Details for: Hsd11b1

Gene ID: 15483

Symbol: Hsd11b1

Ensembl ID: ENSMUSG00000016194

Description: hydroxysteroid 11-beta dehydrogenase 1

Associated with

Other Information

Genular Protein ID: 828417441

Symbol: DHI1_MOUSE

Name: 7-oxosteroid reductase

UniProtKB Accession Codes:

P50172

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 75 ChEMBL 1 ChiTaRS 1 DNASU 1 DrugCentral 1 EC 2 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 30 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 7873449

Title: Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA.

PubMed ID: 7873449

DOI: 10.1016/0960-0760(94)00159-j

PubMed ID: 7851387

Title: Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase.

PubMed ID: 7851387

DOI: 10.1111/j.1432-1033.1995.tb20377.x

PubMed ID: 8973338

Title: The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites.

PubMed ID: 8973338

DOI: 10.1016/s0378-1119(96)00490-8

PubMed ID: 9405715

Title: 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.

PubMed ID: 9405715

DOI: 10.1073/pnas.94.26.14924

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23415904

Title: 11beta-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo.

PubMed ID: 23415904

DOI: 10.1016/j.bcp.2013.02.002

PubMed ID: 30902677

Title: Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2.

PubMed ID: 30902677

DOI: 10.1016/j.jsbmb.2019.03.011

PubMed ID: 15865440

Title: Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes.

PubMed ID: 15865440

DOI: 10.1021/bi047599q

Sequence Information:

  • Length: 292
  • Mass: 32364
  • Checksum: ADE42B11D82DD6CD
  • Sequence:
    • MAVMKNYLLP ILVLFLAYYY YSTNEEFRPE MLQGKKVIVT GASKGIGREM AYHLSKMGAH 
VVLTARSEEG LQKVVSRCLE LGAASAHYIA GTMEDMTFAE QFIVKAGKLM GGLDMLILNH 
ITQTSLSLFH DDIHSVRRVM EVNFLSYVVM STAALPMLKQ SNGSIAVISS LAGKMTQPMI 
APYSASKFAL DGFFSTIRTE LYITKVNVSI TLCVLGLIDT ETAMKEISGI INAQASPKEE 
CALEIIKGTA LRKSEVYYDK SPLTPILLGN PGRKIMEFFS LRYYNKDMFV SN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.