Details for: CYP2A7

Gene ID: 1549

Symbol: CYP2A7

Ensembl ID: ENSG00000198077

Description: cytochrome P450 family 2 subfamily A member 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.2
    Marker Score: 3437
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 4.3
    Marker Score: 2934
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.46
    Marker Score: 2477
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2002
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.36
    Marker Score: 1872
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4824
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.11
    Marker Score: 630
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.81
    Marker Score: 2275
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.79
    Marker Score: 331
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.77
    Marker Score: 406
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1322
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1206
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 471
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 262
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6072
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.34
    Marker Score: 492
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 173
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.26
    Marker Score: 97
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 101
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2
    Marker Score: 145
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.19
    Marker Score: 251
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.15
    Marker Score: 175
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.14
    Marker Score: 120
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.14
    Marker Score: 137
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.13
    Marker Score: 244
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.08
    Marker Score: 258
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.07
    Marker Score: 289
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.06
    Marker Score: 414
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 127
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.06
    Marker Score: 218
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.05
    Marker Score: 453
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 161
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 72
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.04
    Marker Score: 72
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.04
    Marker Score: 197
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.03
    Marker Score: 196
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 24

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Other Information

## Summary The CYP2A7 gene encodes for a cytochrome P450 enzyme, which is a large protein involved in various metabolic pathways. It is significantly expressed in multiple cell types, including erythrocytes, hepatocytes, blood vessel endothelial cells, enterocytes of the epithelium of large intestine, double-negative thymocytes, intestinal crypt stem cells of the small intestine, transit amplifying cells of the colon, enterocytes of the epithelium of small intestine, megakaryocytes, and transit amplifying cells of the colon. ## Key characteristics * The CYP2A7 gene is located on chromosome 19p13.3. * It is a member of the CYP2A subfamily of cytochrome P450 enzymes. * The protein is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a key enzyme in the metabolism of various xenobiotics and reactive oxygen species (ROS). ## Pathways and functions The CYP2A7 gene is involved in multiple metabolic pathways, including: * Arachidonic acid epoxygenase activity * Aromatase activity * Biological oxidations * Coumarin metabolic process * Cyp2e1 reactions * Cytochrome p450 - arranged by substrate type * Phase i - functionalization of compounds * Xenobiotic metabolic process * Xenobiotics ## Clinical significance Mutations in the CYP2A7 gene have been linked to several human diseases, including: * Liver diseases * Cardiovascular disease * Cancer * Metabolic disorders CYP2A7 inhibitors are being investigated as potential therapeutic agents for these diseases.

Genular Protein ID: 2267343573

Symbol: CP2A7_HUMAN

Name: Cytochrome P450 2A7

UniProtKB Accession Codes:

P20853 Q13121

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2322567

Title: The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

PubMed ID: 2322567

DOI: 10.1021/bi00457a031

PubMed ID: 7668294

Title: A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

PubMed ID: 7668294

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 494
  • Mass: 56425
  • Checksum: 4DA10D0C2714E6AA
  • Sequence:
    • MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK 
FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVAFSN 
GERAKQLLRF AIATLRDFGV GKRGIEERIQ EESGFLIEAI RSTHGANIDP TFFLSRTVSN 
VISSIVFGDR FDYEDKEFLS LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL 
LQGLEDFIAK KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI 
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP YMEAVIHEIQ 
RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR DPSFFSNPQD FNPQHFLDDK 
GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF 
ATIPRNYTMS FLPR

Genular Protein ID: 2420209615

Symbol: F8W816_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W816

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 443
  • Mass: 50667
  • Checksum: 31F5A7E6D53EE877
  • Sequence:
    • MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK 
VSQGVAFSNG ERAKQLLRFA IATLRDFGVG KRGIEERIQE ESGFLIEAIR STHGANIDPT 
FFLSRTVSNV ISSIVFGDRF DYEDKEFLSL LSMMLGIFQF TSTSTGQLYE MFSSVMKHLP 
GPQQQAFKLL QGLEDFIAKK VEHNQRTLDP NSPQDFIDSF LIHMQEEEKN PNTEFYLKNL 
MMSTLNLFIA GTETVSTTLR YGFLLLMKHP EVEAKVHEEI DRVIGKNRQP KFEDRTKMPY 
MEAVIHEIQR FGDVIPMSLA RRVKKDTKFR DFFLPKGTEV FPMLGSVLRD PSFFSNPQDF 
NPQHFLDDKG QFKKSDAFVP FSIGKRNCFG EGLARMELFL FFTTVMQNFR LKSSQSPKDI 
DVSPKHVVFA TIPRNYTMSF LPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.