Genular: Defining Cellular Identity and Function

Details for: Hspb1

Gene ID: 15507

Symbol: Hspb1

Ensembl ID: ENSMUSG00000004951

Description: heat shock protein 1

Associated with

Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of rna
(R-MMU-8953854)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Anterograde axonal protein transport
(GO:0099641)
Axon
(GO:0030424)
Cardiac myofibril
(GO:0097512)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Chaperone-mediated protein folding
(GO:0061077)
Contractile fiber
(GO:0043292)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Dendrite
(GO:0030425)
I band
(GO:0031674)
Identical protein binding
(GO:0042802)
Intracellular anatomical structure
(GO:0005622)
Intracellular signal transduction
(GO:0035556)
M band
(GO:0031430)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of cellular response to oxidative stress
(GO:1900408)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of regulatory t cell differentiation
(GO:0045590)
Nucleus
(GO:0005634)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of endothelial cell chemotaxis
(GO:2001028)
Positive regulation of endothelial cell chemotaxis by vegf-activated vascular endothelial growth factor receptor signaling pathway
(GO:0038033)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Postsynaptic density membrane
(GO:0098839)
Proteasome complex
(GO:0000502)
Protein folding chaperone
(GO:0044183)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Protein kinase c inhibitor activity
(GO:0008426)
Protein refolding
(GO:0042026)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of protein phosphorylation
(GO:0001932)
Response to heat
(GO:0009408)
Response to unfolded protein
(GO:0006986)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Ubiquitin binding
(GO:0043130)
Unfolded protein binding
(GO:0051082)
Z disc
(GO:0030018)

Other Information

Proteins

Heat shock protein beta-1

Genular Protein ID: 3091763303

Symbol: HSPB1_MOUSE

Name: Heat shock protein beta-1

UniProtKB Accession Codes:

P14602

Database IDs:

Citations:

PubMed ID: 8514194

Title: Structure and organisation of a murine gene encoding small heat-shock protein Hsp25.

PubMed ID: 8514194

DOI: 10.1016/0378-1119(93)90575-n

PubMed ID: 8514193

Title: Cloning of the mouse hsp25 gene and an extremely conserved hsp25 pseudogene.

PubMed ID: 8514193

DOI: 10.1016/0378-1119(93)90574-m

PubMed ID: 2645135

Title: Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins.

PubMed ID: 2645135

DOI: 10.1111/j.1432-1033.1989.tb14542.x

PubMed ID: 8132504

Title: Differential estrogenic regulation of small M(r) heat shock protein expression in osteoblasts.

PubMed ID: 8132504

DOI: 10.1016/s0021-9258(17)37131-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1860870

Title: Identification of the phosphorylation sites of the murine small heat shock protein hsp25.

PubMed ID: 1860870

DOI: 10.1016/s0021-9258(18)98746-6

PubMed ID: 1332886

Title: Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.

PubMed ID: 1332886

DOI: 10.1016/0014-5793(92)81216-9

PubMed ID: 8093612

Title: Small heat shock proteins are molecular chaperones.

PubMed ID: 8093612

DOI: 10.1016/s0021-9258(18)53882-5

PubMed ID: 10751411

Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.

PubMed ID: 10751411

DOI: 10.1074/jbc.m001981200

PubMed ID: 11342557

Title: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).

PubMed ID: 11342557

DOI: 10.1074/jbc.m103001200

PubMed ID: 11546764

Title: Identification and characterization of hic-5/ARA55 as an hsp27 binding protein.

PubMed ID: 11546764

DOI: 10.1074/jbc.m103510200

PubMed ID: 17661394

Title: Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.

PubMed ID: 17661394

DOI: 10.1002/dvg.20319

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21575178

Title: Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation.

PubMed ID: 21575178

DOI: 10.1186/1750-2187-6-4

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 209
Mass: 23014
Checksum: 31BD9FAF4E107C50
Sequence:

MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA GWPGYVRPLP 
AATAEGPAAV TLAAPAFSRA LNRQLSSGVS EIRQTADRWR VSLDVNHFAP EELTVKTKEG 
VVEITGKHEE RQDEHGYISR CFTRKYTLPP GVDPTLVSSS LSPEGTLTVE APLPKAVTQS 
AEITIPVTFE ARAQIGGPEA GKSEQSGAK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hspb1

Associated with

Other Information

Structure and organisation of a murine gene encoding small heat-shock protein Hsp25. PubMed ID: 8514194

Cloning of the mouse hsp25 gene and an extremely conserved hsp25 pseudogene. PubMed ID: 8514193

Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. PubMed ID: 2645135

Differential estrogenic regulation of small M(r) heat shock protein expression in osteoblasts. PubMed ID: 8132504

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the phosphorylation sites of the murine small heat shock protein hsp25. PubMed ID: 1860870

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. PubMed ID: 1332886

Small heat shock proteins are molecular chaperones. PubMed ID: 8093612

Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27. PubMed ID: 10751411

HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27). PubMed ID: 11342557

Identification and characterization of hic-5/ARA55 as an hsp27 binding protein. PubMed ID: 11546764

Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. PubMed ID: 17661394

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation. PubMed ID: 21575178

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315