Eif2ak1 | ENSMUSG00000029613 | NCBI 15467

Details for: Eif2ak1

Gene ID: 15467

Symbol: Eif2ak1

Ensembl ID: ENSMUSG00000029613

Description: eukaryotic translation initiation factor 2 alpha kinase 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to mitochondrial stress
(R-MMU-9840373)
Acute inflammatory response
(GO:0002526)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment of localization in cell
(GO:0051649)
Eukaryotic translation initiation factor 2alpha kinase activity
(GO:0004694)
Heme binding
(GO:0020037)
Hri-mediated signaling
(GO:0140468)
Integrated stress response signaling
(GO:0140467)
Kinase activity
(GO:0016301)
Macrophage differentiation
(GO:0030225)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of hemoglobin biosynthetic process
(GO:0046986)
Negative regulation of translation
(GO:0017148)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phagocytosis
(GO:0006909)
Phosphorylation
(GO:0016310)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protoporphyrinogen ix metabolic process
(GO:0046501)
Regulation of eif2 alpha phosphorylation by heme
(GO:0010999)
Regulation of hemoglobin biosynthetic process
(GO:0046984)
Regulation of translation
(GO:0006417)
Regulation of translational initiation by eif2 alpha phosphorylation
(GO:0010998)
Response to iron ion starvation
(GO:1990641)
Transferase activity
(GO:0016740)

Other Information

Proteins

Eukaryotic translation initiation factor 2-alpha kinase 1

Genular Protein ID: 1391963217

Symbol: E2AK1_MOUSE

Name: Eukaryotic translation initiation factor 2-alpha kinase 1

UniProtKB Accession Codes:

Q9Z2R9 Q2TA96 Q69ZK8 Q8C024 Q8K123 Q9CTP5 Q9D601

Database IDs:

Citations:

PubMed ID: 9822714

Title: Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells.

PubMed ID: 9822714

DOI: 10.1074/jbc.273.48.32340

PubMed ID: 11726526

Title: Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.

PubMed ID: 11726526

DOI: 10.1093/emboj/20.23.6909

PubMed ID: 15368895

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 15368895

DOI: 10.1093/dnares/11.3.205

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11050009

Title: Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase.

PubMed ID: 11050009

PubMed ID: 11560503

Title: Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase.

PubMed ID: 11560503

DOI: 10.1021/bi010983s

PubMed ID: 11689689

Title: Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses.

PubMed ID: 11689689

DOI: 10.1128/mcb.21.23.7971-7980.2001

PubMed ID: 12767237

Title: Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI.

PubMed ID: 12767237

DOI: 10.1021/bi034005v

PubMed ID: 14752110

Title: Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies.

PubMed ID: 14752110

DOI: 10.1074/jbc.m310273200

PubMed ID: 15931390

Title: Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia.

PubMed ID: 15931390

DOI: 10.1172/jci24141

PubMed ID: 16893190

Title: Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition.

PubMed ID: 16893190

DOI: 10.1021/bi060556k

PubMed ID: 17932563

Title: The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.

PubMed ID: 17932563

DOI: 10.1172/jci32084

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20071449

Title: Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.

PubMed ID: 20071449

DOI: 10.1124/mol.109.061259

PubMed ID: 34404736

Title: Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol 77(4):575-592; doi:10.1124/mol.109.061259.

PubMed ID: 34404736

DOI: 10.1124/mol.109.061259retraction

Sequence Information:

Length: 619
Mass: 69702
Checksum: 39DC5FF950C92F2A
Sequence:

MLGGSSVDGE RDTDDDAAGA VAAPPAIDFP AEVSDPKYDE SDVPAELQVL KEPLQQPTFP 
FLVANQLLLV SLLEHLSHVH EPNPLHSKQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 
NRAITHLMRS AKERVRQDPC QDNSYMQKIR SREIAFEAQT SRYLNEFEEL AILGKGGYGR 
VYKVRNKLDG QHYAIKKILI KSATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVV 
QPQDRVPIQL PSLEVLSEQE GDRDQGGVKD NESSSSIVFA ELTPEKEKPF GESEVKNENN 
NLVSYTANLV VRNSSESESS IELQEDGLTD LSVRPVVRHQ LPLGHSSELE GNFTSTDESS 
EGNLNLLGQT EVRYHLMLHI QMQLCELSLW DWITERNKRS REYVDEAACP YVMASVATKI 
FQELVEGVFY IHNMGIVHRD LKPRNIFLHG PDQQVKIGDF GLACADIIQN ADWTNRNGKG 
TRTHTSRVGT CLYASPEQLE GSQYDAKSDM YSLGVILLEL FQPFGTEMER ATVLTGVRTG 
RIPESLSKRC PVQAKYIQLL TGRNVSQRPS ALQLLQSELF QTTGNVNLTL QMKIIEQEKE 
IEELKKQLSL LSQDRGLKR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eif2ak1

Associated with

Other Information

Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells. PubMed ID: 9822714

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. PubMed ID: 11726526

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 15368895

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase. PubMed ID: 11050009

Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase. PubMed ID: 11560503

Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses. PubMed ID: 11689689

Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI. PubMed ID: 12767237

Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies. PubMed ID: 14752110

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. PubMed ID: 15931390

Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition. PubMed ID: 16893190

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. PubMed ID: 17932563

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. PubMed ID: 20071449