
LVRGSADGAF LDPRPLTVVA VANVMSAVCF GCRYSHDDPE FRELLSHNEE FGRTVGAGSL 
VDVMPWLQYF PNPVRTVFRE FEQLNRNFSN FILDKFLRHC ESLRPGAAPR DMMDAFILSA 
EKKAAGDSHG GGARLDLENV PATITDIFGA SQDTLSTALQ WLLLLFTRYP DVQTRVQAEL 
DQVVGRDRLP CMGDQPNLPY VLAFLYEAMR FSSFVPVTIP HATTANTSVL GYHIPKDTVV 
FVNQWSVNHD PVKWPNPENF DPARFLDKDG LINKDLTSRV MIFSVGKRRC IGEELSKMQL 
FLFISILAHQ CDFRANPNEP AKMNFSYGLT IKPKSFKVNV TLRESMELLD SAVQNLQAKE 
TCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.