Details for: CYP2A7

Gene ID: 1549

Symbol: CYP2A7

Ensembl ID: ENSG00000198077

Description: cytochrome P450 family 2 subfamily A member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 11.7288
    Cell Significance Index: 30.9400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 9.4293
    Cell Significance Index: 87.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.0495
    Cell Significance Index: 186.9700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 2.7970
    Cell Significance Index: 30.8400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.1981
    Cell Significance Index: 16.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1339
    Cell Significance Index: 51.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0124
    Cell Significance Index: 32.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8169
    Cell Significance Index: 155.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7595
    Cell Significance Index: 11.2100
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.6826
    Cell Significance Index: 5.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5948
    Cell Significance Index: 58.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5827
    Cell Significance Index: 7.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4944
    Cell Significance Index: 446.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4066
    Cell Significance Index: 8.6600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3572
    Cell Significance Index: 5.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3119
    Cell Significance Index: 50.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3087
    Cell Significance Index: 33.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1929
    Cell Significance Index: 3.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1863
    Cell Significance Index: 11.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1728
    Cell Significance Index: 11.9500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1409
    Cell Significance Index: 1.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0515
    Cell Significance Index: 1.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0405
    Cell Significance Index: 0.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0377
    Cell Significance Index: 2.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0371
    Cell Significance Index: 0.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0304
    Cell Significance Index: 0.6300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0221
    Cell Significance Index: 0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0212
    Cell Significance Index: 0.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0162
    Cell Significance Index: 0.2400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0151
    Cell Significance Index: 0.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0144
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0087
    Cell Significance Index: 0.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0064
    Cell Significance Index: 0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0043
    Cell Significance Index: 1.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0028
    Cell Significance Index: 0.3800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0028
    Cell Significance Index: 0.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0017
    Cell Significance Index: -0.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0026
    Cell Significance Index: -0.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0033
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0035
    Cell Significance Index: -0.6000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0044
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0051
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0053
    Cell Significance Index: -0.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0059
    Cell Significance Index: -1.0700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0083
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0089
    Cell Significance Index: -1.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0091
    Cell Significance Index: -0.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0099
    Cell Significance Index: -0.5000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0107
    Cell Significance Index: -0.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0111
    Cell Significance Index: -1.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0116
    Cell Significance Index: -0.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0126
    Cell Significance Index: -0.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0129
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0132
    Cell Significance Index: -0.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0143
    Cell Significance Index: -0.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0157
    Cell Significance Index: -0.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0161
    Cell Significance Index: -0.5100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0164
    Cell Significance Index: -0.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0185
    Cell Significance Index: -0.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0190
    Cell Significance Index: -0.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0202
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0210
    Cell Significance Index: -0.3400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0215
    Cell Significance Index: -0.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0217
    Cell Significance Index: -0.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0231
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0233
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0249
    Cell Significance Index: -0.7200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0256
    Cell Significance Index: -0.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0257
    Cell Significance Index: -0.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0264
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0271
    Cell Significance Index: -0.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0272
    Cell Significance Index: -0.6800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0275
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0282
    Cell Significance Index: -0.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0287
    Cell Significance Index: -0.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0287
    Cell Significance Index: -0.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0288
    Cell Significance Index: -0.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0291
    Cell Significance Index: -0.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0296
    Cell Significance Index: -0.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0297
    Cell Significance Index: -0.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CYP2A7 is widely expressed in various tissues, including erythrocytes, hepatocytes, endothelial cells, and intestinal epithelial cells, suggesting its involvement in multiple physiological processes. 2. **Metabolic Functions:** CYP2A7 is a member of the cytochrome P450 family, which is responsible for the oxidation of a wide range of substrates, including arachidonic acid, fatty acids, and xenobiotics. 3. **Immune-Related Functions:** CYP2A7 has been implicated in the regulation of immune responses, particularly in the context of cancer and inflammation, where it modulates the activity of various immune cells, including T cells and macrophages. 4. **Substrate Specificity:** CYP2A7 exhibits a broad substrate specificity, allowing it to metabolize a diverse array of compounds, including environmental toxins and endogenous molecules. **Pathways and Functions:** 1. **Arachidonic Acid Epoxygenase Activity:** CYP2A7 plays a critical role in the oxidation of arachidonic acid, a key precursor for the production of eicosanoids, which are involved in inflammation and immune responses. 2. **Aromatase Activity:** CYP2A7 has been shown to possess aromatase activity, which is essential for the conversion of androgens to estrogens, highlighting its role in reproductive biology. 3. **Biological Oxidations:** CYP2A7 is involved in the oxidation of a wide range of substrates, including fatty acids, xenobiotics, and other endogenous molecules, which is essential for maintaining cellular homeostasis. 4. **Cytochrome P450 - Arranged by Substrate Type:** CYP2A7 is classified as a member of the cytochrome P450 family, which is characterized by its ability to catalyze the oxidation of substrates using molecular oxygen as the final electron acceptor. **Clinical Significance:** 1. **Cancer Therapy:** CYP2A7 has been identified as a potential therapeutic target for cancer treatment, particularly in the context of immunotherapy, where it modulates the activity of immune cells, such as T cells and macrophages. 2. **Inflammatory Disorders:** CYP2A7 has been implicated in the regulation of immune responses, particularly in the context of inflammatory disorders, such as rheumatoid arthritis and asthma, where it modulates the activity of immune cells and the production of inflammatory mediators. 3. **Neurological Disorders:** CYP2A7 has been shown to play a role in the regulation of neurotransmitter synthesis and metabolism, highlighting its potential as a therapeutic target for neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, the CYP2A7 gene is a multifaceted molecule that plays a critical role in metabolism, immune function, and cellular homeostasis. Its diverse roles in various physiological processes underscore its importance as a therapeutic target for diseases such as cancer, inflammatory disorders, and neurological disorders. Further research is necessary to fully elucidate the complex interactions between CYP2A7 and other immune-related genes, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 2267343573

