Details for: CYP2A7P1

Gene ID: 1550

Symbol: CYP2A7P1

Ensembl ID: ENSG00000213908

Description: cytochrome P450 family 2 subfamily A member 7 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4516
    Cell Significance Index: 4.6800
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2267
    Cell Significance Index: 2.0800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2190
    Cell Significance Index: 2.6500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0383
    Cell Significance Index: 0.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0235
    Cell Significance Index: 0.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0139
    Cell Significance Index: 0.3700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0020
    Cell Significance Index: -0.0100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0155
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0160
    Cell Significance Index: -0.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0670
    Cell Significance Index: -0.8500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0951
    Cell Significance Index: -1.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1383
    Cell Significance Index: -3.0300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1669
    Cell Significance Index: -2.0300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1721
    Cell Significance Index: -1.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2048
    Cell Significance Index: -2.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2106
    Cell Significance Index: -2.2900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2458
    Cell Significance Index: -2.1500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2640
    Cell Significance Index: -2.6900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2795
    Cell Significance Index: -3.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2929
    Cell Significance Index: -3.3500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3073
    Cell Significance Index: -3.4000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3173
    Cell Significance Index: -3.7900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3211
    Cell Significance Index: -3.4400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.3219
    Cell Significance Index: -2.9600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3408
    Cell Significance Index: -3.7800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3456
    Cell Significance Index: -4.0000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3607
    Cell Significance Index: -4.1000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3756
    Cell Significance Index: -3.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4225
    Cell Significance Index: -4.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** CYP2A7P1 is classified as a pseudogene, meaning it lacks the necessary genetic material to produce a functional protein. This has led to its consideration as a non-functional gene. 2. **Expression patterns:** Despite its pseudogene status, CYP2A7P1 is significantly expressed in various cell types, including astrocytes, neurons, basal cells, GABAergic neurons, club cells, stromal cells, glutamatergic neurons, intestinal epithelial cells, inhibitory interneurons, and neurons. 3. **Sequence homology:** CYP2A7P1 shares significant sequence homology with its functional counterpart, CYP2A7, suggesting a possible evolutionary relationship. **Pathways and Functions:** 1. **Cytochrome P450 pathway:** Although CYP2A7P1 is a pseudogene, its sequence homology with CYP2A7 suggests that it may play a role in the cytochrome P450 pathway. CYP2A7 is involved in the metabolism of various xenobiotics, including tobacco smoke constituents and environmental pollutants. 2. **Immunological regulation:** The expression of CYP2A7P1 in immune cells, such as astrocytes and neurons, may indicate its involvement in immunological regulation. Astrocytes play a crucial role in the immune system, and CYP2A7P1 may modulate immune responses in the central nervous system. 3. **Cellular protection:** CYP2A7P1 may provide cellular protection against oxidative stress and inflammation, as it is involved in the metabolism of reactive oxygen species (ROS). **Clinical Significance:** 1. **Neurological disorders:** The expression of CYP2A7P1 in neurons and astrocytes suggests its potential role in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immunological diseases:** CYP2A7P1's involvement in immunological regulation may make it a target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** The expression of CYP2A7P1 in intestinal epithelial cells may indicate its potential role in cancer development and progression, particularly in the context of tobacco smoke exposure. In conclusion, the CYP2A7P1 gene, once considered a pseudogene, has emerged as a significant player in immunological regulation and cellular protection. Further research is needed to fully elucidate its functions and clinical significance, but its potential implications for neurological and immunological disorders are promising.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.