CYP2A6 | ENSG00000255974 | NCBI 1548

Details for: CYP2A6

Gene ID: 1548

Symbol: CYP2A6

Ensembl ID: ENSG00000255974

Description: cytochrome P450 family 2 subfamily A member 6

Associated with

Biological oxidations
(R-HSA-211859)
Cyp2e1 reactions
(R-HSA-211999)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Xenobiotics
(R-HSA-211981)
Arachidonic acid epoxygenase activity
(GO:0008392)
Coumarin 7-hydroxylase activity
(GO:0008389)
Coumarin catabolic process
(GO:0046226)
Coumarin metabolic process
(GO:0009804)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule
(GO:0005881)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epoxygenase p450 pathway
(GO:0019373)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Steroid metabolic process
(GO:0008202)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 2A6

Genular Protein ID: 3809079103

Symbol: CP2A6_HUMAN

Name: Cytochrome P450 2A6

UniProtKB Accession Codes:

P11509 A7YAE5 B2R7F6 P00190 P10890 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48

Database IDs:

Citations:

PubMed ID: 2726448

Title: Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

PubMed ID: 2726448

DOI: 10.1093/nar/17.8.2907

PubMed ID: 2748347

Title: cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).

PubMed ID: 2748347

DOI: 10.1093/nar/17.12.4888

PubMed ID: 2322567

Title: The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

PubMed ID: 2322567

DOI: 10.1021/bi00457a031

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1889415

Title: Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes.

PubMed ID: 1889415

DOI: 10.1111/j.1432-1033.1991.tb16212.x

PubMed ID: 1944238

Title: Purification and characterization of human liver microsomal cytochrome P-450 2A6.

PubMed ID: 1944238

PubMed ID: 11278503

Title: CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity.

PubMed ID: 11278503

DOI: 10.1074/jbc.m009432200

PubMed ID: 3856261

Title: Isolation and sequence of a human cytochrome P-450 cDNA clone.

PubMed ID: 3856261

DOI: 10.1073/pnas.82.4.983

PubMed ID: 11695850

Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

PubMed ID: 11695850

DOI: 10.1080/00498250110065595

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16086027

Title: Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen.

PubMed ID: 16086027

DOI: 10.1038/nsmb971

PubMed ID: 17125252

Title: Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

PubMed ID: 17125252

DOI: 10.1021/jm060519r

PubMed ID: 18779312

Title: Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

PubMed ID: 18779312

DOI: 10.1124/dmd.108.023770

PubMed ID: 9409631

Title: A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin.

PubMed ID: 9409631

DOI: 10.1016/s0278-6915(97)00066-5

PubMed ID: 10544257

Title: Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

PubMed ID: 10544257

DOI: 10.1016/s0014-5793(99)01364-2

PubMed ID: 11237731

Title: A novel single nucleotide polymorphism altering stability and activity of CYP2a6.

PubMed ID: 11237731

DOI: 10.1006/bbrc.2001.4422

PubMed ID: 15618701

Title: Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians.

PubMed ID: 15618701

DOI: 10.2133/dmpk.17.482

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 18360915

Title: Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

PubMed ID: 18360915

DOI: 10.1002/humu.20698

PubMed ID: 18216723

Title: A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent.

PubMed ID: 18216723

DOI: 10.1097/fpc.0b013e3282f3606e

Sequence Information:

Length: 494
Mass: 56517
Checksum: 562D697ADE558B04
Sequence:

MLASGMLLVA LLVCLTVMVL MSVWQQRKSK GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK 
ISERYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVVFSN 
GERAKQLRRF SIATLRDFGV GKRGIEERIQ EEAGFLIDAL RGTGGANIDP TFFLSRTVSN 
VISSIVFGDR FDYKDKEFLS LLRMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFQL 
LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFI 
GGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YMEAVIHEIQ 
RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VYPMLGSVLR DPSFFSNPQD FNPQHFLNEK 
GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVGF 
ATIPRNYTMS FLPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP2A6

Associated with

Other Information

Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity. PubMed ID: 2726448

cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). PubMed ID: 2748347

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. PubMed ID: 2322567

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes. PubMed ID: 1889415

Purification and characterization of human liver microsomal cytochrome P-450 2A6. PubMed ID: 1944238

CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. PubMed ID: 11278503

Isolation and sequence of a human cytochrome P-450 cDNA clone. PubMed ID: 3856261

Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. PubMed ID: 11695850

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen. PubMed ID: 16086027

Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. PubMed ID: 17125252

Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes. PubMed ID: 18779312

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin. PubMed ID: 9409631

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. PubMed ID: 10544257

A novel single nucleotide polymorphism altering stability and activity of CYP2a6. PubMed ID: 11237731

Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians. PubMed ID: 15618701

Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. PubMed ID: 12721789

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. PubMed ID: 15469410

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. PubMed ID: 18360915

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. PubMed ID: 18216723