Symbol: CP2A7_HUMAN

Name: Cytochrome P450 2A7

UniProtKB Accession Codes:

P20853 Q13121

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2322567

Title: The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

PubMed ID: 2322567

DOI: 10.1021/bi00457a031

PubMed ID: 7668294

Title: A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

PubMed ID: 7668294

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 494
  • Mass: 56425
  • Checksum: 4DA10D0C2714E6AA
  • Sequence:
    • MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK 
FSECYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVAFSN 
GERAKQLLRF AIATLRDFGV GKRGIEERIQ EESGFLIEAI RSTHGANIDP TFFLSRTVSN 
VISSIVFGDR FDYEDKEFLS LLSMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFKL 
LQGLEDFIAK KVEHNQRTLD PNSPQDFIDS FLIHMQEEEK NPNTEFYLKN LMMSTLNLFI 
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRTKMP YMEAVIHEIQ 
RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR DPSFFSNPQD FNPQHFLDDK 
GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVVF 
ATIPRNYTMS FLPR

Genular Protein ID: 2420209615

Symbol: F8W816_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W816

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 443
  • Mass: 50667
  • Checksum: 31F5A7E6D53EE877
  • Sequence:
    • MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK 
VSQGVAFSNG ERAKQLLRFA IATLRDFGVG KRGIEERIQE ESGFLIEAIR STHGANIDPT 
FFLSRTVSNV ISSIVFGDRF DYEDKEFLSL LSMMLGIFQF TSTSTGQLYE MFSSVMKHLP 
GPQQQAFKLL QGLEDFIAKK VEHNQRTLDP NSPQDFIDSF LIHMQEEEKN PNTEFYLKNL 
MMSTLNLFIA GTETVSTTLR YGFLLLMKHP EVEAKVHEEI DRVIGKNRQP KFEDRTKMPY 
MEAVIHEIQR FGDVIPMSLA RRVKKDTKFR DFFLPKGTEV FPMLGSVLRD PSFFSNPQDF 
NPQHFLDDKG QFKKSDAFVP FSIGKRNCFG EGLARMELFL FFTTVMQNFR LKSSQSPKDI 
DVSPKHVVFA TIPRNYTMSF LPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.