Details for: ADRB3

Gene ID: 155

Symbol: ADRB3

Ensembl ID: ENSG00000188778

Description: adrenoceptor beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.2276
    Cell Significance Index: 46.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.1106
    Cell Significance Index: 27.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.8989
    Cell Significance Index: 116.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6204
    Cell Significance Index: 35.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2846
    Cell Significance Index: 41.1500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.2237
    Cell Significance Index: 7.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0949
    Cell Significance Index: 16.5000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.8619
    Cell Significance Index: 10.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7753
    Cell Significance Index: 18.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7161
    Cell Significance Index: 32.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5905
    Cell Significance Index: 112.3800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.3937
    Cell Significance Index: 6.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3536
    Cell Significance Index: 7.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3213
    Cell Significance Index: 31.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2866
    Cell Significance Index: 258.8200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.2774
    Cell Significance Index: 1.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2552
    Cell Significance Index: 3.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2440
    Cell Significance Index: 14.6500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2414
    Cell Significance Index: 1.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2332
    Cell Significance Index: 25.3600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2162
    Cell Significance Index: 2.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1775
    Cell Significance Index: 28.8800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1714
    Cell Significance Index: 2.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1516
    Cell Significance Index: 2.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1420
    Cell Significance Index: 2.0700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1348
    Cell Significance Index: 0.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1234
    Cell Significance Index: 8.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0447
    Cell Significance Index: 1.5700
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: 0.0274
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0230
    Cell Significance Index: 8.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0142
    Cell Significance Index: 0.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0008
    Cell Significance Index: 0.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0017
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0053
    Cell Significance Index: -0.9100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0061
    Cell Significance Index: -0.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0064
    Cell Significance Index: -0.1400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0069
    Cell Significance Index: -0.1100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0096
    Cell Significance Index: -0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0111
    Cell Significance Index: -2.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0123
    Cell Significance Index: -0.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0145
    Cell Significance Index: -2.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0167
    Cell Significance Index: -0.3600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0167
    Cell Significance Index: -0.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0175
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0201
    Cell Significance Index: -2.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0214
    Cell Significance Index: -2.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0219
    Cell Significance Index: -1.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0226
    Cell Significance Index: -0.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0269
    Cell Significance Index: -0.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0298
    Cell Significance Index: -0.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0307
    Cell Significance Index: -0.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0321
    Cell Significance Index: -1.0500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0327
    Cell Significance Index: -0.4100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0368
    Cell Significance Index: -0.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0390
    Cell Significance Index: -1.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0398
    Cell Significance Index: -1.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0426
    Cell Significance Index: -0.5500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0445
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0447
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0463
    Cell Significance Index: -0.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0465
    Cell Significance Index: -1.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0481
    Cell Significance Index: -0.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0488
    Cell Significance Index: -3.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0502
    Cell Significance Index: -1.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0523
    Cell Significance Index: -1.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0528
    Cell Significance Index: -0.9100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0536
    Cell Significance Index: -0.5400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0543
    Cell Significance Index: -0.6600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0566
    Cell Significance Index: -0.7700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0591
    Cell Significance Index: -0.8400
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0605
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0606
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0606
    Cell Significance Index: -0.8300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0608
    Cell Significance Index: -0.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0629
    Cell Significance Index: -1.5700
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0634
    Cell Significance Index: -0.4800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0638
    Cell Significance Index: -1.2600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0642
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0645
    Cell Significance Index: -1.8400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0657
    Cell Significance Index: -0.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0665
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0673
    Cell Significance Index: -1.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0686
    Cell Significance Index: -0.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0689
    Cell Significance Index: -1.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0694
    Cell Significance Index: -0.7600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0709
    Cell Significance Index: -1.0600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0722
    Cell Significance Index: -0.7000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0725
    Cell Significance Index: -0.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0734
    Cell Significance Index: -1.8300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0736
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0744
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function**: The β3-AR is a G protein-coupled receptor that belongs to the class I (rhodopsin-like receptors) family. It is activated by epinephrine and norepinephrine, leading to the activation of adenylate cyclase and the production of cyclic AMP (cAMP). 2. **Expression Pattern**: β3-AR is highly expressed in BAT, where it plays a key role in thermogenesis. It is also expressed in various other tissues, including the gut, where it regulates energy homeostasis and eating behavior. 3. **Signaling Pathways**: The β3-AR activates several signaling pathways, including the adenylate cyclase-activating adrenergic receptor signaling pathway and the G protein-coupled receptor signaling pathway. These pathways ultimately lead to the generation of heat and the breakdown of energy stores. **Pathways and Functions:** 1. **Thermogenesis**: The β3-AR plays a crucial role in thermogenesis, particularly in BAT. Activation of the β3-AR leads to the generation of heat, which is essential for energy homeostasis. 2. **Energy Metabolism**: The β3-AR regulates energy metabolism by modulating the activity of key enzymes involved in glucose and lipid metabolism. 3. **Eating Behavior**: The β3-AR is also involved in regulating eating behavior, particularly in the gut. Activation of the β3-AR leads to the suppression of appetite and the promotion of energy expenditure. 4. **Cold-Induced Thermogenesis**: The β3-AR is activated by cold stress, leading to an increase in thermogenesis and energy expenditure. **Clinical Significance:** 1. **Obesity and Metabolic Disorders**: The β3-AR has been identified as a potential therapeutic target for the treatment of obesity and metabolic disorders, such as type 2 diabetes and cardiovascular disease. 2. **Thermogenic Defects**: Mutations in the β3-AR gene have been associated with thermogenic defects, which can lead to an increased risk of obesity and metabolic disorders. 3. **Cancer Therapy**: The β3-AR has been identified as a potential therapeutic target for the treatment of certain types of cancer, such as breast and lung cancer. 4. **Neurological Disorders**: The β3-AR has been implicated in the pathogenesis of certain neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the β3-AR plays a crucial role in energy metabolism and thermogenesis, and its dysregulation has been implicated in various diseases, including obesity, metabolic disorders, and cancer. Further research is needed to fully understand the mechanisms of β3-AR signaling and to develop novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 3092376473

