ADRB3 | ENSG00000188778 | NCBI 155

Details for: ADRB3

Gene ID: 155

Symbol: ADRB3

Ensembl ID: ENSG00000188778

Description: adrenoceptor beta 3

Associated with

Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Activation of adenylate cyclase activity
(GO:0007190)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Beta-3 adrenergic receptor binding
(GO:0031699)
Beta-adrenergic receptor activity
(GO:0004939)
Beta3-adrenergic receptor activity
(GO:0015052)
Brown fat cell differentiation
(GO:0050873)
Carbohydrate metabolic process
(GO:0005975)
Desensitization of g protein-coupled receptor signaling pathway by arrestin
(GO:0002032)
Diet induced thermogenesis
(GO:0002024)
Eating behavior
(GO:0042755)
Energy reserve metabolic process
(GO:0006112)
Epinephrine binding
(GO:0051379)
Generation of precursor metabolites and energy
(GO:0006091)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Heat generation
(GO:0031649)
Negative regulation of multicellular organism growth
(GO:0040015)
Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
(GO:0002025)
Norepinephrine binding
(GO:0051380)
Plasma membrane
(GO:0005886)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of mapk cascade
(GO:0043410)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Receptor-mediated endocytosis
(GO:0006898)
Receptor complex
(GO:0043235)
Response to cold
(GO:0009409)

Other Information

Proteins

Beta-3 adrenergic receptor

Genular Protein ID: 3092376473

Symbol: ADRB3_HUMAN

Name: Beta-3 adrenergic receptor

UniProtKB Accession Codes:

P13945 Q4JFT4

Database IDs:

Citations:

PubMed ID: 2570461

Title: Molecular characterization of the human beta 3-adrenergic receptor.

PubMed ID: 2570461

DOI: 10.1126/science.2570461

PubMed ID: 8389293

Title: The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.

PubMed ID: 8389293

DOI: 10.1111/j.1432-1033.1993.tb17861.x

PubMed ID: 8389717

Title: Molecular cloning of a human beta 3-adrenergic receptor cDNA.

PubMed ID: 8389717

DOI: 10.1016/0014-5793(93)81377-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1336117

Title: Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.

PubMed ID: 1336117

PubMed ID: 21982743

Title: The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

PubMed ID: 21982743

DOI: 10.1016/j.cmet.2011.08.011

PubMed ID: 7609752

Title: Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

PubMed ID: 7609752

DOI: 10.1056/nejm199508103330605

PubMed ID: 8721782

Title: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain.

PubMed ID: 8721782

DOI: 10.1007/bf00418352

PubMed ID: 8641219

Title: Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.

PubMed ID: 8641219

DOI: 10.1210/endo.137.6.8641219

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

Length: 408
Mass: 43519
Checksum: E98BD6C130DD977B
Sequence:

MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA TVGGNLLVIV 
AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT GHWPLGATGC ELWTSVDVLC 
VTASIETLCA LAVDRYLAVT NPLRYGALVT KRCARTAVVL VWVVSAAVSF APIMSQWWRV 
GADAEAQRCH SNPRCCAFAS NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG 
ELGRFPPEES PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT 
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP DFRSAFRRLL 
CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL DGASWGVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRB3

Associated with

Other Information

Molecular characterization of the human beta 3-adrenergic receptor. PubMed ID: 2570461

The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes. PubMed ID: 8389293

Molecular cloning of a human beta 3-adrenergic receptor cDNA. PubMed ID: 8389717

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block. PubMed ID: 1336117

The arrestin domain-containing 3 protein regulates body mass and energy expenditure. PubMed ID: 21982743

Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. PubMed ID: 7609752

Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. PubMed ID: 8721782

Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant. PubMed ID: 8641219

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. PubMed ID: 10391210