Genular: Defining Cellular Identity and Function

Details for: Hsph1

Gene ID: 15505

Symbol: Hsph1

Ensembl ID: ENSMUSG00000029657

Description: heat shock 105kDa/110kDa protein 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Adenyl-nucleotide exchange factor activity
(GO:0000774)
Alpha-tubulin binding
(GO:0043014)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular region
(GO:0005576)
Microtubule
(GO:0005874)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of mhc class i biosynthetic process
(GO:0045345)
Positive regulation of nk t cell activation
(GO:0051135)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Response to unfolded protein
(GO:0006986)

Other Information

Proteins

Heat shock protein 105 kDa

Genular Protein ID: 3051443392

Symbol: HS105_MOUSE

Name: Heat shock protein 105 kDa

UniProtKB Accession Codes:

Q61699 Q3TNS2 Q3UIY8 Q62578 Q62579 Q6A0A5 Q8C430 Q8VCW6

Database IDs:

Citations:

PubMed ID: 7556594

Title: HPV16 E7 oncoprotein induces expression of a 110 kDa heat shock protein.

PubMed ID: 7556594

DOI: 10.1016/0014-5793(95)00884-c

PubMed ID: 8530361

Title: Cloning and expression of murine high molecular mass heat shock proteins, HSP105.

PubMed ID: 8530361

DOI: 10.1074/jbc.270.50.29718

PubMed ID: 10066425

Title: Genomic cloning and promoter analysis of the mouse 105-kDa heat shock protein (HSP105) gene.

PubMed ID: 10066425

DOI: 10.1006/bbrc.1999.0283

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15368895

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 15368895

DOI: 10.1093/dnares/11.3.205

PubMed ID: 9675148

Title: Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells.

PubMed ID: 9675148

DOI: 10.1006/bbrc.1998.8979

PubMed ID: 10772927

Title: Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II.

PubMed ID: 10772927

DOI: 10.1006/bbrc.2000.2541

PubMed ID: 10865058

Title: The distribution and localization of hsp110 in brain.

PubMed ID: 10865058

DOI: 10.1016/s0006-8993(00)02346-5

PubMed ID: 12558502

Title: Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function.

PubMed ID: 12558502

DOI: 10.1042/bj20021331

PubMed ID: 14644449

Title: Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP.

PubMed ID: 14644449

DOI: 10.1016/s0014-5793(03)01292-4

PubMed ID: 15292236

Title: Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity.

PubMed ID: 15292236

DOI: 10.1074/jbc.m407947200

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16232202

Title: DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells.

PubMed ID: 16232202

DOI: 10.1111/j.1349-7006.2005.00093.x

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 858
Mass: 96407
Checksum: 0576A4C2C4715032
Sequence:

MSVVGLDVGS QSCYIAVARA GGIETIANEF SDRCTPSVIS FGSKNRTIGV AAKNQQITHA 
NNTVSSFKRF HGRAFNDPFI QKEKENLSYD LVPMKNGGVG IKVMYMDEEH FFSVEQITAM 
LLTKLKETAE NNLKKPVTDC VISVPSFFTD AERRSVLDAA QIVGLNCLRL MNDMTAVALN 
YGIYKQDLPN AEEKPRVVVF VDMGHSSFQV SACAFNKGKL KVLGTAFDPF LGGKNFDEKL 
VEHFCAEFKT KYKLDAKSKI RALLRLHQEC EKLKKLMSSN STDLPLNIEC FMNDKDVSGK 
MNRSQFEELC AELLQKIEVP LHSLMAQTQL KAEDVSAIEI VGGATRIPAV KERIAKFFGK 
DVSTTLNADE AVARGCALQC AILSPAFKVR EFSVTDAVPF PISLVWNHDS EETEGVHEVF 
SRNHAAPFSK VLTFLRRGPF ELEAFYSDPQ GVPYPEAKIG RFVVQNVSAQ KDGEKSRVKV 
KVRVNTHGIF TISTASMVEK VPTEEEDGSS LEADMECPNQ RPTESSDVDK NIQQDNSEAG 
TQPQVQTDGQ QTSQSPPSPE LTSEESKTPD ADKANEKKVD QPPEAKKPKI KVVNVELPVE 
ANLVWQLGRD LLNMYIETEG KMIMQDKLEK ERNDAKNAVE ECVYEFRDKL CGPYEKFICE 
QEHEKFLRLL TETEDWLYEE GEDQAKQAYI DKLEELMKMG TPVKVRFQEA EERPKVLEEL 
GQRLQHYAKI AADFRGKDEK YNHIDESEMK KVEKSVNEVM EWMNNVMNAQ AKRSLDQDPV 
VRTHEIRAKV KELNNVCEPV VTQPKPKIES PKLERTPNGP NIDKKEDLEG KNNLGAEAPH 
QNGECHPNEK GSVNMDLD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hsph1

Associated with

Other Information

HPV16 E7 oncoprotein induces expression of a 110 kDa heat shock protein. PubMed ID: 7556594

Cloning and expression of murine high molecular mass heat shock proteins, HSP105. PubMed ID: 8530361

Genomic cloning and promoter analysis of the mouse 105-kDa heat shock protein (HSP105) gene. PubMed ID: 10066425

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 15368895

Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. PubMed ID: 9675148

Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II. PubMed ID: 10772927

The distribution and localization of hsp110 in brain. PubMed ID: 10865058

Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. PubMed ID: 12558502

Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP. PubMed ID: 14644449

Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity. PubMed ID: 15292236

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells. PubMed ID: 16232202

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337