Genular: Defining Cellular Identity and Function

Details for: Hspa8

Gene ID: 15481

Symbol: Hspa8

Ensembl ID: ENSMUSG00000015656

Description: heat shock protein 8

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Attenuation phase
(R-MMU-3371568)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Cytokine signaling in immune system
(R-MMU-1280215)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Golgi associated vesicle biogenesis
(R-MMU-432722)
Hsf1-dependent transactivation
(R-MMU-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Lysosome vesicle biogenesis
(R-MMU-432720)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Mrna splicing
(R-MMU-72172)
Mrna splicing - major pathway
(R-MMU-72163)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Neutrophil degranulation
(R-MMU-6798695)
Pkr-mediated signaling
(R-MMU-9833482)
Post-translational protein modification
(R-MMU-597592)
Processing of capped intron-containing pre-mrna
(R-MMU-72203)
Protein methylation
(R-MMU-8876725)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Trans-golgi network vesicle budding
(R-MMU-199992)
Transmission across chemical synapses
(R-MMU-112315)
Vesicle-mediated transport
(R-MMU-5653656)
A1 adenosine receptor binding
(GO:0031686)
Adp binding
(GO:0043531)
Atp-dependent protein disaggregase activity
(GO:0140545)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Autophagosome
(GO:0005776)
Autophagy
(GO:0006914)
C3hc4-type ring finger domain binding
(GO:0055131)
Chaperone-mediated autophagy
(GO:0061684)
Chaperone-mediated protein folding
(GO:0061077)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Clathrin-uncoating atpase activity
(GO:1990833)
Clathrin coat disassembly
(GO:0072318)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Hydrolase activity
(GO:0016787)
Intermediate filament
(GO:0005882)
Intracellular anatomical structure
(GO:0005622)
Late endosomal microautophagy
(GO:0061738)
Late endosome
(GO:0005770)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Microtubule
(GO:0005874)
Modulation by host of viral process
(GO:0044788)
Mrna processing
(GO:0006397)
Mrna splicing, via spliceosome
(GO:0000398)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of nlrp3 inflammasome complex assembly
(GO:1900226)
Negative regulation of supramolecular fiber organization
(GO:1902904)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptide binding
(GO:0042277)
Phosphatidylserine binding
(GO:0001786)
Photoreceptor inner segment
(GO:0001917)
Positive regulation by host of viral genome replication
(GO:0044829)
Positive regulation of mrna splicing, via spliceosome
(GO:0048026)
Prostaglandin binding
(GO:1904593)
Protein-containing complex disassembly
(GO:0032984)
Protein-folding chaperone binding
(GO:0051087)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Protein targeting to lysosome involved in chaperone-mediated autophagy
(GO:0061740)
Prp19 complex
(GO:0000974)
Regulation of cell cycle
(GO:0051726)
Regulation of postsynapse organization
(GO:0099175)
Regulation of protein stability
(GO:0031647)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Signaling receptor binding
(GO:0005102)
Spliceosomal complex
(GO:0005681)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Heat shock cognate 71 kDa protein

Genular Protein ID: 1655288801

Symbol: HSP7C_MOUSE

Name: Heat shock cognate 71 kDa protein

UniProtKB Accession Codes:

P63017 P08109 P12225 Q3U6R0 Q3U764 Q3U7D7 Q3U7E2 Q3U9B4 Q3U9G0 Q3UGM0 Q5FWJ6 Q62373 Q62374 Q62375 Q6NZD0

Database IDs:

Citations:

PubMed ID: 3334718

Title: Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein.

PubMed ID: 3334718

DOI: 10.1016/0012-1606(88)90073-5

PubMed ID: 8682318

Title: Developmental regulation of murine integrin beta 1 subunit- and Hsc73-encoding genes in mammary gland: sequence of a new mouse Hsc73 cDNA.

PubMed ID: 8682318

DOI: 10.1016/0378-1119(96)00169-2

PubMed ID: 10095055

Title: Characterization and expression of the mouse Hsc70 gene.

PubMed ID: 10095055

DOI: 10.1016/s0167-4781(98)00285-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2251119

Title: Mouse U14 snRNA is encoded in an intron of the mouse cognate hsc70 heat shock gene.

PubMed ID: 2251119

DOI: 10.1093/nar/18.22.6565

PubMed ID: 9675148

Title: Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells.

PubMed ID: 9675148

DOI: 10.1006/bbrc.1998.8979

PubMed ID: 15292236

Title: Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity.

PubMed ID: 15292236

DOI: 10.1074/jbc.m407947200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17233114

Title: The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family.

PubMed ID: 17233114

DOI: 10.1089/dna.2006.25.704

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21502331

Title: Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells.

PubMed ID: 21502331

DOI: 10.1084/jem.20101192

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 646
Mass: 70871
Checksum: 03A27B30E6C076ED
Sequence:

MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 
MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS 
SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA 
IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH 
FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA 
RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN 
KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI 
PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI 
DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN 
SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIISW LDKNQTAEKE EFEHQQKELE 
KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspa8

Associated with

Other Information

Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. PubMed ID: 3334718

Developmental regulation of murine integrin beta 1 subunit- and Hsc73-encoding genes in mammary gland: sequence of a new mouse Hsc73 cDNA. PubMed ID: 8682318

Characterization and expression of the mouse Hsc70 gene. PubMed ID: 10095055

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mouse U14 snRNA is encoded in an intron of the mouse cognate hsc70 heat shock gene. PubMed ID: 2251119

Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. PubMed ID: 9675148

Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity. PubMed ID: 15292236

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family. PubMed ID: 17233114

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. PubMed ID: 21502331

Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation. PubMed ID: 23921388

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315