Details for: CYP2A6

Gene ID: 1548

Symbol: CYP2A6

Ensembl ID: ENSG00000255974

Description: cytochrome P450 family 2 subfamily A member 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 3.37
    Marker Score: 9519
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1514
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.66
    Marker Score: 8932
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.37
    Marker Score: 11544
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.26
    Marker Score: 5418
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.05
    Marker Score: 6762
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.81
    Marker Score: 871.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.58
    Marker Score: 181
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 219
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 719
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.35
    Marker Score: 133
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 660
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.32
    Marker Score: 415
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3
    Marker Score: 114
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.29
    Marker Score: 533
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.29
    Marker Score: 334
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.26
    Marker Score: 262
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 144
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.24
    Marker Score: 814
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.22
    Marker Score: 1433
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3297
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.17
    Marker Score: 173
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.17
    Marker Score: 1474
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.16
    Marker Score: 978
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.16
    Marker Score: 394
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 134
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.12
    Marker Score: 225
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.11
    Marker Score: 468
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.1
    Marker Score: 722
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.1
    Marker Score: 138.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 193
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 279
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 112.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 83.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.07
    Marker Score: 381
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.07
    Marker Score: 19.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 107
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 77
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.06
    Marker Score: 34.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15

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Other Information

**Key characteristics**: - The CYP2A6 gene is located on chromosome 17q21.1 in humans. - It is a large gene with a molecular weight of approximately 1200 amino acids. - It contains 13 exons and 12 introns. - The protein encoded by CYP2A6 is a transmembrane protein with a molecular weight of approximately 150 kDa. **Pathways and functions**: - CYP2A6 is involved in multiple metabolic pathways, including arachidonic acid epoxygenase activity, biological oxidations, coumarin 7-hydroxylase activity, and the coumarin metabolic process. - It is also involved in the steroid metabolic process, xenobiotic metabolic process, and xenobiotics. **Clinical significance**: - Mutations in the CYP2A6 gene have been linked to several human diseases, including liver cancer, breast cancer, and metabolic disorders. - Inhibition of CYP2A6 activity has been shown to suppress cancer cell growth and metastasis. - Therefore, CYP2A6 is a promising target for cancer therapy. **Conclusion**: The CYP2A6 gene is an important protein involved in various metabolic pathways in the body. Mutations in this gene have been linked to several human diseases, highlighting its clinical significance as a target for cancer therapy.

Genular Protein ID: 3809079103

Symbol: CP2A6_HUMAN

Name: Cytochrome P450 2A6

UniProtKB Accession Codes:

P11509 A7YAE5 B2R7F6 P00190 P10890 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 88 DrugCentral 1 EC 1 EMBL 16 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 11 PIR 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2726448

Title: Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

PubMed ID: 2726448

DOI: 10.1093/nar/17.8.2907

PubMed ID: 2748347

Title: cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).

PubMed ID: 2748347

DOI: 10.1093/nar/17.12.4888

PubMed ID: 2322567

Title: The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

PubMed ID: 2322567

DOI: 10.1021/bi00457a031

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1889415

Title: Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes.

PubMed ID: 1889415

DOI: 10.1111/j.1432-1033.1991.tb16212.x

PubMed ID: 1944238

Title: Purification and characterization of human liver microsomal cytochrome P-450 2A6.

PubMed ID: 1944238

PubMed ID: 11278503

Title: CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity.

PubMed ID: 11278503

DOI: 10.1074/jbc.m009432200

PubMed ID: 3856261

Title: Isolation and sequence of a human cytochrome P-450 cDNA clone.

PubMed ID: 3856261

DOI: 10.1073/pnas.82.4.983

PubMed ID: 11695850

Title: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

PubMed ID: 11695850

DOI: 10.1080/00498250110065595

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16086027

Title: Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen.

PubMed ID: 16086027

DOI: 10.1038/nsmb971

PubMed ID: 17125252

Title: Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

PubMed ID: 17125252

DOI: 10.1021/jm060519r

PubMed ID: 18779312

Title: Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

PubMed ID: 18779312

DOI: 10.1124/dmd.108.023770

PubMed ID: 9409631

Title: A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin.

PubMed ID: 9409631

DOI: 10.1016/s0278-6915(97)00066-5

PubMed ID: 10544257

Title: Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

PubMed ID: 10544257

DOI: 10.1016/s0014-5793(99)01364-2

PubMed ID: 11237731

Title: A novel single nucleotide polymorphism altering stability and activity of CYP2a6.

PubMed ID: 11237731

DOI: 10.1006/bbrc.2001.4422

PubMed ID: 15618701

Title: Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians.

PubMed ID: 15618701

DOI: 10.2133/dmpk.17.482

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

PubMed ID: 15469410

Title: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

PubMed ID: 15469410

DOI: 10.1517/14622416.5.7.895

PubMed ID: 18360915

Title: Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

PubMed ID: 18360915

DOI: 10.1002/humu.20698

PubMed ID: 18216723

Title: A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent.

PubMed ID: 18216723

DOI: 10.1097/fpc.0b013e3282f3606e

Sequence Information:

  • Length: 494
  • Mass: 56517
  • Checksum: 562D697ADE558B04
  • Sequence:
    • MLASGMLLVA LLVCLTVMVL MSVWQQRKSK GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK 
ISERYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVVFSN 
GERAKQLRRF SIATLRDFGV GKRGIEERIQ EEAGFLIDAL RGTGGANIDP TFFLSRTVSN 
VISSIVFGDR FDYKDKEFLS LLRMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFQL 
LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFI 
GGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YMEAVIHEIQ 
RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VYPMLGSVLR DPSFFSNPQD FNPQHFLNEK 
GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVGF 
ATIPRNYTMS FLPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.