Symbol: ADRB3_HUMAN

Name: Beta-3 adrenergic receptor

UniProtKB Accession Codes:

P13945 Q4JFT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 41 DrugCentral 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2570461

Title: Molecular characterization of the human beta 3-adrenergic receptor.

PubMed ID: 2570461

DOI: 10.1126/science.2570461

PubMed ID: 8389293

Title: The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.

PubMed ID: 8389293

DOI: 10.1111/j.1432-1033.1993.tb17861.x

PubMed ID: 8389717

Title: Molecular cloning of a human beta 3-adrenergic receptor cDNA.

PubMed ID: 8389717

DOI: 10.1016/0014-5793(93)81377-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1336117

Title: Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.

PubMed ID: 1336117

PubMed ID: 21982743

Title: The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

PubMed ID: 21982743

DOI: 10.1016/j.cmet.2011.08.011

PubMed ID: 7609752

Title: Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

PubMed ID: 7609752

DOI: 10.1056/nejm199508103330605

PubMed ID: 8721782

Title: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain.

PubMed ID: 8721782

DOI: 10.1007/bf00418352

PubMed ID: 8641219

Title: Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.

PubMed ID: 8641219

DOI: 10.1210/endo.137.6.8641219

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

  • Length: 408
  • Mass: 43519
  • Checksum: E98BD6C130DD977B
  • Sequence:
    • MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA TVGGNLLVIV 
AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT GHWPLGATGC ELWTSVDVLC 
VTASIETLCA LAVDRYLAVT NPLRYGALVT KRCARTAVVL VWVVSAAVSF APIMSQWWRV 
GADAEAQRCH SNPRCCAFAS NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG 
ELGRFPPEES PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT 
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP DFRSAFRRLL 
CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL DGASWGVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.