Details for: ADRB3

Gene ID: 155

Symbol: ADRB3

Ensembl ID: ENSG00000188778

Description: adrenoceptor beta 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.59
    Marker Score: 2694.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.97
    Marker Score: 6321
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 482
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.78
    Marker Score: 832
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1566
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 661
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8403
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.53
    Marker Score: 503
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 947
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.46
    Marker Score: 161
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.39
    Marker Score: 114
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 218
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.35
    Marker Score: 393
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.32
    Marker Score: 832.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1913
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.29
    Marker Score: 499
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.28
    Marker Score: 2778.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 236
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.24
    Marker Score: 133
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 272
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.21
    Marker Score: 69
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.21
    Marker Score: 145
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.2
    Marker Score: 2664.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 409
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 122
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.18
    Marker Score: 344
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 290.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.15
    Marker Score: 346
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.12
    Marker Score: 1856
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.11
    Marker Score: 177.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 188
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1
    Marker Score: 118
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.09
    Marker Score: 110
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.09
    Marker Score: 140
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.07
    Marker Score: 26

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Other Information

**Key characteristics:** - Beta-3 adrenergic receptor - Ensembl ID: ENSG00000188778 - Protein: ADRB3_HUMAN - Protein function: G protein-coupled receptor **Pathways and functions:** - Adrenoceptor signaling pathway - Desensitization of G protein-coupled receptor signaling pathway by arrestin - Regulation of systemic arterial blood pressure - Epinephrine binding - G alpha (s) signaling events - Gpcr downstream signaling - Norepinephrine-epinephrine-mediated vasodilation **Clinical significance:** - ADRB3 gene polymorphisms have been linked to obesity, insulin resistance, and metabolic syndrome. - Targeting ADRB3 signaling has been explored as a therapeutic strategy for metabolic disorders. - ADRB3 inhibitors have been shown to reduce inflammation and improve insulin sensitivity in animal models of obesity. **Other relevant information:** - ADRB3 is a member of the beta-3 adrenergic receptor family, which is a superfamily of G protein-coupled receptors that are involved in a variety of physiological and pathological processes. - The gene expression is regulated by various factors, including hormones, nutrients, and genetic variants. - ADRB3 is a key regulator of energy metabolism, inflammation, and blood pressure.

Genular Protein ID: 3092376473

Symbol: ADRB3_HUMAN

Name: Beta-3 adrenergic receptor

UniProtKB Accession Codes:

P13945 Q4JFT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 41 DrugCentral 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2570461

Title: Molecular characterization of the human beta 3-adrenergic receptor.

PubMed ID: 2570461

DOI: 10.1126/science.2570461

PubMed ID: 8389293

Title: The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.

PubMed ID: 8389293

DOI: 10.1111/j.1432-1033.1993.tb17861.x

PubMed ID: 8389717

Title: Molecular cloning of a human beta 3-adrenergic receptor cDNA.

PubMed ID: 8389717

DOI: 10.1016/0014-5793(93)81377-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1336117

Title: Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.

PubMed ID: 1336117

PubMed ID: 21982743

Title: The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

PubMed ID: 21982743

DOI: 10.1016/j.cmet.2011.08.011

PubMed ID: 7609752

Title: Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

PubMed ID: 7609752

DOI: 10.1056/nejm199508103330605

PubMed ID: 8721782

Title: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain.

PubMed ID: 8721782

DOI: 10.1007/bf00418352

PubMed ID: 8641219

Title: Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.

PubMed ID: 8641219

DOI: 10.1210/endo.137.6.8641219

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

Sequence Information:

  • Length: 408
  • Mass: 43519
  • Checksum: E98BD6C130DD977B
  • Sequence:
    • MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA TVGGNLLVIV 
AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT GHWPLGATGC ELWTSVDVLC 
VTASIETLCA LAVDRYLAVT NPLRYGALVT KRCARTAVVL VWVVSAAVSF APIMSQWWRV 
GADAEAQRCH SNPRCCAFAS NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG 
ELGRFPPEES PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT 
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP DFRSAFRRLL 
CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL DGASWGVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.